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1. 发明申请

US20180093202A1 MATERIALS AND METHODS FOR THE SELECTIVE RECOVERY OF MONOVALENT PRODUCTS FROM AQUEOUS SOLUTIONS USING CONTINUOUS ION EXCHANGE 审中-公开
公开(公告)号：US20180093202A1
公开(公告)日：2018-04-05
申请号：US15564888
申请日：2016-04-08
申请人： INVISTA NORTH AMERICA S.A.R.L.
发明人： Alex Conradie
IPC分类号： B01D15/36 , B01D15/20 , B01D15/18 , C07C227/40 , C07C229/06 , C07C51/47 , C07C53/126
CPC分类号： B01D15/362 , B01D15/1892 , B01D15/20 , B01D15/361 , C07C51/47 , C07C53/126 , C07C67/58 , C07C227/40 , C07C229/06
摘要： This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further downstream purification.

2. 发明申请

US20170348266A1 INHIBITION OF PROLINE CATABOLISM FOR THE TREATMENT OF CANCER AND OTHER THERAPEUTIC APPLICATIONS 审中-公开
公开(公告)号：US20170348266A1
公开(公告)日：2017-12-07
申请号：US15519504
申请日：2015-11-12
申请人： Buck Institute for Research on Aging
发明人： GARY K. SCOTT , CHRISTOPHER C. BENZ
IPC分类号： A61K31/198 , A61K31/365 , A61K31/496 , A61K31/5377 , G01N33/574 , A61K31/341 , A61K31/713 , C12N15/113 , A61K31/501
CPC分类号： A61K31/198 , A61K31/341 , A61K31/365 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/713 , A61K45/06 , C07C229/06 , C07C229/20 , C07C229/30 , C12N15/1137 , C12N2310/14 , C12N2320/31 , G01N33/57415 , G01N33/57484 , G01N2333/9065 , G01N2800/52 , A61K2300/00
摘要： In various embodiments a cancer treatment method is provided based on inhibition of proline catabolism. When combined with p53 restoration therapy and/or inhibition of glutaminase, the inhibition of proline catabolism results in a “synthetic lethal” and synergistic anticancer response. Novel suicide inhibitors that induce the degradation of proline dehydrogenase (PRODH) are also provided. Also provided is a method of assaying PRODH to identify responders/non-responders to inhibition of proline catabolism and/or glutaminase.

3. 发明申请

US20170210912A1 HYDROPHILIC OIL REPELLENT AND PRODUCTION METHOD OF SAME, SURFACE COATING MATERIAL, COATING FILM, RESIN COMPOSITION, OIL-WATER SEPARATION FILTER MATERIAL, AND POROUS BODY 审中-公开
公开(公告)号：US20170210912A1
公开(公告)日：2017-07-27
申请号：US15329408
申请日：2015-07-29
申请人： MITSUBISHI MATERIALS CORPORATION , Mitsubishi Materials Electronic Chemicals Co., Ltd.
发明人： Masato Fujita , Masakazu Uotani , Takeshi Kamiya , Tsunetoshi Honda , Daisuke Takano
IPC分类号： C09D5/16 , B01D17/02 , C09D7/00 , C07C229/12 , C07C227/16 , C07C233/05 , C07C231/02 , C07C311/05 , C07C303/38 , C07C309/13 , C07C303/02 , C07D211/38 , C07D265/30 , C07D207/10 , C07D241/04 , C02F1/40
CPC分类号： C09D5/1625 , B01D17/02 , C02F1/40 , C07C227/06 , C07C227/08 , C07C227/16 , C07C227/18 , C07C229/06 , C07C229/12 , C07C231/02 , C07C231/12 , C07C233/05 , C07C233/08 , C07C303/02 , C07C303/22 , C07C303/38 , C07C303/40 , C07C309/04 , C07C309/13 , C07C309/29 , C07C311/03 , C07C311/05 , C07D207/10 , C07D211/38 , C07D241/04 , C07D265/30 , C08K5/17 , C08L101/00 , C09D5/16 , C09D7/20 , C09D7/40 , C09D201/00 , C09K3/00 , Y02W10/37
摘要： The hydrophilic oil repellent includes one or more types of nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes any one hydrophilicity imparting group selected from the group consisting of anion type hydrophilicity imparting groups, cation type hydrophilicity imparting groups, and amphoteric type hydrophilicity imparting groups in the molecule.

