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1. 发明申请

US20160227762A1 Method and Apparatus for Prevention of Thermo-Mechanical Fracturing in Vitrified Tissue Using Rapid Cooling and Warming by Persufflation 审中-公开
标题翻译：用于通过吹泡快速冷却和变暖来预防玻璃化组织中热机械压裂的方法和装置
公开(公告)号：US20160227762A1
公开(公告)日：2016-08-11
申请号：US15131771
申请日：2016-04-18
申请人： Arigos Biomedical, Inc.
发明人： Stephen Van Sickle , Tanya Jones
IPC分类号： A01N1/02
CPC分类号： A01N1/021 , A01N1/0247 , A01N1/0257 , A01N1/0284 , A01N1/0289
摘要： A method and apparatus are disclosed for avoiding fracturing, e.g., thermo-mechanical fracturing, in vitrified biological systems via rapid cooling and/or warming persufflation techniques, by reducing the domain size of fracturing and by reducing thermal gradients. Also disclosed is a system adapted to rapidly cool and warm vitrifiable vascular biological tissue by persufflation, significantly reducing cryoprotectant toxicity from that of surface cooled tissue, in which the system is constructed and configured to use one or more of helium gas, hydrogen gas, neon gas, argon gas, krypton gas, xenon gas, oxygen gas, or various gaseous compounds. The system can he operated under pressure to increase the density and heat capacity of the gas relative to its density and heat capacity at atmospheric pressure and to cool the gas by one or more of mechanical action and by the phase change of a material such as a cryogenic gas or solid.
摘要翻译：公开了一种方法和装置，用于通过快速冷却和/或升温渗透技术，通过减小压裂的畴尺寸和减少热梯度来避免玻璃化生物系统中的压裂，例如热机械压裂。还公开了一种适于通过透气快速冷却和温暖玻璃化血管生物组织的系统，显着降低来自表面冷却组织的冷冻保护剂毒性，其中系统被构造和配置为使用氦气，氢气，氖中的一种或多种气体，氩气，氪气，氙气，氧气或各种气态化合物。该系统可以在压力下操作，以增加气体的密度和热容量相对于其在大气压下的密度和热容量，并通过一种或多种机械作用和相变材料来冷却气体，例如低温气体或固体。

2. 发明申请

US20140011182A1 METHOD AND APPARATUS FOR PREVENTION OF THERMO-MECHANICAL FRACTURING IN VITRIFIED TISSUE USING RAPID COOLING AND WARMING BY PERSUFFLATION 有权
标题翻译：方法和装置，用于通过快速冷却和加热保护来修复维修组织中的热机械断裂
公开(公告)号：US20140011182A1
公开(公告)日：2014-01-09
申请号：US13936069
申请日：2013-07-05
申请人： Arigos Biomedical, Inc.
发明人： Stephen Van Sickle , Tanya Jones
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/021 , A01N1/0257 , A01N1/0284 , A01N1/0289
摘要： A method and apparatus are disclosed for avoiding fracturing, e.g., thermo-mechanical fracturing, in vitrified biological systems via rapid cooling and/or warming persufflation techniques, by reducing the domain size of fracturing and by reducing thermal gradients. Also disclosed is a system adapted to rapidly cool and warm vitrifiable vascular biological tissue by persufflation, significantly reducing cryoprotectant toxicity from that of surface cooled tissue, in which the system is constructed and configured to use one or more of helium gas, hydrogen gas, neon gas, argon gas, krypton gas, xenon gas, oxygen gas, or various gaseous compounds. The system can be operated under pressure to increase the density and heat capacity of the gas relative to its density and heat capacity at atmospheric pressure and to cool the gas by one or more of mechanical action and by the phase change of a material such as a cryogenic gas or solid.
摘要翻译：公开了一种方法和装置，用于通过快速冷却和/或升温渗透技术，通过减小压裂的畴尺寸和减少热梯度来避免玻璃化生物系统中的压裂，例如热机械压裂。还公开了一种适于通过透气快速冷却和温暖玻璃化血管生物组织的系统，显着降低来自表面冷却组织的冷冻保护剂毒性，其中系统被构造和配置为使用氦气，氢气，氖中的一种或多种气体，氩气，氪气，氙气，氧气或各种气态化合物。该系统可以在压力下操作，以增加气体的密度和热容量相对于其在大气压力下的密度和热容量，并通过一种或多种机械作用和诸如低温气体或固体。

3. 发明授权

US09314015B2 Method and apparatus for prevention of thermo-mechanical fracturing in vitrified tissue using rapid cooling and warming by persufflation 有权
$Method and apparatus for prevention of thermo-mechanical fracturing in vitrified tissue using rapid cooling and warming by persufflation$
标题翻译：用透热快速冷却和升温来预防玻璃化组织中热机械压裂的方法和装置
公开(公告)号：US09314015B2
公开(公告)日：2016-04-19
申请号：US13936069
申请日：2013-07-05
申请人： Arigos Biomedical, Inc.
发明人： Stephen Van Sickle , Tanya Jones
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/021 , A01N1/0257 , A01N1/0284 , A01N1/0289
摘要： A method and apparatus are disclosed for avoiding fracturing, e.g., thermo-mechanical fracturing, in vitrified biological systems via rapid cooling and/or warming persufflation techniques, by reducing the domain size of fracturing and by reducing thermal gradients. Also disclosed is a system adapted to rapidly cool and warm vitrifiable vascular biological tissue by persufflation, significantly reducing cryoprotectant toxicity from that of surface cooled tissue, in which the system is constructed and configured to use one or more of helium gas, hydrogen gas, neon gas, argon gas, krypton gas, xenon gas, oxygen gas, or various gaseous compounds. The system can be operated under pressure to increase the density and heat capacity of the gas relative to its density and heat capacity at atmospheric pressure and to cool the gas by one or more of mechanical action and by the phase change of a material such as a cryogenic gas or solid.
摘要翻译：公开了一种方法和装置，用于通过快速冷却和/或升温渗透技术，通过减小压裂的畴尺寸和减少热梯度来避免玻璃化生物系统中的压裂，例如热机械压裂。还公开了一种适于通过透气快速冷却和温暖玻璃化血管生物组织的系统，显着降低来自表面冷却组织的冷冻保护剂毒性，其中系统被构造和配置为使用氦气，氢气，氖中的一种或多种气体，氩气，氪气，氙气，氧气或各种气态化合物。该系统可以在压力下操作，以增加气体的密度和热容量相对于其在大气压力下的密度和热容量，并通过一种或多种机械作用和诸如低温气体或固体。

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