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1. 发明申请

US20170160194A1 SENSOR ARRANGEMENT FOR DETERMINING TURBIDITY 审中-公开
公开(公告)号：US20170160194A1
公开(公告)日：2017-06-08
申请号：US15372491
申请日：2016-12-08
申请人： Endress+Hauser Conducta GmbH+Co. KG
发明人： Thilo Krätschmer , Ralf Bernhard , Matthias Grossmann , Benjamin Bertsch
IPC分类号： G01N21/51
CPC分类号： G01N21/51 , G01N21/53 , G01N21/8507 , G01N2021/4709 , G01N2021/4711 , G01N2021/4728 , G01N2021/513 , G01N2021/8521
摘要： The present disclosure relates to a sensor arrangement for determining the turbidity of a liquid medium. The sensor arrangement includes a sensor section with at least one light source for sending transmission light into a measuring chamber, and at least one receiver associated with the light source for receiving reception light from the measuring chamber, wherein the transmission light is converted into the reception light in the measuring chamber by the medium by means of scattering at a measurement angle, and the reception light received by the receiver is a measure of the turbidity. The reception light is back reflected at a reflection element in contact with the medium, whereby an optical path from the light source through the measuring chamber to the reflection element and from the reflection element through the measuring chamber to the receiver results.

2. 发明授权

US10060847B2 Detection and signal processing system for particle assays 有权
公开(公告)号：US10060847B2
公开(公告)日：2018-08-28
申请号：US15394624
申请日：2016-12-29
申请人： Bio-Rad Laboratories, Inc.
发明人： Yunfeng Ling , David P. Stumbo , George Carman , Denis Pristinski
IPC分类号： G01N15/14
CPC分类号： G01N15/1429 , G01N15/1404 , G01N15/1434 , G01N15/1459 , G01N2015/1461 , G01N2015/1488 , G01N2021/4707 , G01N2021/4728
摘要： Systems and methods for detecting and processing signals from particles. In an exemplary method, particles may be passed through a zone of a channel, while the zone is irradiated with light. Interaction of the light with the particles may deflect light and induce photoluminescence. A deflection signal and a photoluminescence signal may be detected from the zone. Particle waveforms may be identified in the deflection signal. At least a subset of the particle waveforms may be double-peak waveforms including a pair of peaks corresponding to a particle entering and exiting the zone. Amplitudes may be obtained from the photoluminescence signal. The amplitudes may correspond to respective particles and their particle waveforms, and at least a subset of the amplitudes may correspond to the double-peak waveforms. Individual particles may be assigned as positive or as negative for an analyte based on the corresponding amplitudes.

3. 发明申请

US20100045977A1 Methods of Analyzing Samples Using Broadband Laser Light 有权
标题翻译：使用宽带激光分析样品的方法
公开(公告)号：US20100045977A1
公开(公告)日：2010-02-25
申请号：US12578629
申请日：2009-10-14
申请人： Kenneth A. Puzey
发明人： Kenneth A. Puzey
IPC分类号： G01J3/26
CPC分类号： C12Q1/04 , G01N21/31 , G01N21/3504 , G01N21/53 , G01N2021/1793 , G01N2021/3137 , G01N2021/3166 , G01N2021/3513 , G01N2021/4707 , G01N2021/4709 , G01N2021/4728
摘要： Broadband light, for example, from a Fabry-Perot quantum cascade laser, is shone onto a sample, and spectral data concerning the broadband light reflected from the sample is collected. The spectral data is analyzed to determine information about one or more substances in the sample. For example, if the sample contains micro-organisms, such as bacteria or fungus, the biological classification(s) (e.g., species) of the micro-organisms can be determined from the spectral data. As another example, if the sample contains virus, the biological classification(s) (e.g., species) of the virus(es) can be determined from the spectral data. As yet another example, if the sample contains particles, size, location and velocity can be determined from the spectral data.
摘要翻译：例如，来自法布里 - 珀罗量子级联激光器的宽带光照射到样品上，并收集与样品反射的宽带光有关的光谱数据。分析光谱数据以确定样品中一种或多种物质的信息。例如，如果样品含有诸如细菌或真菌的微生物，则可以根据光谱数据确定微生物的生物分类（例如物种）。作为另一个例子，如果样品含有病毒，则可以从光谱数据确定病毒的生物分类（例如，种类）。作为又一示例，如果样品含有颗粒，则可以从光谱数据确定大小，位置和速度。

