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1. 发明授权

US12110267B2 Methods for vicinal diol separation 有权
公开(公告)号：US12110267B2
公开(公告)日：2024-10-08
申请号：US17283090
申请日：2019-10-07
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Dennis J. Miller , Carl T. Lira , Lars Peereboom , Scott F. Parker , Thomas D. Dionise , William G. Killian
IPC分类号： C07C29/92 , B01J19/00 , B01J19/18 , C07C29/09 , C07C29/88 , C07C31/20
CPC分类号： C07C29/92 , B01J19/0066 , B01J19/1862 , C07C29/095 , C07C29/88 , C07C31/202 , C07C31/205 , C07C31/207
摘要： The disclosure relates to methods for separating mixtures of polyols, in particular mixtures of two of more different vicinal diols having close boiling points, thus making them difficult or impossible to separate using conventional distillation techniques. The polyol mixture is reacted with an aldehyde or ketone acetalization agent to form one or more acetals as corresponding acetalization reaction products. The acetalization reaction products are more easily separable either from each other (such as via distillation) or from an unreacted vicinal diol (such as via extraction, settling, or other phase separation). After separation, hydrolysis is performed on the acetalization reaction products to recover the vicinal diols as separate, purified components. The methods provide cost-effective processes for separating different polyols originally formed in admixture.

2. 发明授权

US09700524B2 Pharmaceutical compositions comprising monoterpenes 有权
公开(公告)号：US09700524B2
公开(公告)日：2017-07-11
申请号：US15040002
申请日：2016-02-10
申请人： NEONC Technologies, Inc.
发明人： Thomas Chen , Daniel Levin , Satish Puppali
IPC分类号： A61K31/045 , C07C29/92 , C07C67/14 , C07C201/12 , C07C29/78 , C07C29/88 , C07C201/16 , A61K31/4188 , A61K45/06 , A61N5/10
CPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16 , C07C2601/16 , C07C33/14 , C07C205/57 , C07C69/76 , C07C69/92
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

3. 发明申请

US20150368173A1 PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES 有权
标题翻译：包含单体的药物组合物
公开(公告)号：US20150368173A1
公开(公告)日：2015-12-24
申请号：US14817286
申请日：2015-08-04
申请人： NEONC Technologies, Inc.
发明人： Thomas CHEN , DANIEL LEVIN , SATISH PUPPALI
IPC分类号： C07C29/88 , C07C201/12 , C07C67/14 , C07C201/16
CPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16 , C07C2601/16 , C07C33/14 , C07C205/57 , C07C69/76 , C07C69/92
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.
摘要翻译：本发明提供纯化大于约98.5％（w / w）的单萜或倍半萜的方法。该方法包括衍生单萜（或倍半萜烯）以产生单萜（或倍半萜烯）衍生物，分离单萜（或倍半萜烯）衍生物和从衍生物中释放单萜（或倍半萜烯）的步骤。包括本发明范围的药物组合物是包含纯度大于约98.5％（w / w）的单萜（或倍半萜烯）的药物组合物。纯化的单萜可用于治疗癌症等疾病。本单萜（或倍半萜烯）可以单独施用，或者可以与辐射或其它治疗剂如化学治疗剂共同施用。

4. 发明授权

US08889921B2 Methods of synthesis of scyllitol and related compounds 有权
标题翻译：合成角叉菜胶和相关化合物的方法
公开(公告)号：US08889921B2
公开(公告)日：2014-11-18
申请号：US13273069
申请日：2011-10-13
申请人： Scott Greenfield
发明人： Scott Greenfield
IPC分类号： C07C35/14 , C07C29/12 , C07C29/92 , C07C29/56 , C07C29/78
CPC分类号： C07C29/12 , C07C29/56 , C07C29/78 , C07C29/92 , C07C2601/14 , C07C35/16
摘要： Methods of synthesis of scyllitol diborate and related compounds are provided, including methods that are performed in all-aqueous solutions. Also provided are methods in which the reaction products are recycled to increase the efficiency of the process. The methods include the steps of conversion of a solution of inositol to scyllitol, conversion of scyllitol in the solution to scyllitol diborate, and isolation of the scyllitol diborate from the solution. The scyllitol diborate is reacted to form substantially pure scyllitol diborate, and the remaining solution is efficiently recycled to scyllitol diborate, then to additional substantially pure scyllitol. This scyllitol diborate recycling step can be applied to a variety of processes to improve the yield of scyllitol. The methods are highly efficient and result in large scale reaction products of high purity.
摘要翻译：提供了合成鲨烯醇二醇和相关化合物的方法，包括在全水溶液中进行的方法。还提供了反应产物被再循环以提高该方法的效率的方法。所述方法包括将肌醇溶液转化成西欧糖醇的步骤，将溶液中的辛二醇溶液转化为雪莲醇二硼酸酯，以及从该溶液中分离出雪莲二醇二硼酸酯。反应形成基本上纯的鲨烯糖醇二硼酸盐，并将残留的溶液有效地再循环至雪利醇醇二硼酸盐，然后再添加到另外基本上纯的鲨烯醇。这种雪莲醇二硼酸盐回收步骤可以应用于各种工艺以提高青霉烷醇的产率。该方法高效，产生高纯度的大规模反应产物。

