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1. 发明授权

US08822721B2 Method for separation of racemic compound-forming chiral substances by a cyclic crystallization process and a crystallization device 有权
标题翻译：通过循环结晶法和结晶装置分离外消旋化合物形成手性物质的方法
公开(公告)号：US08822721B2
公开(公告)日：2014-09-02
申请号：US13368638
申请日：2012-02-08
申请人： Heike Lorenz , Daniel Polenske , Linzhu Klukas , Andreas Seidel-Morgenstern
发明人： Heike Lorenz , Daniel Polenske , Linzhu Klukas , Andreas Seidel-Morgenstern
IPC分类号： C07B55/00 , C07B57/00 , B01D9/00
CPC分类号： C07B57/00 , B01D9/0013 , B01D9/0036 , C07B2200/01
摘要： The invention concerns a method for separating a racemic compound-forming chiral substance by a cyclic crystallization process which is conducted in at least one first crystallization unit (10) and in at least one second crystallization unit (18), wherein in a first process cycle an enantiomer is crystallized in the first crystallization unit (10) and a racemic compound is crystallized in the second crystallization unit (18), wherein in a second process cycle the enantiomer is crystallized in the second crystallization unit (18) and the racemic compound is crystallized in the first crystallization unit (10), wherein during each process cycle in at least one process sub-step (B→C, F→G) a mother liquor (12) being contained in the first crystallization unit (10) is mutually exchanged with a mother liquor (20) being contained in the second crystallization unit (18). An auto-seeding process sub-step is applied at the beginning of a process cycle.
摘要翻译：本发明涉及通过在至少一个第一结晶单元（10）和至少一个第二结晶单元（18）中进行的循环结晶过程分离外消旋化合物形成手性物质的方法，其中在第一工艺循环第一结晶单元（10）中的对映异构体结晶，外消旋化合物在第二结晶单元（18）中结晶，其中在第二工艺循环中，对映异构体在第二结晶单元（18）中结晶，外消旋化合物为在第一结晶单元（10）中结晶，其中在至少一个工艺子步骤（B→C，F→G）中的每个工艺循环期间，包含在第一结晶单元（10）中的母液（12）相互与包含在第二结晶单元（18）中的母液（20）交换。自动播种过程子步骤在过程周期开始时被应用。

2. 发明申请

US20120197040A1 Method for separation of racemic compound-forming chiral substances by a cyclic crystallization process and a crystallization device 有权
标题翻译：通过循环结晶法和结晶装置分离外消旋化合物形成手性物质的方法
公开(公告)号：US20120197040A1
公开(公告)日：2012-08-02
申请号：US13368638
申请日：2012-02-08
申请人： Heike LORENZ , Daniel POLENSKE , Linzhu KLUKAS , Andreas SEIDEL-MORGENSTERN
发明人： Heike LORENZ , Daniel POLENSKE , Linzhu KLUKAS , Andreas SEIDEL-MORGENSTERN
IPC分类号： C07B57/00 , B01D9/04
CPC分类号： C07B57/00 , B01D9/0013 , B01D9/0036 , C07B2200/01
摘要： The invention concerns a method for separating a racemic compound-forming chiral substance by a cyclic crystallization process which is conducted in at least one first crystallization unit (10) and in at least one second crystallization unit (18), wherein in a first process cycle an enantiomer is crystallized in the first crystallization unit (10) and a racemic compound is crystallized in the second crystallization unit (18), wherein in a second process cycle the enantiomer is crystallized in the second crystallization unit (18) and the racemic compound is crystallized in the first crystallization unit (10), wherein during each process cycle in at least one process sub-step (B→C, F→G) a mother liquor (12) being contained in the first crystallization unit (10) is mutually exchanged with a mother liquor (20) being contained in the second crystallization unit (18). An auto-seeding process sub-step is applied at the beginning of a process cycle.
摘要翻译：本发明涉及通过在至少一个第一结晶单元（10）和至少一个第二结晶单元（18）中进行的循环结晶过程分离外消旋化合物形成手性物质的方法，其中在第一工艺循环第一结晶单元（10）中的对映异构体结晶，外消旋化合物在第二结晶单元（18）中结晶，其中在第二工艺循环中，对映异构体在第二结晶单元（18）中结晶，外消旋化合物为在第一结晶单元（10）中结晶，其中在至少一个工艺子步骤（B→C，F→G）中的每个工艺循环期间，包含在第一结晶单元（10）中的母液（12）相互与包含在第二结晶单元（18）中的母液（20）交换。自动播种过程子步骤在过程周期开始时被应用。

