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1. 发明授权

US06562364B2 Desmethylselegiline enantiomers and their use to treat drug withdrawal symptoms 失效
标题翻译：去甲司来吉兰对映异构体及其用于治疗药物戒断症状的用途
公开(公告)号：US06562364B2
公开(公告)日：2003-05-13
申请号：US09805281
申请日：2001-03-13
申请人： Anthony R. DiSanto , Cheryl D. Blume
发明人： Anthony R. DiSanto , Cheryl D. Blume
IPC分类号： A61F614
CPC分类号： A61K31/137 , G06F13/4022 , G06F15/173
摘要： The application is directed to the treatment of one or more symptoms associated with drug withdrawal by administering desmethylselegiline.
摘要翻译：本申请旨在通过施用去甲司来吉兰治疗与药物戒断相关的一种或多种症状。

2. 发明授权

US06436428B1 Device and method for treating urinary incontinence in females 有权
标题翻译：用于治疗女性尿失禁的装置和方法
公开(公告)号：US06436428B1
公开(公告)日：2002-08-20
申请号：US09531856
申请日：2000-03-21
申请人： Anu Mahashabde , Martha Francine Kay , Donald F. Koelmel
发明人： Anu Mahashabde , Martha Francine Kay , Donald F. Koelmel
IPC分类号： A61F614
CPC分类号： A61K9/0036 , A61K31/216
摘要： Provided herein is a novel and useful device and method for locally delivering and controllably releasing oxybutynin in the cervical region of a female. A device of the invention comprises a ring comprising trifluoropropylmethyl/dimethyl siloxane elastomer. A pharmaceutical composition comprising oxybutynin and an excipient is placed within a bore located in the ring, wherein the bore runs from the surface of the ring into the ring. The ring has a sufficient size such that it can be inserted into the vaginal canal of a female. A cap comprising is placed over the bore at the surface of the ring in order to contain the pharmaceutical composition within the bore. When the ring is inserted into the vaginal canal, the trifluoropropylmethyl/dimethyl siloxane elastomer controllably releases and locally delivers a therapeutically effective amount of oxybutynin to the detrusor muscle to treat the female's urinary incontinence.
摘要翻译：本文提供了一种用于局部递送和可控地释放女性颈部区域中的奥昔布宁的新颖且有用的装置和方法。本发明的装置包括含有三氟丙基甲基/二甲基硅氧烷弹性体的环。包含奥昔布宁和赋形剂的药物组合物放置在位于环中的孔中，其中孔从环的表面延伸到环中。环具有足够的尺寸，使得其可以插入到女性的阴道管中。将包括的盖子放置在环的表面上的孔上，以将药物组合物包含在孔内。当环插入阴道内时，三氟丙基甲基/二甲基硅氧烷弹性体可控地释放并局部地将治疗有效量的奥昔布宁输送到逼尿肌以治疗女性的尿失禁。

3. 发明授权

US06264973B1 Apparatus and method for anesthetizing the cervical region of a female 有权
标题翻译：用于麻醉女性颈部区域的装置和方法
公开(公告)号：US06264973B1
公开(公告)日：2001-07-24
申请号：US09383887
申请日：1999-08-26
申请人： Anu Mahashabde , Martha Francine Kay , Louis J. Mestichelli , Ann Elizabeth Gooding , Suzanne Wilford Ruth
发明人： Anu Mahashabde , Martha Francine Kay , Louis J. Mestichelli , Ann Elizabeth Gooding , Suzanne Wilford Ruth
IPC分类号： A61F614
CPC分类号： A61K9/0034 , A61K9/0036 , A61K31/167 , A61M31/00
摘要： A novel and useful apparatus for delivering an anesthetic locally to the cervical region of a female is provided, wherein the apparatus comprises a ring having a surface and at least one depression on the surface. An anesthetic composition comprising an anesthetic agent and an excipient are placed within the at least one depression. The ring is comprised of a pharmaceutically acceptable inert material that is biocompatible. Furthermore, the ring is of sufficient size such that it can be inserted into the vaginal canal of a female. In the vaginal canal, the anesthetic agent is immediately released from the anesthetic composition and directly anesthetizes the cervical region.
摘要翻译：提供了一种用于将麻醉剂局部递送到女性的颈部区域的新颖且有用的装置，其中该装置包括具有表面和表面上的至少一个凹陷部的环。将包含麻醉剂和赋形剂的麻醉剂组合物置于所述至少一个凹陷内。该环由生物相容的药学上可接受的惰性物质组成。此外，环具有足够的尺寸，使得其可以插入到女性的阴道管中。在阴道内，麻醉剂立即从麻醉组合物中释放并直接麻醉宫颈区域。

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