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1. 发明授权

US06264973B1 Apparatus and method for anesthetizing the cervical region of a female 有权
标题翻译：用于麻醉女性颈部区域的装置和方法
公开(公告)号：US06264973B1
公开(公告)日：2001-07-24
申请号：US09383887
申请日：1999-08-26
申请人： Anu Mahashabde , Martha Francine Kay , Louis J. Mestichelli , Ann Elizabeth Gooding , Suzanne Wilford Ruth
发明人： Anu Mahashabde , Martha Francine Kay , Louis J. Mestichelli , Ann Elizabeth Gooding , Suzanne Wilford Ruth
IPC分类号： A61F614
CPC分类号： A61K9/0034 , A61K9/0036 , A61K31/167 , A61M31/00
摘要： A novel and useful apparatus for delivering an anesthetic locally to the cervical region of a female is provided, wherein the apparatus comprises a ring having a surface and at least one depression on the surface. An anesthetic composition comprising an anesthetic agent and an excipient are placed within the at least one depression. The ring is comprised of a pharmaceutically acceptable inert material that is biocompatible. Furthermore, the ring is of sufficient size such that it can be inserted into the vaginal canal of a female. In the vaginal canal, the anesthetic agent is immediately released from the anesthetic composition and directly anesthetizes the cervical region.
摘要翻译：提供了一种用于将麻醉剂局部递送到女性的颈部区域的新颖且有用的装置，其中该装置包括具有表面和表面上的至少一个凹陷部的环。将包含麻醉剂和赋形剂的麻醉剂组合物置于所述至少一个凹陷内。该环由生物相容的药学上可接受的惰性物质组成。此外，环具有足够的尺寸，使得其可以插入到女性的阴道管中。在阴道内，麻醉剂立即从麻醉组合物中释放并直接麻醉宫颈区域。

2. 发明授权

US07005138B2 Method of systematically delivering SSRIs 失效
标题翻译：系统地提供SSRIs的方法
公开(公告)号：US07005138B2
公开(公告)日：2006-02-28
申请号：US10095558
申请日：2002-03-12
申请人： Anu Mahashabde , Martha Francine Kay , Brian Glazer , Junxiong Zhang
发明人： Anu Mahashabde , Martha Francine Kay , Brian Glazer , Junxiong Zhang
IPC分类号： A61F13/00 , A61F6/06 , A61F6/14
CPC分类号： A61K9/02 , A61F2250/0067 , A61K9/0031 , A61K9/0034 , A61K9/0036 , A61K9/12 , A61K9/122 , A61K9/7007
摘要： Methods and compositions are disclosed for the intravaginal or rectal delivery of selected serotonin reuptake inhibitors (SSRIs) to the systemic circulation. Such methods and compositions are useful in the treatment of depression, migraine headaches, chronic pain, psychoactive substance abuse disorders, pre-menstrual dysphoric disorder (PMDD) and obsessive compulsive disorders. The compositions may be formulated for the immediate release or controlled release of SSRIs over an extended period of time. A preferred SSRI is fluoxetine.
摘要翻译：公开了将所选择的5-羟色胺再摄取抑制剂（SSRIs）的阴道内或直肠递送给系统循环的方法和组合物。这些方法和组合物可用于治疗抑郁症，偏头痛，慢性疼痛，精神活性物质滥用障碍，月经前焦虑症（PMDD）和强迫症。组合物可以配制成在长时间内立即释放或控释SSRIs。优选的SSRI是氟西汀。