3. 发明申请

US20150031758A1 TRANSITION METAL COMPLEXES OF A BIS[THIOHYDRAZIDE AMIDE] COMPOUND 审中-公开
标题翻译： BIS [THOHOHDRAZIDE AMIDE]化合物的过渡金属络合物
公开(公告)号：US20150031758A1
公开(公告)日：2015-01-29
申请号：US14455458
申请日：2014-08-08
申请人： Synta Pharmaceuticals Corp.
发明人： Masazumi Nagai , Jianhua Shen
IPC分类号： C07F15/04 , A61K31/28 , A61K31/30 , A61K31/337 , C07F1/08
CPC分类号： C07F15/045 , A61K31/28 , A61K31/30 , A61K31/337 , A61K31/555 , C07B2200/01 , C07C327/56 , C07F1/08 , A61K2300/00
摘要： The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
摘要翻译：本发明涉及包含与过渡金属阳离子络合的双[硫代酰肼酰胺]或其去质子化形式的化合物，其中双[硫代酰肼]由结构式（I）表示：或前药，异构体，酯，盐，水合物，溶剂合物，多晶型物或去质子化形式。本发明还提供了包含本发明化合物及其使用方法的药物组合物。

4. 发明申请

US20130184489A2 Method for Separation of Racemic Compound-Forming Chiral Substances by a Cyclic-Crystallization Process and a Crystallization Device 有权
标题翻译：通过循环结晶法和结晶装置分离外消旋化合物形成的手性物质的方法
公开(公告)号：US20130184489A2
公开(公告)日：2013-07-18
申请号：US13368638
申请日：2012-02-08
申请人： Heike LORENZ , Daniel POLENSKE , Linzhu KLUKAS , Andreas SEIDEL-MORGENSTERN
发明人： Heike LORENZ , Daniel POLENSKE , Linzhu KLUKAS , Andreas SEIDEL-MORGENSTERN
IPC分类号： C07B57/00 , B01D9/04
CPC分类号： C07B57/00 , B01D9/0013 , B01D9/0036 , C07B2200/01
摘要： The invention concerns a method for separating a racemic compound-forming chiral substance by a cyclic crystallization process which is conducted in at least one first crystallization unit (10) and in at least one second crystallization unit (18), wherein in a first process cycle an enantiomer is crystallized in the first crystallization unit (10) and a racemic compound is crystallized in the second crystallization unit (18), wherein in a second process cycle the enantiomer is crystallized in the second crystallization unit (18) and the racemic compound is crystallized in the first crystallization unit (10), wherein during each process cycle in at least one process sub-step (B→C, F→G) a mother liquor (12) being contained in the first crystallization unit (10) is mutually exchanged with a mother liquor (20) being contained in the second crystallization unit (18). An auto-seeding process sub-step is applied at the beginning of a process cycle.
摘要翻译：本发明涉及通过在至少一个第一结晶单元（10）和至少一个第二结晶单元（18）中进行的循环结晶过程分离外消旋化合物形成手性物质的方法，其中在第一工艺循环第一结晶单元（10）中的对映异构体结晶，外消旋化合物在第二结晶单元（18）中结晶，其中在第二工艺循环中，对映异构体在第二结晶单元（18）中结晶，外消旋化合物为在第一结晶单元（10）中结晶的第一结晶单元（10）中的母液（12）在每个工艺循环期间在至少一个工艺子步骤（B-> C，F→G）与包含在第二结晶单元（18）中的母液（20）相互交换。自动播种过程子步骤在过程周期开始时被应用。

