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1. 发明授权

US08241861B1 Methods and compositions for diagnosis or prognosis of cardiovascular disease 有权
标题翻译：心血管疾病诊断或预后的方法和组成
公开(公告)号：US08241861B1
公开(公告)日：2012-08-14
申请号：US12499711
申请日：2009-07-08
申请人： Jay W. Heinecke , Tomas Vaisar , Bryan Prazen , Erik Nilsson
发明人： Jay W. Heinecke , Tomas Vaisar , Bryan Prazen , Erik Nilsson
IPC分类号： G01N31/00 , G01N33/53
CPC分类号： G01N33/92 , G01N2333/775 , G01N2800/32
摘要： The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an HDL subfraction, or in a complex containing apoA-I or apoA-II isolated from a biological sample obtained from the subject, wherein the at least two biomarkers are selected from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof, and comparing the measurable features of the at least two biomarkers from the biological sample to a reference standard, wherein a difference in the measurable features of the at least two biomarkers from the biological sample and the reference standard is indicative of the presence or risk of cardiovascular disease in the subject.
摘要翻译：本发明提供筛选哺乳动物受试者以确定受试者是否处于发展或正在患有心血管疾病的风险中的方法。在一个实施方案中，所述方法包括检测HDL亚分级中的至少两个生物标志物的可测量特征，或在从所述受试者获得的生物样品中分离的含有载脂蛋白A-I或载脂蛋白A-apo的复合物中，其中所述至少两种生物标记是选自由apoA-I，apoA-II，apoB-100，Lp（a），apoC-1和apoC-III组成的组，其组合或部分和/或衍生物，并将至少可测量特征来自生物样品的两个生物标志物到参考标准，其中来自生物样品和参考标准的至少两种生物标志物的可测量特征的差异指示受试者心血管疾病的存在或风险。

2. 发明申请

US20060172429A1 Methods of identification of biomarkers with mass spectrometry techniques 审中-公开
标题翻译：用质谱技术鉴定生物标志物的方法
公开(公告)号：US20060172429A1
公开(公告)日：2006-08-03
申请号：US11345612
申请日：2006-01-31
申请人： Erik Nilsson , Brian Pratt , Bryan Prazen
发明人： Erik Nilsson , Brian Pratt , Bryan Prazen
IPC分类号： G01N24/00
CPC分类号： G01N33/86 , G01N33/6851 , G01N33/92 , G01N2800/2821 , G01N2800/2835 , G01N2800/323 , G01N2800/324 , G01N2800/325
摘要： The present invention provides methods for identifying various biological states. Methods for diagnosis of diseases, in particular cardiovascular and brain diseases, are provided herein. One aspect of the invention is the analysis of lipoprotein complexes with summary survey scan mass spectrum for the analysis of biological states. Another aspect of the invention is the use of matrix assisted laser desorption ionization (MALDI) mass spectrometer to analysis lipoprotein complexes for the diagnosis of cardiovascular and brain diseases. Yet another aspect of the invention is a method of diagnosis of brain diseases by evaluating the characteristics of lipoprotein complexes.
摘要翻译：本发明提供用于鉴定各种生物状态的方法。本文提供了诊断疾病，特别是心血管和脑疾病的方法。本发明的一个方面是用分析生物学状态的总体测量扫描质谱分析脂蛋白复合物。本发明的另一方面是使用基质辅助激光解吸电离（MALDI）质谱仪来分析心血管和脑疾病的诊断中的脂蛋白复合物。本发明的另一方面是通过评估脂蛋白复合物的特征来诊断脑疾病的方法。

3. 发明授权

US08460889B2 Methods and compositions for diagnosis or prognosis of cardiovascular disease 失效
标题翻译：心血管疾病诊断或预后的方法和组成
公开(公告)号：US08460889B2
公开(公告)日：2013-06-11
申请号：US13543745
申请日：2012-07-06
申请人： Jay W. Heinecke , Tomas Vaisar , Bryan Prazen , Erik Nilsson
发明人： Jay W. Heinecke , Tomas Vaisar , Bryan Prazen , Erik Nilsson
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N33/92 , G01N2333/775 , G01N2800/32
摘要： The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an HDL subfraction, or in a complex containing apoA-I or apoA-III isolated from a biological sample obtained from the subject, wherein the at least two biomarkers are selected from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof, and comparing the measurable features of the at least two biomarkers from the biological sample to a reference standard, wherein a difference in the measurable features of the at least two biomarkers from the biological sample and the reference standard is indicative of the presence or risk of cardiovascular disease in the subject.
摘要翻译：本发明提供筛选哺乳动物受试者以确定受试者是否处于发展或正在患有心血管疾病的风险中的方法。在一个实施方案中，所述方法包括检测HDL亚分级中的至少两个生物标志物的可测量特征，或在从所述受试者获得的生物样品中分离的含有apoA-I或apoA-III的复合物中，其中所述至少两种生物标志物是选自由apoA-I，apoA-II，apoB-100，Lp（a），apoC-1和apoC-III组成的组，其组合或部分和/或衍生物，并将至少可测量特征来自生物样品的两个生物标志物到参考标准，其中来自生物样品和参考标准的至少两种生物标志物的可测量特征的差异指示受试者心血管疾病的存在或风险。

4. 发明申请

US20120288880A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS OR PROGNOSIS OF CARDIOVASCULAR DISEASE 失效
标题翻译：用于诊断或预防心血管疾病的方法和组合物
公开(公告)号：US20120288880A1
公开(公告)日：2012-11-15
申请号：US13543745
申请日：2012-07-06
申请人： Jay W. Heinecke , Tomas Vaisar , Bryan Prazen , Erik Nilsson
发明人： Jay W. Heinecke , Tomas Vaisar , Bryan Prazen , Erik Nilsson
IPC分类号： H01J49/26 , G01N33/53
CPC分类号： G01N33/92 , G01N2333/775 , G01N2800/32
摘要： The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an EMT subfraction, or in a complex containing apoA-I or apoA-III isolated from a biological sample obtained from the subject, wherein the at least two biomarkers are selected from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof, and comparing the measurable features of the at least two biomarkers from the biological sample to a reference standard, wherein a difference in the measurable features of the at least two biomarkers from the biological sample and the reference standard is indicative of the presence or risk of cardiovascular disease in the subject.
摘要翻译：本发明提供筛选哺乳动物受试者以确定受试者是否处于发展或正在患有心血管疾病的风险中的方法。在一个实施方案中，所述方法包括检测EMT亚分级中的至少两个生物标志物的可测量特征，或在从受试者获得的生物样品中分离的含有载脂蛋白A-I或载脂蛋白-A-apo的复合物中，其中所述至少两种生物标志物是选自由apoA-I，apoA-II，apoB-100，Lp（a），apoC-1和apoC-III组成的组，其组合或部分和/或衍生物，并将至少来自生物样品的两个生物标志物到参考标准，其中来自生物样品和参考标准的至少两种生物标志物的可测量特征的差异指示受试者心血管疾病的存在或风险。

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