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1. 发明申请

US20140309288A1 GENE THERAPY INDUCED PYROPTOSIS FOR THE TREATMENT OF TUMORS 有权
标题翻译：基因治疗诱导肿瘤治疗肿瘤
公开(公告)号：US20140309288A1
公开(公告)日：2014-10-16
申请号：US14169112
申请日：2014-01-30
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Gary J. Brenner , Xandra O. Breakefield , Giulia Fulci
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/005 , C12N9/16 , C12N2750/14143 , C12N2830/008 , C12Y304/22036
摘要： Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter.
摘要翻译：本文描述了用于治疗，抑制，预防，降低神经鞘瘤的进展和/或降低神经鞘瘤进展的组合物和方法，以及神经鞘瘤起作用的任何疾病或生理疾病状态。组合物包含包含胱天蛋白酶-1基因或其变体和雪旺细胞特异性启动子的rAAV载体。

2. 发明申请

US20020136714A1 Relatedness of human interleukin-1beta convertase gene to a C. elegans cell death gene, inhibitory portions of these genes and uses therefor 失效
标题翻译：人白细胞介素-1β转化酶基因与线虫细胞死亡基因的相关性，这些基因的抑制部分及其用途
公开(公告)号：US20020136714A1
公开(公告)日：2002-09-26
申请号：US09888243
申请日：2001-06-22
发明人： H. Robert Horvitz , Junying Yuan , Shai Shaham
IPC分类号： A61K038/48 , C12N009/64 , C12P021/02 , C12N005/06
CPC分类号： C12N9/641 , A61K38/00 , C07K14/43581 , C07K14/4747 , C07K2319/00 , C12N9/6475 , C12Q1/6876 , C12Q2600/156 , C12Y304/22036 , C12Y304/22055
摘要： Described herein is the discovery that human interleukin-1null convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 protein may be a cysteine protease like ICE and that ICE may be a human equivalent of the nematode cell death gene. Another mammalian protein, the murine NEDD-2 protein, was also found to be similar to Ced-3. The NEDD-2 gene is implicated in the development of the murine central nervous system. On the basis of these findings, novel drugs for enhancing or inhibiting the activity of ICE, ced-3, or related genes are provided. Such drugs may be useful for treating inflammatory diseases and/or diseases characterized by cell deaths, as well as cancers, autoimmune disorders, infections, and hair growth and hair loss. Furthermore, such drugs may be useful for controlling pests, parasites and genetically engineered organisms. Furthermore, novel inhibitors of the activity of ced-3, ICE and related genes are described which comprise portions of the genes or their encoded products.
摘要翻译：本文描述了人白细胞介素-1β转化酶（ICE）在结构上类似于由线虫类细胞死亡基因ced-3编码的蛋白质的发现。两种蛋白质的比较和突变分析结合以前的观察结果表明，Ced-3蛋白可能是像ICE这样的半胱氨酸蛋白酶，并且ICE可能是人类等效于线虫细胞死亡基因。还发现另一种哺乳动物蛋白，鼠类NEDD-2蛋白质与Ced-3相似。 NEDD-2基因涉及鼠中枢神经系统的发展。在这些发现的基础上，提供了用于增强或抑制ICE，ced-3或相关基因活性的新型药物。这些药物可用于治疗以细胞死亡为特征的炎性疾病和/或疾病，以及癌症，自身免疫性疾病，感染和毛发生长和脱发。此外，这些药物可用于控制害虫，寄生虫和遗传工程生物体。此外，描述了包含部分基因或其编码产物的ced-3，ICE和相关基因的活性的新型抑制剂。

