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1. 发明授权

US10617790B2 Decellularized biomaterial from non-mammalian tissue 有权
公开(公告)号：US10617790B2
公开(公告)日：2020-04-14
申请号：US14759895
申请日：2014-01-09
申请人： ISE Professional Testing & Consulting Services, Inc.
发明人： Ryanne Early
IPC分类号： A61L27/36 , A61K9/70 , A61L27/58 , A61K35/12 , C12N5/071 , A61L27/60 , A61L27/54 , A61K38/17 , A61L27/38 , A61K35/65 , A61L27/52
CPC分类号： A61L27/3687 , A61K9/70 , A61K35/12 , A61K35/65 , A61K38/1703 , A61L27/362 , A61L27/3604 , A61L27/3625 , A61L27/3633 , A61L27/3691 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L27/60 , C12N5/0625 , A61L2300/252 , A61L2300/412 , A61L2300/604 , A61L2300/606 , A61L2300/64 , A61L2430/34 , A61L2430/40 , C12N2533/90 , C12N2533/92
摘要： The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and non-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes. The resultant urodele-derived biomaterial can be used to enhance restoration of skin homeostasis, to reduce the severity, duration and associated damage caused by post-surgical inflammation, and to promote progression of natural healing and regeneration processes. In addition, the biomaterial promotes the formation of remodeled tissue that is comparable in quality, function, and compliance to undamaged human tissue.

2. 发明申请

US20160058796A1 RETINA EXTRACELLULAR MATRIX BASED BIOMATERIAL 审中-公开
标题翻译： RETINA细胞基质基于生物材料
公开(公告)号：US20160058796A1
公开(公告)日：2016-03-03
申请号：US14787359
申请日：2014-05-05
申请人： NORTHEASTERN UNIVERSITY
发明人： Rebecca Lyn Carrier , Joydip Kundu
IPC分类号： A61K35/30 , A61K47/46 , C12N5/079 , A61K9/00
CPC分类号： A61K35/30 , A61K9/0051 , A61K35/60 , A61K35/65 , A61K47/46 , A61L27/3633 , A61L27/3804 , A61L2430/16 , C12N5/0621 , C12N2533/90
摘要： The present technology relates to compositions and methods useful for preventing and treating degenerative eye diseases or disorders. The compositions and methods include ocular biomaterials. In some embodiments, the ocular biomaterial compositions include retinal biomaterial, interphotoreceptor matrix biomaterial or a combination thereof. In some embodiments, the ocular biomaterial compositions are formed into films, gels, scaffolds and matrices for cell delivery.
摘要翻译：本技术涉及可用于预防和治疗退行性眼病或病症的组合物和方法。组合物和方法包括眼部生物材料。在一些实施方案中，眼睛生物材料组合物包括视网膜生物材料，光感受器基质生物材料或其组合。在一些实施方案中，眼睛生物材料组合物形成用于细胞递送的膜，凝胶，支架和基质。

3. 发明申请

US20150056295A1 CELLULAR EXTRACTS 有权
标题翻译：细胞提取物
公开(公告)号：US20150056295A1
公开(公告)日：2015-02-26
申请号：US14526751
申请日：2014-10-29
申请人： REGENICS AS
发明人： Runhild Gammelsaeter , Jan Remmereit
IPC分类号： A61K35/60 , A61K9/06
CPC分类号： A61K35/60 , A61K8/987 , A61K9/06 , A61K35/65 , A61K2800/805 , A61Q19/00 , A61Q19/08
摘要： The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.
摘要翻译：本发明描述了用于改善美容外观，促进，改善或恢复细胞和组织，优选皮肤的健康的方法和试剂，更优选地，将老化或损伤的皮肤恢复到健康的外观。试剂包括细胞，卵，细胞提取物，卵提取物和提取物组分如纯化的核酸，多肽，脂质，碳水化合物或其它天然产物的组合物。

4. 发明申请

US20180303880A1 CELLULAR EXTRACTS 审中-公开
公开(公告)号：US20180303880A1
公开(公告)日：2018-10-25
申请号：US16011134
申请日：2018-06-18
申请人： REGENICS AS
发明人： Runhild Gammelsaeter , Jan Remmereit
IPC分类号： A61K35/60 , A61K9/06 , A61K35/65 , A61Q19/08 , A61K8/98 , A61Q19/00
CPC分类号： A61K35/60 , A61K8/987 , A61K9/06 , A61K35/65 , A61K2800/805 , A61Q19/00 , A61Q19/08
摘要： The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.

