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1. 发明授权

US06703387B2 Inhibitors of HPV E1 helicase enzyme 失效
标题翻译： HPV E1解酶酶抑制剂
公开(公告)号：US06703387B2
公开(公告)日：2004-03-09
申请号：US09892148
申请日：2001-06-26
申请人： David N. Hurst , Philip Stephen Jones , Kevin Edward Burdon Parkes , Martin John Parratt , Francis Xavier Wilson
发明人： David N. Hurst , Philip Stephen Jones , Kevin Edward Burdon Parkes , Martin John Parratt , Francis Xavier Wilson
IPC分类号： A61K315513
CPC分类号： C07D401/06 , C07D243/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04
摘要： The invention is concerned with novel benzodiazepine derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are inhibitors of the human papillomavirus E1 helicase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HPV mediated diseases.
摘要翻译：本发明涉及新型苯二氮卓衍生物，其制备方法，药物组合物和这些化合物在医药中的用途。特别地，这些化合物是涉及病毒复制的人乳头瘤病毒E1解旋酶的抑制剂。因此，本发明的化合物可有利地用作HPV介导的疾病的治疗剂。

2. 发明授权

US06335330B1 Crystalline pharmaceutical product 失效
标题翻译：结晶药品
公开(公告)号：US06335330B1
公开(公告)日：2002-01-01
申请号：US09254305
申请日：1999-03-03
申请人： Stephen Torey Ross
发明人： Stephen Torey Ross
IPC分类号： A61K315513
CPC分类号： C07D401/14
摘要： This invention provides (S)-7-[(4,4′-bipiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid, hydrochloride, processes for its preparation and methods for its use.
摘要翻译：本发明提供（S）-7 - [（4,4'-联哌啶-1-基）羰基] -2,3,4,5-四氢-4-甲基-3-氧代-1H-1,4-苯并二氮杂 -2-乙酸盐酸盐，其制备方法及其使用方法

3. 发明授权

US06339083B1 Multiheterocyclic pharmAceuticals 失效
标题翻译：多杂环药物治疗
公开(公告)号：US06339083B1
公开(公告)日：2002-01-15
申请号：US09211274
申请日：1998-12-14
申请人： Klaus Urbahns , Delf Schmidt , Ulf Brueggemeier , Christoph Gerdes , Beatrix Stelte-Ludwig , Jörg Keldenich , Elke Stahl
发明人： Klaus Urbahns , Delf Schmidt , Ulf Brueggemeier , Christoph Gerdes , Beatrix Stelte-Ludwig , Jörg Keldenich , Elke Stahl
IPC分类号： A61K315513
CPC分类号： C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of the general formula (I): and their preparation and use for the production of pharmaceuticals, and pharmaceuticals comprising these compounds.
摘要翻译：本发明涉及通式（I）的化合物及其药物制备和用途以及包含这些化合物的药物。

4. 发明授权

US06291452B1 1,4-benzodiazepinones and their uses as CCK antagonists 失效
标题翻译： 1,4-苯并二氮杂酮及其用作CCK拮抗剂
公开(公告)号：US06291452B1
公开(公告)日：2001-09-18
申请号：US09269752
申请日：1999-04-30
申请人： Yoshinari Sato , Seiichiro Tabuchi , Hitoshi Mitsui , Ikuyo Katsumi , Naoko Yamamoto
发明人： Yoshinari Sato , Seiichiro Tabuchi , Hitoshi Mitsui , Ikuyo Katsumi , Naoko Yamamoto
IPC分类号： A61K315513
CPC分类号： C07K5/0821 , A61K38/00 , C07D243/14 , C07D243/18 , C07K5/0205 , C07K5/06139
摘要： Benzodiazepine derivatives of the formula: wherein R2 is alkyl or cycloalkyl-alkyl when R4 is hydrogen, or R2 is a variety of specified groups when R4 is alkyl, halogen or dialkylamino, are useful as cholecystokinin antagonists.
摘要翻译：下式的苯并二氮杂衍生物：当R 4为氢时，R 2为烷基或环烷基 - 烷基，或者当R 4为烷基，卤素或二烷基氨基时，R 2为多种规定基团，可用作缩胆囊素拮抗剂。

5. 再颁专利

USRE38332E1 Selected soluble esters of hydroxyl-containing indolocarbazoles 有权
标题翻译：选择的含羟基的吲哚并唑的可溶性酯
公开(公告)号：USRE38332E1
公开(公告)日：2003-11-25
申请号：US09811725
申请日：2001-03-19
申请人： John P. Mallamo , Robert L. Hudkins
发明人： John P. Mallamo , Robert L. Hudkins
IPC分类号： A61K315513
CPC分类号： C07D498/22 , C07H9/06 , C07H19/044
摘要： Esters of hydroxyl-containing indolocarbazoles and acids containing selected solubilizing groups are provided. Compositions including the indolocarbazole esters and methods for the use of the indolocarbazole esters are also provided.

