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1. 发明申请

US20180154186A1 HISTOTRIPSY THERAPY SYSTEMS AND METHODS FOR THE TREATMENT OF BRAIN TISSUE 审中-公开
公开(公告)号：US20180154186A1
公开(公告)日：2018-06-07
申请号：US15737761
申请日：2016-06-23
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Zhen XU , Jonathan SUKOVICH , Aditya S. PANDEY , Charles A. CAIN , Hitinder S. GURM
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61N7/00 , A61N2007/003 , A61N2007/0039 , A61N2007/0047 , A61N2007/0065 , A61N2007/0078 , A61N2007/0086 , A61N2007/0095
摘要： A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

2. 发明授权

US09937364B2 High intensity focused ultrasound with capacitive micromachined transducers 有权
公开(公告)号：US09937364B2
公开(公告)日：2018-04-10
申请号：US14391142
申请日：2013-04-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Max Oskar Köhler
IPC分类号： A61N7/00 , A61N7/02
CPC分类号： A61N7/00 , A61N7/02 , A61N2007/0004 , A61N2007/0043 , A61N2007/0078 , A61N2007/0086
摘要： A medical instrument (900, 1000) comprising a high intensity focused ultrasound system (911) comprising an ultrasound transducer (102, 104, 202, 204, 302, 407, 08) with an adjustable sonication frequency. The ultrasound transducer comprises capacitive micromachined transducers (102, 104, 202, 204, 302, 407, 508). Execution of machine executable instructions by a processor causes the processor to: receive (700, 800) a treatment plan (924) descriptive of a target zone (908) within a subject (902); determine (702, 802) a traversal distance (926) through the subject to the target zone using the treatment plan, wherein the traversal distance is descriptive of the traversal of ultrasound from the ultrasound transducer to the target zone; determine (704, 804) a sonication frequency (829) using the traversal distance for focusing the sonication volume onto the target zone; and sonicate (706, 806) the target zone using the high intensity focused ultrasound system at the sonication frequency.

3. 发明申请

US20170312002A1 Ultrasonic Lesion Feedback, Antipop Monitoring, and Force Detection 审中-公开
公开(公告)号：US20170312002A1
公开(公告)日：2017-11-02
申请号：US15637896
申请日：2017-06-29
申请人： St. Jude Medical, Inc.
发明人： John W. Sliwa , Zhenyi Ma , Stephen A. Morse
IPC分类号： A61B18/04 , A61B18/14 , A61B90/00 , A61B18/00 , A61B17/00 , A61N7/00
CPC分类号： A61B18/04 , A61B18/1492 , A61B90/06 , A61B2017/00106 , A61B2018/00577 , A61B2090/061 , A61B2090/065 , A61B2090/3784 , A61B2218/002 , A61N2007/0004 , A61N2007/0086
摘要： An ablation catheter comprises: an elongated catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis; a distal member disposed adjacent the distal end, the distal member including an ablation element to ablate a biological member; one or more acoustic transducers disposed in the distal member and each configured to direct an acoustic signal toward a respective target ablation region and receive reflection echoes therefrom; and an acoustic redirection member disposed in the distal member to at least partially redirect the acoustic signal from at least one of the acoustic transducers toward a tissue target. The distal member includes a most-distal portion, a proximal portion, and a deflectable portion between the most-distal portion and proximal portion to permit deflection between the most-distal portion and proximal portion of the distal member. The transducers and redirection member are mounted on opposite sides of the deflectable portion.

4. 发明申请

US20150142034A1 HIGH INTENSITY FOCUSED ULTRASOUND TARGETING 有权
标题翻译：高强度聚焦超声波瞄准
公开(公告)号：US20150142034A1
公开(公告)日：2015-05-21
申请号：US14406550
申请日：2013-06-21
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Max Oskar Köhler
IPC分类号： A61N7/00 , A61B5/01 , A61B5/055
CPC分类号： A61N7/00 , A61B5/015 , A61B5/055 , A61B2018/00577 , A61B2018/00738 , A61B2018/00791 , A61B2018/00898 , A61B2018/00988 , A61B2090/374 , A61N7/02 , A61N2007/0086
摘要： The invention provides for a medical instrument (200) comprising a magnetic resonance imaging system (202) and a high intensity focused ultrasound system (202) with an adjustable focus (238). Execution of instructions causes a processor to control (100) medical instrument to sonicate the multiple sonication points while repeatedly acquire the thermal magnetic resonance imaging data. Multiple thermal maps are reconstructed using the thermal magnetic resonance imaging data and a heating center of mass is calculated for each. By comparing each of the heating center of masses to the sonication points a spatially dependent targeting correction (266) is determined. The spatially dependent targeting correction is then used to offset the adjustable focus.
摘要翻译：本发明提供了一种包括磁共振成像系统（202）和具有可调焦点（238）的高强度聚焦超声系统（202）的医疗器械（200）。指令的执行使得处理器控制（100）医疗仪器来重复获取热磁共振成像数据，以超声波处理多个超声处理点。使用热磁共振成像数据重建多个热图，并且计算每个热图的质量加热中心。通过将质量的加热中心与超声处理点进行比较，确定空间依赖的目标校正（266）。然后使用空间相关的瞄准校正来抵消可调焦点。

