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1. 发明申请

US20110165077A1 IN VIVO TUMOR TARGETING AND SPECTROSCOPIC DETECTION WITH SURFACE ENHANCED RAMAN NANOPARTICLE TAGS 审中-公开
标题翻译：在体外肿瘤定位和光谱检测与表面增强拉曼纳米标签
公开(公告)号：US20110165077A1
公开(公告)日：2011-07-07
申请号：US12593359
申请日：2008-04-02
申请人： Ximei Qian , Dominic Ansari , Shuming Nie
发明人： Ximei Qian , Dominic Ansari , Shuming Nie
IPC分类号： A61K49/00 , A61P35/00
CPC分类号： A61K49/0089 , A61B5/0059 , A61B5/416 , A61B2503/40 , A61K49/0023 , A61K49/0032 , A61K49/0041 , A61K49/0065 , A61K49/0093 , B82Y5/00 , G01N21/658 , Y10S977/773 , Y10S977/81
摘要： Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a metallic gold surface-enhanced Raman scattering nanoparticle, a Raman reporter and a protection structure. The protection structure may include a thiol-polyethylene glycol to which may be attached a target-specific probe.
摘要翻译：公开了纳米结构，制备纳米结构的方法，检测受试者中靶标的方法和治疗受试者疾病的方法。纳米结构的一个实施方案包括金属金表面增强拉曼散射纳米颗粒，拉曼报告物和保护结构。保护结构可以包括硫醇 - 聚乙二醇，其可以连接目标特异性探针。

2. 发明授权

US08889430B2 Nanostructures, methods of synthesizing thereof, and methods of use thereof 有权
标题翻译：纳米结构，其合成方法及其使用方法
公开(公告)号：US08889430B2
公开(公告)日：2014-11-18
申请号：US12299079
申请日：2007-05-04
申请人： Lily Yang , Hui Mao , Shuming Nie , Xiaohu Gao
发明人： Lily Yang , Hui Mao , Shuming Nie , Xiaohu Gao
IPC分类号： G01N33/553 , A61K49/18 , A61K49/00 , B82Y5/00 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2863 , A61K49/0032 , A61K49/0034 , A61K49/0056 , A61K49/0058 , A61K49/0093 , A61K49/1866 , A61K2039/505 , B82Y5/00 , C07K2317/622 , C07K2317/77
摘要： A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a magnetic iron oxide nanoparticle, a hydrophobic protection structure including at least an amphiphilic copolymer, wherein the hydrophobic protection structure encapsulates the magnetic iron oxide nanoparticle, and at least one amino-terminal fragment (ATF) peptide or epidermal growth factor receptor (EGFR) antibody conjugated to the amphiphilic copolymer.
摘要翻译：纳米结构及其合成方法。在一个实施方案中，纳米结构包括磁性氧化铁纳米颗粒，至少包含两亲性共聚物的疏水保护结构，其中所述疏水保护结构包封磁性氧化铁纳米颗粒，以及至少一个氨基末端片段（ATF）肽或表皮与两亲共聚物缀合的生长因子受体（EGFR）抗体。

3. 发明申请

US20130259944A1 METHODS AND COMPOSITIONS FOR TREATING CANCER WITH PLATINUM PARTICLES 审中-公开
标题翻译：用铂处理癌症的方法和组合物
公开(公告)号：US20130259944A1
公开(公告)日：2013-10-03
申请号：US13791027
申请日：2013-03-08
申请人： Dong M. Shin , Shuming Nie , XiangHong Peng , Yiqing Wang
发明人： Dong M. Shin , Shuming Nie , XiangHong Peng , Yiqing Wang
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K31/282 , A61K47/61 , A61K47/6845
摘要： This disclosure relates to methods and compositions for treating cancer with platinum particles. In certain embodiments, the disclosure relates to platinum particle coated with a polysaccharide, such as a heparin or modified heparin, conjugated to a polypeptide that has affinity for a cell surface cancer marker and uses related thereto.
摘要翻译：本公开涉及用铂颗粒治疗癌症的方法和组合物。在某些实施方案中，本公开涉及涂覆有多糖（例如肝素或修饰的肝素）的铂颗粒，其与对细胞表面癌症标志物具有亲和力并与其有关的多肽缀合。

