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1. 发明授权

US06291452B1 1,4-benzodiazepinones and their uses as CCK antagonists 失效
标题翻译： 1,4-苯并二氮杂酮及其用作CCK拮抗剂
公开(公告)号：US06291452B1
公开(公告)日：2001-09-18
申请号：US09269752
申请日：1999-04-30
申请人： Yoshinari Sato , Seiichiro Tabuchi , Hitoshi Mitsui , Ikuyo Katsumi , Naoko Yamamoto
发明人： Yoshinari Sato , Seiichiro Tabuchi , Hitoshi Mitsui , Ikuyo Katsumi , Naoko Yamamoto
IPC分类号： A61K315513
CPC分类号： C07K5/0821 , A61K38/00 , C07D243/14 , C07D243/18 , C07K5/0205 , C07K5/06139
摘要： Benzodiazepine derivatives of the formula: wherein R2 is alkyl or cycloalkyl-alkyl when R4 is hydrogen, or R2 is a variety of specified groups when R4 is alkyl, halogen or dialkylamino, are useful as cholecystokinin antagonists.
摘要翻译：下式的苯并二氮杂衍生物：当R 4为氢时，R 2为烷基或环烷基 - 烷基，或者当R 4为烷基，卤素或二烷基氨基时，R 2为多种规定基团，可用作缩胆囊素拮抗剂。

2. 发明授权

US5763437A Benzodiazepine derivatives 失效
标题翻译：苯并二氮杂衍生物
公开(公告)号：US5763437A
公开(公告)日：1998-06-09
申请号：US776196
申请日：1997-01-29
申请人： Yoshinari Sato , Kazuo Sakane , Seiichiro Tabuchi , Hitoshi Mitsui , Ikuyo Katsumi , Yuichi Satoh
发明人： Yoshinari Sato , Kazuo Sakane , Seiichiro Tabuchi , Hitoshi Mitsui , Ikuyo Katsumi , Yuichi Satoh
IPC分类号： C07D243/14 , A61K31/55 , A61K31/551 , A61P1/00 , A61P25/04 , A61P25/18 , C07D243/24 , C07D243/26 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D487/08
CPC分类号： C07D243/24
摘要： Benzodiazepine derivatives of formula (I) wherein R.sup.1 is aryl which may have one or more suitable substituent(s), R.sup.2 is C.sub.3 -C.sub.8 cycloalkyl which may have one or more suitable substituent(s), A is lower alkylene, R.sup.3 is a heterocyclic group selected from the group consisting of tetrahydrofuryl, dioxolanyl, filryl, thienyl, isoxazolyl, pyridyl, benzimidazolyl, benzotiazolyl, benzoxazolyl, benzopyrany, quinolyl, isoquinolyl, tetrahydroisoquinolyl, benzothienyl and benzofuryl, each of which may have one or more suitable substituent(s), or a pharmaceutically acceptable salt thereof, which are useful as a medicament.
摘要翻译： PCT No.PCT / JP95 / 01497 Sec。 371日期1997年1月29日 102（e）1997年1月29日PCT PCT 1995年7月27日PCT公布。公开号WO96 / 04254 日期：1996年2月15日，式（I）的苯并二氮杂衍生物，其中R 1为可具有一个或多个合适取代基的芳基，R 2为可具有一个或多个合适取代基的C 3 -C 8环烷基，A为低级亚烷基 R3是选自四氢呋喃基，二氧戊环基，二烯丙基，噻吩基，异恶唑基，吡啶基，苯并咪唑基，苯并噻唑基，苯并恶唑基，苯并吡喃基，喹啉基，异喹啉基，四氢异喹啉基，苯并噻吩基和苯并呋喃基的杂环基，其各自可以具有一个或多个合适的取代基或其药学上可接受的盐，其可用作药物。