4. 发明申请

US20160297747A1 MATERIALS AND METHODS FOR THE SELECTIVE RECOVERY OF MONOVALENT PRODUCTS FROM AQUEOUS SOLUTIONS USING CONTINUOUS ION EXCHANGE 审中-公开
标题翻译：使用连续离子交换从水溶液中选择性回收单一产物的材料和方法
公开(公告)号：US20160297747A1
公开(公告)日：2016-10-13
申请号：US15094791
申请日：2016-04-08
申请人： INVISTA NORTH AMERICA S.A.R.L.
发明人： Alex Conradie
IPC分类号： C07C227/40 , B01D15/18 , B01D15/20 , C07C67/58 , B01D15/36
CPC分类号： B01D15/362 , B01D15/1892 , B01D15/20 , B01D15/361 , C07C51/47 , C07C53/126 , C07C67/58 , C07C227/40 , C07C229/06
摘要： This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further down-stream purification.
摘要翻译：该文献描述了通过从水溶液经由连续离子交换从而进一步下游纯化的高纯度和高浓度回收单价产物的方法。

5. 发明申请

US20150225439A1 Dendrimer Scaffolds for Pharmaceutical Use 有权
标题翻译：树枝状支架用于制药用途
公开(公告)号：US20150225439A1
公开(公告)日：2015-08-13
申请号：US14425602
申请日：2013-09-05
申请人： Victoria Link Limited
发明人： Phillip Martin Rendle , Steven Toms
IPC分类号： C07H15/04 , C07C229/06 , C07C229/38
CPC分类号： C07H15/04 , A61K47/32 , A61K47/48192 , A61K47/59 , A61K49/0021 , A61K49/0054 , A61K49/124 , C07C229/06 , C07C229/10 , C07C229/38 , C07C233/18 , C07C237/08
摘要： This invention relates to certain dendrimer compounds. In particular, this invention relates to novel dendrimer compounds that can be elaborated to give increasingly large and complex compounds. These elaborated compounds can be attached to, or can encapsulate within, active agent(s) so as to beneficially modify the characteristics of that active agent. Alternatively, the elaborated compounds can themselves be beneficially modified into therapeutic agents by the attachment of inactive agents.
摘要翻译：本发明涉及某些树枝状大分子化合物。特别地，本发明涉及新颖的树枝状大分子化合物，其可以被精心制备以产生越来越大的和复杂的化合物。这些精制化合物可以附着于活性剂或可以包封在活性剂中，以有利地改变该活性剂的特性。或者，精制的化合物本身可以通过无活性剂的附着而有益地修饰成治疗剂。

6. 发明申请

US20140343289A1 PROCESS FOR PRODUCING SOLID AMINO ACID 有权
标题翻译：生产固体氨基酸的方法
公开(公告)号：US20140343289A1
公开(公告)日：2014-11-20
申请号：US14375975
申请日：2013-01-21
申请人： KANEKA CORPORATION
发明人： Masatoshi Ohnuki , Akira Nishiyama
IPC分类号： C07C227/18 , C07D211/60 , C07D207/16
CPC分类号： C07C227/18 , C07C227/42 , C07C2601/02 , C07D207/16 , C07D211/60 , C07C229/06 , C07C229/08 , C07C229/12 , C07C229/32 , C07C229/48
摘要： The problem to be solved by the present invention is to ea lily and efficiently produce an amino acid having 2 to 7 carbon atoms as a high-purity solid without complicated operation, which is useful as a synthetic intermediate for medicines or agrochemicals.The present invention is characterized in comprising a step of precipitating solid amino acid with high purity. In the present invention, the by-produced salt composed of the sulfonic acid and the amine was removed to the mother liquor by reacting an amine with a sulfonic acid salt of amino acid in an aprotic polar solvent, or by reacting a sulfonic acid with an amine salt of amino acid in an aprotic polar solvent.The sulfonic acid salt of amino acid, for example, may be produced by reacting a N-(tert-butoxycarbonyl) amino acid with a sulfonic acid, or by reacting an amino acid tert-butyl ester with a sulfonic acid.
摘要翻译：本发明要解决的问题是在没有复杂操作的情况下生产具有2-7个碳原子的氨基酸作为高纯度固体，其可用作药物或农用化学品的合成中间体。本发明的特征在于包括以高纯度沉淀固体氨基酸的步骤。在本发明中，将由磺酸和胺组成的副产物盐除去到母液中，使胺与氨基酸的磺酸盐在非质子极性溶剂中反应，或者通过使磺酸与氨基酸的胺盐在非质子极性溶剂中。氨基酸的磺酸盐例如可以通过使N-（叔丁氧基羰基）氨基酸与磺酸反应，或者使氨基酸叔丁酯与磺酸反应来制备。