4. 发明申请

US20050207943A1 System and method for detecting and identifying an analyte 有权
标题翻译：用于检测和鉴定分析物的系统和方法
公开(公告)号：US20050207943A1
公开(公告)日：2005-09-22
申请号：US11087939
申请日：2005-03-22
申请人： Kenneth Puzey
发明人： Kenneth Puzey
IPC分类号： B32B5/02 , C12Q1/04 , G01N21/29 , G01N21/31 , G01N21/35 , G01N21/41 , G01N21/47 , G01N21/53
CPC分类号： C12Q1/04 , G01N21/31 , G01N21/3504 , G01N21/53 , G01N2021/1793 , G01N2021/3137 , G01N2021/3166 , G01N2021/3513 , G01N2021/4707 , G01N2021/4709 , G01N2021/4728
摘要： A sensor (200, 900) comprising an illuminator (212, 500, 804, 832, 858, 904), a receiver (216, 400, 420, 460, 480, 808, 836, 862, 924) and an analyzer (240) for detecting and identifying an analyte having a characteristic absorption band that is present in a sample region (208, 812, 824, 874, 922). The illuminator includes an illumination source (220) for illuminating the sample region with spectral energy across at least a portion of the characteristic absorption band. The receiver includes a detector (228, 404, 424, 460, 484, 866, 928) for sensing predetermined portions of the spectral energy band and for creating a sample spectral data vector (236). The analyzer uses the spectral data vector and known characteristic data to detect and identify the analyte.
摘要翻译：一种传感器（200,900），包括照明器（212,500,804,832,885,904），接收器（216,400,420,460,480,808,836,862,924）和分析器（240）），用于检测和识别存在于样品区域（208,812,824,874,922）中的特征吸收带的分析物。照明器包括用于通过穿过特征吸收带的至少一部分的光谱能量照射样本区域的照明源（220）。接收机包括用于感测光谱能带的预定部分并用于创建采样光谱数据矢量（236）的检测器（228,404,424,460,448,866,928）。分析仪使用光谱数据矢量和已知特征数据来检测和识别分析物。

5. 发明申请

US20110205524A1 Methods of Analyzing Samples Using Broadband Laser Light 审中-公开
标题翻译：使用宽带激光分析样品的方法
公开(公告)号：US20110205524A1
公开(公告)日：2011-08-25
申请号：US13007876
申请日：2011-01-17
申请人： Kenneth A. Puzey
发明人： Kenneth A. Puzey
IPC分类号： G01N21/25 , G01N15/02 , G01P3/36
CPC分类号： C12Q1/04 , G01N21/31 , G01N21/3504 , G01N21/53 , G01N2021/1793 , G01N2021/3137 , G01N2021/3166 , G01N2021/3513 , G01N2021/4707 , G01N2021/4709 , G01N2021/4728
摘要： Broadband light, for example, from a Fabry-Perot quantum cascade laser, is shone onto a sample, and spectral data concerning the broadband light reflected from the sample is collected. The spectral data is analyzed to determine information about one or more substances in the sample. For example, if the sample contains micro-organisms, such as bacteria or fungus, the biological classification(s) (e.g., species) of the micro-organisms can be determined from the spectral data. As another example, if the sample contains virus, the biological classification(s) (e.g., species) of the virus(es) can be determined from the spectral data. As yet another example, if the sample contains particles, size, location and velocity can be determined from the spectral data.
摘要翻译：例如，来自法布里 - 珀罗量子级联激光器的宽带光照射到样品上，并收集与样品反射的宽带光有关的光谱数据。分析光谱数据以确定样品中一种或多种物质的信息。例如，如果样品含有诸如细菌或真菌的微生物，则可以根据光谱数据确定微生物的生物分类（例如物种）。作为另一个例子，如果样品含有病毒，则可以从光谱数据确定病毒的生物分类（例如，种类）。作为又一示例，如果样品含有颗粒，则可以从光谱数据确定大小，位置和速度。