3. 发明授权

US4618610A Triazine derivatives, and pharmaceutical compositions comprising the same 失效
标题翻译：三嗪衍生物和包含其的药物组合物
公开(公告)号：US4618610A
公开(公告)日：1986-10-21
申请号：US603173
申请日：1984-04-23
申请人： Tsutomu Teraji , Youichi Shiokawa , Kazuo Okumura , Yoshinari Sato
发明人： Tsutomu Teraji , Youichi Shiokawa , Kazuo Okumura , Yoshinari Sato
IPC分类号： A61K31/53 , A61P1/04 , A61P7/02 , A61P9/12 , C07D253/06
CPC分类号： C07D253/06
摘要： New triazine derivatives represented by the formula: ##STR1## wherein R.sup.1 is hydrogen or halogen;R.sup.2 is a hydroxy, protected hydroxy, amino, cyano, mercapto, lower alkylthio, arylthio, sulfamoyl, lower alkylsulfonylamino, lower alkylureido, arylureido, lower alkyl-thioureido, aryl-thioureido, lower alkenoylamino, lower alkoxycarbonylamino, lower alkoxy(thiocarbonyl)thio, or cyclic or acyclic alkanoylamino in which the cyclic and acyclic alkanoylamino group may have a substituent selected from lower alkoxy, aryl, hydroxyaryl and protected hydroxyaryl; andX is O or S;and pharmaceutically acceptable salt thereof, which are useful in the treatment of hypertension, thrombosis and ulcer in human beings and animals.
摘要翻译：由下式表示的新的三嗪衍生物：其中R 1是氢或卤素; R2是羟基，保护的羟基，氨基，氰基，巯基，低级烷硫基，芳硫基，氨磺酰基，低级烷基磺酰基氨基，低级烷基脲基，芳基脲基，低级烷基 - 硫脲基，芳基 - 硫脲基，低级烯酰基氨基，低级烷氧基羰基氨基，低级烷氧基（硫代羰基）或环状或无环烷酰氨基，其中环状和非环状烷酰基氨基可以具有选自低级烷氧基，芳基，羟基芳基和被保护的羟基芳基的取代基; X为O或S; 和其药学上可接受的盐，其可用于治疗人和动物中的高血压，血栓形成和溃疡。

4. 发明授权

US4525478A Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties 失效
标题翻译：某些具有血管舒张和抗高血压特性的4-芳基-1,4-二氢-3,5-吡啶二羧酸酯
公开(公告)号：US4525478A
公开(公告)日：1985-06-25
申请号：US414842
申请日：1982-09-03
申请人： Yoshinari Sato
发明人： Yoshinari Sato
IPC分类号： C07C205/56 , C07D211/90 , C07D213/55 , C07D307/54 , C07D333/24 , C07D401/04 , C07D405/04 , C07D405/06 , C07D409/04 , C07D471/04 , A61K31/455
CPC分类号： C07D401/04 , C07C205/56 , C07D211/90 , C07D213/55 , C07D307/54 , C07D333/24 , C07D405/04 , C07D405/06 , C07D409/04 , C07D471/04
摘要： 1,4-Dihydropyridine derivatives of the general formula ##STR1## having vasodilating and anti-hypertensive activity, processes for preparing same, and pharmaceutical compositions thereof for treating cardiovascular diseases.
摘要翻译：具有血管扩张和抗高血压活性的通式“IMAGE”的1,4-二氢吡啶衍生物，其制备方法及其用于治疗心血管疾病的药物组合物。

5. 发明授权

US5322842A Tricyclic benzodiazepine derivates, their preparation, and pharmaceutical compositions containing them 失效
标题翻译：三环苯并二氮杂衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5322842A
公开(公告)日：1994-06-21
申请号：US971830
申请日：1993-02-19
申请人： Yoshinari Sato , Teruaki Matuo , Takatomo Ogahara
发明人： Yoshinari Sato , Teruaki Matuo , Takatomo Ogahara
IPC分类号： A61K31/55 , A61P1/00 , A61P1/08 , A61P1/16 , C07D487/06 , C07D487/04
CPC分类号： C07D487/06
摘要： Tricyclic compounds of the formula: ##STR1## wherein R.sup.1 1 is hydrogen or an organic group,R.sup.2 is aryl which may have suitable substituent(s),R.sup.3 is hydrogen or an acyl group andA is lower alkylene,and pharmaceutically acceptable salts thereof which are useful as a medicament.
摘要翻译： PCT No.PCT / JP91 / 01112 Sec。 371日期：1993年2月19日 102（e）日期1993年2月19日PCT 1991年8月22日PCT公布。公开号WO92 / 03438 日本3月5日，1992年。下式的三环化合物：其中R 1为氢或有机基团，R 2为可具有合适取代基的芳基，R 3为氢或酰基，A为低级亚烷基及其药学上可接受的盐，其可用作药物。

