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1. 发明授权

US09486285B2 Treatment of skin by spatial modulation of thermal heating 有权
标题翻译：通过热加热的空间调制处理皮肤
公开(公告)号：US09486285B2
公开(公告)日：2016-11-08
申请号：US13584440
申请日：2012-08-13
申请人： Dilip Y. Paithankar , Jayant D. Bhawalkar , James C. Hsia
发明人： Dilip Y. Paithankar , Jayant D. Bhawalkar , James C. Hsia
IPC分类号： A61B18/18 , A61B18/20 , A61B18/00
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00029 , A61B2018/00452 , A61B2018/00458 , A61B2018/208
摘要： Treating skin can include delivering a beam of radiation to a target region of the skin to cause a zone of thermal injury including a lateral pattern of varying depths of thermal injury distributed along the target region. The lateral pattern includes at least one first sub-zone of a first depth of thermal injury laterally adjacent to at least one second sub-zone of a second depth of thermal injury. The first depth is greater than the second depth. The at least one first sub-zone of the first depth and the at least one second sub-zone of the second depth extend from a surface of the target region of the skin to form a substantially continuous surface thermal injury. The at least one first sub-zone of the first depth and the at least one second sub-zone of the second depth are substantially heated to at least a critical temperature.
摘要翻译：治疗皮肤可以包括将辐射束传送到皮肤的目标区域，以引起热损伤区域，包括沿着目标区域分布的不同深度的热损伤的横向图案。横向图案包括与第二热损伤深度的至少一个第二子区域相邻的第一热损伤深度的至少一个第一子区域。第一个深度大于第二个深度。第一深度的至少一个第一子区域和第二深度的至少一个第二子区域从皮肤的目标区域的表面延伸以形成基本上连续的表面热损伤。第一深度的至少一个第一子区域和第二深度的至少一个第二子区域基本上被加热至至少临界温度。

2. 发明申请

US20120310235A1 TREATMENT OF SKIN BY SPATIAL MODULATION OF THERMAL HEATING 有权
标题翻译：通过热加热空间调节处理皮肤
公开(公告)号：US20120310235A1
公开(公告)日：2012-12-06
申请号：US13584440
申请日：2012-08-13
申请人： Dilip Y. Paithankar , Jayant D. Bhawalkar , James C. Hsia
发明人： Dilip Y. Paithankar , Jayant D. Bhawalkar , James C. Hsia
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00029 , A61B2018/00452 , A61B2018/00458 , A61B2018/208
摘要： Treating skin can include delivering a beam of radiation to a target region of the skin to cause a zone of thermal injury including a lateral pattern of varying depths of thermal injury distributed along the target region. The lateral pattern includes at least one first sub-zone of a first depth of thermal injury laterally adjacent to at least one second sub-zone of a second depth of thermal injury. The first depth is greater than the second depth. The at least one first sub-zone of the first depth and the at least one second sub-zone of the second depth extend from a surface of the target region of the skin to form a substantially continuous surface thermal injury. The at least one first sub-zone of the first depth and the at least one second sub-zone of the second depth are substantially heated to at least a critical temperature.
摘要翻译：治疗皮肤可以包括将辐射束传送到皮肤的目标区域，以引起热损伤区域，包括沿着目标区域分布的不同深度的热损伤的横向图案。横向图案包括与第二热损伤深度的至少一个第二子区域相邻的第一热损伤深度的至少一个第一子区域。第一个深度大于第二个深度。第一深度的至少一个第一子区域和第二深度的至少一个第二子区域从皮肤的目标区域的表面延伸以形成基本上连续的表面热损伤。第一深度的至少一个第一子区域和第二深度的至少一个第二子区域基本上被加热至至少临界温度。

3. 发明授权

US08246611B2 Treatment of skin by spatial modulation of thermal heating 有权
标题翻译：通过热加热的空间调制处理皮肤
公开(公告)号：US08246611B2
公开(公告)日：2012-08-21
申请号：US11763111
申请日：2007-06-14
申请人： Dilip Y. Paithankar , Jayant D. Bhawalkar , James C. Hsia
发明人： Dilip Y. Paithankar , Jayant D. Bhawalkar , James C. Hsia
IPC分类号： A61F7/00 , A61B18/00 , A61B18/04 , A61B18/18
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00029 , A61B2018/00452 , A61B2018/00458 , A61B2018/208
摘要： Treating skin can include delivering a beam of radiation to a target region of the skin to cause a zone of thermal injury including a lateral pattern of varying depths of thermal injury distributed along the target region. The lateral pattern includes at least one first sub-zone of a first depth of thermal injury laterally adjacent to at least one second sub-zone of a second depth of thermal injury. The first depth is greater than the second depth. The at least one first sub-zone of the first depth and the at least one second sub-zone of the second depth extend from a surface of the target region of the skin to form a substantially continuous surface thermal injury. The at least one first sub-zone of the first depth and the at least one second sub-zone of the second depth are substantially heated to at least a critical temperature.
摘要翻译：治疗皮肤可以包括将辐射束传送到皮肤的目标区域，以引起热损伤区域，包括沿着目标区域分布的不同深度的热损伤的横向图案。横向图案包括与第二热损伤深度的至少一个第二子区域相邻的第一热损伤深度的至少一个第一子区域。第一个深度大于第二个深度。第一深度的至少一个第一子区域和第二深度的至少一个第二子区域从皮肤的目标区域的表面延伸以形成基本上连续的表面热损伤。第一深度的至少一个第一子区域和第二深度的至少一个第二子区域基本上被加热至至少临界温度。