5. 发明授权

US09999639B2 Cellular extracts 有权
公开(公告)号：US09999639B2
公开(公告)日：2018-06-19
申请号：US15131198
申请日：2016-04-18
申请人： REGENICS AS
发明人： Runhild Gammelsaeter , Jan Remmereit
IPC分类号： A61K35/60 , A61K8/98 , A61Q19/00 , A61Q19/08 , A61K35/65 , A61K9/06
CPC分类号： A61K35/60 , A61K8/987 , A61K9/06 , A61K35/65 , A61K2800/805 , A61Q19/00 , A61Q19/08
摘要： The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.

6. 发明授权

US5709887A Method and composition for treating tumors 失效
标题翻译：治疗肿瘤的方法和组成
公开(公告)号：US5709887A
公开(公告)日：1998-01-20
申请号：US466435
申请日：1995-06-06
申请人： Clifford R. Bryan, deceased , by Marguerite Bryan, administratrix
发明人： Clifford R. Bryan, deceased , by Marguerite Bryan, administratrix
IPC分类号： A61K35/12 , A61K35/56 , A61K35/65 , A61K35/655 , A61K41/00 , A61K35/34 , A61K35/37 , A61K35/54
CPC分类号： A61K41/00 , A61K35/65 , A61K35/655
摘要： A biological is used as a therapeutic agent or booster to produce sustained responses in the immune cells against tumors. The biological of the present invention is derived from the pleuroperitoneal organs of a neotenic amphibian, e.g., axolotl, or from the notochord and surrounding tissues of an Agnathan, e.g., Lamprey eel, or from mesenteries and visceral organs from the pleuroperitoneal cavity of older fetuses or baby vertebrates from fish to humans, or from tadpoles of frogs at the stage when both the tail and the four legs are present, i.e., just before completion of the metamorphosis period.
摘要翻译：使用生物学作为治疗剂或加强剂以在针对肿瘤的免疫细胞中产生持续的反应。本发明的生物学衍生自新型两栖动物（例如axolotl）的胸膜腹膜器官，或来自Agnathan（例如Lamprey eel）的脊索和周围组织，或来自老年胎儿胸膜腹膜腔的肠系膜和内脏器官或从鱼到人的婴儿脊椎动物，或者在尾巴和四条腿都存在的阶段，即在变形期结束之前的阶段，从青蛙的ad。。

7. 发明申请

US20160228475A1 CELLULAR EXTRACTS 有权
公开(公告)号：US20160228475A1
公开(公告)日：2016-08-11
申请号：US15131198
申请日：2016-04-18
申请人： REGENICS AS
发明人： Runhild Gammelsaeter , Jan Remmereit
IPC分类号： A61K35/60 , A61Q19/08 , A61Q19/00 , A61K9/06 , A61K8/98
CPC分类号： A61K35/60 , A61K8/987 , A61K9/06 , A61K35/65 , A61K2800/805 , A61Q19/00 , A61Q19/08
摘要： The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.

8. 发明申请

US20150352257A1 DECELLULARIZED BIOMATERIAL FROM NON-MAMMALIAN TISSUE 审中-公开
标题翻译：非生物组织的细菌生物材料
公开(公告)号：US20150352257A1
公开(公告)日：2015-12-10
申请号：US14759895
申请日：2014-01-09
申请人： ISE Professional Testing & Consulting Services, Inc.
发明人： Ryanne Early
IPC分类号： A61L27/36 , A61K9/70 , A61L27/58 , A61K35/12 , A61L27/54 , A61L27/38 , A61K38/17 , A61K35/65 , A61L27/60
CPC分类号： A61L27/3687 , A61K9/70 , A61K35/12 , A61K35/65 , A61K38/1703 , A61L27/3604 , A61L27/362 , A61L27/3625 , A61L27/3633 , A61L27/3691 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L27/60 , A61L2300/252 , A61L2300/412 , A61L2300/604 , A61L2300/606 , A61L2300/64 , A61L2430/34 , A61L2430/40 , C12N5/0625 , C12N2533/90 , C12N2533/92
摘要： The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and non-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes. The resultant urodele-derived biomaterial can be used to enhance restoration of skin homeostasis, to reduce the severity, duration and associated damage caused by post-surgical inflammation, and to promote progression of natural healing and regeneration processes. In addition, the biomaterial promotes the formation of remodeled tissue that is comparable in quality, function, and compliance to undamaged human tissue.
摘要翻译： Urodele细胞外基质（ECM）和伴随皮肤组织的生长因子分布，结缔组织基质成分和免疫缺陷状态加上抗微生物肽的存在使得urodele衍生组织成为用于异种移植的生物支架的理想来源。特别地，生物支架生物材料可以通过以下方法获得：（A）从尿布获得组织样品，其中组织包括ECM，包括基底膜，和（B）使组织样品经脱细胞化过程通过保留其纤维和非纤维蛋白，糖胺聚糖（GAG）和蛋白多糖来维持细胞外基质的结构和功能完整性，同时去除样品的足够的细胞组分以减少或消除异种移植物目的的抗原性和免疫原性。所得到的urodele衍生的生物材料可用于增强皮肤稳态的恢复，以减少手术后炎症引起的严重程度，持续时间和相关的损伤，并促进自然愈合和再生过程的进展。此外，生物材料促进了改性组织的形成，其质量，功能和对未损伤的人体组织的依从性。

