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1. 发明授权

US09150909B2 Determination of the integrity of RNA 有权
标题翻译：确定RNA的完整性
公开(公告)号：US09150909B2
公开(公告)日：2015-10-06
申请号：US12548226
申请日：2009-08-26
申请人： Vladimir Denisov
发明人： Vladimir Denisov
IPC分类号： G01N27/26 , C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6816 , C12Q1/6806 , C12Q2545/113 , C12Q2563/107 , C12Q2565/125 , G01N2333/4728 , G01N2800/34 , C12Q2561/12 , C12Q2539/101
摘要： Methods, systems, and apparatus make a determination of a level of integrity of a sample of biomolecules. For example, the determination of the integrity of RNA in a sample may be done in a fast and reproducible manner, such that the user can be assured of accuracy of a test (e.g. quantitative polymerase chain reaction qPCR) on the sample and compare results of different samples. The determination of integrity of an RNA sample is performed by comparing a size profile to reference size profiles (degradation standards) obtained from degradation over different lengths of times. As the reference scale of the level of integrity is derived from the actual degradation that occurs in a sample, high accuracy, reproducibility, and efficiency is provided.
摘要翻译：方法，系统和装置确定生物分子样品的完整性水平。例如，样品中RNA的完整性的确定可以以快速和可再现的方式进行，使得用户可以确保样品的测试准确性（例如定量聚合酶链式反应qPCR）并比较结果不同样品。 RNA样品的完整性的确定通过将尺寸分布与不同长度的降解获得的参考尺寸分布（降解标准）进行比较来进行。由于完整性水平的参考比例来源于样品中发生的实际降解，因此提供了高精度，重复性和效率。

2. 发明申请

US20100057371A1 DETERMINATION OF THE INTEGRITY OF RNA 有权
标题翻译：确定RNA的完整性
公开(公告)号：US20100057371A1
公开(公告)日：2010-03-04
申请号：US12548226
申请日：2009-08-26
申请人： Vladimir Denisov
发明人： Vladimir Denisov
IPC分类号： G01N27/26 , G06F19/00
CPC分类号： C12Q1/6816 , C12Q1/6806 , C12Q2545/113 , C12Q2563/107 , C12Q2565/125 , G01N2333/4728 , G01N2800/34 , C12Q2561/12 , C12Q2539/101
摘要： Methods, systems, and apparatus make a determination of a level of integrity of a sample of biomolecules. For example, the determination of the integrity of RNA in a sample may be done in a fast and reproducible manner, such that the user can be assured of accuracy of a test (e.g. quantitative polymerase chain reaction qPCR) on the sample and compare results of different samples. The determination of integrity of an RNA sample is performed by comparing a size profile to reference size profiles (degradation standards) obtained from degradation over different lengths of times. As the reference scale of the level of integrity is derived from the actual degradation that occurs in a sample, high accuracy, reproducibility, and efficiency is provided.
摘要翻译：方法，系统和装置确定生物分子样品的完整性水平。例如，样品中RNA的完整性的确定可以以快速和可再现的方式进行，使得用户可以确保样品的测试准确性（例如定量聚合酶链式反应qPCR）并比较结果不同样品。 RNA样品的完整性的确定通过将尺寸分布与不同长度的降解获得的参考尺寸分布（降解标准）进行比较来进行。由于完整性水平的参考比例来源于样品中发生的实际降解，因此提供了高精度，重复性和效率。

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