5. 发明申请

US20020022111A1 Nanoparticle structures utilizing synthetic DNA lattices 有权
标题翻译：利用合成DNA晶格的纳米颗粒结构
公开(公告)号：US20020022111A1
公开(公告)日：2002-02-21
申请号：US09733968
申请日：2000-12-12
发明人： Charles T. Black , Stephen M. Gates , Christopher B. Murray , Shouheng Sun
IPC分类号： B32B003/10
CPC分类号： B82Y25/00 , C07B2200/01 , C12N15/10 , C40B40/00 , H01F1/0054 , H01F1/0063 , Y10T428/13 , Y10T428/24331 , Y10T428/249978 , Y10T428/249979 , Y10T428/24999 , Y10T428/32
摘要： A laminar structure upon a substrate is formed from a) a lattice layer comprising DNA (deoxyribonucleic acid) segments arranged to form cells of the lattice layer, and b), at least one nanoparticle being disposed within each cell of the lattice layer. The nanoparticles are preferably of substantially uniform diameter not exceeding 50 nanometers. A coating may be applied to adhere the the particles to the substrate and to maintain their substantially uniform spaced-apart relationship. The DNA lattice layer is fabricated using known automated synthetis methods, and is designed to contain specific nucleotide base sequences which cause the DNA to form an ordered array of openings, or lattice cells, by self-assembly. Self-assembly of the DNA lattice may be at an air-liquid interface, or in solution. A preferred embodiment is a magnetic storage medium in which the particles are magnetic particles with diameters in the range of 5-20 nm., the particles being organized in square information bits with each bit holding of 4, 9, 16, 25 etc. particles to produce areal information storage densities on the order of 1000 gigabits (one terabit) per square inch. The lattice of bits may be stabilized and protected by a deposited thin film, hard, abrasion-resistant coating.
摘要翻译：基底上的层状结构由a）由布置成形成晶格层的单元的DNA（脱氧核糖核酸）区的晶格层形成，以及b）至少一个纳米颗粒设置在晶格层的每个单元内。纳米颗粒优选具有不超过50纳米的基本均匀的直径。可以施加涂层以将颗粒附着到基材上并保持其基本均匀的间隔关系。使用已知的自动化合成方法制造DNA晶格层，并且被设计为含有特定的核苷酸碱基序列，其通过自组装使DNA形成有序的开口阵列或晶格细胞。 DNA晶格的自组装可以在空气 - 液体界面处或在溶液中。优选的实施方案是磁性存储介质，其中颗粒是直径在5-20nm范围内的磁性颗粒，颗粒被组织成平方信息位，每个位保持4,9,16,25等颗粒以产生大约1000吉比特（1兆比特）每平方英寸的面积信息存储密度。位的晶格可以被沉积的薄膜，硬的耐磨涂层稳定和保护。

6. 发明申请

US20020008038A1 Combinatorial Electrochemical Synthesis 审中-公开
标题翻译：组合电化学合成
公开(公告)号：US20020008038A1
公开(公告)日：2002-01-24
申请号：US09746840
申请日：2000-12-22
申请人： TheraSense, Inc.
发明人： Adam Heller , Daren J. Caruana
IPC分类号： C25D003/00 , C25C007/02 , C25B011/00 , C25D017/10 , C25B011/04 , C25B011/12 , C25B003/00
CPC分类号： C40B80/00 , B01J19/0046 , B01J2219/00353 , B01J2219/00389 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00689 , B01J2219/00713 , B01J2219/00745 , B01J2219/00752 , C07B2200/01 , C07H21/00 , C40B40/18 , C40B60/14
摘要： Abstract of DisclosureAn array of selectively addressible microelectrodes for combinatorial synthesis of complex polymers or alloys.
摘要翻译：摘要摘要一种用于组合合成复合聚合物或合金的可选择性寻址微电极阵列。