6. 发明授权

US07894057B2 Methods of analyzing samples using broadband laser light 有权
标题翻译：使用宽带激光分析样品的方法
公开(公告)号：US07894057B2
公开(公告)日：2011-02-22
申请号：US12578629
申请日：2009-10-14
申请人： Kenneth A. Puzey
发明人： Kenneth A. Puzey
IPC分类号： G01J3/28
CPC分类号： C12Q1/04 , G01N21/31 , G01N21/3504 , G01N21/53 , G01N2021/1793 , G01N2021/3137 , G01N2021/3166 , G01N2021/3513 , G01N2021/4707 , G01N2021/4709 , G01N2021/4728
摘要： Broadband light, for example, from a Fabry-Perot quantum cascade laser, is shone onto a sample, and spectral data concerning the broadband light reflected from the sample is collected. The spectral data is analyzed to determine information about one or more substances in the sample. For example, if the sample contains micro-organisms, such as bacteria or fungus, the biological classification(s) (e.g., species) of the micro-organisms can be determined from the spectral data. As another example, if the sample contains virus, the biological classification(s) (e.g., species) of the virus(es) can be determined from the spectral data. As yet another example, if the sample contains particles, size, location and velocity can be determined from the spectral data.
摘要翻译：例如，来自法布里 - 珀罗量子级联激光器的宽带光照射到样品上，并收集与样品反射的宽带光有关的光谱数据。分析光谱数据以确定样品中一种或多种物质的信息。例如，如果样品含有诸如细菌或真菌的微生物，则可以根据光谱数据确定微生物的生物分类（例如物种）。作为另一个例子，如果样品含有病毒，则可以从光谱数据确定病毒的生物分类（例如，种类）。作为又一示例，如果样品含有颗粒，则可以从光谱数据确定大小，位置和速度。

7. 发明授权

US5015843A Fiber optic chemical sensors based on polymer swelling 失效
标题翻译：基于聚合物溶胀的光纤化学传感器
公开(公告)号：US5015843A
公开(公告)日：1991-05-14
申请号：US480548
申请日：1990-02-15
申请人： William R. Seitz , Marian F. McCurley
发明人： William R. Seitz , Marian F. McCurley
IPC分类号： C08J3/24 , C08J9/00 , C12Q1/00 , G01M3/04 , G01N21/49 , G01N21/77 , G01N21/80 , G01N30/00 , G01N33/543 , G02B6/26 , G02B6/36
CPC分类号： G02B6/241 , C12Q1/001 , G01M3/047 , G01N21/474 , G01N21/77 , G01N33/54373 , G02B6/262 , G01N2021/4709 , G01N2021/4728 , G01N2021/495 , G01N2021/7723 , G01N21/80 , G01N30/00 , G02B6/264 , Y10S435/808 , Y10S435/817 , Y10S436/805
摘要： Chemical sensors can detect the presence of chemical species in solution based upon polymer swelling in response to the chemical species. Polymer swelling is indirectly determined by measuring light reflected from a reflector affixed directly or indirectly to the polymer. Such that increase or decrease in the size of the polymer changes the distance between the reflector and a light source. Measurements of the light reflected from the reflector indicate the amount of swelling or shrinkage of the polymer in response to the chemical species.
摘要翻译：化学传感器可以基于化学物质响应聚合物溶胀来检测溶液中化学物质的存在。通过测量从直接或间接地固定在聚合物上的反射器反射的光来间接确定聚合物溶胀度。使得聚合物尺寸的增加或减小改变了反射体和光源之间的距离。从反射器反射的光的测量表明响应于化学物质的聚合物的膨胀或收缩量。

8. 发明申请

US20170276585A1 PARTICLE CHARACTERIZATION 审中-公开
公开(公告)号：US20170276585A1
公开(公告)日：2017-09-28
申请号：US15507155
申请日：2015-09-07
申请人： Malvern Instruments Limited
发明人： Jason Cecil William CORBETT
IPC分类号： G01N15/02 , G01N21/47 , G02B6/32 , G01N21/51
CPC分类号： G01N15/0205 , G01N21/474 , G01N21/51 , G01N2015/03 , G01N2021/4709 , G01N2021/4728 , G02B6/32
摘要： A particle characterization apparatus is disclosed comprising: a sample cell for holding a sample, a light source for producing a light beam for illuminating the sample in the sample cell, thereby producing scattered light by the interaction of the light beam with the sample; a focussing lens for focussing the light beam within the sample; and a detector for detecting the backscattered light along a detection optical path that intersects the focussed light beam within the sample. The intersection of the light beam and the detection optical path in the sample define a detection region. The apparatus comprises an optical arrangement for varying the volume of the detection region.