4. 发明授权

US09028469B2 Method of treating cellulite 有权
标题翻译：治疗脂肪团的方法
公开(公告)号：US09028469B2
公开(公告)日：2015-05-12
申请号：US11529737
申请日：2006-09-28
申请人： Christopher J. Jones , James C. Hsia , Dilip Y. Paithankar
发明人： Christopher J. Jones , James C. Hsia , Dilip Y. Paithankar
IPC分类号： A61N5/067 , A61N5/06 , A61B18/20 , A61B17/00 , A61B18/00 , A61B18/18 , A61N5/00
CPC分类号： A61N5/0616 , A61B18/203 , A61B2017/00084 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00452 , A61B2018/1807 , A61N2005/007 , A61N2005/063 , A61N2005/0644 , A61N2005/0659 , A61N2005/067
摘要： A treatment for subcutaneous fat and/or cellulite includes delivering a beam of radiation to a subcutaneous fat region disposed relative to a dermal interface in a target region of skin. The beam of radiation affects at least one fat cell in the subcutaneous fat region without causing substantial unwanted injury to the epidermal region and causes thermal injury to a dermal region to induce collagen formation to strengthen the target region of skin in a target region of skin. The treatment can include cooling an epidermal region of the target region of skin.
摘要翻译：用于皮下脂肪和/或脂肪团的治疗包括将辐射束递送到相对于皮肤目标区域中的皮肤界面设置的皮下脂肪区域。辐射束影响皮下脂肪区域中的至少一个脂肪细胞，而不会对表皮区域造成实质上的不必要的损伤，并且对皮肤区域引起热损伤以诱导胶原形成，以加强皮肤目标区域中的皮肤的目标区域。治疗可以包括冷却皮肤目标区域的表皮区域。

5. 发明申请

US20080215040A1 VARIABLE DEPTH SKIN HEATING WITH LASERS 审中-公开
标题翻译：可变深度皮肤加热激光
公开(公告)号：US20080215040A1
公开(公告)日：2008-09-04
申请号：US12041527
申请日：2008-03-03
申请人： Dilip Y. Paithankar , Christopher J. Jones , James C. Hsia
发明人： Dilip Y. Paithankar , Christopher J. Jones , James C. Hsia
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2017/00106 , A61B2018/00005 , A61B2018/00452 , A61B2018/00458
摘要： Treating biological tissue can include selecting parameter for electromagnetic radiation based on at least one parameter of a target region within the biological tissue. Treating biological tissue also includes methods, systems, and kits for delivering the electromagnetic radiation through a surface of the biological tissue to the target region to induce within the target region a sub-surface thermal injury characterized, for example, by a desired degree and a desired depth and confining the sub-surface thermal injury to substantially within the target region.
摘要翻译：治疗生物组织可以包括基于生物组织内的目标区域的至少一个参数来选择用于电磁辐射的参数。治疗生物组织还包括用于将电磁辐射通过生物组织的表面递送到靶区域的方法，系统和试剂盒，以在目标区域内诱导亚表面热损伤，其表征为例如期望的程度和期望的深度并将基底表面热损伤限制在目标区域内。

6. 发明申请

US20090187169A1 Method of Treating Disorders Associated with Sebaceous Follicles 审中-公开
标题翻译：治疗与皮脂腺相关的疾病的方法
公开(公告)号：US20090187169A1
公开(公告)日：2009-07-23
申请号：US12414316
申请日：2009-03-30
申请人： Anthony J. Durkin , Dilip Y. Paithankar , Yacov Domankevitz
发明人： Anthony J. Durkin , Dilip Y. Paithankar , Yacov Domankevitz
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00011 , A61B2018/00452 , A61B2018/00476 , A61B2018/1807
摘要： Disclosed herein is a method of treating mammalian, for example, human, skin afflicted with a sebaceous follicle disorder, for example, acne. The method involves cooling an exposed surface of a region afflicted with the disorder and applying light, for example, light from a coherent or incoherent light source, to the region. The applied light reduces the size and/or density of lesions associated with the disorder in the treated region, and can reduce or otherwise alleviate lesion-associated skin inflammation in the treated region. Cooling preserves the surface, for example, epidermis, of the skin. The method, therefore, is effective at treating the disorder while at the same time avoiding or minimizing thermal damage to the exposed surface of the skin.
摘要翻译：本文公开了一种治疗哺乳动物例如患有皮脂腺滤泡障碍（例如痤疮）的人类皮肤的方法。该方法包括冷却受到障碍的区域的暴露表面，并将光（例如，来自相干或非相干光源的光）施加到该区域。所应用的光减少与处理区域中的病症相关的损伤的大小和/或密度，并且可以减少或以其它方式减轻治疗区域中与病变相关的皮肤炎症。冷却保留皮肤表面，例如皮肤表皮。因此，该方法在治疗疾病方面是有效的，同时避免或最小化对皮肤暴露表面的热损伤。