3. 发明授权

US07928197B2 Feline IL-18 proteins 有权
标题翻译：猫IL-18蛋白
公开(公告)号：US07928197B2
公开(公告)日：2011-04-19
申请号：US12128440
申请日：2008-05-28
申请人： Ramani S. Wonderling
发明人： Ramani S. Wonderling
IPC分类号： C07K14/435 , C07K14/46 , C07K14/54
CPC分类号： C12N9/6475 , A61K38/00 , A61K48/00 , C07K14/54 , C07K14/5434 , C07K2319/00 , C12Y304/22036
摘要： The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includes feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain nucleic acid molecules encoding such proteins, antibodies raised against such proteins and/or inhibitors of such proteins or nucleic acid molecules. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and/or inhibitors, as well as their use to evaluate and regulate an immune response in an animal.
摘要翻译：本发明涉及犬和猫科动物蛋白。特别地，本发明公开了白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白介素-12单链蛋白。本发明还包括编码这种蛋白质的白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白细胞介素-12单链核酸分子，针对这种蛋白产生的抗体和/或这种蛋白质或核酸的抑制剂分子。本发明还包括包含这种核酸分子，蛋白质，抗体和/或抑制剂的治疗组合物，以及它们在动物中评价和调节免疫应答的用途。

4. 发明授权

US07556963B2 Feline IL-18 nucleic acid molecules 失效
标题翻译：猫IL-18核酸分子
公开(公告)号：US07556963B2
公开(公告)日：2009-07-07
申请号：US11514728
申请日：2006-09-01
申请人： Ramani S. Wonderling
发明人： Ramani S. Wonderling
IPC分类号： C12N15/00 , C12N15/11 , C12N15/12
CPC分类号： C12N9/6475 , A61K38/00 , A61K48/00 , C07K14/54 , C07K14/5434 , C07K2319/00 , C12Y304/22036
摘要： The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includes feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain nucleic acid molecules encoding such proteins, antibodies raised against such proteins and/or inhibitors of such proteins or nucleic acid molecules. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and/or inhibitors, as well as their use to evaluate and regulate an immune response in an animal.
摘要翻译：本发明涉及犬和猫科动物蛋白。特别地，本发明公开了白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白介素-12单链蛋白。本发明还包括编码这种蛋白质的白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白细胞介素-12单链核酸分子，针对这种蛋白产生的抗体和/或这种蛋白质或核酸的抑制剂分子。本发明还包括包含这种核酸分子，蛋白质，抗体和/或抑制剂的治疗组合物，以及它们在动物中评价和调节免疫应答的用途。

5. 发明申请

US20040132023A1 Regulation of human caspase-1-like protease 审中-公开
标题翻译：人类半胱天冬酶-1样蛋白酶的调节
公开(公告)号：US20040132023A1
公开(公告)日：2004-07-08
申请号：US10311954
申请日：2003-02-27
发明人： Shyam Ramakrishnan
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/64
CPC分类号： C12N9/6475 , A61K38/00 , C07K2319/00 , C12Y304/22036
摘要： Reagents which regulate human caspase-1-like protease activity and reagents which bind to human caspase-1-like protease gene products can be used to treat an allergic disease, asthma, cancer and neurodegenerative diseases.
摘要翻译：调节人胱天蛋白酶-1样蛋白酶活性的试剂和结合人半胱天冬酶-1样蛋白酶基因产物的试剂可用于治疗过敏性疾病，哮喘，癌症和神经变性疾病。

6. 发明申请

US20070059283A1 Feline IL-18 nucleic acid molecules 失效
标题翻译：猫IL-18核酸分子
公开(公告)号：US20070059283A1
公开(公告)日：2007-03-15
申请号：US11514728
申请日：2006-09-01
申请人： Ramani Wonderling
发明人： Ramani Wonderling
IPC分类号： A61K38/20 , C07K14/54 , C07H21/04 , C12P21/04
CPC分类号： C12N9/6475 , A61K38/00 , A61K48/00 , C07K14/54 , C07K14/5434 , C07K2319/00 , C12Y304/22036
摘要： The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includes feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain nucleic acid molecules encoding such proteins, antibodies raised against such proteins and/or inhibitors of such proteins or nucleic acid molecules. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and/or inhibitors, as well as their use to evaluate and regulate an immune response in an animal.
摘要翻译：本发明涉及犬和猫科动物蛋白。特别地，本发明公开了白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白介素-12单链蛋白。本发明还包括编码这种蛋白质的白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白细胞介素-12单链核酸分子，针对这种蛋白产生的抗体和/或这种蛋白质或核酸的抑制剂分子。本发明还包括包含这种核酸分子，蛋白质，抗体和/或抑制剂的治疗组合物，以及它们在动物中评价和调节免疫应答的用途。