9. 发明授权

US07623234B2 System and method for detecting and identifying an analyte 有权
标题翻译：用于检测和鉴定分析物的系统和方法
公开(公告)号：US07623234B2
公开(公告)日：2009-11-24
申请号：US11087939
申请日：2005-03-22
申请人： Kenneth A. Puzey
发明人： Kenneth A. Puzey
IPC分类号： G01J3/28
CPC分类号： C12Q1/04 , G01N21/31 , G01N21/3504 , G01N21/53 , G01N2021/1793 , G01N2021/3137 , G01N2021/3166 , G01N2021/3513 , G01N2021/4707 , G01N2021/4709 , G01N2021/4728
摘要： A sensor (200, 900) comprising an illuminator (212, 500, 804, 832, 858, 904), a receiver (216, 400, 420, 460, 480, 808, 836, 862, 924) and an analyzer (240) for detecting and identifying an analyte having a characteristic absorption band that is present in a sample region (208, 812, 824, 874, 922). The illuminator includes an illumination source (220) for illuminating the sample region with spectral energy across at least a portion of the characteristic absorption band. The receiver includes a detector (228, 404, 424, 460, 484, 866, 928) for sensing predetermined portions of the spectral energy band and for creating a sample spectral data vector (236). The analyzer uses the spectral data vector and known characteristic data to detect and identify the analyte.
摘要翻译：一种传感器（200,900），包括照明器（212,500,804,832,885,904），接收器（216,400,420,460,480,808,836,862,924）和分析器（240）），用于检测和识别存在于样品区域（208,812,824,874,922）中的特征吸收带的分析物。照明器包括用于通过穿过特征吸收带的至少一部分的光谱能量照射样本区域的照明源（220）。接收机包括用于感测光谱能带的预定部分并用于创建采样光谱数据矢量（236）的检测器（228,404,424,460,448,866,928）。分析仪使用光谱数据矢量和已知特征数据来检测和识别分析物。

10. 发明授权

US5305073A Methods and apparatus for molecular characterization 失效
标题翻译：分子表征的方法和装置
公开(公告)号：US5305073A
公开(公告)日：1994-04-19
申请号：US834415
申请日：1992-02-12
申请人： Norman C. Ford, Jr.
发明人： Norman C. Ford, Jr.
IPC分类号： G01N21/21 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/53 , G01N30/74 , G01N15/06
CPC分类号： G01N21/49 , G01N2021/0346 , G01N2021/0392 , G01N2021/4711 , G01N2021/4728 , G01N21/53 , G01N2201/064 , G01N2201/0642
摘要： A molecular characterization detector includes a scattering cell containing a sample for molecular characterization, a light source for directing a light beam through the cell so that the light beam is scattered by the sample, optical elements for selecting from the scattered light a measurement beam comprising light that is scattered by the sample from a predetermined portion of the cell in a predetermined range of angles relative to the optical axis, and a detector for detecting the measurement beam and providing an output electrical signal representative of the measurement beam. The detector typically selects light scattered from a central portion of the scattering cell at angles in the range of 14.degree. to 16.degree.. A single spherical lens is preferably utilized. As a result, interference from stray scattered light is minimized. A beam dump attenuates the light beam after it passes through the scattering cell. Additional detectors detect light scattered at 90.degree. to the light beam. The outputs of the detectors are processed to provide molecular characterization of the sample.
摘要翻译：分子表征检测器包括含有用于分子表征的样品的散射单元，用于引导光束通过单元的光源，使得光束被样品散射，用于从散射光中选择的光学元件包括光的测量光其被来自单元的预定部分的样本以相对于光轴的预定角度范围散射;以及检测器，用于检测测量光束并提供表示测量光束的输出电信号。检测器通常以14度至16度的范围内的角度选择从散射单元的中心部分散射的光。优选使用单个球面透镜。结果，来自杂散散射光的干扰被最小化。光束转移器在通过散射单元之后会衰减光束。附加的检测器检测光束以90度散射的光。处理检测器的输出以提供样品的分子表征。

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