5. 发明申请

US20150066014A1 Ultrasonic lesion feedback, antipop monitoring, and force detection 有权
标题翻译：超声波病变反馈，对抗监测和力检测
公开(公告)号：US20150066014A1
公开(公告)日：2015-03-05
申请号：US14394164
申请日：2013-03-15
申请人： St. Jude Medical, Inc.
发明人： John Sliwa , Zhenyi Ma , Stephen Morse
IPC分类号： A61B18/04 , A61B19/00
CPC分类号： A61B18/04 , A61B18/1492 , A61B90/06 , A61B2017/00106 , A61B2018/00577 , A61B2090/061 , A61B2090/065 , A61B2090/3784 , A61B2218/002 , A61N2007/0004 , A61N2007/0086
摘要： An ablation catheter comprises: an elongated catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis; a distal member disposed adjacent the distal end, the distal member including an ablation element to ablate a biological member; one or more acoustic transducers disposed in the distal member and each configured to direct an acoustic signal toward a respective target ablation region and receive reflection echoes therefrom; and an acoustic redirection member disposed in the distal member to at least partially redirect the acoustic signal from at least one of the acoustic transducers toward a tissue target. The distal member includes a most-distal portion, a proximal portion, and a deflectable portion between the most-distal portion and proximal portion to permit deflection between the most-distal portion and proximal portion of the distal member. The transducers and redirection member are mounted on opposite sides of the deflectable portion.
摘要翻译：消融导管包括：细长的导管主体，沿纵向轴线在近端和远端之间纵向延伸; 远端构件邻近所述远端设置，所述远端构件包括消融元件以烧蚀生物构件; 一个或多个声学换能器设置在远端构件中，并且每个声学换能器被配置为将声信号引导到相应的目标消融区域并从其接收反射回波; 以及设置在所述远端构件中以至少部分地将来自所述声学换能器中的至少一个声学信号的声学信号重定向到组织靶的声学重定向构件。远侧构件包括最远侧部分，近端部分和最远侧部分和近侧部分之间的可偏转部分，以允许远侧部件的最远侧部分和近端部分之间的偏转。换能器和重定向构件安装在可偏转部分的相对侧上。

6. 发明申请

US20130289671A1 Method for Hypopigmentation Tattooing 审中-公开
标题翻译：色素沉着纹理的方法
公开(公告)号：US20130289671A1
公开(公告)日：2013-10-31
申请号：US13458117
申请日：2012-04-27
申请人： Gregg S. Homer
发明人： Gregg S. Homer
IPC分类号： A61N5/067 , A61N5/06
CPC分类号： A61B18/203 , A61B2018/0047 , A61N5/02 , A61N5/0616 , A61N7/00 , A61N2005/0659 , A61N2005/0663 , A61N2005/067 , A61N2007/0034 , A61N2007/0086
摘要： The present invention is directed to a method for creating permanent or semi-permanent images on a pre-determined treatment area of the skin wherein electromagnetic radiation (“EMR”) is applied to the treatment area. Based on the EMR energy density selected, no hypertrophic scarring occurs. The skin is nevertheless hypopigmented where the spot is directed. When the treated area is tanned, the selected image appears. When the skin is pale, the selected image does not appear.
摘要翻译：本发明涉及一种用于在皮肤的预定治疗区域上产生永久或半永久性图像的方法，其中电磁辐射（“EMR”）被施加到治疗区域。基于选择的EMR能量密度，不发生肥厚性瘢痕形成。皮肤在斑点指向的地方色素沉着。当处理区域被鞣制时，将显示所选图像。当皮肤变浅时，所选图像不会出现。

