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1. 发明公开

US20230273119A1 LIGHT RECYCLING ARTICLE FOR BIO-ASSAY 审中-公开
公开(公告)号：US20230273119A1
公开(公告)日：2023-08-31
申请号：US18111056
申请日：2023-02-17
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： Bharat R. Acharya , Raj Rajagopal , Gregory W. Sitton , Benjamin G. Sonnek , Robert M. Biegler , Gilles J. Benoit , Timothy J. Lindquist , John A. Wheatley , Kristal L. Schutta , James A. Phipps
IPC分类号： G01N21/31
CPC分类号： G01N21/314 , G01N2021/317 , G01N2201/0453
摘要： An optical well is configured to receive a test sample for examining an optical characteristic of the sample at a first wavelength in a predetermined wavelength range. The optical well includes a wall having a bottom wall portion and a sidewall portion defining a chamber for receiving the test sample, and an optical film formed into a shape so that a portion of the sidewall portion includes a first portion of the optical film, and a portion of the bottom wall portion includes a second portion of the optical film. For a normally incident light, the microlayers in each of the first and second portions have an average optical reflectance of greater than about 80% in the predetermined wavelength range. The forming results in the plurality of microlayers of the integral formed optical film having a thinnest portion and a thickest portion having a thickness difference of at least 30%.

2. 发明授权

US08696990B2 Device for the photometric examination of samples 有权
标题翻译：样品光度检测装置
公开(公告)号：US08696990B2
公开(公告)日：2014-04-15
申请号：US12876405
申请日：2010-09-07
申请人： Paul Meller , Holger Pufahl
发明人： Paul Meller , Holger Pufahl
IPC分类号： G01N15/06
CPC分类号： G01N21/253 , G01N21/0332 , G01N21/255 , G01N35/02 , G01N2021/0325 , G01N2021/825 , G01N2035/00534 , G01N2201/0407 , G01N2201/0423 , G01N2201/0453 , G01N2201/0627
摘要： A device for the photometric examination of samples has a sample-holder apparatus for at least two sample vessels, and a measuring apparatus and a moveable apparatus. The sample-holder apparatus is designed to be stationary, and the measuring apparatus is arranged on the moveable apparatus such that it can be displaced by means of the moveable apparatus.
摘要翻译：用于样品的光度检查的装置具有用于至少两个样品容器的样品保持器装置，以及测量装置和可移动装置。样品架设备被设计为静止的，并且测量设备被布置在可移动设备上，使得其可以借助于可移动设备而移位。

3. 发明授权

US07843568B2 Enhanced instrumentation and method for optical measurement of samples 有权
标题翻译：增强了样品光学测量仪器和方法
公开(公告)号：US07843568B2
公开(公告)日：2010-11-30
申请号：US12692758
申请日：2010-01-25
申请人： Petri Kivela
发明人： Petri Kivela
IPC分类号： G01N21/25
CPC分类号： G01N21/253 , G01N21/13 , G01N21/6428 , G01N21/6452 , G01N21/76 , G01N2021/6421 , G01N2021/6441 , G01N2021/6471 , G01N2021/6482 , G01N2021/6484 , G01N2201/0446 , G01N2201/0453 , G01N2201/0826 , G01N2201/103
摘要： The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation wherein a sample (281-285) is activated (212AS, 218AS) and the emission is detected (291, 292), wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and means (218) directing the activation radiation to the sample as well as in the relative position between the sample and the means (293) receiving the emission radiation from the sample. This can be implemented e.g. by moving (299) the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.
摘要翻译：本发明一般涉及生物化学实验室仪器的领域，用于不同应用样品的测量性质。微量滴定板和相应的样品支架。本发明的目的是通过提供一种光学测量仪器实现的，其中样品（281-285）被激活（212AS，218AS）并且检测到发射（291,292），其中在测量样品的激活和检测阶段之间在样品和将激活辐射指向样品的装置（218）之间的相对位置以及样品和接收来自样品的发射辐射的装置（293）之间的相对位置进行位移。这可以被实现。通过在样品的活化和发射阶段之间移动（299）样品测定板和/或测量头。本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。