6. 发明授权

US5110729A Method of producing peptides using baculovirus vectors in cultured cells 失效
标题翻译：在培养细胞中使用细菌病毒载体生产肽的方法
公开(公告)号：US5110729A
公开(公告)日：1992-05-05
申请号：US641795
申请日：1991-01-16
申请人： Susumu Maeda , Mitsuru Furusawa , Yasumasa Marumoto , Tadashi Horiuchi , Yoshinari Sato , Yoshiyuki Saeki
发明人： Susumu Maeda , Mitsuru Furusawa , Yasumasa Marumoto , Tadashi Horiuchi , Yoshinari Sato , Yoshiyuki Saeki
IPC分类号： C12N15/09 , C07K14/01 , C07K14/56 , C07K14/65 , C12N7/00 , C12N7/02 , C12N7/04 , C12N15/00 , C12N15/62 , C12N15/866 , C12P21/00 , C12P21/02 , C12R1/91
CPC分类号： C12N15/86 , C07K14/005 , C07K14/56 , C07K14/65 , C07K2319/00 , C07K2319/09 , C07K2319/735 , C07K2319/75 , C12N2710/14122 , C12N2710/14143
摘要： Recombinant Bombyx mori nuclear polyhedrosis viruses having, in the polyhedral protein-encoding structural gene portion of the Bombyx mori nuclear polyhedrosis virus DNA (BmNPV DNA), a structural gene for a desired protein as joined to the whole of or a part of the polyhedral protein-encoding structural gene with or without interposition of a linker base sequence are provided.By propagating the above viruses in silkworm-derived cells or silkworms, fused proteins of a desired protein and the whole of or a part of the polyhedral protein as joined together with or without interposition of a linking amino acid or peptide are produced. The desired proteins can be obtained from the fused proteins by cleavage or decomposition at the linking site.
摘要翻译：在家蚕核型多角体病毒DNA（BmNPV DNA）的多面体蛋白质编码结构基因部分中具有与多面体蛋白质全部或部分连接的所需蛋白质的结构基因的重组家蚕核型多角体病毒提供了具有或没有插入连接体碱基序列的编码结构基因。通过在蚕衍生的细胞或家蚕中繁殖上述病毒，产生所需蛋白质的融合蛋白质和多面体蛋白质的全部或部分结合在一起或不插入连接氨基酸或肽。可以通过在连接位点的切割或分解从融合的蛋白质获得所需的蛋白质。

7. 发明授权

US4307103A Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same 失效
标题翻译：二氢吡啶衍生物，其制备方法和包含其的药物组合物
公开(公告)号：US4307103A
公开(公告)日：1981-12-22
申请号：US70098
申请日：1979-08-27
申请人： Yoshinari Sato , Tsutomu Teraji
发明人： Yoshinari Sato , Tsutomu Teraji
IPC分类号： A61K31/4427 , A61K31/455 , A61P9/08 , A61P9/10 , A61P9/12 , C07D211/90 , C07D401/12 , A61K31/44 , C07D213/55 , C07D213/57
CPC分类号： C07D401/12 , C07C323/00 , C07D211/90
摘要： This invention relates to a dihydropyridine derivative and a salt thereof. More particularly, it relates to a new dihydropyridine derivative and a pharmaceutically acceptable salt thereof which have vasodilating and anti-hypertensive activities, to processes for the preparation thereof, and to pharmaceutical composition comprising the same for therapeutical treatment of cardiovascular disorder and hypertension in human being.
摘要翻译：本发明涉及二氢吡啶衍生物及其盐。更具体地说，本发明涉及一种具有血管扩张和抗高血压活性的新的二氢吡啶衍生物及其药学上可接受的盐，其制备方法以及包含其的药物组合物用于人类心血管疾病和高血压的治疗治疗。

