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1. 发明授权

US4906095A Apparatus and method for performing two-frequency interferometry 失效
标题翻译：用于执行双频干涉测量的装置和方法
公开(公告)号：US4906095A
公开(公告)日：1990-03-06
申请号：US147468
申请日：1988-01-25
申请人： Roger G. Johnston
发明人： Roger G. Johnston
IPC分类号： G01J9/02 , G01N21/17 , G01N21/19
CPC分类号： G01J9/02 , G01N21/171 , G01J2009/0207 , G01J2009/0261 , G01J2009/0269 , G01N21/19
摘要： The present apparatus includes a two-frequency, Zeeman-effect laser and matched, doubly refracting crystals in the construction of an accurate interferometer. Unlike other interferometric devices, the subject invention exhibits excellent phase stability owing to the use of single piece means for producing parallel interferometer arms, making the interferometer relatively insensitive to thermal and mechanical instabilities. Interferometers respond to differences in optical path length between their two arms. Unlike many interferometric techniques, which require the measurement of the location of interference fringes in a brightly illuminated background, the present invention permits the determination of the optical path length difference by measuring the phase of an electronic sine wave. The present apparatus is demonstrated as a differential thermooptic spectrometer for measuring differential optical absorption simply and accurately which is but one of many applications therefor. The relative intensities of the heating beams along each arm of the interferometer can be easily adjusted by observing a zero phase difference with identical samples when this condition is obtained.
摘要翻译：本设备包括一个双频塞曼效应激光器和匹配的双折射晶体，构建精确的干涉仪。与其他干涉仪装置不同，本发明由于使用用于产生平行干涉仪臂的单件装置显示出优异的相位稳定性，使得干涉仪对热和机械不稳定性相对不敏感。干涉仪响应两臂之间光程长度的差异。与需要在明亮照明背景中测量干涉条纹的位置的许多干涉测量技术不同，本发明允许通过测量电子正弦波的相位来确定光程长度差异。本装置被证明是用于简单且精确地测量差分光吸收的差分热光谱仪，其仅是许多应用之一。当获得该条件时，可以通过观察相同样品的零相位差来容易地调节沿着干涉仪的每个臂的加热束的相对强度。

2. 发明公开

US20230175893A1 Conformal imaging vibrometer using adaptive optics with scene-based wave-front sensing 审中-公开
公开(公告)号：US20230175893A1
公开(公告)日：2023-06-08
申请号：US17544877
申请日：2021-12-08
申请人： David Mort Pepper
发明人： David Mort Pepper
IPC分类号： G01J9/04 , G01J9/02
CPC分类号： G01J9/04 , G01J9/02 , G01J2009/0249 , G01J2009/0269
摘要： Conformal imaging vibrometer using adaptive optics with scene-based wave front sensing. An extended object is located at the first end of a link, and a reference-free, adaptive optical, conformal imaging vibrometer using scene-based wave front sensing is located at the second end of the link. An aberrated, free space or guided-wave path exists between the ends of the link. The adaptive optical system compensates for path distortions. Using a single interrogation beam, whole-body vibrations of opaque and reflective objects can be probed, as well as transparent and translucent objects, the latter pair employing a Zernike heterodyne interferometer.

3. 发明公开

US20240004176A1 QUANTITATIVE PHASE IMAGE GENERATING METHOD, QUANTITATIVE PHASE IMAGE GENERATING DEVICE, AND PROGRAM 审中-公开
公开(公告)号：US20240004176A1
公开(公告)日：2024-01-04
申请号：US18368621
申请日：2023-09-15
申请人： NIKON CORPORATION
发明人： Shota TSUCHIDA , Satoshi IKEDA
IPC分类号： G02B21/00 , G01J9/00 , G01J9/02
CPC分类号： G02B21/0056 , G01J9/00 , G01J9/0246 , G01J2009/0211 , G01J2009/0269
摘要： A quantitative phase image generating method for a microscope, includes: irradiating an object with illumination light; disposing a focal point of an objective lens at each of a plurality of positions that are mutually separated by gaps Δz along an optical axis of the objective lens, and detecting light from the object; generating sets of light intensity distribution data corresponding to each of the plurality of positions based upon the detected light; and generating a quantitative phase image based upon the light intensity distribution data; wherein the gap Δz is set based upon setting information of the microscope.

