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1. 发明授权

US08637266B2 Anti bone-loss and anti attachment-loss effects of an oral composition 有权
标题翻译：口服组合物的抗骨丢失和抗附着损伤作用
公开(公告)号：US08637266B2
公开(公告)日：2014-01-28
申请号：US13262027
申请日：2010-04-01
申请人： Virginia Barnes , Harsh M. Trivedi , Wei Wang , Tao Xu , Emi Shimizu , Nicola C. Partridge
发明人： Virginia Barnes , Harsh M. Trivedi , Wei Wang , Tao Xu , Emi Shimizu , Nicola C. Partridge
IPC分类号： G01N33/53
CPC分类号： G01N33/56955 , G01N2333/96486
摘要： Methods for identifying compounds useful for treating diseases and conditions of the oral cavity are described herein.
摘要翻译：本文描述了用于鉴定可用于治疗口腔疾病和病症的化合物的方法。

2. 发明授权

US06403637B1 Methods of modulating matrix metalloproteinase activity and uses thereof 失效
标题翻译：调节基质金属蛋白酶活性的方法及其应用
公开(公告)号：US06403637B1
公开(公告)日：2002-06-11
申请号：US09370738
申请日：1999-08-09
申请人： Nicola C. Partridge
发明人： Nicola C. Partridge
IPC分类号： A61K3135
CPC分类号： C12Q1/37 , A61K31/00 , A61K31/22 , A61K31/366 , A61K31/40 , G01N2500/10
摘要： Methods for inactivating matrix metalloproteinases in a vertebrate cell are disclosed. The methods comprise administering to the cell an agent which causes increased endocytosis of the matrix metalloproteinase. Methods for treating vertebrates with disorders mediated by matrix metalloproteinases are also disclosed. These methods comprise administering the above-described agents to the vertebrate. Also disclosed is the use of HMG-CoA reductase inhibitors, also known as statins, as an agent which causes increased endocytosis of matrix metalloproteinases. Assays for determining whether an agent is effective in treating a disorder are also disclosed. These assays comprise testing the agent for activity in increasing endocytosis of a matrix metalloproteinase which mediates the disorder.
摘要翻译：公开了在脊椎动物细胞中灭活基质金属蛋白酶的方法。所述方法包括向细胞施用引起基质金属蛋白酶内吞作用的试剂。还公开了用基质金属蛋白酶介导的疾病治疗脊椎动物的方法。这些方法包括将上述试剂施用于脊椎动物。还公开了HMG-CoA还原酶抑制剂（也称为他汀类）作为引起基质金属蛋白酶内吞的药物的用途。还公开了用于确定试剂是否有效治疗病症的测定。这些测定法包括测试该药物的活性，以增加介导病症的基质金属蛋白酶的内吞作用。

3. 发明申请

US20120107843A1 ANTI BONE-LOSS AND ANTI ATTACHMENT-LOSS EFFECTS OF AN ORAL COMPOSITION 有权
标题翻译：口服组合物的抗骨折和抗附着损伤作用
公开(公告)号：US20120107843A1
公开(公告)日：2012-05-03
申请号：US13262027
申请日：2010-04-01
申请人： Virginia Barnes , Harsh M. Trivedi , Wei Wang , Tao Xu , Emi Shimizu , Nicola C. Partridge
发明人： Virginia Barnes , Harsh M. Trivedi , Wei Wang , Tao Xu , Emi Shimizu , Nicola C. Partridge
IPC分类号： G01N33/573 , C12Q1/37
CPC分类号： G01N33/56955 , G01N2333/96486
摘要： Methods for identifying compounds useful for treating diseases and conditions of the oral cavity are described herein.
摘要翻译：本文描述了用于鉴定可用于治疗口腔疾病和病症的化合物的方法。

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