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1. 发明授权

US11712502B2 Systems, devices, and methods for extracorporeal removal of carbon dioxide 有权
公开(公告)号：US11712502B2
公开(公告)日：2023-08-01
申请号：US16647942
申请日：2018-09-17
申请人： Steven Paul Keller , Brian Yale Chang , Jayon Wang
发明人： Steven Paul Keller , Brian Yale Chang , Jayon Wang
IPC分类号： A61M1/16 , B01D19/00
CPC分类号： A61M1/1647 , A61M1/1627 , B01D19/0031 , A61M2202/0225 , A61M2230/208
摘要： Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

2. 发明申请

US20180043072A1 Balancing Method and Balancing Unit Being Independent of Temperature Disturbance 审中-公开
公开(公告)号：US20180043072A1
公开(公告)日：2018-02-15
申请号：US15559559
申请日：2016-03-21
申请人： Fresenius Medical Care Deutschland GmbH
发明人： Petra Abel , Alexander Heide , Dejan Nikolic , Arne Peters , Elke Schulte , Christoph Wiktor
IPC分类号： A61M1/16 , G01F1/60
CPC分类号： A61M1/1635 , A61M1/1647 , A61M1/1662 , A61M1/1664 , A61M2205/127 , A61M2205/3317 , A61M2205/3334 , A61M2205/3372 , A61M2205/366 , G01F1/60
摘要： This disclosure relates to a method for determining a fluid balance between a first volume flow in a first section of a fluid circuit and a second volume flow of a second section of the fluid circuit. The method may also include adjusting, assuming or detecting a first temperature in the first section of the fluid circuit and a second temperature in the second section of the fluid circuit, or detecting a temperature difference between the first and the second sections. The method may also include detecting a second volume flow in a second section of the fluid circuit and forming a balance from at least the first volume flow and a corrected value of the second volume flow. The corrected value is determined from the detected second volume flow and the second temperature and/or the temperature difference.

3. 发明授权

US09724456B2 Dialysis system having non-invasive fluid velocity sensing 有权
公开(公告)号：US09724456B2
公开(公告)日：2017-08-08
申请号：US14509323
申请日：2014-10-08
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Matthew Muller , Donald Busby , Justin B. Rohde , Mark E. Jablonski
IPC分类号： A61M1/16 , A61M1/36 , G01F1/708 , A61M1/28 , A61M1/34
CPC分类号： A61M1/1613 , A61M1/16 , A61M1/1607 , A61M1/1645 , A61M1/1647 , A61M1/1658 , A61M1/288 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3413 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/365 , A61M1/3656 , A61M2205/12 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , A61M2230/20 , G01F1/708
摘要： A dialysis system includes a dialysis instrument including a blood pump, a dialysate inlet pump, a dialysate outlet pump, and at least one fluid velocity sensor, each sensor including an emitter and a receiver, a dialyzer arranged (i) to receive blood pumped by the blood pump, (ii) to receive fresh dialysate pumped by the dialysate inlet pump and (iii) such that used dialysate is pumped from the dialyzer by the dialysate outlet pump, and a disposable cassette including a to-dialyzer dialysate pathway carrying dialysate pumped by the dialysate inlet pump and a from-dialyzer dialysate pathway carrying used dialysate pumped by the dialysate outlet pump, wherein at least one of the to-dialyzer dialysate pathway or the from-dialyzer dialysate pathway includes at least one sensing area so positioned and arranged such that when the disposable cassette is mounted to the instrument, the sensing area is coupled operably with both the emitter and the receiver of the at least one fluid velocity sensor.

4. 发明申请

US20160354528A1 APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD 审中-公开
公开(公告)号：US20160354528A1
公开(公告)日：2016-12-08
申请号：US15240231
申请日：2016-08-18
申请人： GAMBRO LUNDIA AB
发明人： Dominique Pouchoulin
IPC分类号： A61M1/16 , A61M1/36 , A61M1/34
CPC分类号： A61M1/1647 , A61M1/16 , A61M1/1605 , A61M1/1643 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3413 , A61M1/3434 , A61M1/3441 , A61M1/3451 , A61M1/361 , A61M1/3638 , A61M2205/18 , A61M2205/3334 , A61M2205/3393 , A61M2205/502 , A61M2205/505 , A61M2205/52
摘要： An apparatus for extracorporeal treatment of blood (1) comprising a filtration unit (2), a blood withdrawal line (6), a blood return line (7), an effluent fluid line (13), a pre and/or post-dilution fluid line (15, 25) connected to the blood withdrawal line, and a dialysis fluid line. Pumps (17, 18, 21, 22, 27) act on the fluid lines for regulating the flow of fluid. A control unit (10) is configured to periodically calculate a new value for the patient fluid removal rate to be imposed on an ultrafiltration actuator in order to keep a predefined patient fluid removal rate across a reference time interval irrespective of machine down times.