7. 发明申请

US20070026076A1 Molecular vaccines employing nucleic acid encoding anti-apoptotic proteins 审中-公开
标题翻译：使用编码抗凋亡蛋白的核酸的分子疫苗
公开(公告)号：US20070026076A1
公开(公告)日：2007-02-01
申请号：US10546810
申请日：2004-02-24
申请人： Tzyy-Choou Wu , Chien Hung , Tae-Woo Kim
发明人： Tzyy-Choou Wu , Chien Hung , Tae-Woo Kim
IPC分类号： A61K48/00 , C12N15/09 , C12N15/87 , A61K9/14
CPC分类号： A61K39/12 , A61K9/0019 , A61K38/4873 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61K2039/585 , A61K2039/6006 , A61K2039/6031 , A61K2039/6043 , C07K14/005 , C07K14/4747 , C07K2319/01 , C07K2319/02 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2800/107 , C12Y304/22036 , C12Y304/22055 , C12Y304/22056 , C12Y304/22057 , C12Y304/22058 , C12Y304/22059 , C12Y304/2206 , C12Y304/22061 , C12Y304/22062 , C12Y304/22063 , C12Y304/22064
摘要： T cell immune responses are enhanced by presentation of antigen to CD8+ T cells using a chimeric nucleic acid immunogen or vaccine that links DNA encoding an antigen with DNA encoding a polypeptide that targets or translocates the antigenic polypeptide to which it is fused (immunogenicity-potentiating polypeptides or “IPP”). By inhibiting apoptosis in the vicinity of a T cell responses to such a nucleic acid immunogen, even more potent immune responses are attained. The present strategy prolongs the survival of DNA-transduced cells, including dendritic cells (DCs), thereby enhancing the priming of antigen-specific T cells and increase potency. Co-delivery of DNA encoding an inhibitor of apoptosis, including (a) BCL-xL, (b) BCL-2, (c) XIAP, (d) dominant negative caspase-9, or (e) dominant negative caspase-8, or (f) serine protease inhibitor 6 (SPI-6) which inhibits granzyme B, with DNA encoding an antigen, prolongs the survival of transduced DCs and results in significant enhancement of antigenspecific T cell immune responses that provide potent antitumor effects. Thus, co-administration of a DNA vaccine encoding antigen linked to an IPP along with one or more DNA constructs encoding an anti-apoptotic protein provides a novel way to enhance vaccine potency.
摘要翻译：使用将编码抗原的编码抗原的DNA与编码靶向或转位抗原多肽的多肽连接的嵌合核酸免疫原或疫苗将CD8 + T细胞呈递抗原来增强T细胞免疫应答，它是融合的（免疫原性增强多肽或“IPP”）。通过抑制对这种核酸免疫原的T细胞应答附近的细胞凋亡，获得更强大的免疫应答。目前的策略延长了DNA转导细胞（包括树突状细胞（DCs））的存活，从而增强了抗原特异性T细胞的引发并提高了效力。包括（a）BCL-xL，（b）BCL-2，（c）XIAP，（d）显性负性胱天蛋白酶-9或（e）显性负性胱天蛋白酶-8的DNA的编码凋亡抑制剂的DNA共转染，或（f）用编码抗原的DNA抑制粒酶B的丝氨酸蛋白酶抑制剂6（SPI-6）延长了转导的DC的存活并且导致提供有效的抗肿瘤作用的抗原特异性T细胞免疫应答的显着增强。因此，编码与IPP连接的抗原的DNA疫苗与编码抗凋亡蛋白的一种或多种DNA构建体的共同给药提供了增强疫苗效力的新方法。

