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1. 发明申请

US20150044273A1 MOLLUSCUM CONTAGIOSUM VIRAL FUSION PROTEIN TREATMENT FOR ATOPIC DERMATITIS DISEASES 有权
标题翻译：毛细血管粘膜病毒融合蛋白治疗原发性疾病
公开(公告)号：US20150044273A1
公开(公告)日：2015-02-12
申请号：US13962757
申请日：2013-08-08
申请人： David A. PASLIN
发明人： David A. PASLIN
IPC分类号： C07K14/005 , A61K9/127 , A61N1/32 , A61K38/16
CPC分类号： C07K14/001 , A61K9/0014 , A61K9/0019 , A61K9/0021 , A61K9/14 , A61K38/162 , A61N1/325 , A61N1/327 , C07K14/005 , C07K2319/00 , C07K2319/10 , C07K2319/21 , C12N2710/24022 , C12N2710/24033 , C12N2710/24071 , Y10S530/826
摘要： Compositions, methods, and kits are provided for treating CCR8 mediated diseases with applicability to atopic dermatitis and potential applicability to asthma, prurigo nodularis, nummular dermatitis, neurodermatitis, and lichen simplex chronicus and some lymphomas, multiple sclerosis, acquired immunodeficiency disease, peritoneal adhesions, Kaposi's sarcoma and atherogenesis—the expression of all of which, at least in part, is mediated by cells expressing the chemokine receptor CCR8. The compositions include proteins and fusion proteins from Molluscum contagiosum Virus (MCV) or variants, analogs and derivatives thereof which exhibit inhibitory activity. Examples of such MCV proteins are MC148 fusion protein (MC148fp) identified as MC148P-TAT-6xHis (“6xHis” disclosed as SEQ ID NO: 11), and its variants, fragments, analogs and derivatives which possess inhibitory activity. The variants, fragments, analogs and derivatives of MC148p and of MC148fp may be less than 100% homologous to MCV proteins as long as they are sufficiently homologous that inhibitory activity is preserved.
摘要翻译：提供用于治疗CCR8介导的疾病的组合物，方法和试剂盒，适用于特应性皮炎和潜在适用于哮喘，结节性痒疹，麻疹性皮炎，神经性皮炎，单纯疱疹性慢性肾炎和一些淋巴瘤，多发性硬化，获得性免疫缺陷病，腹膜粘连，卡波西氏肉瘤和动脉粥样硬化形成 - 所有这些的表达至少部分地由表达趋化因子受体CCR8的细胞介导。组合物包括来自软体动物传染性病毒（MCV）的蛋白质和融合蛋白或其变体，类似物和衍生物，其表现出抑制活性。鉴定为MC148P-TAT-6xHis（“6xHis”如SEQ ID NO：11所公开）的MC148融合蛋白（MC148fp）及其具有抑制活性的其变体，片段，类似物和衍生物的实例。 MC148p和MC148fp的变体，片段，类似物和衍生物可以与MCV蛋白质小于100％同源，只要它们具有足够的同源性即可抑制活性被保留。

2. 发明授权

US08017590B1 Method of inducing and/or enhancing an immune response to tumor antigens 有权
标题翻译：诱导和/或增强对肿瘤抗原的免疫应答的方法
公开(公告)号：US08017590B1
公开(公告)日：2011-09-13
申请号：US09693754
申请日：2000-10-20
申请人： Neil Berinstein , James Tartaglia , Philippe Moingeon , Brian Barber
发明人： Neil Berinstein , James Tartaglia , Philippe Moingeon , Brian Barber
IPC分类号： A61K48/00 , A61K38/00 , A61K38/04 , A61K39/00
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
摘要翻译：公开了诱导和/或增强对肿瘤抗原的免疫应答的改进方法。该方法包括将肿瘤抗原，其编码的核酸，包含所述核酸的载体和/或细胞或包含上述的疫苗施用于淋巴结位点。