3. 发明授权

US06436428B1 Device and method for treating urinary incontinence in females 有权
标题翻译：用于治疗女性尿失禁的装置和方法
公开(公告)号：US06436428B1
公开(公告)日：2002-08-20
申请号：US09531856
申请日：2000-03-21
申请人： Anu Mahashabde , Martha Francine Kay , Donald F. Koelmel
发明人： Anu Mahashabde , Martha Francine Kay , Donald F. Koelmel
IPC分类号： A61F614
CPC分类号： A61K9/0036 , A61K31/216
摘要： Provided herein is a novel and useful device and method for locally delivering and controllably releasing oxybutynin in the cervical region of a female. A device of the invention comprises a ring comprising trifluoropropylmethyl/dimethyl siloxane elastomer. A pharmaceutical composition comprising oxybutynin and an excipient is placed within a bore located in the ring, wherein the bore runs from the surface of the ring into the ring. The ring has a sufficient size such that it can be inserted into the vaginal canal of a female. A cap comprising is placed over the bore at the surface of the ring in order to contain the pharmaceutical composition within the bore. When the ring is inserted into the vaginal canal, the trifluoropropylmethyl/dimethyl siloxane elastomer controllably releases and locally delivers a therapeutically effective amount of oxybutynin to the detrusor muscle to treat the female's urinary incontinence.
摘要翻译：本文提供了一种用于局部递送和可控地释放女性颈部区域中的奥昔布宁的新颖且有用的装置和方法。本发明的装置包括含有三氟丙基甲基/二甲基硅氧烷弹性体的环。包含奥昔布宁和赋形剂的药物组合物放置在位于环中的孔中，其中孔从环的表面延伸到环中。环具有足够的尺寸，使得其可以插入到女性的阴道管中。将包括的盖子放置在环的表面上的孔上，以将药物组合物包含在孔内。当环插入阴道内时，三氟丙基甲基/二甲基硅氧烷弹性体可控地释放并局部地将治疗有效量的奥昔布宁输送到逼尿肌以治疗女性的尿失禁。

4. 发明申请

US20120053534A1 INTRAVAGINAL DEVICES COMPRISING ANTICHOLINERGIC AGENTS, AND METHODS OF MAKING THEREOF 审中-公开
标题翻译：包含抗胆碱剂的内装置及其制备方法
公开(公告)号：US20120053534A1
公开(公告)日：2012-03-01
申请号：US13166309
申请日：2011-06-22
申请人： Anu Mahashabde , Jiaxiang Tsao
发明人： Anu Mahashabde , Jiaxiang Tsao
IPC分类号： A61M31/00 , B28B1/14
CPC分类号： A61K9/0036
摘要： The present invention is directed to an intravaginal device comprising: (a) an annular first matrix comprising a pocket and a pocket wall, wherein the pocket wall has a uniform thickness, and wherein the pocket wall encompasses the pocket; and (b) a second matrix comprising an anticholinergic agent, wherein the second matrix is located in the pocket.The present invention is also directed to a method of making an intravaginal device, the method comprising: (a) placing a first matrix into a mold, the mold being shaped so as to form an annular intravaginal device comprising a pocket and a pocket wall, wherein the pocket wall has a uniform thickness, and wherein the pocket wall encompasses the pocket; (b) curing the first matrix; (c) placing a second matrix comprising an anticholinergic agent in the pocket; and (d) curing the second matrix.
摘要翻译：本发明涉及一种阴道内装置，其包括：（a）环形第一矩阵，其包括口袋和口袋壁，其中所述口袋壁具有均匀的厚度，并且其中所述口袋壁包围所述口袋; 和（b）包含抗胆碱剂的第二基质，其中所述第二基质位于所述口袋中。本发明还涉及一种制造阴道内装置的方法，所述方法包括：（a）将第一基质放置在模具中，所述模具成形为形成包括口袋和口袋壁的环形阴道内装置，其中所述口袋壁具有均匀的厚度，并且其中所述口袋壁包围所述口袋; （b）固化第一基质; （c）将包含抗胆碱剂的第二基质置于口袋中; 和（d）固化第二基质。

