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    • 5. 发明申请
    • In situ process for making quaternary ammonium bicarbonates and quaternary ammonium carbonates
    • 制备碳酸氢铵和碳酸季铵的原位方法
    • US20040162343A1
    • 2004-08-19
    • US10776368
    • 2004-02-10
    • Leigh E. Walker
    • A61K031/265C07C069/96
    • C07C209/20C07C211/63
    • Applicant has discovered an in situ method of preparing quaternary ammonium methocarbonate salts and quaternary ammonium alkylcarbonate salts in high yield from tertiary amines, methanol, and at least one of a cyclic carbonate, an aliphatic polyester (such as a polycarbonate), or an ester (such as a carbonate ester), and their subsequent conversion to quaternary ammonium bicarbonates, quaternary ammonium carbonates or both in a one-pot reaction. According to one embodiment of the invention, the method includes reacting an amine and methanol with at least one of a cyclic carbonate and an aliphatic polyester to yield a quaternary ammonium methocarbonate. This method does not produce or require the handling of corrosive quaternary ammonium hydroxides. Another embodiment is a method of preparing quaternary ammonium alkylcarbonate salts by reacting tertiary amines, methanol, and an ester. The quaternary ammonium methocarbonate or alkylcarbonate can be converted to the corresponding bicarbonate, carbonate, or mixture thereof by methods known in the art.
    • 申请人已经发现了从叔胺,甲醇和环状碳酸酯,脂肪族聚酯(如聚碳酸酯)或酯(至少一种)中的至少一种制备高产率的季铵碳酸氢盐和季铵烷基碳酸盐的原位方法 例如碳酸酯),并且它们随后在一锅反应中转化为季铵碳酸氢盐,碳酸季铵盐或二者。 根据本发明的一个实施方案,该方法包括使胺和甲醇与环状碳酸酯和脂肪族聚酯中的至少一种反应,得到季铵碳酸酯。 该方法不产生或要求处理腐蚀性季铵氢氧化物。 另一个实施方案是通过叔胺,甲醇和酯反应制备烷基碳酸季铵盐的方法。 通过本领域已知的方法,可将碳酸季铵或碳酸烷基酯转化为相应的碳酸氢盐,碳酸盐或其混合物。