3. 发明申请

US20080107687A1 FELINE VACCINES AGAINST AVIAN INFLUENZA 审中-公开
标题翻译： FELINE VACCINES AVAAN INFLUENZA
公开(公告)号：US20080107687A1
公开(公告)日：2008-05-08
申请号：US11767276
申请日：2007-06-22
申请人： Herve Poulet
发明人： Herve Poulet
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K2039/55566 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12N2760/16134
摘要： The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing avian influenza antigens, epitopes or immunogens which can be used to protect animals, in particular felids, against avian influenza.
摘要翻译：本发明包括流感疫苗，特别是禽流感疫苗。疫苗可以是重组痘病毒疫苗或灭活疫苗。本发明还包括编码和表达禽流感抗原，表位或免疫原的重组痘病毒载体，其可用于保护动物，特别是猫科动物免受禽流感。

4. 发明授权

US09434781B2 Method for augmenting vision in persons suffering from photoreceptor cell degeneration 有权
标题翻译：增加感光细胞变性患者视力的方法
公开(公告)号：US09434781B2
公开(公告)日：2016-09-06
申请号：US11036629
申请日：2005-01-13
申请人： Richard H. Masland
发明人： Richard H. Masland
IPC分类号： A61K48/00 , C12N15/63 , C07K14/705 , A01K67/00
CPC分类号： C07K14/705 , A01K2217/05 , A01K2267/03 , A61K9/0048 , A61K38/177 , A61K48/00 , A61K48/0075 , C12N7/00 , C12N2710/10043 , C12N2710/10071 , C12N2710/16043 , C12N2710/16071 , C12N2710/16243 , C12N2710/16271 , C12N2710/22043 , C12N2710/22071 , C12N2710/24043 , C12N2710/24071 , C12N2740/10043 , C12N2740/10071 , C12N2740/15043 , C12N2740/15071 , C12N2799/021 , C12N2799/04 , C12N2830/008
摘要： The invention provides compositions and methods of treating subjects afflicted with a photoreceptor disorder. Methods for treating a subject suffering from a disorder characterized by photoreceptor cell degeneration are provided, wherein a gene encoding a photosensitive protein is introduced into a retinal cell of a subject. In one aspect of the invention, the retinal cells which receive the photosensitive protein include non-photoreceptor cells such as horizontal cells, amacrine cells, bipolar cells, and ganglion cells.
摘要翻译：本发明提供了治疗患有感光细胞病症的受试者的组合物和方法。提供了治疗患有感光细胞变性特征性疾病的受试者的方法，其中将编码感光性蛋白质的基因导入受试者的视网膜细胞。在本发明的一个方面，接受感光性蛋白质的视网膜细胞包括非感光细胞，例如水平细胞，无长突细胞，双极细胞和神经节细胞。

5. 发明申请

US20160136212A1 MYXOMA VIRUS MUTANTS FOR CANCER TREATMENT 有权
公开(公告)号：US20160136212A1
公开(公告)日：2016-05-19
申请号：US15002971
申请日：2016-01-21
申请人： ROBARTS RESEARCH INSTITUTE
发明人： JOHN W. BARRETT , GRANT MCFADDEN
IPC分类号： A61K35/768 , C12N7/00
CPC分类号： A61K35/768 , A61K35/76 , C12N7/00 , C12N2710/24032 , C12N2710/24062 , C12N2710/24071
摘要： Myxoma viruses that are deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M 136, M-T4 and M-T7 are useful for treating cancer.

6. 发明申请

US20150045417A1 A NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP 审中-公开
标题翻译：基于JCV-VLP的新型药物递送系统
公开(公告)号：US20150045417A1
公开(公告)日：2015-02-12
申请号：US14383267
申请日：2013-03-06
申请人： Life Science Inkubator Betriebs GmbH & Co. KG
发明人： Victoria DEMINA , Heiko MANNINGA , Armin GOTZKE , Alexander GLASSMANN
IPC分类号： A61K48/00 , C12N15/86 , C12N7/00
CPC分类号： A61K48/0025 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/22022 , C12N2710/22023 , C12N2710/22041 , C12N2710/22042 , C12N2710/22043 , C12N2710/22071 , C12N2710/24023 , C12N2710/24042 , C12N2710/24043 , C12N2710/24071
摘要： The invention relates to VLP derived from human polyoma virus loaded with a drug (cargo) as a drug delivery system for transporting said drug into the CNS, in particular of living humans.
摘要翻译：本发明涉及来自装载有药物（货物）的人多瘤病毒作为药物递送系统的VLP，用于将所述药物输送到CNS，特别是活的人中。