7. 发明授权

US06743222B2 Method of treating disorders associated with sebaceous follicles 有权
标题翻译：治疗与皮脂腺滤泡相关疾病的方法
公开(公告)号：US06743222B2
公开(公告)日：2004-06-01
申请号：US09731496
申请日：2000-12-07
申请人： Anthony J. Durkin , Dilip Y. Paithankar
发明人： Anthony J. Durkin , Dilip Y. Paithankar
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00011 , A61B2018/00452 , A61B2018/00476 , A61B2018/1807
摘要： Disclosed herein is a method of treating mammalian, for example, human, skin afflicted with a sebaceous follicle disorder, for example, acne. The method involves cooling an exposed surface of a region afflicted with the disorder and applying energy, for example, energy from a coherent or incoherent light source, to the region. The applied energy reduces the size and/or density of lesions associated with the disorder in the treated region, and can reduce or otherwise alleviate lesion-associated skin inflammation in the treated region. Cooling preserves the surface, for example, epidermis, of the skin. The method, therefore, is effective at treating the disorder while at the same time avoiding or minimizing thermal damage to the exposed surface of the skin.
摘要翻译：本文公开了一种治疗哺乳动物例如患有皮脂腺滤泡障碍（例如痤疮）的人类皮肤的方法。该方法包括冷却受病症影响的区域的暴露表面，并将能量（例如，来自相干或非相干光源的能量）施加到该区域。施加的能量减少与处理区域中的病症相关的损伤的大小和/或密度，并且可以减少或以其它方式减轻治疗区域中与病变相关的皮肤炎症。冷却保留皮肤表面，例如皮肤表皮。因此，该方法在治疗疾病方面是有效的，同时避免或最小化对皮肤暴露表面的热损伤。

8. 发明授权

US5865754A Fluorescence imaging system and method 失效
标题翻译：荧光成像系统及方法
公开(公告)号：US5865754A
公开(公告)日：1999-02-02
申请号：US702060
申请日：1996-08-23
申请人： Eva M. Sevick-Muraca , Dilip Y. Paithankar
发明人： Eva M. Sevick-Muraca , Dilip Y. Paithankar
IPC分类号： A61B5/00 , A61B10/00 , G01J3/44 , G01N21/47 , G01N21/64
CPC分类号： G01N21/6408 , G01J3/4406 , G01N21/4795 , G01N21/6456
摘要： A system and method non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique consists of a modulated light source (120) coupled to tissue (100) of a patient to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with sensor (148). The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor (160) operatively coupled to sensor (148). Processor (160) employs the measured re-emission kinetics of excitation and fluorescent light to "map" the spatial variation of one or more fluorescence characteristics of the tissue (100). The fluorescence characteristic may be provided by exogenous contract agents, endogenous fluorophores, or both. The variation is determined by solving frequency domain diffusion equations at a number of designated points in the tissue as part of a recursive estimation algorithm. Processor (160) generates an imaging signal in accordance with the spatial variation of the fluorescence characteristic for provision to an output device (164). The output device (164) displays an image corresponding spatial variation of the fluorescence characteristic which corresponds to tissue (100) to aid in the detection and diagnosis of disease.
摘要翻译：描述了具有低水平光的系统和方法非侵入性生物医学光学成像和光谱学。该技术包括耦合到患者组织（100）的调制光源（120）以引入激发光。用传感器（148）检测响应于激发光发射的荧光。将激发和检测的荧光的AC强度和相位提供给可操作地耦合到传感器（148）的处理器（160）。处理器（160）使用所测量的激发和荧光的再发射动力学来“映射”组织（100）的一个或多个荧光特征的空间变化。荧光特征可以由外源性合成试剂，内源荧光团或两者提供。通过在组织中的多个指定点处求解频域扩散方程来确定变化，作为递归估计算法的一部分。处理器（160）根据用于提供给输出装置（164）的荧光特性的空间变化产生成像信号。输出装置（164）显示对应于对应于组织（100）的荧光特性的空间变化的图像，以有助于疾病的检测和诊断。

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