5. 发明申请

US20060185678A1 Devices for delivering agents to a vaginal tract 审中-公开
标题翻译：将药剂递送至阴道的装置
公开(公告)号：US20060185678A1
公开(公告)日：2006-08-24
申请号：US11346560
申请日：2006-02-03
申请人： Lance Bronnenkant , Anu Mahashabde
发明人： Lance Bronnenkant , Anu Mahashabde
IPC分类号： A61F6/02
CPC分类号： A61K9/0036 , A61F6/08 , A61K31/56 , A61K31/565
摘要： The present invention is directed to devices for delivering agents to a vaginal tract, a device of the invention comprises a non-porous polymeric material substantially impermeable to an environment of the vaginal tract, the non-porous polymeric material forming a closed envelope which forms an internal space, wherein the closed envelope contains two or more distinct apertures.
摘要翻译：本发明涉及用于将药剂递送至阴道的装置，本发明的装置包括基本上不可渗透到阴道的环境的无孔聚合材料，所述无孔聚合物材料形成封闭的外壳，其形成内部空间，其中封闭的信封包含两个或多个不同的孔。

6. 发明授权

US09220692B2 Methods of reducing symptoms in subjects using single dosage forms with tapering release rates 有权
标题翻译：使用单剂量形式减轻受试者症状的方法，具有渐松释放速率
公开(公告)号：US09220692B2
公开(公告)日：2015-12-29
申请号：US13101929
申请日：2011-05-05
申请人： Charles E. DiLiberti , Anu Mahashabde
发明人： Charles E. DiLiberti , Anu Mahashabde
IPC分类号： A61F6/06 , A61K31/00 , A61K31/137 , A61K31/465 , A61K31/515 , A61K31/522 , A61K31/551 , A61M31/00 , A61M37/00
CPC分类号： A61K31/00 , A61K31/137 , A61K31/465 , A61K31/515 , A61K31/522 , A61K31/551 , A61M31/002 , A61M37/00
摘要： The present invention is directed to methods of reducing symptoms associated with an abrupt reduction in an endogenous or exogenous chemical in subjects, the methods comprising: (a) administering to the subject a single dosage form comprising an active agent, wherein the release rate of the active agent from the single dosage form tapers throughout the administration; and (b) removing the single dosage form from the subjects after the release rate of the active agent is at or below a terminal symptom threshold level.
摘要翻译：本发明涉及减少与受试者内源或外源化学物质突然减少有关的症状的方法，所述方法包括：（a）向受试者施用包含活性剂的单一剂型，其中，单剂量活性剂在整个给药过程中逐渐变细; 和（b）在活性剂的释放速率处于或低于终末症状阈值水平之前，从受试者中除去单一剂型。

7. 发明申请

US20090202612A1 Monolithic Intravaginal Rings Comprising Progesterone and Methods of Making and Uses Thereof 有权
标题翻译：包括孕酮的单片性阴道戒指及其制作及其使用方法
公开(公告)号：US20090202612A1
公开(公告)日：2009-08-13
申请号：US12364990
申请日：2009-02-03
申请人： Salah U. AHMED , Jiaxiang Tsao , Anu Mahashabde , Diane D. Harrison
发明人： Salah U. AHMED , Jiaxiang Tsao , Anu Mahashabde , Diane D. Harrison
IPC分类号： A61F6/14 , A61K31/57 , A61P15/18
CPC分类号： A61K31/57 , A61F6/08 , A61K9/0036 , A61K47/34 , A61K47/44 , B29C45/0001 , B29C45/7207 , B29K2083/00 , B29K2105/0035 , B29L2031/753
摘要： The present invention relates to monolithic intravaginal rings comprising progesterone, methods of making, and uses thereof. The intravaginal rings comprise progesterone, a polysiloxane elastomer, and a pharmaceutically acceptable hydrocarbon or glycerol esters of a fatty acid.
摘要翻译：本发明涉及包含孕酮的整体式阴道环，其制备方法和用途。阴道内环包含孕酮，聚硅氧烷弹性体和药学上可接受的脂肪酸的烃或甘油酯。