5. 发明申请

US20160121037A1 ACUTE RENAL REPLACEMENT THERAPY APPARATUS 有权
标题翻译：急性肾脏替代治疗装置
公开(公告)号：US20160121037A1
公开(公告)日：2016-05-05
申请号：US14870613
申请日：2015-09-30
申请人： B. BRAUN AVITUM AG
发明人： István Golarits , Botond Tényi
IPC分类号： A61M1/34 , A61M1/36 , A61M1/16
CPC分类号： A61M1/3451 , A61M1/16 , A61M1/1615 , A61M1/1643 , A61M1/1647 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/342 , A61M1/3441 , A61M1/3607 , A61M1/3663 , A61M2205/3331 , A61M2205/3334 , A61M2205/3379 , A61M2205/3393 , A61M2205/50
摘要： A renal therapy apparatus including at least two feedback controls is disclosed. Each control includes an estimated volume calculator to calculate an estimated volume based on a set flow, a comparator to compare the estimated volume with a measured volume, a volume deviation determining means to determine a volume deviation based on the comparison, a correction calculator to calculate a correction based on the volume deviation, a flow control generator to generate a flow control signal based on the calculated correction amount and the set flow, and a feedback control output to output the controlled flow control signal to a pump associated with each feedback control. A flow correction distributor includes an input to receive correction signals from the correction calculator, a limited correction signal calculator to calculate a limited correction signal for the input correction required signals, and an output to output each calculated limited correction signal to the feedback control from which its underlying correction required signal has been received.
摘要翻译：公开了包括至少两个反馈控制的肾治疗装置。每个控制器包括估计体积计算器，用于基于设定流量计算估计体积，将估计体积与测量体积进行比较的比较器;基于比较确定体积偏差的体积偏差确定装置，计算计算器基于体积偏差的校正，用于基于所计算的校正量和设定流量生成流量控制信号的流量控制发生器以及反馈控制输出，以将受控流量控制信号输出到与每个反馈控制相关联的泵。流量校正分配器包括用于接收来自校正计算器的校正信号的输入端，用于计算用于输入校正所需信号的有限校正信号的有限校正信号计算器，以及将每个计算的限制校正信号输出到反馈控制器的输出端，其底层校正信号已被接收。

6. 发明授权

US09295770B2 Method for determining a volume flow in a blood treatment apparatus, calculating device and blood treatment apparatus 有权
标题翻译：用于确定血液处理装置，计算装置和血液处理装置中的体积流量的方法
公开(公告)号：US09295770B2
公开(公告)日：2016-03-29
申请号：US13479850
申请日：2012-05-24
申请人： Alfred Gagel
发明人： Alfred Gagel
IPC分类号： A61M37/00 , A61M1/34 , A61M1/16 , A61M1/36
CPC分类号： A61M1/342 , A61M1/1647 , A61M1/34 , A61M1/341 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3465 , A61M1/3635 , A61M1/3663 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： The present invention relates to a method for determining at least a first volume flow in a blood treatment apparatus which comprises: a primary circuit for conducting the blood to be treated; a secondary circuit for conducting a fluid that is used for the blood treatment; a blood treatment module provided for exchanging fluids and/or substances between the primary circuit and the secondary circuit; and an optionally provided fluid connection between the primary circuit and the secondary circuit, provided for introducing the first volume flow from the secondary circuit into the primary circuit; wherein the method encompasses determining the first volume flow of the secondary circuit taking into account a first pressure value or pressure measurement and a second pressure value or pressure measurement in the secondary circuit. The present invention further relates to a calculating device and a blood treatment apparatus.
摘要翻译：本发明涉及一种用于确定血液处理设备中的至少第一体积流量的方法，该方法包括：用于进行待处理血液的初级回路; 用于进行用于血液处理的流体的次级回路; 血液处理模块，用于在一次回路和二次回路之间交换流体和/或物质; 以及在所述主电路和所述次级电路之间可选地提供的流体连接，用于将所述第一体积流从所述次级电路引入所述初级电路; 其中所述方法包括在二次回路中考虑第一压力值或压力测量值以及第二压力值或压力测量值来确定次级回路的第一体积流量。本发明还涉及计算装置和血液处理装置。

7. 发明申请

US20150060362A1 APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD 审中-公开
标题翻译：用于血液提取物治疗的装置
公开(公告)号：US20150060362A1
公开(公告)日：2015-03-05
申请号：US14388295
申请日：2013-03-22
申请人： GAMBRO LUNDIA AB
发明人： Dominique Pouchoulin
IPC分类号： A61M1/34
CPC分类号： A61M1/1647 , A61M1/16 , A61M1/1605 , A61M1/1643 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3413 , A61M1/3434 , A61M1/3441 , A61M1/3451 , A61M1/361 , A61M1/3638 , A61M2205/18 , A61M2205/3334 , A61M2205/3393 , A61M2205/502 , A61M2205/505 , A61M2205/52
摘要： An apparatus for extracorporeal treatment of blood (1) comprising a filtration unit (2), a blood withdrawal line (6), a blood return line (7), an effluent fluid line (13), a pre and/or post-dilution fluid line (15, 25) connected to the blood withdrawal line, and a dialysis fluid line. Pumps (17, 18, 21, 22, 27) act on the fluid lines for regulating the flow of fluid. A control unit (10) is configured to periodically calculate a new value for the patient fluid removal rate to be imposed on an ultrafiltration actuator in order to keep a predefined patient fluid removal rate across a reference time interval irrespective of machine down times.
摘要翻译：一种用于血液体外处理的装置（1），包括过滤单元（2），抽血管线（6），血液回流管线（7），流出液体管线（13），前和/或后稀释连接到抽血管线的流体管线（15,25）和透析流体管线。泵（17,18,21,22,27）作用于用于调节流体流动的流体管线。控制单元（10）被配置为周期性地计算要施加在超滤致动器上的患者流体去除速率的新值，以便在参考时间间隔内保持预定的患者流体去除率，而与机器停机时间无关。