7. 发明公开

US20240123264A1 System and Method for Open-Loop Ultrasound Therapy 审中-公开
公开(公告)号：US20240123264A1
公开(公告)日：2024-04-18
申请号：US18398565
申请日：2023-12-28
申请人： Profound Medical Inc.
发明人： Mathieu Allard
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61N2007/0004 , A61N2007/0043 , A61N2007/0052 , A61N2007/0078 , A61N2007/0086
摘要： A method for delivering ultrasound therapy using open-loop controls comprises inserting a distal tip of a therapeutic ultrasound applicator into a patient's urethra, the distal tip including an ultrasound transducer; acquiring ultrasound images of the patient's urethra and prostate with an ultrasound imaging probe; aligning the distal tip of the therapeutic ultrasound applicator with the patient's prostate using the ultrasound images; delivering therapeutic ultrasound energy to the patient's prostate, with the ultrasound transducer, according to a treatment plan, the treatment plan including a predetermined limited angular range for the therapeutic ultrasound energy that avoids the patient's rectum and neurovascular bundles, wherein the therapeutic ultrasound is delivered without temperature feedback data.

8. 发明授权

US11937981B2 Ultrasound phased array patch on flexible CMOS and methods for fabricating thereof 有权
公开(公告)号：US11937981B2
公开(公告)日：2024-03-26
申请号：US16474986
申请日：2017-12-27
申请人： The Trustees of Columbia University in the City of New York
发明人： Kenneth Shepard , Tiago Costa , Kevin Tien , Chen Shi
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61B8/4488 , A61B8/4494 , A61B8/42 , A61N2007/0026 , A61N2007/0086
摘要： An ultrasound phased array integrated in flexible CMOS technology is provided. The CMOS IC chip is fabricated through various chip-thinning techniques, resulting in mechanical flexibility, robustness, and minimized mechanical loading for the piezoelectric transducers. The ultrasound phased array CMOS patch can allow for the generation of high intensity focal regions for maximum penetration in regions of interest.

9. 发明公开

US20240024649A1 ULTRASOUND ARRAYS FOR ENHANCED SONODYNAMIC THERAPY FOR TREATING CANCER 审中-公开
公开(公告)号：US20240024649A1
公开(公告)日：2024-01-25
申请号：US18040610
申请日：2021-08-04
申请人： Alpheus Medical, Inc.
发明人： Vijay AGARWAL , Braden ELIASON , Jeremy LING , John BALLARD , Gregg MILLER
IPC分类号： A61M37/00 , A61N7/00 , B06B1/02 , B06B1/06
CPC分类号： A61M37/0092 , A61N7/00 , B06B1/0215 , B06B1/0625 , A61N2007/0086 , B06B2201/55 , B06B2201/76
摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

10. 发明申请

US20180085023A1 Medical Instrument For Sonicating A Set Of Target Volumes 审中-公开
公开(公告)号：US20180085023A1
公开(公告)日：2018-03-29
申请号：US15562235
申请日：2016-03-16
申请人： PROFOUND MEDICAL INC.
发明人： Matti Oskari Tillander
IPC分类号： A61B5/055 , A61B5/01 , A61B5/00 , G01R33/48 , A61N7/02
CPC分类号： A61B5/055 , A61B5/015 , A61B5/4836 , A61B2017/00084 , A61B2018/00791 , A61B2090/374 , A61B2505/05 , A61N7/02 , A61N2007/0086 , A61N2007/0095 , G01R33/4804 , G01R33/4814
摘要： The invention provides for a medical instrument (100) comprising: a high intensity focused ultrasound system (104) a magnetic resonance imaging system (102). Machine executable instructions (180, 182, 184, 186) cause a processor (144) controlling the medical instrument to: receive (300) sonication commands (160), wherein the sonication commands specify a set of multiple target volumes (202) within the target zone; and receive (302) a selection of a current target volume (200) selected from the set of multiple target volumes. The machine executable instructions further cause the processor to repeatedly: acquire (304) the thermal magnetic resonance data by controlling the magnetic resonance imaging system with the thermometry pulse sequence commands (164); calculate (306) a temperature map (168) using the thermal magnetic resonance data; control (308) the high intensity focused ultrasound system to sonicate the current target volume by steering the sonication location to the current target volume; remove (310) the current target volume from the set of multiple target volumes after controlling the high intensity focused ultrasound system to sonicate the current target volume; calculate (312) a sonication energy (172) for each of the multiple target volumes by using the temperature map; select (314) a next target volume from the multiple target volumes using the calculation of the sonication energy for each of the multiple target volumes, wherein the selection of the next target volume comprises searching for the sonication energy with a minimum value; and set (316) the next target volume as the current target volume.

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