8. 发明申请

US20060141552A1 Regulation of human caspase-1-like protease 失效
标题翻译：人类半胱天冬酶-1样蛋白酶的调节
公开(公告)号：US20060141552A1
公开(公告)日：2006-06-29
申请号：US11357125
申请日：2006-02-21
申请人： Shyam Ramakrishnan
发明人： Shyam Ramakrishnan
IPC分类号： C12Q1/37
CPC分类号： C12N9/6475 , A61K38/00 , C07K2319/00 , C12Y304/22036
摘要： Screening methods to identify candidate therapeutic agents using a newly identified human caspases-1-like protease.
摘要翻译：使用新鉴定的人类半胱天冬酶-1样蛋白酶鉴定候选治疗剂的筛选方法。

9. 发明申请

US20090198043A1 FELINE IL-18 PROTEINS 有权
标题翻译： FELINE IL-18蛋白
公开(公告)号：US20090198043A1
公开(公告)日：2009-08-06
申请号：US12128440
申请日：2008-05-28
申请人： RAMANI S. WONDERLING
发明人： RAMANI S. WONDERLING
IPC分类号： C07K14/54
CPC分类号： C12N9/6475 , A61K38/00 , A61K48/00 , C07K14/54 , C07K14/5434 , C07K2319/00 , C12Y304/22036
摘要： The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includes feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain nucleic acid molecules encoding such proteins, antibodies raised against such proteins and/or inhibitors of such proteins or nucleic acid molecules. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and/or inhibitors, as well as their use to evaluate and regulate an immune response in an animal.
摘要翻译：本发明涉及犬和猫科动物蛋白。特别地，本发明公开了白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白介素-12单链蛋白。本发明还包括编码这种蛋白质的白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白细胞介素-12单链核酸分子，针对这种蛋白产生的抗体和/或这种蛋白质或核酸的抑制剂分子。本发明还包括包含这种核酸分子，蛋白质，抗体和/或抑制剂的治疗组合物，以及它们在动物中评价和调节免疫应答的用途。

10. 发明授权

US07205143B2 Feline IL-12 single chain nucleic acid molecules 有权
标题翻译：猫IL-12单链核酸分子
公开(公告)号：US07205143B2
公开(公告)日：2007-04-17
申请号：US10821670
申请日：2004-04-09
申请人： Ramani S. Wonderling , Karen L. Boroughs
发明人： Ramani S. Wonderling , Karen L. Boroughs
IPC分类号： C12N15/00 , C12N15/19 , C12N15/12 , C12N15/62 , C12N15/86 , C12N15/85
CPC分类号： C12N9/6475 , A61K38/00 , A61K48/00 , C07K14/54 , C07K14/5434 , C07K2319/00 , C12Y304/22036
摘要： The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includes feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain nucleic acid molecules encoding such proteins, antibodies raised against such proteins and/or inhibitors of such proteins or nucleic acid molecules. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and/or inhibitors, as well as their use to evaluate and regulate an immune response in an animal.
摘要翻译：本发明涉及犬和猫科动物蛋白。特别地，本发明公开了白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白介素-12单链蛋白。本发明还包括编码这种蛋白质的白细胞介素-18，猫半胱天冬酶-1，猫白细胞介素-12单链和犬白细胞介素-12单链核酸分子，针对这种蛋白产生的抗体和/或这种蛋白质或核酸的抑制剂分子。本发明还包括包含这种核酸分子，蛋白质，抗体和/或抑制剂的治疗组合物，以及它们在动物中评价和调节免疫应答的用途。

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