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1. 发明申请

US20150373937A1 STABLE TRANSFORMATION OF A POPULATION AND A METHOD OF BIOCONTAINMENT USING HAPLOINSUFFICIENCY AND UNDERDOMINANCE PRINCIPLES 审中-公开
标题翻译：人口的稳定转型和利用生物多样性和不良原则的生物量化方法
公开(公告)号：US20150373937A1
公开(公告)日：2015-12-31
申请号：US14654450
申请日：2013-12-20
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： Guy Reeves , Floyd Reed
IPC分类号： A01H1/02 , C12N15/82 , A01K67/033 , C12N15/113
CPC分类号： A01H1/02 , A01H1/00 , A01K67/033 , A01K67/0333 , A01K67/0339 , A01K2207/05 , A01K2217/15 , A01K2227/706 , A01K2267/02 , C12N15/113 , C12N15/8218 , C12N2310/14 , Y02A90/40
摘要： The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus. The present invention also relates to a method for decreasing the introgression of a transgenic locus in an organism into a population of otherwise interfertile sexually reproducing organisms comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, and (c) using a transgenic organism obtained in step (b) in an environment comprising otherwise interfertile sexually reproducing wildtype individuals of the organism, wherein the competitive fitness of hemizygous progeny is reduced, thereby decreasing the rate of sexually reproduction and/or viability and/or the competitive fitness of hemizygous progeny. Further envisaged are corresponding genetic systems and genetically modified organisms.
摘要翻译：本发明涉及一种用于降低与转基因座位纯合的生物体相比转基因基因座的竞争适应性的方法，该方法包括以下步骤：（a）降低生物体中不存在足够的基因的表达，其中所述由生物体中的转基因位点传递减少; 并且（b）拯救生物体中的减少的表达，其中所述拯救由生物体中相同的转基因位点传递，产生如果对于转基因基因座是半合子的竞争性较弱的生物体，如果对于转基因基因座是纯合的。本发明还涉及一种用于将生物体中的转基因基因座的渐渗作用降低到否则干扰性性再生生物群体的方法，所述方法包括以下步骤：（a）降低所述生物体中不存在足够的基因的表达，其中所述还原由生物体中的转基因位点传递; （b）拯救生物中的表达减少，其中所述营救由生物体内相同的转基因位点传递，和（c）使用步骤（b）中得到的转基因生物体在包括另外干扰性性繁殖野生型个体的环境中有机体，其中半合子后代的竞争适应性降低，从而降低了半合子后代的性生殖和/或活力和/或竞争适应性的比率。进一步设想的是相应的遗传系统和转基因生物。

2. 发明授权

US12031139B2 Stable transformation of a population and a method of biocontainment using haploinsufficiency and underdominance principles 有权
公开(公告)号：US12031139B2
公开(公告)日：2024-07-09
申请号：US16538602
申请日：2019-08-12
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： Guy Reeves , Floyd Reed
IPC分类号： C12N15/113 , A01K67/033 , C12N15/82
CPC分类号： C12N15/8218 , A01K67/033 , A01K67/0333 , A01K67/0339 , C12N15/113 , A01K2207/05 , A01K2217/15 , A01K2227/706 , A01K2267/02 , C12N2310/14
摘要： The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus. The present invention also relates to a method for decreasing the introgression of a transgenic locus in an organism into a population of otherwise interfertile sexually reproducing organisms comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, and (c) using a transgenic organism obtained in step (b) in an environment comprising otherwise interfertile sexually reproducing wildtype individuals of the organism, wherein the competitive fitness of hemizygous progeny is reduced, thereby decreasing the rate of sexually reproduction and/or viability and/or the competitive fitness of hemizygous progeny. Further envisaged are corresponding genetic systems and genetically modified organisms.

3. 发明申请

US20200093084A1 STABLE TRANSFORMATION OF A POPULATION AND A METHOD OF BIOCONTAINMENT USING HAPLOINSUFFICIENCY AND UNDERDOMINANCE PRINCIPLES 审中-公开
公开(公告)号：US20200093084A1
公开(公告)日：2020-03-26
申请号：US16538602
申请日：2019-08-12
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： Guy Reeves , Floyd Reed
IPC分类号： A01H1/02 , A01K67/033 , A01H1/00 , C12N15/113 , C12N15/82
摘要： The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus. The present invention also relates to a method for decreasing the introgression of a transgenic locus in an organism into a population of otherwise interfertile sexually reproducing organisms comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, and (c) using a transgenic organism obtained in step (b) in an environment comprising otherwise interfertile sexually reproducing wildtype individuals of the organism, wherein the competitive fitness of hemizygous progeny is reduced, thereby decreasing the rate of sexually reproduction and/or viability and/or the competitive fitness of hemizygous progeny. Further envisaged are corresponding genetic systems and genetically modified organisms.

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