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1. 发明授权

US11891654B2 Methods of making gene expression libraries 有权
公开(公告)号：US11891654B2
公开(公告)日：2024-02-06
申请号：US17184117
申请日：2021-02-24
申请人： 10x Genomics, Inc.
发明人： Luigi Jhon Alvarado Martinez , Eswar Prasad Ramachandran Iyer
IPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q1/6827
CPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q1/6827 , C12Q2543/101 , C12Q2565/514
摘要： Provided herein are methods of determining a location of a target nucleic acid in a biological sample.

2. 发明授权

US11873528B2 Methods and compositions for nucleic acid analysis 有权
公开(公告)号：US11873528B2
公开(公告)日：2024-01-16
申请号：US17943064
申请日：2022-09-12
申请人： 10X GENOMICS, INC.
发明人： Xinying Zheng , Serge Saxonov , Michael Schnall-Levin , Kevin Ness , Rajiv Bharadwaj
IPC分类号： C12Q1/6809 , C12Q1/6806 , C12Q1/6834 , C12Q1/6869
CPC分类号： C12Q1/6809 , C12Q1/6806 , C12Q1/6834 , C12Q1/6869 , C12Q1/6806 , C12Q2521/501 , C12Q2523/101 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122 , C12Q2543/101 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/631 , C12Q1/6869 , C12Q2521/501 , C12Q2523/101 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122 , C12Q2543/101 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/631
摘要： The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.

3. 发明申请

US20180057873A1 METHODS FOR PERFORMING SPATIAL PROFILING OF BIOLOGICAL MATERIALS 审中-公开
公开(公告)号：US20180057873A1
公开(公告)日：2018-03-01
申请号：US15563015
申请日：2016-04-18
申请人： CENTRILLION TECHNOLOGY HOLDINGS CORPORATION
发明人： Wei ZHOU , Janet WARRINGTON
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12Q1/6874 , C12N15/1065 , C12N15/1068 , C12Q1/6804 , G01N33/54306 , G01N2458/10 , C12Q2535/122 , C12Q2543/101 , C12Q2565/514
摘要： Provided herein are methods and compositions for profiling the spatial distribution of a wide variety of biological molecules in a sample. The methods and compositions are suited for spatial labeling and sequencing of biological molecules (e.g., nucleic acids, proteins) in a biological sample.

4. 发明授权

US09732113B2 Dendrimeric dye-containing oligonucleotide probes and methods of preparation and uses thereof 有权
公开(公告)号：US09732113B2
公开(公告)日：2017-08-15
申请号：US14153062
申请日：2014-01-12
申请人： Agilent Technologies, Inc.
发明人： Jeremy Lackey , Siyuan Chen , Maithreyan Srinivasan
IPC分类号： C07H19/04 , C07H21/00 , C12Q1/68 , C40B40/06
CPC分类号： C07H21/00 , C12Q1/682 , C12Q1/6841 , C12Q2525/313 , C12Q2543/101 , C12Q2563/107
摘要： The invention provides novel oligonucleotide probes that have dendrimeric dyes useful for detecting and analyzing biological samples, and compositions and methods thereof. The dendrimeric dye-containing oligonucleotide probes are useful for high sensitivity fluorescence in situ hybridization (FISH) of nucleic acids such as DNA and RNA.

5. 发明授权

US09540684B2 Methods and devices for detection and acquisition of biomarkers 有权
标题翻译：用于检测和获取生物标志物的方法和装置
公开(公告)号：US09540684B2
公开(公告)日：2017-01-10
申请号：US14106661
申请日：2013-12-13
申请人： MINDERA Corporation , The Scripps Research Institute
发明人： Tahir A. Mahmood , Tobin J. Dickerson , Nadir A. Mahmood , Petr Capek
IPC分类号： C12Q1/68 , A61B5/15 , A61B5/145 , A61B5/1468 , A61K9/00 , A61B5/00
CPC分类号： C12Q1/6841 , A61B5/14503 , A61B5/14514 , A61B5/1468 , A61B5/150015 , A61B5/150022 , A61B5/150984 , A61B5/685 , A61B10/0045 , A61B10/0233 , A61B2010/008 , A61B2562/046 , A61K9/0021 , C12Q1/6806 , C12Q1/6837 , C12Q1/6876 , C12Q2600/16 , G01N1/08 , C12Q2531/113 , C12Q2565/501 , C12Q2565/607 , C12Q2565/629 , C12Q2543/101
摘要： The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).
摘要翻译：本发明提供了用于从原位原位检测和捕获分子生物标志物的装置和方法。具体地，这些装置包含一组微针，其上附着有针对感兴趣的一种或多种生物标志物的探针。在检测受试者体内的生物标志（例如，组织，血液）中时，这些装置可以直接用于受试者（例如通过皮肤刺穿）。