7. 发明申请

US20110158945A1 MYXOMA VIRUS MUTANTS FOR CANCER TREATMENT 有权
标题翻译：用于癌症治疗的MYXOMA VIRUS MUTANT
公开(公告)号：US20110158945A1
公开(公告)日：2011-06-30
申请号：US12301961
申请日：2007-06-01
申请人： John W. Barrett , Grant McFadden
发明人： John W. Barrett , Grant McFadden
IPC分类号： A61K35/76 , C12N7/01 , A61P35/00
CPC分类号： A61K35/768 , A61K35/76 , C12N7/00 , C12N2710/24032 , C12N2710/24062 , C12N2710/24071
摘要： Myxoma viruses that are deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M 136, M-T4 and M-T7 are useful for treating cancer.
摘要翻译：缺乏选自M11L，M063，M 136，M-T4和M-T7的粘液瘤病毒蛋白的活性的粘液瘤病毒可用于治疗癌症。

8. 发明申请

US20100260807A1 Methods of Inducing and/or Enhancing an Immune Response To Tumor Antigens 审中-公开
标题翻译：诱导和/或增强对肿瘤抗原的免疫应答的方法
公开(公告)号：US20100260807A1
公开(公告)日：2010-10-14
申请号：US12604320
申请日：2009-10-22
申请人： Neil Berinstein , James Tartaglia , Philippe Moingeon , Brian Barber
发明人： Neil Berinstein , James Tartaglia , Philippe Moingeon , Brian Barber
IPC分类号： A61K39/395 , A61K31/7052 , A61K35/76 , A61K35/74 , A61K35/00 , A61P37/04
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
摘要翻译：公开了诱导和/或增强对肿瘤抗原的免疫应答的改进方法。该方法包括将肿瘤抗原，其编码的核酸，包含所述核酸的载体和/或细胞或包含上述的疫苗施用于淋巴结位点。

9. 发明申请

US20170335343A1 RECOMBINANT SWINEPOX VIRUS AND VACCINES 审中-公开
公开(公告)号：US20170335343A1
公开(公告)日：2017-11-23
申请号：US15536058
申请日：2015-12-18
申请人： CEVA SANTE ANIMALE
发明人： Takanori Sato
IPC分类号： C12N15/86 , A61K39/12 , A61K39/00
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , A61K2039/552 , C12N2710/24043 , C12N2710/24071 , C12N2750/10034
摘要： The present invention relates to novel recombinant swinepox viruses and their use in vaccine compositions. The re-combinant swinepox viruses of the invention are produced 5 by inserting one or more foreign genes into IL-18 binding protein (IL18bp) gene of swinepox virus. The invention is particularly suited to produce swine vaccines, particularly for vaccinating swine against PCV2 infection.

10. 发明申请

US20160082128A1 ST-246 LIQUID FORMULATIONS AND METHODS 有权
标题翻译： ST-246液体制剂和方法
公开(公告)号：US20160082128A1
公开(公告)日：2016-03-24
申请号：US14955674
申请日：2015-12-01
申请人： Siga Technologies, Inc.
发明人： Shanthakumar R. TYAVANAGIMATT , Melialani A.C.L.S. ANDERSON , William WEIMERS , Gopi Krishna KASI , N K Peter SAMUEL , Tove' C. Bolken , Dennis E. HRUBY
IPC分类号： A61K47/48 , A61K9/08 , A61K47/10 , A61K31/4035 , A61K47/26
CPC分类号： A61K31/715 , A61K9/0014 , A61K9/0019 , A61K9/08 , A61K31/4035 , A61K31/724 , A61K47/10 , A61K47/40 , A61K47/6951 , C12N2710/24071 , A61K2300/00
摘要： The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
摘要翻译：本发明提供了用于将难溶性ST-246溶解在环糊精中的新型液体制剂和制备该制剂的新方法。

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