8. 发明授权

US08048310B2 Method and device for the removal of partially protein bound substances 有权
标题翻译：去除部分蛋白质结合物质的方法和装置
公开(公告)号：US08048310B2
公开(公告)日：2011-11-01
申请号：US12976653
申请日：2010-12-22
申请人： Jan Sternby , Berit Sternby
发明人： Jan Sternby , Berit Sternby
IPC分类号： B01D61/14 , B01D61/18 , B01D65/02
CPC分类号： B01D61/243 , A61M1/16 , A61M1/1607 , A61M1/1633 , A61M1/1647 , A61M1/165 , A61M1/1692 , A61M1/1696 , A61M1/341 , A61M1/3431 , A61M1/3465 , A61M2205/3317 , A61M2205/3324 , A61M2205/3334 , A61M2205/3368 , A61M2205/3393
摘要： A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.
摘要翻译：一种提高透析效率的方法和装置，用于从血液中去除或多或少紧密结合载体如白蛋白的物质。根据本发明，这是通过与常规透析相比，同时显着增加透析流体的流速和从透析液分离血液的膜的面积而实现的。

9. 发明申请

US20110132838A1 DIALYSIS SYSTEM WITH ULTRAFILTRATION CONTROL 有权
标题翻译：具有超声波控制的透析系统
公开(公告)号：US20110132838A1
公开(公告)日：2011-06-09
申请号：US12795498
申请日：2010-06-07
申请人： James R. Curtis , Ladislaus F. Nonn , Julie Wrazel
发明人： James R. Curtis , Ladislaus F. Nonn , Julie Wrazel
IPC分类号： B01D61/32 , B01D61/24
CPC分类号： A61M1/1647 , A61M1/16 , A61M1/1601 , A61M1/1619 , A61M1/165 , A61M1/34 , A61M1/3403 , A61M1/3413 , A61M1/3427 , A61M2205/3331 , A61M2205/3334 , A61M2205/70 , A61M2205/702 , G05D7/0676
摘要： Systems and methods are disclosed for performing hemodialysis that include fluid handling systems that provide accurate control over the type and level of hemodialysis being performed. The system includes a first pump for pumping dialysate into a dialyzer and a second pump for pumping dialysate out of the dialyzer. The system also includes a third pump that provides improved control of a level of ultrafiltration, hemodiafiltration, or both.
摘要翻译：公开了用于执行血液透析的系统和方法，其包括提供对正在执行的血液透析的类型和水平的精确控制的流体处理系统。该系统包括用于将透析液泵入透析器的第一泵和用于将透析液泵出透析器的第二泵。该系统还包括第三泵，其提供对超滤水平，血液透析滤液或两者的改进的控制。

10. 发明授权

US07879241B2 Method of treating a bodily fluid 有权
标题翻译：治疗体液的方法
公开(公告)号：US07879241B2
公开(公告)日：2011-02-01
申请号：US12106642
申请日：2008-04-21
申请人： Douglas Ray Sparks , Nader Najafi
发明人： Douglas Ray Sparks , Nader Najafi
IPC分类号： B01D61/24 , B01D61/28
CPC分类号： B01D61/32 , A61M1/1647 , A61M1/1656 , A61M1/3626 , A61M1/3639 , A61M1/3663 , G01F1/8445 , G01F1/8472
摘要： A method of treating a bodily fluid withdrawn and then returned to a living body. The method involves withdrawing the bodily fluid from the living body and causing the bodily fluid to flow through a treatment system, altering at least the density of the bodily fluid through the action of a second fluid as the bodily fluid flows through the treatment system, sensing at least the density and flow rate of the bodily fluid before the density thereof is altered by the second fluid, sensing at least the density and flow rate of the bodily fluid after the density thereof is altered by the second fluid, sensing at least the density and flow rate of the second fluid, controlling the density and/or flow rate of the second fluid based on the sensed densities and flow rates, and returning the bodily fluid to the living body.
摘要翻译：一种处理体液的方法，然后将其返回生物体。该方法包括从身体排出体液，并使体液流过治疗系统，当体液流过治疗系统时，通过第二流体的作用至少改变体液的密度，感测至少其体积密度和密度之间的密度和流速由第二流体改变，至少在第二流体改变其体密度之后至少检测体液的密度和流速，至少检测密度和第二流体的流量，基于感测的密度和流速控制第二流体的密度和/或流速，并将体液返回到生物体。

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