4. 发明申请

US20080062421A1 SPECTROPHOTOMETRIC OPTICAL SYSTEM OF MICROPLATE READER AND FILTER WHEEL THEREOF 有权
标题翻译：微波读数器和滤光片的光谱光学系统
公开(公告)号：US20080062421A1
公开(公告)日：2008-03-13
申请号：US11564446
申请日：2006-11-29
申请人： Lihua ZHOU , Jinhong QIU
发明人： Lihua ZHOU , Jinhong QIU
IPC分类号： G01N21/25 , G01N21/51
CPC分类号： G01J3/51 , G01J3/0243 , G01J3/12 , G01J2003/1217 , G01N2201/0453
摘要： A spectrophotometric optical system of a microplate reader and a filter wheel thereof are disclosed. The filter wheel comprises a pivotable wheel body, at least one narrow-band filter with a relatively long central wavelength mounted to the wheel body, and at least one narrow-band filter with a relatively short central wavelength mounted to the wheel body. The narrow-band filter with a relatively long central wavelength is provided with a diaphragm on a front surface thereof The diaphragm is formed with a plurality of apertures. A ratio of a total effective area of the plurality of apertures to an effective area of the narrow-band filter with a relatively short central wavelength is equivalent to a ratio of energy amounts of shorter wavelength light passed through the narrow-band filter with a relatively short central wavelength to energy amounts of longer wavelength light passed through the narrow-band filter with a relatively long central wavelength when the diaphragm is not disposed. By the diaphragm attached to the front surface of the narrow-band filter with a relatively long central wavelength, an energy matching between light of longer wavelength and light of shorter wavelength may be achieved. Further, due to the uniformly distributed apertures in the diaphragm, an even light spot may be obtained.
摘要翻译：公开了微板读数器及其滤光轮的分光光度学系统。所述滤光轮包括可枢转的轮体，至少一个安装在所述车轮主体上的具有较长的中心波长的窄带过滤器以及至少一个具有相对短的中心波长的窄带过滤器，安装在所述车轮主体上。具有相对长的中心波长的窄带滤光片在其前表面上设置有隔膜。隔膜形成有多个孔。多个孔的总有效面积与具有相对短的中心波长的窄带滤光器的有效面积的比率等于通过窄带滤光器的较短波长光的能量比与相对当不设置隔膜时，较长的中心波长与较长波长的光的能量通过具有较长的中心波长的窄带滤光器。通过附着在具有较长中心波长的窄带滤光片的前表面的光阑，可以实现较长波长的光与较短波长的光之间的能量匹配。此外，由于隔膜中均匀分布的孔，可以获得均匀的光点。

5. 发明申请

US20070247628A1 Instrumentation and Method Adapted For Optical Measurement of an Amplified Luminescent Proximity Homogeneous Assay 审中-公开
标题翻译：适用于放大发光近距均匀测定的光学测量的仪器和方法
公开(公告)号：US20070247628A1
公开(公告)日：2007-10-25
申请号：US11662468
申请日：2004-09-10
申请人： Petri Kivelä
发明人： Petri Kivelä
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/13 , G01N21/6428 , G01N21/6452 , G01N21/76 , G01N2021/6421 , G01N2021/6441 , G01N2021/6471 , G01N2021/6482 , G01N2021/6484 , G01N2201/0446 , G01N2201/0453 , G01N2201/0826 , G01N2201/103
摘要： The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on microtitration plates and corresponding sample supports. An optical measurement instrumentation is provided, a sample is activated and the emission is detected, wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and elements directing the activation radiation to the sample as well as in the relative position between the sample and the elements receiving the emission radiation from the sample. This can be implemented e.g. by moving the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.
摘要翻译：本发明一般涉及生物化学实验室仪器领域，用于不同应用样品在微量滴定板和相应样品载体上的测量性质。提供光学测量仪器，激活样品并检测发射，其中在测量样品的激活和检测阶段之间，在将样品和将激活辐射指向样品的元件之间的相对位置进行偏移，作为以及在样品和接收来自样品的发射辐射的元件之间的相对位置。这可以被实现。通过在样品的活化和发射阶段之间移动样品测定板和/或测量头。本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。