4. 发明申请

US20110189102A1 COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：涂层量子及其制备方法和使用方法
公开(公告)号：US20110189102A1
公开(公告)日：2011-08-04
申请号：US12864763
申请日：2009-02-05
申请人： Brad A. Kairdolf , Shuming Nie
发明人： Brad A. Kairdolf , Shuming Nie
IPC分类号： H01L33/06 , A61B5/00 , H01L33/52 , B82Y99/00 , B82Y40/00 , B82Y20/00
CPC分类号： G01N21/6486 , B82Y30/00
摘要： The present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific cellular binding and to maintain the small size of quantum dot probes. Embodiments of the coated quantum dots of the disclosure are just slightly larger than the diameter of uncoated quantum dots, and are bright with high quantum yields. They are also very stable under both basic and acidic conditions. Embodiments of the hydroxylated quantum dots result in significant reductions in non-specific binding relative to that of carboxylated dots, and to protein and PEG-coated dots. Embodiments of the disclosure are advantageous in a range of biological applications where non-specific binding is a major problem, such as in multiplexed biomarker staining in cells and tissues, detection of biomarkers in body fluid samples (blood, urine, etc.), as well as live cell imaging.
摘要翻译：本公开提供了一类新型羟基化量子点的实施方案。量子点具有设置在其上的羟基化涂层，其用于最小化非特异性细胞结合并维持量子点探针的小尺寸。本公开的涂覆的量子点的实施例略大于未涂覆的量子点的直径，并且具有高量子产率的明亮。它们在碱性和酸性条件下也非常稳定。羟基化量子点的实施方案导致非特异性结合相对于羧化点，以及蛋白质和PEG-包被点的显着降低。本公开的实施方案在生物应用范围内是有利的，其中非特异性结合是主要问题，例如细胞和组织中多重生物标志物染色，体液样品（血液，尿液等）中生物标志物的检测，如以及活细胞成像。

5. 发明申请

US20110152692A1 SYSTEM AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DIAGNOSTIC OR THERAPEUTIC PROCEDURE 审中-公开
标题翻译：用于在诊断或治疗过程中提供实时解剖学指导的系统和方法
公开(公告)号：US20110152692A1
公开(公告)日：2011-06-23
申请号：US12969396
申请日：2010-12-15
申请人： Shuming Nie , Aaron Mohs , Michael Mancini
发明人： Shuming Nie , Aaron Mohs , Michael Mancini
IPC分类号： A61B6/00
CPC分类号： A61B5/0035 , A61B5/0071 , A61B5/0075 , A61B5/0077 , A61B5/0086 , A61B5/06 , A61B5/415 , A61B5/418 , A61B5/7425 , A61B90/361 , A61B90/37 , A61B2090/365 , A61K49/0017
摘要： According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light source configured to emit a beam of visible light; second light source configured to emit a beam of near-infrared light; a handheld probe optically coupled to the second light source; a second imaging device configured to detect visible light; a third imaging device configured to detect near-infrared light having a first predetermined wavelength; a fourth imaging device configured to detect near-infrared light having a second predetermined wavelength; a display for displaying at least one visual representation of data; and, a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure.
摘要翻译：根据一个方面，公开了一种用于在诊断或治疗过程中在手术中提供解剖指导的系统。在一个实施例中，该系统包括：被配置为发射可见光束的第一光源; 第二光源，被配置为发射近红外光束; 光学耦合到第二光源的手持式探针; 被配置为检测可见光的第二成像装置; 第三成像装置，被配置为检测具有第一预定波长的近红外光; 第四成像装置，被配置为检测具有第二预定波长的近红外光; 用于显示数据的至少一个视觉表示的显示器; 以及控制器，被编程为生成感兴趣区域的至少一个实时集成视觉表示，并且在诊断或治疗过程期间在显示器上显示实时视觉表示以进行指导。

