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1. 发明申请

US20120156186A1 NON-CYTOTOXIC PROTEIN CONJUGATES 有权
标题翻译：非细胞毒素蛋白结合
公开(公告)号：US20120156186A1
公开(公告)日：2012-06-21
申请号：US13343892
申请日：2012-01-05
申请人： Keith FOSTER , John CHADDOCK , Charles PENN , Kei Roger AOKI , Joseph FRANCIS , Lance STEWARD
发明人： Keith FOSTER , John CHADDOCK , Charles PENN , Kei Roger AOKI , Joseph FRANCIS , Lance STEWARD
IPC分类号： A61K38/48 , A61P21/00 , C12P21/00 , C12N9/96 , C12N15/57
CPC分类号： A61K38/4893 , A61K38/4886 , C07K14/575 , C07K2319/00 , C07K2319/01 , C12N9/52 , C12Y304/21072
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a galanin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are is also described.
摘要翻译：本发明涉及用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物。所述蛋白质缀合物包括：（i）甘丙肽靶向部分（TM），其中所述TM是存在于伤害性感觉传入细胞上的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入物内的内体细胞; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。

2. 发明申请

US20180125961A1 NEISSERIA MENINGITIDIS TRYPSIN-LIKE SERINE PROTEASE POLYPEPTIDES AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：US20180125961A1
公开(公告)日：2018-05-10
申请号：US15534443
申请日：2015-12-08
申请人： SANOFI PASTEUR
发明人： Nadège ARNAUD-BARBE , Geneviève RENAULD-MONGENIE , Bachra ROKBI
IPC分类号： A61K39/095 , C12N9/52
CPC分类号： A61K39/095 , C07K2319/40 , C12N9/52 , C12Y304/21072
摘要： The present invention relates to novel polypeptides derived from Neisseria meningitidis proteins, in particular auto-transporters of the trypsin-like serine protease subclass, such as IgA1P, App and AusI, and their use in immunogenic compositions i.a., vaccine compositions for the prevention and/or treatment of meningococcal infections. In particular, it provides fragments of IgA1P, App and AusI and polypeptides comprising or consisting of these fragments and fusions thereof, which may be used in immunogenic compositions, for example vaccine compositions.

3. 发明申请

US20170327810A1 FUSION PROTEINS AND METHODS FOR TREATING, PREVENTING OR AMELIORATING PAIN 审中-公开
公开(公告)号：US20170327810A1
公开(公告)日：2017-11-16
申请号：US15661433
申请日：2017-07-27
申请人： IPSEN BIOINNOVATION LIMITED , Allergan, Inc.
发明人： Peter JAMES , Keith FOSTER , John CHADDOCK , Roger Kei AOKI , Lance STEWARD , Joseph FRANCIS
IPC分类号： C12N9/52 , C07K14/575
CPC分类号： C12N9/52 , A61K38/00 , A61K47/64 , A61K47/65 , C07K14/575 , C07K2319/01 , C07K2319/50 , C07K2319/55 , C07K2319/74 , C12N15/625 , C12Y304/21072 , C12Y304/24013 , C12Y304/24068 , C12Y304/24069
摘要： A single chain polypeptide fusion protein, comprising: a non-cytotoxic protease capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin targeting moiety; a protease cleavage site at which site the fusion protein is cleavable by a protease; a translocation domain capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent; a first spacer located between the non-cytotoxic protease and the protease cleavage site; and a second spacer located between the galanin targeting moiety and the translocation domain.

4. 发明申请

US20160137999A1 SUPPRESSION OF ITCH 审中-公开
标题翻译：抑制ITCH
公开(公告)号：US20160137999A1
公开(公告)日：2016-05-19
申请号：US14900892
申请日：2014-07-09
申请人： IPSEN BIOINNOVATION LIMITED
发明人： Keith FOSTER
IPC分类号： C12N9/52 , C07K7/08
CPC分类号： C12N9/52 , A61K38/00 , A61K38/48 , C07K7/08 , C07K2319/10 , C07K2319/55 , C12Y304/21072 , C12Y304/24013 , C12Y304/24069
摘要： The invention provides a polypeptide, for use in suppressing or treating itch, wherein the polypeptide comprises: a non-cytotoxic protease, which protease is capable of cleaving a SNARE protein in an itch-specific DRG neuron or a pruriceptor; a Targeting Moiety (TM) that is capable of binding to a Binding Site on the itch-specific DRG neuron or a pruriceptor, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the itch-specific DRG neuron or a pruriceptor, and wherein said itch-specific DRG neuron or a pruriceptor expresses said SNARE protein; and a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the itch-specific DRG neuron or a pruriceptor; with the proviso that the polypeptide is not a clostridial neurotoxin (holotoxin) molecule.
摘要翻译：本发明提供了用于抑制或治疗瘙痒的多肽，其中所述多肽包含：非细胞毒性蛋白酶，所述蛋白酶能够在瘙痒特异性DRG神经元或瘙痒感受物中切割SNARE蛋白; 能够结合瘙痒特异性DRG神经元上的结合位点的靶向物（TM），或者可以将结合位点能够进行内吞作用的瘙痒特异性DRG神经元或瘙痒剂，并且其中所述瘙痒特异性DRG神经元或pruriceptor表达所述SNARE蛋白; 以及易位区域，其能够将蛋白酶从内体内穿过内体膜并进入瘙痒特异性DRG神经元的细胞质溶液或精华中; 条件是多肽不是梭菌神经毒素（全毒素）分子。

5. 发明授权

US08603779B2 Non-cytotoxic protein conjugates 有权
标题翻译：非细胞毒性蛋白偶联物
公开(公告)号：US08603779B2
公开(公告)日：2013-12-10
申请号：US13343892
申请日：2012-01-05
申请人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
IPC分类号： C07K14/00 , A61K38/16 , C12P21/04 , C12P21/06
CPC分类号： A61K38/4893 , A61K38/4886 , C07K14/575 , C07K2319/00 , C07K2319/01 , C12N9/52 , C12Y304/21072
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a galanin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are is also described.
摘要翻译：本发明涉及用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物。所述蛋白质缀合物包括：（i）甘丙肽靶向部分（TM），其中所述TM是存在于伤害性感觉传入细胞上的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入物内的内体细胞; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。

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