6. 发明授权

US06649607B2 Compositions and methods for treating or preventing convulsions or seizures 有权
公开(公告)号：US06649607B2
公开(公告)日：2003-11-18
申请号：US10008516
申请日：2001-11-08
申请人： Steven M. Leventer , Robert Kucharik
发明人： Steven M. Leventer , Robert Kucharik
IPC分类号： A61K315513
CPC分类号： A61K31/551 , A61K31/5513 , A61K2300/00
摘要： The present invention relates to compositions comprising S-tofisopam substantially free of R-tofisopam, and methods for treating or preventing convulsions and/or seizures comprising administration of the composition to subjects in need of treatment therefor. Also provided are compositions and methods for treating or preventing convulsions and/or seizures comprising administering S-tofisopam substantially free of R-tofisopam with another anti-convulsant.

7. 发明授权

US06433167B1 Triazolo-1,4-diazepine compounds and medicinal composition containing the same 失效
标题翻译：三唑并-1,4-二氮杂化合物及含有它们的药物组合物
公开(公告)号：US06433167B1
公开(公告)日：2002-08-13
申请号：US09446736
申请日：1999-12-23
申请人： Masakazu Fujita , Taketsugu Seki , Haruaki Inada , Tetsuro Sano
发明人： Masakazu Fujita , Taketsugu Seki , Haruaki Inada , Tetsuro Sano
IPC分类号： A61K315513
CPC分类号： C07D495/22
摘要： A triazolo-1,4-diazepine compound having the formula (I): wherein A represents CO, CO—B, or B, B represents a C1 to C6 alkylene group or a C2 to C6 alkylene group having an oxygen atom interposed in the middle thereof, X represents N—O or CH, n represents an integer of 2 to 6, R represents a hydroxyl group, a C1 to C6 lower alkyloxy group or a C1 to C6 lower alkylamino group, provided that these groups may be substituted with an N,N-dimethylamino group, an N,N-diethylamino group, a phenyl group, or a heterocyclic group, and R1 represents a hydrogen atom or a C1 to C3 lower alkyl group having both a PAF antagonistic action and a thromboxane synthesis inhibiting action, and a pharmaceutical composition containing the same as an active ingredient.
摘要翻译：具有式（I）的三唑并[1,4-diazepine]化合物：其中A表示CO，CO-B或B，B表示C1〜C6亚烷基或碳原子上具有氧原子的C2〜C6亚烷基中间，X表示NO或CH，n表示2〜6的整数，R表示羟基，C1〜C6低级烷氧基或C1〜C6低级烷基氨基，条件是这些基团可以被N ，N-二甲基氨基，N，N-二乙基氨基，苯基或杂环基，R 1表示氢原子或具有PAF拮抗作用和血栓烷烷合成抑制作用的C1〜C3低级烷基，以及含有活性成分的药物组合物。

8. 发明授权

US06232308B1 Bezazepine derivatives as &agr;v integrin receptor antagonists 失效
标题翻译：贝沙西平衍生物作为alphav整合素受体拮抗剂
公开(公告)号：US06232308B1
公开(公告)日：2001-05-15
申请号：US09496525
申请日：2000-02-02
申请人： Ben C. Askew
发明人： Ben C. Askew
IPC分类号： A61K315513
CPC分类号： C07D491/04
摘要： The present invention relates to benzazepine derivatives and their use as &agr;v integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors &agr;v&bgr;3, &agr;v&bgr;5, and/or &agr;v&bgr;6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
摘要翻译：本发明涉及苯并氮杂衍生物及其作为alphav整联蛋白受体拮抗剂的用途。更具体地说，本发明的化合物是整联蛋白受体alphavbeta3，alphavbeta5和/或alphavbeta6的拮抗剂，可用于抑制骨吸收，治疗和预防骨质疏松，抑制血管再狭窄，糖尿病性视网膜病变，黄斑变性，血管生成，动脉粥样硬化，炎症，伤口愈合，病毒性疾病，肿瘤生长和转移。

9. 发明授权

US06214822B1 Substituted aza and diazacycloheptane and cyclooctane compounds and their use 失效
标题翻译：取代的氮杂和二氮杂环庚烷和环辛烷化合物及其用途
公开(公告)号：US06214822B1
公开(公告)日：2001-04-10
申请号：US09101265
申请日：1998-07-06
申请人： Hans-Jörg Treiber , Stefan Blank , Dorothea Starck , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke
发明人： Hans-Jörg Treiber , Stefan Blank , Dorothea Starck , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke
IPC分类号： A61K315513
CPC分类号： C07D403/04 , C07D403/12 , C07D403/14 , C07D417/14
摘要： Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar1—A—B—Ar2 (I) where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
摘要翻译：下式的氮杂 - 和二氮杂环己烷和 - 环辛烷化合物：其中Ar1，A，B和Ar2具有说明书中所述的含义，对多巴胺D3受体具有高亲和力，因此可用于治疗对多巴胺D3 配体。

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