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1. 发明申请

US20090130772A1 Apparatus and method for collecting data on light-emitting reactions 审中-公开
标题翻译：用于收集发光反应数据的装置和方法
公开(公告)号：US20090130772A1
公开(公告)日：2009-05-21
申请号：US11984332
申请日：2007-11-15
申请人： Kauko Lehtinen , Petri Kivela
发明人： Kauko Lehtinen , Petri Kivela
IPC分类号： G01N21/76
CPC分类号： G01N21/763
摘要： The invention concerns an apparatus and a method for collecting data on a set of light-emitting molecular reactions. The apparatus comprises a holder for a reaction vessel comprising a plurality of reaction spaces containing first reaction substance, feeder for supplying second reaction substance to said reaction spaces for initiating said reaction set, and a plurality of light detectors for measuring light emitted from said reaction spaces in synchronized relationship with said feeding. According to the invention, at least two of said light detectors are arranged on opposing sides of the reaction vessel and being adapted to simultaneously measure different properties of the reaction set, that is, different wells or wavelengths, for example. The invention allows doubling the measurement speed in aequorin-based intracellular Ca-measurements.
摘要翻译：本发明涉及用于收集关于一组发光分子反应的数据的装置和方法。该装置包括用于反应容器的保持器，其包括多个含有第一反应物质的反应空间，用于向所述反应空间供应第二反应物质的进料器，用于引发所述反应装置，以及多个光检测器，用于测量从所述反应空间与所述饲养同步关系。根据本发明，至少两个所述光检测器布置在反应容器的相对侧上，并且适于同时测量反应组的不同性质，即例如不同的阱或波长。本发明允许在基于水母发光蛋白的细胞内Ca-测量中加倍测量速度。

2. 发明授权

US6112603A Method and a device for handling sample plates 有权
标题翻译：方法和处理样品板的装置
公开(公告)号：US6112603A
公开(公告)日：2000-09-05
申请号：US210570
申请日：1998-12-14
申请人： Pekka Pietila , Petri Kivela
发明人： Pekka Pietila , Petri Kivela
IPC分类号： B01L3/02 , B01L99/00 , G01N35/02 , G01N1/00
CPC分类号： B01L3/0203 , B01L99/00 , G01N35/028 , B01L2200/0684 , B01L2400/0409
摘要： A method for handling a microplate, in which liquid (22) is dosed into a sample well (21) and the liquid is removed and, if necessary, the sample wells are further washed and/or rinsed. According to the invention, the liquid to be dosed is dosed into the sample well (21) of the sample plate (10), after which the sample plate is centrifuged so that the centrifugal force is exerted towards the bottom of the sample well to remove air bubbles, and/or the sample plate is centrifuged so that the centrifugal force is exerted away from the bottom of the sample well to empty the sample plate. The device relating to the invention comprises a dosing device and at least one centrifuge (24). In dosing, a distributing valve (14) and a dosing nozzle (12) are usually needed, and where necessary, a vibrator device (32, 33) to bring the liquid (22) in the sample well (21) of the sample plate (10) into a motion. According to one embodiment, the vibrator device (33) comprises a needle (34) that is dipped into the liquid (22) in the sample well (21) of the sample plate (10), and by means of the vibration of the needle air bubbles can also be removed from the liquid.
摘要翻译：一种用于处理微板的方法，其中将液体（22）计量到样品池（21）中并除去液体，如果需要，将样品池进一步洗涤和/或漂洗。根据本发明，将待定量的液体放入样品板（10）的样品孔（21）中，然后将样品板离心，使得离心力朝向样品池的底部施加以除去将气泡和/或样品板离心，使得离心力远离样品井的底部排出样品板。与本发明相关的装置包括计量装置和至少一个离心机（24）。在计量中，通常需要分配阀（14）和计量喷嘴（12），并且如果需要的话，将样品板（22）中的液体（22）带入样品板（21）中的振动器装置（32,33）（10）成动作。根据一个实施例，振动器装置（33）包括浸入样品板（10）的样品孔（21）中的液体（22）中的针（34），并且借助于针的振动也可以从液体中除去气泡。

3. 发明授权

US07843568B2 Enhanced instrumentation and method for optical measurement of samples 有权
标题翻译：增强了样品光学测量仪器和方法
公开(公告)号：US07843568B2
公开(公告)日：2010-11-30
申请号：US12692758
申请日：2010-01-25
申请人： Petri Kivela
发明人： Petri Kivela
IPC分类号： G01N21/25
CPC分类号： G01N21/253 , G01N21/13 , G01N21/6428 , G01N21/6452 , G01N21/76 , G01N2021/6421 , G01N2021/6441 , G01N2021/6471 , G01N2021/6482 , G01N2021/6484 , G01N2201/0446 , G01N2201/0453 , G01N2201/0826 , G01N2201/103
摘要： The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation wherein a sample (281-285) is activated (212AS, 218AS) and the emission is detected (291, 292), wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and means (218) directing the activation radiation to the sample as well as in the relative position between the sample and the means (293) receiving the emission radiation from the sample. This can be implemented e.g. by moving (299) the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.
摘要翻译：本发明一般涉及生物化学实验室仪器的领域，用于不同应用样品的测量性质。微量滴定板和相应的样品支架。本发明的目的是通过提供一种光学测量仪器实现的，其中样品（281-285）被激活（212AS，218AS）并且检测到发射（291,292），其中在测量样品的激活和检测阶段之间在样品和将激活辐射指向样品的装置（218）之间的相对位置以及样品和接收来自样品的发射辐射的装置（293）之间的相对位置进行位移。这可以被实现。通过在样品的活化和发射阶段之间移动（299）样品测定板和/或测量头。本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。

4. 发明申请

US20070177149A1 Instrumentation and method for optical measurement of samples 审中-公开
标题翻译：样品光学测量仪器和方法
公开(公告)号：US20070177149A1
公开(公告)日：2007-08-02
申请号：US11644865
申请日：2006-12-26
申请人： Petri Aronkyto , Raimo Harju , Ari Kuusisto , Petri Kivela , Mikko Vaisala
发明人： Petri Aronkyto , Raimo Harju , Ari Kuusisto , Petri Kivela , Mikko Vaisala
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452
摘要： The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation which comprises a point detector (531) for the measurement of homogeneous samples, and an image detector (591) for the measurement samples wherein the substance to be measured is inside or attached to details such as cells. The instrumentation has thus two measurement modes for the measurement of different types of samples. In measurement of details, improved measurement accuracy is obtained, as well as better insensitivity to the number and location of the details such as cells or particles within a sample.
摘要翻译：本发明一般涉及生物化学实验室仪器领域，用于不同应用样品的测量性质。微量滴定板和相应的样品支架。本发明的目的是通过提供一种光学测量仪器来实现，该测量仪器包括用于测量均匀样品的点检测器（531）和用于测量样品的图像检测器（591），其中待测物质在其内或附着于细节如细胞。因此，仪器具有用于测量不同类型样品的两种测量模式。在细节的测量中，获得了改进的测量精度，以及对样品中的细胞或细胞的细节的数量和位置的更好的不敏感性。

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