7. 发明授权

US06174455B1 Liquid crystalline compounds and process for producing the same 失效
标题翻译：液晶化合物及其制备方法
公开(公告)号：US06174455B1
公开(公告)日：2001-01-16
申请号：US09025249
申请日：1998-02-18
申请人： Junichi Hanna , Masahiro Funahashi , Komei Kafuku , Kyoko Kogo
发明人： Junichi Hanna , Masahiro Funahashi , Komei Kafuku , Kyoko Kogo
IPC分类号： C09K1932
CPC分类号： C07C15/24 , C07B2200/01 , C07C43/202 , C07C43/225 , C07C69/63 , C07C69/76 , C07C205/35 , C07C245/10 , C07C251/24 , C07C323/18 , C07C323/62 , C09K19/322 , G03G5/02
摘要： A liquid crystalline compound having a novel structure and a process for producing the same are provided. The liquid crystalline compound is represented by the following general formula (I): wherein R1 and R2 each independently represent a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon group having 1 to 22 carbon atoms and may be attached directly to the aromatic ring without through X1 or X2; R3 represents a hydrogen atom, a cyano group, a nitro group, a fluorine atom, or a methyl group; and X1 and X2 each independently represent an oxygen atom, a sulfur atom, or a —CO—, —OCO—, —COO—, —N═CH—, —CONH—, —NH—, —NHCO—, or —CH2— group.
摘要翻译：提供具有新颖结构的液晶化合物及其制备方法。液晶化合物由以下通式（I）表示：其中R 1和R 2各自独立地表示具有1至22个碳原子的直链，支链或环状，饱和或不饱和的烃基，并且可以直接连接到芳族环通过X1或X2; R3表示氢原子，氰基，硝基，氟原子或甲基; 并且X 1和X 2各自独立地表示氧原子，硫原子或-CO-，-OCO - ， - COO - ， - N = CH - ， - CONH-，-NH-，-NHCO-或-CH 2 - 组。

8. 发明申请

US20150196669A1 COMPLEX OF GARCINOL, CYCLODEXTRIN AND METHOD THEREOF 有权
标题翻译：葡萄糖苷，环糊精的复合物及其方法
公开(公告)号：US20150196669A1
公开(公告)日：2015-07-16
申请号：US14593882
申请日：2015-01-09
申请人： Indus Biotech Private Limited
发明人： Sunil Bhaskaran , Mohan Vishwaraman
IPC分类号： A61K47/48 , C07C45/79 , A61K31/122
CPC分类号： A61K47/6951 , A61K31/122 , B82Y5/00 , C07B2200/01 , C07C45/79 , C07C49/835 , C07C2602/46 , C08B37/0015
摘要： The present disclosure discloses a pharmaceutical molecule of Garcinol chemically complexed with cyclodextrins and the use of the complexed molecule in prevention and management of cardiac dysfunction induced by chemotherapy, drugs and/or other insults to the heart caused by lifestyle and disease conditions. The disclosure also relates to a method of extraction and purification of high yield of 95-99% pure Garcinol from Garcinia species and a method of chemically complexing Garcinol with cyclodextrins to improve its stability and bioavailability.
摘要翻译：本公开公开了一种与环糊精化学络合的Garcinol的药物分子，以及复合分子在预防和控制由生理和疾病状况引起的由化学疗法，药物和/或其他侮辱引起的心脏功能障碍中的用途。本公开还涉及从藤黄属物种中提取和纯化高产量的95-99％纯的Garcinol的方法，以及将Garcinol与环糊精化学络合以提高其稳定性和生物利用度的方法。