4. 发明申请

US20150204728A1 SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY 审中-公开
标题翻译：空域低相位定量相位显微镜
公开(公告)号：US20150204728A1
公开(公告)日：2015-07-23
申请号：US14562092
申请日：2014-12-05
申请人： Yang Liu , Randall E. Brand , Hoa V. Pham , Shikhar Fnu
发明人： Yang Liu , Randall E. Brand , Hoa V. Pham , Shikhar Fnu
IPC分类号： G01J9/02
CPC分类号： G01J9/02 , G01J2009/0223 , G01J2009/0253 , G01J2009/0269 , G01N15/1429 , G01N15/1434 , G01N15/1475 , G01N2015/1402 , G01N2015/1479 , G02B21/14 , G02B21/365
摘要： Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for “nano-pathological diagnosis” of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses. The nuclear nano-morphology derived from SL-QPM offers significant diagnostic value in clinical care and subcellular mechanistic insights for basic and translational research. Techniques that provide for depth selective investigation of nuclear and other cellular features are disclosed.
摘要翻译：本文描述了与空间域低相干定量相位显微镜（SL-QPM）相关联的系统，方法和其它实施例。 SL-QPM可以检测细胞核内的结构变化，具有纳米级灵敏度（0.9 nm）（或核纳米形态），用于癌症的“纳米病理诊断”。 SL-QPM使用原始，未修改的细胞学和组织学标本，用标准临床方案和污渍制备。 SL-QPM可以轻松整合到现有的临床病理实验室。结果量化了具有纳米尺度敏感性的单个核中光程长度或折射率的空间分布，可用于研究核纳米形态作为癌症进展。来自SL-QPM的核纳米形态为临床护理和亚细胞机械学基础和翻译研究提供了显着的诊断价值。公开了提供对核和其他蜂窝特征的深度选择性研究的技术。

5. 发明授权

US11808929B2 Quantitative phase image generating method, quantitative phase image generating device, and program 有权
公开(公告)号：US11808929B2
公开(公告)日：2023-11-07
申请号：US15931995
申请日：2020-05-14
申请人： NIKON CORPORATION
发明人： Shota Tsuchida , Satoshi Ikeda
IPC分类号： G02B21/00 , G01J9/00 , G01J9/02
CPC分类号： G02B21/0056 , G01J9/00 , G01J9/0246 , G01J2009/0211 , G01J2009/0269
摘要： A quantitative phase image generating method for a microscope, includes: irradiating an object with illumination light; disposing a focal point of an objective lens at each of a plurality of positions that are mutually separated by gaps Δz along an optical axis of the objective lens, and detecting light from the object; generating sets of light intensity distribution data corresponding to each of the plurality of positions based upon the detected light; and generating a quantitative phase image based upon the light intensity distribution data; wherein the gap Δz is set based upon setting information of the microscope.

6. 发明申请

US20180149467A1 VISUALIZATION SYSTEMS AND METHODS FOR OPTIMIZED OPTICAL COHERENCE TOMOGRAPHY 审中-公开
公开(公告)号：US20180149467A1
公开(公告)日：2018-05-31
申请号：US15808070
申请日：2017-11-09
申请人： Novartis AG
发明人： Hugang Ren , Lingfeng Yu
IPC分类号： G01B9/02 , A61B3/10 , A61B3/14
CPC分类号： G01B9/02091 , A61B3/0083 , A61B3/102 , A61B3/14 , A61B3/152 , G01J2009/0269
摘要： The present disclosure provides a visualization system for performing optimized optical coherence tomography (OCT) by determining the absolute distance between the OCT source and a sample. The present disclosure also provides a method for optimizing OCT, which includes determining an absolute distance between the OCT source and a sample using data relating to the focal length or position of an autofocus imager lens.

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