5. 发明申请

US20110112336A1 PURIFICATION OF CRUDE GLYCEROL 有权
标题翻译：纯化甘油
公开(公告)号：US20110112336A1
公开(公告)日：2011-05-12
申请号：US12993137
申请日：2009-05-18
申请人： Richard Macret , Celio Ferraz Wagner Lourenco
发明人： Richard Macret , Celio Ferraz Wagner Lourenco
IPC分类号： C07C29/74
CPC分类号： C07C29/92 , C07C31/225
摘要： Crude glycerol obtained from raw materials, such as the glycerol obtained during the production of biodiesel or glycerol obtained during the conversion of fats or oils, is purified by forming a dioxolane therefrom by reacting the crude glycerol with a ketone or aldehyde, separating the dioxolane thus formed, converting the dioxolane into purified glycerol and ketone/aldehyde, and recovering the glycerol thus purified.
摘要翻译：从原料获得的粗甘油，例如在脂肪或油转化期间获得的生物柴油或甘油生产过程中获得的甘油，通过使粗甘油与酮或醛反应形成二氧戊环，从而分离二氧戊环形成，将二氧戊环转化成纯化的甘油和酮/醛，并回收如此纯化的甘油。

6. 发明授权

US5105003A Separation of 1,2-dihydroxycyclohexa-3,5-diene compounds 失效
标题翻译： 1,2-二羟基环己基-3,5-二烯化合物的分离
公开(公告)号：US5105003A
公开(公告)日：1992-04-14
申请号：US464519
申请日：1990-01-16
申请人： Andrew B. Herbert , Gary N. Sheldrake , Peter J. Somers , John A. Meredith
发明人： Andrew B. Herbert , Gary N. Sheldrake , Peter J. Somers , John A. Meredith
IPC分类号： C07C29/88 , C07C29/92 , C07C35/18 , C07C35/48 , C07F5/02
CPC分类号： C07F5/025 , C07C29/92 , C07C35/18 , C07C35/48 , C07B2200/09 , C07C2101/16
摘要： A process for the separation of a compound comprising a 1,2-dihydroxycyclohexa-3,5-diene ring from a medium containing it in which the compound reacts with a phenylboronate ion to form a phenylboronate ester which is insoluble in the medium. Novel phenylboronate esters formed during the separation process are also claimed.

7. 发明授权

US2897244A Purification process 失效
公开(公告)号：US2897244A
公开(公告)日：1959-07-28
申请号：US64767157
申请日：1957-03-21
申请人： GULF RESEARCH DEVELOPMENT CO
发明人： SELWITZ CHARLES M
IPC分类号： C07C29/92
CPC分类号： C07C29/92 , C07C31/02 , C07C31/125

8. 发明授权

US2813910A Removal of formic acid catalyst from hydroxylation products of ethylenic alcohols 失效
标题翻译：从乙烯醇的羟基化产物中除去甲酸催化剂
公开(公告)号：US2813910A
公开(公告)日：1957-11-19
申请号：US50830055
申请日：1955-05-13
申请人： SHELL DEV
发明人： JAN TJEPKEMA JACOBUS
IPC分类号： C07C29/92
CPC分类号： C07C29/92 , C07C31/225

9. 发明授权

US1416859A Process of producing benzyl alcohol 失效
标题翻译：生产苄醇的方法
公开(公告)号：US1416859A
公开(公告)日：1922-05-23
申请号：US47068621
申请日：1921-05-18
申请人： SEMET SOLVAY CO
发明人： MONTONNA RALPH E
IPC分类号： C07C29/00 , C07C29/92
CPC分类号： C07C29/00 , C07C29/92 , C07C33/22

10. 发明授权

US11970436B2 Pharmaceutical compositions comprising monoterpenes 有权
公开(公告)号：US11970436B2
公开(公告)日：2024-04-30
申请号：US17749293
申请日：2022-05-20
申请人： NEONC Technologies, Inc.
发明人： Thomas Chen , Daniel Levin , Satish Puppali
IPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16
CPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16 , C07B2200/07 , C07C2601/16 , C07C29/92 , C07C33/14 , C07C201/12 , C07C205/57 , C07C67/14 , C07C69/76 , C07C67/14 , C07C69/92
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

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