6. 发明授权

US08951733B2 Methods of polynucleotide detection 有权
标题翻译：多核苷酸检测方法
公开(公告)号：US08951733B2
公开(公告)日：2015-02-10
申请号：US13501155
申请日：2010-10-15
申请人： Ryan K. Bartlett , Allen T. Christian , Mingqi Deng , Sonya J. Franklin , Larry A. Gilbertson , G. David Grothaus , R. Douglas Sammons , Jianping Xu
发明人： Ryan K. Bartlett , Allen T. Christian , Mingqi Deng , Sonya J. Franklin , Larry A. Gilbertson , G. David Grothaus , R. Douglas Sammons , Jianping Xu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q2543/101
摘要： The present invention provides methods of detecting for the presence of a polynucleotide in vivo. These methods are particularly useful for performing identification and/or analysis of samples or specimens in which it is impossible, impractical, or undesirable to move or remove them from their current environment. Methods of practicing the present invention for the purpose of identifying and/or analyzing transgenic plant tissue or cells, in addition to animal tissue or cells and bacterial cells are also provided.
摘要翻译：本发明提供了在体内检测多核苷酸的存在的方法。这些方法对于进行样品或样品的鉴定和/或分析特别有用，在样品或样品中，不可能，不切实际或不希望将其从当前环境中移出或移除。还提供了用于鉴定和/或分析转基因植物组织或细胞（除动物组织或细胞和细菌细胞）之外的实施本发明的方法。

7. 发明申请

US20140272934A1 DENDRIMERIC DYE-CONTAINING OLIGONUCLEOTIDE PROBES AND METHODS OF PREPARATION AND USES THEREOF 有权
标题翻译：含有半乳糖的含半乳糖探针及其制备方法及用途
公开(公告)号：US20140272934A1
公开(公告)日：2014-09-18
申请号：US14153062
申请日：2014-01-12
申请人： AgilentTechnologies, Inc.
发明人： Jeremy Lackey , Siyuan Chen , Maithreyan Srinivasan
IPC分类号： C12Q1/68
CPC分类号： C07H21/00 , C12Q1/682 , C12Q1/6841 , C12Q2525/313 , C12Q2543/101 , C12Q2563/107
摘要： The invention provides novel oligonucleotide probes that have dendrimeric dyes useful for detecting and analyzing biological samples, and compositions and methods thereof. The dendrimeric dye-containing oligonucleotide probes are useful for high sensitivity fluorescence in situ hybridization (FISH) of nucleic acids such as DNA and RNA.
摘要翻译：本发明提供了具有用于检测和分析生物样品的树状聚合染料的新型寡核苷酸探针及其组合物和方法。含有树枝状染料的寡核苷酸探针可用于核酸如DNA和RNA的高灵敏度荧光原位杂交（FISH）。

8. 发明授权

US06447804B1 Dry solid medium for storage and analysis of genetic material 失效
标题翻译：用于储存和分析遗传物质的干固体培养基
公开(公告)号：US06447804B1
公开(公告)日：2002-09-10
申请号：US09393991
申请日：1999-09-10
申请人： Leigh Alexander Burgoyne
发明人： Leigh Alexander Burgoyne
IPC分类号： A61K914
CPC分类号： C12Q1/6806 , C12N15/1006 , C12Q1/686 , C12Q1/6879 , C12Q1/6886 , C12Q2549/101 , C12Q2547/107 , C12Q2565/518 , C12Q2543/101 , C12Q2521/301
摘要： A dry solid medium for storage of a sample includes a solid matrix of sorbing genetic material thereon and a mechanism for preserving and protecting the genetic material applied to the matrix. A method for storing the sample genetic material includes the steps of sorbing genetic material on the solid matrix and protecting the genetic material.
摘要翻译：用于储存样品的干燥固体培养基包括其上的吸附遗传物质的固体基质和用于保存和保护施用于基质的遗传物质的机制。用于储存样品遗传物质的方法包括在固体基质上吸附遗传物质并保护遗传物质的步骤。