9. 发明申请

US20090274770A1 CELLULAR EXTRACTS 有权
标题翻译：细胞提取物
公开(公告)号：US20090274770A1
公开(公告)日：2009-11-05
申请号：US12437100
申请日：2009-05-07
申请人： Runhild Gammelsaeter , Jan Remmereit
发明人： Runhild Gammelsaeter , Jan Remmereit
IPC分类号： A61K35/54 , A61K38/17 , C12P21/00 , A61P17/00
CPC分类号： A61K35/60 , A61K8/987 , A61K9/06 , A61K35/65 , A61K2800/805 , A61Q19/00 , A61Q19/08
摘要： The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. This invention relates to the use of cells and cellular extracts in rejuvenation and healing technologies thereby improving healing and regeneration of all bodily tissues and organs. The present invention relates to compositions and methods of managing, preventing, and treating scars. The invention also relates to prevention of deterioration, damage and malfunction of cells and tissues, and to promote, improve or exceed cellular function in order to promote, improve and exceed appearance, vitality and health. In some embodiments, the invention relates to compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.
摘要翻译：本发明描述了用于改善美容外观，促进，改善或恢复细胞和组织，优选皮肤的健康的方法和试剂，更优选地，将老化或损伤的皮肤恢复到健康的外观。本发明涉及细胞和细胞提取物在复原和愈合技术中的用途，从而改善所有身体组织和器官的愈合和再生。本发明涉及治疗，预防和治疗瘢痕的组合物和方法。本发明还涉及预防细胞和组织的恶化，损伤和失常，以及促进，改善或超过细胞功能以促进，改善和超越外观，活力和健康。在一些实施方案中，本发明涉及细胞，卵，细胞提取物，卵提取物和提取物组分如纯化的核酸，多肽，脂质，碳水化合物或其它天然产物的组合物。

10. 发明授权

US06726935B2 Pharmaceutical composition for preventing and treating erectile impotence using purified sumsoo extract 失效
标题翻译：使用纯化的sumsoo提取物预防和治疗勃起阳的药物组合物
公开(公告)号：US06726935B2
公开(公告)日：2004-04-27
申请号：US10168596
申请日：2002-06-24
申请人： Joon Whan Ji , Jae Ku Kang , Young Hoon Kim , Sung Hak Jung , Hee Jae Cho , Kwang Hyuk Lee
发明人： Joon Whan Ji , Jae Ku Kang , Young Hoon Kim , Sung Hak Jung , Hee Jae Cho , Kwang Hyuk Lee
IPC分类号： A61K3578
CPC分类号： A61K35/65
摘要： A pharmaceutical composition for prevention or treatment of premature ejaculation and/or hypersensitivity of sexual stimulation is provided, which contains a therapeutically effective amount of a purified essence of Bufonis venenum for prevention or treatment of dysspermia or the symptom of non-controlled ejaculation in male, due to premature ejaculation and/or hypersensitivity of sexual stimulation. The Bufonis venenum may be a purified essence of Bufonis venenum extracted by use of one or more organic solvent selected from a group consisting of ethyl acetate, dichloromethane or chloroform, and concentrated, and is purified and fractionated by use of silica gel column. The composition may be formulated in a pharmaccutically acceptable formulation of ointment, suspension, gel, spray, patch or solution.
摘要翻译：提供了用于预防或治疗性激素过敏和/或性刺激过敏的药物组合物，其包含治疗有效量的用于预防或治疗精子症的精华液，或男性非控制性射精的症状，由于早泄和/或性刺激的超敏反应。水蛭可以是通过使用选自乙酸乙酯，二氯甲烷或氯仿的一种或多种有机溶剂萃取并浓缩的纯化的芦苇提取物，并通过使用硅胶柱进行纯化和分级。组合物可以配制成软膏剂，悬浮液，凝胶剂，喷雾剂，贴剂或溶液的药理学上可接受的制剂。

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