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    • 1. 发明授权
    • Chlamydia protein, gene sequence and the uses thereof
    • 衣原体蛋白,基因序列及其用途
    • US07537772B1
    • 2009-05-26
    • US09677752
    • 2000-10-02
    • W. James Jackson
    • W. James Jackson
    • A61K39/118A61K39/00A61K39/02A61K39/116A61K38/00
    • C07K14/295A61K39/00A61K2039/53C07K2319/00
    • The invention discloses the Chlamydia PMPE and PMPI polypeptide, polypeptides derived thereof (PMP-derived polypeptides), nucleotide sequences encoding said polypeptides, antibodies that specifically bind the PMP polypeptides and PMP-derived polypeptides and T-cells specific for PMP polypeptides and PMP-derived polypeptides. Also disclosed are prophylactic and therapeutic compositions, including immunogenic compositions, e.g., vaccines, comprising PMP polypeptides or PMP-derived polypeptides or antibodies thereto. The invention additionally discloses methods of inducing in animals an immune response to Chlamydia cells, Chlamydia elementary bodies, and/or cells expressing Chlamydial proteins, e.g., cell infected with Chlamydia.
    • 本发明公开了衣原体PMPE和PMPI多肽,其衍生的多肽(PMP衍生的多肽),编码所述多肽的核苷酸序列,特异性结合PMP多肽和PMP衍生多肽的抗体以及对PMP多肽和PMP衍生的多肽特异的T细胞 多肽。 还公开了预防和治疗组合物,包括免疫原性组合物,例如包含PMP多肽或PMP衍生的多肽或其抗体的疫苗。 本发明还公开了在动物中诱导对衣原体细胞,衣原体基因体和/或表达衣原体蛋白(例如感染衣原体的细胞)的细胞的免疫应答的方法。