6. 发明授权

US09243996B2 LED densitometer for microtiter plate 有权
标题翻译：用于微量滴定板的LED光密度计
公开(公告)号：US09243996B2
公开(公告)日：2016-01-26
申请号：US13383986
申请日：2010-07-16
申请人： Peter Van Praet
发明人： Peter Van Praet
IPC分类号： G01N21/00 , G01N21/25
CPC分类号： G01N21/00 , G01N21/253 , G01N2201/0446 , G01N2201/0453 , G01N2201/0627 , G01N2201/10
摘要： Light emitting diodes (LEDs) are mounted in an array to an upper structure overlying a lower structure with a plurality of light detectors thereon. Each LED is configured to overlie a separate detector. Each LED emits light at a frequency relevant for measuring optical density of a specimen. LEDs having different frequencies are included within the LED array. A corresponding array of detectors is also provided, mounted to the lower structure. Spacing between adjacent LEDs and between adjacent detectors match a spacing between wells in a microtiter plate. Spacing between the lower structure and the upper structure supporting the LEDs is sufficient for the microtiter plate to fit between. Circuitry sequentially fires individual LEDs and gathers optical density data through the detectors for specimens in the wells of the microtiter plate. The structures are then moved to a next adjacent well position on the microtiter plate and the process repeated.
摘要翻译：发光二极管（LED）以阵列的形式安装在覆盖下部结构的上部结构上，其上具有多个光检测器。每个LED被配置为覆盖单独的检测器。每个LED以与测量样品的光密度相关的频率发光。具有不同频率的LED包括在LED阵列内。还提供了相应的检测器阵列，安装到下部结构。相邻LED之间和相邻检测器之间的间距与微量滴定板中的孔之间的间距相匹配。支撑LED的下部结构和上部结构之间的间距足以使微量滴定板相适应。电路依次点火各个LED，并通过微量滴定板孔中的标本的检测器收集光密度数据。然后将结构移动到微量滴定板上的下一个相邻的孔位置，并重复该过程。

7. 发明授权

US09194793B2 Sample analysis device 有权
标题翻译：样品分析装置
公开(公告)号：US09194793B2
公开(公告)日：2015-11-24
申请号：US13002664
申请日：2009-07-30
申请人： Sakuichiro Adachi , Kunio Harada , Isao Yamazaki , Masaharu Kiyama , Takeshi Fujita
发明人： Sakuichiro Adachi , Kunio Harada , Isao Yamazaki , Masaharu Kiyama , Takeshi Fujita
IPC分类号： G01N21/59 , G01N21/25 , G01N35/02 , G01N21/03 , G01N35/00 , G01N35/04
CPC分类号： G01N21/253 , G01N21/0332 , G01N21/255 , G01N35/025 , G01N2035/00386 , G01N2035/0455 , G01N2201/0231 , G01N2201/0415 , G01N2201/0453 , G01N2201/0624 , G01N2201/0627
摘要： Using an LED element as a light source, a photometric unit including the light source, a light receiving element and other components therebetween is reduced in size. A holder 30 detachable from the device as a unit holds a light emission unit 15 formed of an LED and a light receiving element 21, and the holder is placed inside a thermostatic chamber 18 which holds a constant temperature fluid 17. Thus, the photometric unit is reduced in size.
摘要翻译：使用LED元件作为光源，包括光源，光接收元件和其间的其它部件的光度单元的尺寸减小。从装置作为一个单元可拆卸的保持器30保持由LED和光接收元件21形成的发光单元15，并且保持器放置在保持恒温流体17的恒温室18内部。因此，测光单元尺寸减小。