6. 发明申请

US20110060036A1 Branched Multifunctional Nanoparticle Conjugates And Their Use 审中-公开
标题翻译：分支多功能纳米粒子共轭体及其用途
公开(公告)号：US20110060036A1
公开(公告)日：2011-03-10
申请号：US12888767
申请日：2010-09-23
申请人： Shuming Nie , Hongwei Duan , Min Kuang
发明人： Shuming Nie , Hongwei Duan , Min Kuang
IPC分类号： A61K31/337 , C07D305/14 , A61P35/00 , B82Y5/00
CPC分类号： C08G83/006 , A61K47/56 , A61K47/6939 , B82Y5/00 , C08G83/005
摘要： Disclosed herein are compounds and compositions including a polyglycerol nanocarrier, a therapeutic agent or imaging agent, and optionally a targeting agent. In certain aspects the disclosed compounds include biocompatible hyperbranched polymer nanocarriers. Such compounds and compositions are useful for the targeted delivery of antitumor agents and imaging agents to tumors in vivo. Methods are also disclosed for detecting and treating such tumors.
摘要翻译：本文公开了包含聚甘油纳米载体，治疗剂或成像剂以及任选的靶向剂的化合物和组合物。在某些方面，所公开的化合物包括生物相容性超支化聚合物纳米载体。这样的化合物和组合物可用于体内向肿瘤靶向递送抗肿瘤剂和成像剂。还公开了用于检测和治疗这些肿瘤的方法。

7. 发明授权

US07588827B2 Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof 有权
标题翻译：表面增强拉曼光谱（SERS）活性复合纳米颗粒，其制造方法及其使用方法
公开(公告)号：US07588827B2
公开(公告)日：2009-09-15
申请号：US10919944
申请日：2004-08-17
申请人： Shuming Nie , William Doering
发明人： Shuming Nie , William Doering
IPC分类号： B32B5/66
CPC分类号： G01N21/658 , B82Y10/00 , B82Y30/00 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among others, includes a surface-enhanced Raman spectroscopic active composite nanostructure. The surface-enhanced Raman spectroscopic active composite nanostructure includes a core, at least one reporter molecule, and an encapsulating material. The reporter molecule is bonded to the core. The reporter molecule is selected from: an isothiocyanate dye, a multi-sulfur organic dye, a multi-heterosulfur organic dye, a benzotriazole dye, and combinations thereof. The encapsulating material is disposed over the core and the reporter molecule. After encapsulation with the encapsulating material, the reporter molecule has a measurable surface-enhanced Raman spectroscopic signature.
摘要翻译：公开了纳米颗粒，其制备方法和使用纳米颗粒的实施方案检测靶分子的方法。示例性纳米颗粒的一个实施方案包括表面增强拉曼光谱活性复合纳米结构。表面增强拉曼光谱活性复合纳米结构包括芯，至少一个报道分子和封装材料。报道分子与芯结合。报告分子选自：异硫氰酸酯染料，多硫有机染料，多异硫有机染料，苯并三唑染料及其组合。封装材料设置在核心和报告分子之上。封装材料封装后，报告分子具有可测量的表面增强拉曼光谱特征。