7. 发明申请

US20120116106A1 CO-PRECIPITATED SALTS OF FATTY ACIDS 有权
标题翻译：脂肪酸共同降低的盐
公开(公告)号：US20120116106A1
公开(公告)日：2012-05-10
申请号：US13354033
申请日：2012-01-19
申请人： John Gleason , Douglas Jost , Philip H. Merrell , Doug Caskey
发明人： John Gleason , Douglas Jost , Philip H. Merrell , Doug Caskey
IPC分类号： C07C57/03 , C07F9/09 , C07C57/12
CPC分类号： C07D233/64 , C07C51/412 , C07C53/02 , C07C53/10 , C07C53/122 , C07C53/126 , C07C55/08 , C07C55/10 , C07C55/12 , C07C55/14 , C07C55/16 , C07C57/03 , C07C57/10 , C07C57/12 , C07C57/145 , C07C57/15 , C07C59/08 , C07C59/105 , C07C59/19 , C07C59/245 , C07C59/265 , C07C63/06 , C07C63/16 , C07C65/10 , C07C229/06 , C07C229/24 , C07C229/26 , C07C279/14 , C07C323/58 , C07D307/62 , C07F9/091
摘要： A co-salt of a polyunsaturated fatty acid and a non-fatty acid is formed as a precipitate. The co-salt formed is free flowing and does not tend to agglomerate (cake) in storage. The resultant co-salt product will be easy to blend with other products to produce dietary supplements. These novel co-salt products may also tablet very well and may be added to current dietary supplement tablets.
摘要翻译：形成多不饱和脂肪酸和非脂肪酸的共盐作为沉淀物。形成的共盐是自由流动的，并且在储存中不趋于聚集（饼）。所得的共盐产品将容易与其他产品混合以产生膳食补充剂。这些新型共盐产品还可以非常好地加入片剂，并且可以加入到目前的膳食补充剂片剂中。

8. 发明授权

US10081598B2 Cationic lipid 有权
公开(公告)号：US10081598B2
公开(公告)日：2018-09-25
申请号：US15533576
申请日：2015-12-24
申请人： Eisai R&D Management Co., Ltd. , Sogo Pharmaceutical Co., Ltd.
发明人： Yuta Suzuki , Kenji Hyodo , Yohei Tanaka
IPC分类号： A61K31/713 , C07D211/62 , C12N15/113 , C07C229/06 , A61K47/10 , A61K47/22 , A61K47/28 , C07C229/12 , C12N15/09
CPC分类号： C07D211/62 , A61K31/713 , A61K47/10 , A61K47/22 , A61K47/28 , C07C229/06 , C07C229/12 , C12N15/09 , C12N15/113 , C12N15/1137 , C12N2310/14
摘要： The present invention provides a cationic lipid which can be utilized for nucleic acid delivery into the cytoplasm. The cationic lipid of the present invention is, for example, a compound represented by the following Formula (1) or a pharmaceutically acceptable salt thereof.

9. 发明申请

US20180179120A1 Atropisomers and Methods of Altering Enantiomeric Excess 审中-公开
公开(公告)号：US20180179120A1
公开(公告)日：2018-06-28
申请号：US15854885
申请日：2017-12-27
申请人： Florida State University Research Foundation, Inc.
发明人： Kenneth Hanson , Suliman A. Ayad , Victoria A. Posey
IPC分类号： C07B55/00 , C07C309/71 , C07C68/06 , C07C69/96 , C07C227/36 , C07C229/06 , C07D207/16 , C07D209/18
CPC分类号： C07B55/00 , C07B2200/07 , C07C68/06 , C07C69/96 , C07C227/36 , C07C229/06 , C07C269/06 , C07C309/65 , C07C309/71 , C07C2601/14 , C07C2602/42 , C07D207/16 , C07D209/18 , C07C271/22
摘要： Provided herein are methods of altering enantiomeric excess. The methods may include irradiating an atropisomer that includes at least one chiral substituent to alter the enantiomeric excess of the atropisomer. The at least one chiral substituent may be removed following irradiation.

10. 发明申请

US20180037975A1 Production of Nanocrystalline Metal Powders via Combustion Reaction Synthesis 审中-公开
公开(公告)号：US20180037975A1
公开(公告)日：2018-02-08
申请号：US15786289
申请日：2017-10-17
申请人： Battelle Memorial Institute
发明人： John G. Frye , Kenneth Scott Weil , Curt A. Lavender , Jin Yong Kim
IPC分类号： C22B34/24 , C22C27/02
CPC分类号： C22B34/24 , B22F1/0044 , B22F9/24 , C01B21/38 , C01G33/00 , C01G39/02 , C01G41/02 , C01G47/00 , C07C229/06 , C22C1/045 , C22C1/058 , C22C27/02 , C22C27/04 , G01N23/20075
摘要： Nanocrystalline metal powders comprising tungsten, molybdenum, rhenium or niobium can be synthesized using a combustion reaction. Methods for synthesizing the nanocrystalline metal powders are characterized by forming a combustion synthesis solution by dissolving in water an oxidizer, a fuel, and a base-soluble, ammonium precursor of tungsten, molybdenum, rhenium, or niobium in amounts that yield a soichiometric burn when combusted. The combustion synthesis solution is then heated to a temperature sufficient to substantially remove water and to initiate a self-sustaining combustion reaction. The resulting powder can be subsequently reduced to metal form by heating in a reducing gas environment.

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