发明申请
US20170059581A1 METHODS FOR DIAGNOSIS AND PROGNOSIS OF INFLAMMATORY BOWEL DISEASE USING CYTOKINE PROFILES
审中-公开
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基本信息:
- 专利标题: METHODS FOR DIAGNOSIS AND PROGNOSIS OF INFLAMMATORY BOWEL DISEASE USING CYTOKINE PROFILES
- 专利标题(中):使用细胞因子轮廓诊断和预防炎症性皮肤病的方法
- 申请号:US15258050 申请日:2016-09-07
- 公开(公告)号:US20170059581A1 公开(公告)日:2017-03-02
- 发明人: Xuhang Li , Philip J. Alex , Michael B. Centola , Nicholas Knowlton
- 申请人: THE JOHNS HOPKINS UNIVERSITY , Oklahoma Medical Research Foundation
- 主分类号: G01N33/68
- IPC分类号: G01N33/68
摘要:
The present invention relates to the field of inflammatory bowel disease. More specifically, the present invention relates to the use of cytokines to detect, diagnose, and assess inflammatory bowel disease. In one embodiment, a method for diagnosing Crohn's Disease (CD) in a patient comprises the steps of (a) collecting a sample from the patient; (b) measuring the levels of at least one cytokine in the sample collected from the patient; and (c) comparing the levels of the at least one cytokine with predefined cytokine levels, wherein a correlation between the cytokine levels in the patient sample and predefined cytokine levels indicates that the patient has CD. In a specific embodiment, the at least one cytokine comprises Interferon (IFN)-gamma, Interleukin (IL)-1beta, IL-6, IL-8, IL-12, IL-17 and CXCL10.
摘要(中):
本发明涉及炎症性肠病领域。 更具体地,本发明涉及细胞因子用于检测,诊断和评估炎症性肠病的用途。 在一个实施方案中,用于诊断患者中的克罗恩病(CD)的方法包括以下步骤:(a)从患者收集样品; (b)测量从患者收集的样品中至少一种细胞因子的水平; 和(c)将至少一种细胞因子的水平与预定的细胞因子水平进行比较,其中患者样品中的细胞因子水平与预定的细胞因子水平之间的相关性指示患者具有CD。 在一个具体的实施方案中,所述至少一种细胞因子包括干扰素(IFN)-γ,白介素(IL)-1β,IL-6,IL-8,IL-12,IL-17和CXCL10。
公开/授权文献:
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