8. 发明授权

US4105781A Chromone compounds and preparation thereof 失效
标题翻译：色酮化合物及其制备方法
公开(公告)号：US4105781A
公开(公告)日：1978-08-08
申请号：US788735
申请日：1977-04-19
申请人： Suminori Umio , Shizuo Maeno , Ikuo Ueda , Yoshinari Sato , Masaaki Matsuo
发明人： Suminori Umio , Shizuo Maeno , Ikuo Ueda , Yoshinari Sato , Masaaki Matsuo
IPC分类号： C07D407/12 , C07D407/14 , A61K31/34
CPC分类号： C07D407/12 , Y02P20/55
摘要： Chromone compounds having the structure ##STR1## wherein R is aryl, substituted aryl, thienyl, furyl or pyridyl, Y is hydroxy (lower) alkylene, R.sub.1 is hydrogen, lower alkyl, aryl, substituted aryl or a heterocyclic group, R.sub.2 is hydrogen or lower alkoxy, Y.sub.1 is lower alkylene or hydroxyl (lower) alkylene, Z is oxygen or sulfur and R.sub.3 is hydrogen, lower alkyl, aryl, substituted aryl, or ar (lower) alkyl have anti-allergic activity and are useful in the treatment of asthma. Compounds of the structure [I] are prepared by reacting ##STR2## wherein Y' is hydroxy (lower) alkylene whose hydroxy group is optimally protected or a reactive derivative of [II] with a carboxylic acid of the formula R--COOH in the presence of a basic catalyst. The resulting compound is then reacted with an acid. Compounds of the structure [I'] are prepared by reacting the compound ##STR3## with the compound X--Y.sub.1 '--Z--R.sub.3 ' wherein X is an acid residue, Y' is lower alkylene or hydroxy (lower) alkylene whose hydroxy group is optionally protected by a protective group, R.sub.3 ' is hydrogen, lower alkyl, aryl, substituted aryl, or ar (lower) alkyl and Z is as defined above. When R.sub.3 ' is hydrogen, --Z--R.sub.3 ' is optionally protected by a protective group. The resultant compound is subjected to an elimination reaction when Y' is a protected group or when --Z--R.sub.3 ' is protected to split off the protective group.
摘要翻译：具有结构（I）或者其中R是芳基，取代的芳基，噻吩基，呋喃基或吡啶基的结构的色酮化合物，Y是羟基（低级）亚烷基，R 1是氢，低级烷基，芳基，取代的芳基或杂环基，R2是氢或低级烷氧基，Y1是低级亚烷基或羟基（低级）亚烷基，Z是氧或硫，R3是氢，低级烷基，芳基，取代芳基或芳（低级）抗过敏活性，可用于治疗哮喘。结构[I]的化合物通过其中Y'是羟基被最佳保护的羟基（低级）亚烷基或其[II]的反应性衍生物与式R-COOH的羧酸反应制备在碱性催化剂的存在下。然后将所得化合物与酸反应。通过使化合物＆lt; IMAGE＆gt;与化合物X-Y1'-Z-R3'反应其中X是酸残基，Y'是低级亚烷基或羟基（低级）亚烷基其羟基任选被保护基保护，R 3'是氢，低级烷基，芳基，取代的芳基或芳（低级）烷基，Z如上所定义。当R3'为氢时，-Z-R3'任选被保护基保护。当Y'为受保护基团时或当-Z-R3'被保护以分离保护基团时，所得化合物进行消除反应。