8. 发明授权

US07978325B2 Biochemical analyzer 有权
标题翻译：生化分析仪
公开(公告)号：US07978325B2
公开(公告)日：2011-07-12
申请号：US12121120
申请日：2008-05-15
申请人： Sakuichiro Adachi
发明人： Sakuichiro Adachi
IPC分类号： G01J3/04 , G01J3/28
CPC分类号： G01N21/253 , G01J3/02 , G01J3/0218 , G01J3/0229 , G01J3/0262 , G01J3/04 , G01J3/36 , G01J3/42 , G01N21/13 , G01N21/255 , G01N2021/0325 , G01N2021/115 , G01N2021/3155 , G01N2201/0415 , G01N2201/0446 , G01N2201/0453 , G01N2201/0618
摘要： A light amount is increased and an analyzing accuracy can be kept in accordance with an enlargement of a load angle, however, a scattered light tends to be loaded in an analysis accompanying the scattered light and a dynamic range of a concentration which can be measured becomes narrow. A light is dispersed by a light dispersing portion, a load angle of the received light is changed per wavelength, the load angle is made larger in the light of a wavelength having a small light amount, and the load angle is made smaller in the light a wavelength having a large light amount and used for an analysis accompanying a scattered light. Accordingly, it is possible to gain a dynamic range of a concentration which can be measured in the analysis accompanying the scattered light, while increasing the light amount and maintaining the analyzing accuracy.
摘要翻译：光量增加，并且可以根据负载角的放大来保持分析精度，然而，伴随散射光的分析倾向于加载散射光，并且可测量的浓度的动态范围变为狭窄。通过光分散部分散射光，每波长改变接收光的负载角度，在具有小光量的波长的光中使负载角变大，并且使光的负载角变小具有大光量的波长并用于伴随散射光的分析。因此，在增加光量并保持分析精度的同时，可以获得在伴随散射光的分析中可以测量的浓度的动态范围。

9. 发明申请

US20030222222A1 Multiphoton excitation microscope for biochip fluorescence assay 有权
标题翻译：用于生物芯片荧光测定的多光子激发显微镜
公开(公告)号：US20030222222A1
公开(公告)日：2003-12-04
申请号：US10160251
申请日：2002-06-04
申请人： National Taiwan University
发明人： Chen-Yuan Dong , Peter T.C. So , Sunney I. Chan
IPC分类号： G01N021/64
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/0446 , G01N2201/0453
摘要： This invention provides a multiphoton excitaion microscope for simultaneously detecting differently colored fluorescence materials on biochips, which includes a multiphoton excitation source, objectives, and a plurality of detection channels. The biochip is hybridized and labeled with fluorescence materials for expressing hybridized biological signals. The multiphoton excitation source is focused to a light spot on the biochip to excite the fluorescence materials bound thereon. After that, the fluorescence emission at different wavelengths from the different fluorescent materials can be detected by the plural detection channels.
摘要翻译：本发明提供了一种多光子激发显微镜，用于同时检测生物芯片上的不同颜色的荧光材料，其包括多光子激发源，物镜和多个检测通道。将生物芯片杂交并用用于表达杂交的生物信号的荧光材料标记。多光子激发源被聚焦到生物芯片上的光点以激发结合在其上的荧光材料。之后，可以通过多个检测通道检测来自不同荧光材料的不同波长的荧光发射。

10. 发明申请

US20130100434A1 OPTICAL DETECTION APPARATUS AND OPTICAL MEASUREMENT SYSTEM 有权
标题翻译：光学检测装置和光学测量系统
公开(公告)号：US20130100434A1
公开(公告)日：2013-04-25
申请号：US13307004
申请日：2011-11-30
申请人： Chao-Ming Chen
发明人： Chao-Ming Chen
IPC分类号： G01N33/48 , G01N21/17
CPC分类号： G01N33/49 , G01N21/253 , G01N2201/0423 , G01N2201/0453 , G01N2201/0627
摘要： An optical detection apparatus which is capable of measuring a sample is provided. The optical detection apparatus includes a plurality of light emission units, a light receiving unit, a driving unit, and an analyzing unit. Each of the light emission units is capable of emitting a light beam. The light receiving unit is capable of receiving the light beam passing through the sample and is capable of converting the received light beam to an electrical signal. The driving unit is capable of changing the relative position of the light emission units and the sample. The analyzing unit is electrically connected to the light receiving unit and is capable of measuring a property of the sample by using the electrical signal. A number of the light receiving unit is less than a number of the light emission units. An optical measurement system including the optical detection apparatus is also provided.
摘要翻译：提供了能够测量样品的光学检测装置。光检测装置包括多个发光单元，光接收单元，驱动单元和分析单元。每个发光单元能够发射光束。光接收单元能够接收通过样本的光束，并且能够将接收到的光束转换成电信号。驱动单元能够改变发光单元和样品的相对位置。分析单元电连接到光接收单元，并且能够通过使用电信号来测量样品的性质。光接收单元的数量少于多个发光单元。还提供了一种包括光学检测装置的光学测量系统。

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