9. 发明申请

US20140011864A1 TRANSITION METAL COMPLEXES OF A BIS[THIOHYDRAZIDE AMIDE] COMPOUND 有权
标题翻译： BIS [THOHOHDRAZIDE AMIDE]化合物的过渡金属络合物
公开(公告)号：US20140011864A1
公开(公告)日：2014-01-09
申请号：US13902270
申请日：2013-05-24
申请人： Masazumi Nagai , Jianhua Shen
发明人： Masazumi Nagai , Jianhua Shen
IPC分类号： C07F15/04 , C07F1/08 , A61K31/28 , A61K31/30 , A61K31/337
CPC分类号： C07F15/045 , A61K31/28 , A61K31/30 , A61K31/337 , A61K31/555 , C07B2200/01 , C07C327/56 , C07F1/08 , A61K2300/00
摘要： The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
摘要翻译：本发明涉及包含与过渡金属阳离子络合的双[硫代酰肼酰胺]或其去质子化形式的化合物，其中双[硫代酰肼]由结构式（I）表示：或前药，异构体，酯，盐，水合物，溶剂合物，多晶型物或去质子化形式。本发明还提供了包含本发明化合物及其使用方法的药物组合物。

10. 发明授权

US06673401B2 Nanoparticle structures utilizing synthetic DNA lattices 有权
标题翻译：利用合成DNA晶格的纳米颗粒结构
公开(公告)号：US06673401B2
公开(公告)日：2004-01-06
申请号：US09733968
申请日：2000-12-12
申请人： Charles T. Black , Stephen M. Gates , Christopher B. Murray , Shouheng Sun
发明人： Charles T. Black , Stephen M. Gates , Christopher B. Murray , Shouheng Sun
IPC分类号： B32B1102
CPC分类号： B82Y25/00 , C07B2200/01 , C12N15/10 , C40B40/00 , H01F1/0054 , H01F1/0063 , Y10T428/13 , Y10T428/24331 , Y10T428/249978 , Y10T428/249979 , Y10T428/24999 , Y10T428/32
摘要： A laminar structure upon a substrate is formed from a) a lattice layer comprising DNA (deoxyribonucleic acid) segments arranged to form cells of the lattice layer, and b), at least one nanoparticle being disposed within each cell of the lattice layer. The nanoparticles are preferably of substantially uniform diameter not exceeding 50 nanometers. A coating may be applied to adhere the the particles to the substrate and to maintain their substantially uniform spaced-apart relationship. The DNA lattice layer is fabricated using known automated synthetis methods, and is designed to contain specific nucleotide base sequences which cause the DNA to form an ordered array of openings, or lattice cells, by self-assembly. Self-assembly of the DNA lattice may be at an air-liquid interface, or in solution. A preferred embodiment is a magnetic storage medium in which the particles are magnetic particles with diameters in the range of 5-20 nm., the particles being organized in square information bits with each bit holding of 4, 9, 16, 25 etc. particles to produce areal information storage densities on the order of 1000 gigabits (one terabit) per square inch. The lattice of bits may be stabilized and protected by a deposited thin film, hard, abrasion-resistant coating.
摘要翻译：基底上的层状结构由a）由布置成形成晶格层的单元的DNA（脱氧核糖核酸）区的晶格层形成，以及b）至少一个纳米颗粒设置在晶格层的每个单元内。纳米颗粒优选具有不超过50纳米的基本均匀的直径。可以施加涂层以将颗粒附着到基材上并保持其基本均匀的间隔关系。使用已知的自动化合成方法制造DNA晶格层，并且被设计为含有特定的核苷酸碱基序列，其通过自组装使DNA形成有序的开口阵列或晶格细胞。 DNA晶格的自组装可以在空气 - 液体界面处或在溶液中。优选的实施方案是磁性存储介质，其中颗粒是直径在5-20nm范围内的磁性颗粒，颗粒被组织成平方信息位，每个位保持4,9,16,25等颗粒以产生大约1000吉比特（1兆比特）每平方英寸的面积信息存储密度。位的晶格可以被沉积的薄膜，硬的耐磨涂层稳定和保护。

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