9. 发明授权

US4049664A Chromone compounds 失效
标题翻译：色酮化合物
公开(公告)号：US4049664A
公开(公告)日：1977-09-20
申请号：US679140
申请日：1976-04-22
申请人： Suminori Umio , Shizuo Maeno , Ikuo Ueda , Yoshinari Sato , Masaaki Matsuo
发明人： Suminori Umio , Shizuo Maeno , Ikuo Ueda , Yoshinari Sato , Masaaki Matsuo
IPC分类号： C07D407/12 , C07D311/22
CPC分类号： C07D407/12 , Y02P20/55 , Y10S514/826
摘要： Chromone compounds having the structure ##STR1## wherein R is aryl, substituted aryl, thienyl, furyl or pyridyl, Y is hydroxy (lower) alkylene, R.sub.1 is hydrogen, lower alkyl, aryl, substituted aryl or a heterocyclic group, R.sub.2 is hydrogen or lower alkoxy, Y.sub.1 is lower alkylene or hydroxyl (lower) alkylene, Z is oxygen or sulfur and R.sub.3 is hydrogen, lower alkyl, aryl, substituted aryl, or ar(lower)alkyl have anti-allergic activity and are useful in the treatment of asthma. Compounds of the structure [I] are prepared by reacting ##STR2## wherein Y' is hydroxy (lower) alkylene whose hydroxy group is optimally protected or a reactive derivative of [II] with a carboxylic acid of the formula R--COOH in the presence of a basic catalyst. The resulting compound is then reacted with an acid. Compounds of the structure [I] are prepared by reacting the compound ##STR3## with the compound X--Y.sub.1 '--Z--R.sub.3 ' wherein X is an acid residue, Y' is lower alkylene or hydroxy (lower) alkylene whose hydroxy group is optionally protected by a protective group, R.sub.3 ' is hydrogen, lower alkyl, aryl, substituted aryl, or ar(lower)alkyl and Z is defined above. When R.sub.3 ' is hydrogen, --Z--R.sub.3 ' is optionally protected by a protective group. The resultant compound is subjected to an elimination reaction when Y' is a protected group or when --Z--R.sub.3 ' is protected to split off the protective group.
摘要翻译：具有结构（I）的色酮化合物其中R是芳基，取代的芳基，噻吩基，呋喃基或吡啶基，Y是羟基（低级）亚烷基，R1是氢，低级烷基，芳基，取代的芳基或杂环基，R2是氢或低级烷氧基，Y1是低级亚烷基或羟基（低级）亚烷基，Z是氧或硫，R3是氢，低级烷基，芳基，取代芳基或芳（低级）烷基具有抗 - 过敏活性，可用于治疗哮喘。结构[I]的化合物通过使（II）其中Y'是羟基被最佳保护的羟基（低级）亚烷基或[II]的反应性衍生物与式R-COOH的羧酸反应制备在碱性催化剂的存在下。然后将所得化合物与酸反应。结构[I]化合物通过使化合物（Ⅳ）与化合物X-Y1'-Z-R3'反应而制备，其中X为酸残基，Y'为低级亚烷基或羟基（低级）亚烷基羟基任选被保护基保护，R 3'是氢，低级烷基，芳基，取代的芳基或芳（低级）烷基，Z如上所定义。当R3'为氢时，-Z-R3'任选被保护基保护。当Y'为受保护基团时或当-Z-R3'被保护以分离保护基团时，所得化合物进行消除反应。

10. 发明授权

US5264433A Benzodiazepine derivatives 失效
标题翻译：苯并二氮杂衍生物
公开(公告)号：US5264433A
公开(公告)日：1993-11-23
申请号：US815041
申请日：1991-12-31
申请人： Yoshinari Sato , Teruaki Matuo
发明人： Yoshinari Sato , Teruaki Matuo
IPC分类号： A61K38/00 , C07K5/078 , C07K5/097 , A61K31/55 , C07D243/14
CPC分类号： C07K5/06139 , C07K5/0821 , A61K38/00 , Y02P20/55
摘要： A compound of the formula ##STR1## the process for its preparation and intermediate thereof. The compound is useful as a cholecystokinin antagonist.
摘要翻译：化学式为“IMAGE”的化合物及其制备方法及其中间体。该化合物可用作缩胆囊素拮抗剂。

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