8. 发明申请

US20060286172A1 Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same 审中-公开
标题翻译：包含前列腺素类受体激动剂的药物组合物及其制备和使用方法
公开(公告)号：US20060286172A1
公开(公告)日：2006-12-21
申请号：US11446525
申请日：2006-06-05
申请人： Anu Mahashabde
发明人： Anu Mahashabde
IPC分类号： A61K9/14
CPC分类号： A61K31/557 , A61K9/0036 , A61K47/10 , A61K47/26
摘要： The present invention is related to pharmaceutical compositions comprising prostanoid-receptor agonists, intravaginal dosage forms comprising the same, and methods of making and using the same. The present invention is also related to a controlled release pharmaceutical gel for vaginal administration, the pharmaceutical gel comprising: (a) misoprostol; (b) a cellulose derivative; and (c) a polyol; wherein the gel is a substantially nonaqueous gel, and wherein the gel forms a hydrogel when placed in a vaginal tract.
摘要翻译：本发明涉及含有前列腺素类受体激动剂的药物组合物，包含其的阴道内剂型及其制备和使用方法。本发明还涉及用于阴道给药的控释药物凝胶，所述药物凝胶包含：（a）米索前列醇; （b）纤维素衍生物; 和（c）多元醇; 其中所述凝胶是基本非水性凝胶，并且其中所述凝胶在置于阴道中时形成水凝胶。

9. 发明申请

US20060183724A1 Compositions of unconjugated estrogens and methods for their use 审中-公开
标题翻译：非共轭雌激素的组成及其使用方法
公开(公告)号：US20060183724A1
公开(公告)日：2006-08-17
申请号：US11346232
申请日：2006-02-03
申请人： Charles Diliberti , Anu Mahashabde
发明人： Charles Diliberti , Anu Mahashabde
IPC分类号： A61K31/56
CPC分类号： A61K31/565 , A61K9/0034 , A61K9/0036 , A61K31/566 , A61K2300/00
摘要： The present invention relates to compositions containing unconjugated estrogens and methods of their use in the treatment of conditions associated with hypoestrogenism or reduced estrogen levels in females.
摘要翻译：本发明涉及含有非共轭雌激素的组合物及其用于治疗与雌激素降低或雌激素水平降低相关的病症的方法。

10. 发明申请

US20120107385A1 METHOD OF TREATING CONDITIONS ASSOCIATED WITH OVERACTIVE BLADDER 审中-公开
标题翻译：处理与过滤刀相关的条件的方法
公开(公告)号：US20120107385A1
公开(公告)日：2012-05-03
申请号：US13166302
申请日：2011-06-22
申请人： Anu Mahashabde , Jiaxiang Tsao
发明人： Anu Mahashabde , Jiaxiang Tsao
IPC分类号： A61K9/00 , A61P13/00 , A61K31/215
CPC分类号： A61K9/0036 , A61K31/137 , A61K31/215 , A61K31/216 , A61K31/221 , A61K31/27 , A61K31/352 , A61K31/4025 , A61K31/445 , A61K31/46 , A61K31/4725
摘要： The present invention is directed to a method of treating a condition associated with an overactive bladder, comprising administering to a female an intravaginal device, comprising: (a) an annular first matrix comprising a pocket and a pocket wall, wherein the pocket wall has a uniform thickness, and wherein the pocket wall encompasses the pocket; and (b) a second matrix comprising an anticholinergic agent located in the pocket.
摘要翻译：本发明涉及一种治疗与膀胱过度活动症相关的病症的方法，包括对女性阴道内装置施用，所述阴道内装置包括：（a）包括口袋和口袋壁的环形第一基质，其中所述口袋壁具有均匀的厚度，并且其中所述口袋壁包围所述口袋; 和（b）包含位于口袋中的抗胆碱剂的第二基质。

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