8. 发明申请

US20070111324A1 Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto 有权
标题翻译：合金半导体量子点和浓度梯度合金量子点，其系列及其相关方法
公开(公告)号：US20070111324A1
公开(公告)日：2007-05-17
申请号：US10555729
申请日：2004-04-28
申请人： Shuming Nie , Robert Bailey
发明人： Shuming Nie , Robert Bailey
IPC分类号： C09K11/77 , C09K11/08 , C09K11/54
CPC分类号： H01L29/2203 , A61K47/6923 , A61K49/0067 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y20/00 , B82Y30/00 , C01B19/002 , C01B19/007 , C01B21/0632 , C01P2002/01 , C01P2002/50 , C01P2002/72 , C01P2002/84 , C01P2002/85 , C01P2004/04 , C01P2004/64 , C01P2004/84 , C09K11/565 , C09K11/62 , C09K11/883 , C09K11/89 , G01N33/588 , H01L29/127 , H01L31/0352 , H01L31/03529 , Y02E10/50 , Y10S435/967
摘要： An alloyed semiconductor quantum dot comprising an alloy of at least two semiconductors, wherein the quantum dot has a homogeneous composition and is characterized by a band gap energy that is non-linearly related to the molar ratio of the at least two semiconductors; a series of alloyed semiconductor quantum dots related thereto; a concentration-gradient quantum dot comprising an alloy of a first semiconductor and a second semiconductor, wherein the concentration of the first semiconductor gradually increases from the core of the quantum dot to the surface of the quantum dot and the concentration of the second semiconductor gradually decreases from the core of the quantum dot to the surface of the quantum dot; a series of concentration-gradient quantum dots related thereto; in vitro and in vivo methods of use; and methods of producing the alloyed semiconductor and concentration-gradient quantum dots and the series of quantum dots related thereto.
摘要翻译：包含至少两个半导体的合金的合金半导体量子点，其中所述量子点具有均匀的组成，其特征在于与所述至少两个半导体的摩尔比非线性相关的带隙能; 一系列与之相关的合金半导体量子点; 包括第一半导体和第二半导体的合金的浓度梯度量子点，其中第一半导体的浓度从量子点的核心逐渐增加到量子点的表面，并且第二半导体的浓度逐渐减小从量子点的核心到量子点的表面; 与其相关的一系列浓度梯度量子点; 体外和体内使用方法; 以及制造合金化半导体和浓度梯度量子点的方法以及与其相关的一系列量子点。

9. 发明授权

US08394760B2 Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof 有权
公开(公告)号：US08394760B2
公开(公告)日：2013-03-12
申请号：US11919681
申请日：2006-05-02
申请人： Lily Yang , Shuming Nie , Xiaohu Gao , Xiang Hong Peng
发明人： Lily Yang , Shuming Nie , Xiaohu Gao , Xiang Hong Peng
IPC分类号： C07K14/00
CPC分类号： G01N33/574 , B82Y5/00 , B82Y30/00 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68
摘要： A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a capping ligand, an amphiphilic copolymer, and combinations thereof, wherein the hydrophobic protection structure encapsulates the nanospecies, and at least one histidine-tagged peptide or protein conjugated to the hydrophobic protection structure, wherein the at least one histidine-tagged peptide or protein has at least one binding site.

10. 发明申请

US20110311453A1 Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto 有权
公开(公告)号：US20110311453A1
公开(公告)日：2011-12-22
申请号：US13157099
申请日：2011-06-09
申请人： Shuming Nie , Robert E. Bailey
发明人： Shuming Nie , Robert E. Bailey
IPC分类号： A61K49/00 , H01B1/02 , G01N33/53 , B82Y5/00 , B82Y30/00
CPC分类号： H01L29/2203 , A61K47/6923 , A61K49/0067 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y20/00 , B82Y30/00 , C01B19/002 , C01B19/007 , C01B21/0632 , C01P2002/01 , C01P2002/50 , C01P2002/72 , C01P2002/84 , C01P2002/85 , C01P2004/04 , C01P2004/64 , C01P2004/84 , C09K11/565 , C09K11/62 , C09K11/883 , C09K11/89 , G01N33/588 , H01L29/127 , H01L31/0352 , H01L31/03529 , Y02E10/50 , Y10S435/967
摘要： An alloyed semiconductor quantum dot comprising an alloy of at least two semiconductors, wherein the quantum dot has a homogeneous composition and is characterized by a band gap energy that is non-linearly related to the molar ratio of the at least two semiconductors; a series of alloyed semiconductor quantum dots related thereto; a concentration-gradient quantum dot comprising an alloy of a first semiconductor and a second semiconductor, wherein the concentration of the first semiconductor gradually increases from the core of the quantum dot to the surface of the quantum dot and the concentration of the second semiconductor gradually decreases from the core of the quantum dot to the surface of the quantum dot; a series of concentration-gradient quantum dots related thereto; in vitro and in vivo methods of use; and methods of producing the alloyed semiconductor and concentration-gradient quantum dots and the series of quantum dots related thereto.

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