9. 发明申请

US20020031764A1 CASCADE NUCLEIC ACID AMPLIFICATION REACTION 有权
标题翻译： CASCADE核酸放大反应
公开(公告)号：US20020031764A1
公开(公告)日：2002-03-14
申请号：US09465589
申请日：1999-12-17
发明人： JORN ERLAND KOCH
IPC分类号： C12Q001/68 , C12P019/34
CPC分类号： C12Q1/6844 , C12N15/10 , C12Q1/6804 , C12Q1/682 , C12Q2525/301 , C12Q2531/125 , C12Q2543/101 , C12Q2525/143 , C12Q2563/131
摘要： A DNA template consisting of multiple tandem repetitions of an oligonucleotide unit is produced by stepwise copying of an oligonucleotide comprising at least one and a half units of a nucleotide sequence showing dyad symmetry by means of a template- and primer-dependent DNA polymerase in the presence of the necessary nucleoside triphosphates during repeated cycles of denaturation and annealing, or by endless copying of a circular oligonucleotide comprising at least one copy of said oligonucleotide unit by means of a nucleic acid polymerase, which is capable of strand displacement and is substantially without 5null-3null exonuclease activity, in the presence of the necessary nucleoside triphosphates and, if necessary, a primer capable of binding to some portion of the oligonucleotide, or by known reactions. Thereafter, in a cascade nucleic acid amplification reaction, a great number of partial and complete DNA or RNA copies of said DNA template is produced by means of a nucleic acid polymerase, which is capable of strand displacement and is substantially without 5null-3null exonuclease activity, by contacting the template with said nucleic acid polymerase in the presence of the necessary nucleoside triphosphates and, if necessary, a primer capable of binding to the oligonucleotide unit, the polymerase thus synthesizing DNA or RNA originating from, ideally, each repeating oligonucleotide unit in the DNA template. These reactions can be used in methods for detecting a target molecule or group and in processes for the amplification of a particular DNA sequence
摘要翻译：由寡核苷酸单位的多重串联重复组成的DNA模板通过在存在下通过模板和引物依赖性DNA聚合酶逐步复制包含至少一个单位的显示二重对称性的核苷酸序列的寡核苷酸来产生的重复变性和退火循环中必需的核苷三磷酸酯，或通过无限制复制包含至少一个拷贝的所述寡核苷酸单元的环状寡核苷酸，所述核苷酸聚合酶能够进行链置换并且基本上不具有5' -3'核酸外切酶活性，在必需的核苷三磷酸存在下，如果需要，可以与一些部分寡核苷酸结合的引物，或已知的反应。此后，在级联核酸扩增反应中，通过核酸聚合酶产生大量部分和完整的所述DNA模板的DNA或RNA拷贝，所述核酸聚合酶能够进行链置换并且基本上不含5'-3' 外切核酸酶活性，通过在必需的核苷三磷酸存在下将模板与所述核酸聚合酶接触，并且如果需要，可以与能够结合寡核苷酸单元的引物接触，从而合成来自理想的每一个重复寡核苷酸的DNA或RNA 单元在DNA模板中。这些反应可用于检测靶分子或基团的方法和用于扩增特定DNA序列的方法

10. 发明公开

US20240158838A1 METHODS OF MAKING GENE EXPRESSION LIBRARIES 审中-公开
公开(公告)号：US20240158838A1
公开(公告)日：2024-05-16
申请号：US18418967
申请日：2024-01-22
申请人： 10x Genomics, Inc.
发明人： Luigi Jhon Alvarado Martinez , Eswar Prasad Ramachandran Iyer
IPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q1/6827
CPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q1/6827 , C12Q2543/101 , C12Q2565/514
摘要： Provided herein are methods of determining a location of a target nucleic acid in a biological sample.

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