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    • 1. 发明申请
    • METHODS AND COMPOSITIONS FOR DIAGNOSIS OR PROGNOSIS OF CARDIOVASCULAR DISEASE
    • 用于诊断或预防心血管疾病的方法和组合物
    • US20120288880A1
    • 2012-11-15
    • US13543745
    • 2012-07-06
    • Jay W. HeineckeTomas VaisarBryan PrazenErik Nilsson
    • Jay W. HeineckeTomas VaisarBryan PrazenErik Nilsson
    • H01J49/26G01N33/53
    • G01N33/92G01N2333/775G01N2800/32
    • The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an EMT subfraction, or in a complex containing apoA-I or apoA-III isolated from a biological sample obtained from the subject, wherein the at least two biomarkers are selected from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof, and comparing the measurable features of the at least two biomarkers from the biological sample to a reference standard, wherein a difference in the measurable features of the at least two biomarkers from the biological sample and the reference standard is indicative of the presence or risk of cardiovascular disease in the subject.
    • 本发明提供筛选哺乳动物受试者以确定受试者是否处于发展或正在患有心血管疾病的风险中的方法。 在一个实施方案中,所述方法包括检测EMT亚分级中的至少两个生物标志物的可测量特征,或在从受试者获得的生物样品中分离的含有载脂蛋白A-I或载脂蛋白-A-apo的复合物中,其中所述至少两种生物标志物是 选自由apoA-I,apoA-II,apoB-100,Lp(a),apoC-1和apoC-III组成的组,其组合或部分和/或衍生物,并将至少 来自生物样品的两个生物标志物到参考标准,其中来自生物样品和参考标准的至少两种生物标志物的可测量特征的差异指示受试者心血管疾病的存在或风险。