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1. 发明申请

US20140024017A1 IDENTIFICATION OF A NOVEL HUMAN POLYOMAVIRUS (IPPyV) AND APPLICATIONS 审中-公开
标题翻译：鉴定新型人血型（IPPyV）和应用
公开(公告)号：US20140024017A1
公开(公告)日：2014-01-23
申请号：US13977043
申请日：2011-12-27
申请人： Marc Eloit , Justine Cheval , Virginie Sauvage
发明人： Marc Eloit , Justine Cheval , Virginie Sauvage
IPC分类号： C12Q1/70 , G01N33/68
CPC分类号： G01N33/68 , A61K39/00 , C07K14/005 , C12N2710/20022 , C12N2710/22021 , C12N2710/22041 , C12Q1/701 , Y02A50/467
摘要： The invention relates to the identification of a novel human polyomavirus species (designated IPPyV) and applications derived from the identified features and properties of this virus. The IPPy virus species of the invention qualifies as a human virus, in view of the fact that it is capable of infecting a human host. Having identified a novel human polyomavirus species, IPPyV, the inventors have been able to propose means for the detection of exposure or infection by such a virus, especially detection in a biological sample previously obtained from a human host. The invention also concerns means suitable for obtaining an immune response in a host with a view to prevent the onset or the development of an infection with an IPPyV.
摘要翻译：本发明涉及新型人多瘤病毒物种（指定为IPPyV）的鉴定以及从该病毒鉴定的特征和性质衍生的应用。鉴于其能够感染人类宿主的事实，本发明的IPPy病毒物种符合人类病毒的资格。鉴定出新的人多瘤病毒种IPPyV后，本发明人已经能够提出用于检测这种病毒的暴露或感染的方法，特别是先前从人宿主获得的生物样品中的检测。本发明还涉及适于在宿主中获得免疫应答的方法，以防止IPPyV感染的发生或发展。

2. 发明申请

US20150045417A1 A NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP 审中-公开
标题翻译：基于JCV-VLP的新型药物递送系统
公开(公告)号：US20150045417A1
公开(公告)日：2015-02-12
申请号：US14383267
申请日：2013-03-06
申请人： Life Science Inkubator Betriebs GmbH & Co. KG
发明人： Victoria DEMINA , Heiko MANNINGA , Armin GOTZKE , Alexander GLASSMANN
IPC分类号： A61K48/00 , C12N15/86 , C12N7/00
CPC分类号： A61K48/0025 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/22022 , C12N2710/22023 , C12N2710/22041 , C12N2710/22042 , C12N2710/22043 , C12N2710/22071 , C12N2710/24023 , C12N2710/24042 , C12N2710/24043 , C12N2710/24071
摘要： The invention relates to VLP derived from human polyoma virus loaded with a drug (cargo) as a drug delivery system for transporting said drug into the CNS, in particular of living humans.
摘要翻译：本发明涉及来自装载有药物（货物）的人多瘤病毒作为药物递送系统的VLP，用于将所述药物输送到CNS，特别是活的人中。

3. 发明申请

US20190201549A1 NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP 审中-公开
公开(公告)号：US20190201549A1
公开(公告)日：2019-07-04
申请号：US16354739
申请日：2019-03-15
申请人： LIFE SCIENCE INKUBATOR BETRIEBS GMBH & CO. KG
发明人： Victoria Demina , Heiko Manninga , Armin Götzke , Alexander Glassmann
IPC分类号： A61K48/00 , C12N15/86 , C12N7/00
CPC分类号： A61K48/0025 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/22022 , C12N2710/22023 , C12N2710/22041 , C12N2710/22042 , C12N2710/22043 , C12N2710/22071 , C12N2710/24023 , C12N2710/24042 , C12N2710/24043 , C12N2710/24071
摘要： The invention relates to VLP derived from human polyoma virus loaded with a drug (cargo) as a drug delivery system for transporting said drug into the CNS, in particular of living humans.

4. 发明申请

US20160287685A1 METHOD FOR RESTORING IMMUNE TOLERANCE IN VIVO 审中-公开
标题翻译：在体内恢复免疫耐受的方法
公开(公告)号：US20160287685A1
公开(公告)日：2016-10-06
申请号：US15038443
申请日：2014-11-22
申请人： AMARNA HOLDING B.V.
发明人： Petrus Theodorus De Haan
IPC分类号： A61K39/00 , C12N7/00
CPC分类号： A61K39/0008 , A61K2039/53 , A61K2039/54 , A61K2039/577 , C12N7/00 , C12N2710/22041 , C12N2710/22043 , C12N2800/30 , Y02A50/401
摘要： The present invention provides a method for restoring immune tolerance in vivo. The invention relates to the use of a recombinant gene encoding auto-antigens or parts thereof for restoring immune tolerance to the auto-antigens in vivo, under transcriptional control of polyomaviral early and late promoters. In a preferred embodiment, the invention relates to the use of recombinant polyomaviral gene delivery vector particles, such as simian virus 40 (SV40) viral vector particles encoding one or multiple auto-antigens or parts thereof under transcriptional control of the SV40 early and late promoter, for restoring immune tolerance to the auto-antigens in vivo. The invention also relates to compositions comprising recombinant genes or polyomaviral vectors and uses thereof as treatment for degenerative or dystrophic diseases.
摘要翻译：本发明提供了体内恢复免疫耐受的方法。本发明涉及编码自身抗原或其部分的重组基因在复制多分子生物学早期和晚期启动子的转录控制下恢复体内对自身抗原的免疫耐受性的用途。在优选的实施方案中，本发明涉及在SV40早期和晚期启动子的转录控制下使用重组多瘤病毒基因递送载体颗粒，例如编码一种或多种自身抗原或其部分的猿猴病毒40（SV40）病毒载体颗粒，用于在体内恢复对自身抗原的免疫耐受性。本发明还涉及包含重组基因或多瘤病毒载体的组合物及其用于退行性或营养不良疾病的治疗的用途。

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