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1. 发明申请

US20150044201A1 CYCLON EXPRESSION FOR THE IDENTIFICATION AND CONTROL OF CANCER CELLS 审中-公开
标题翻译： CYCLON表达用于癌细胞的鉴定和控制
公开(公告)号：US20150044201A1
公开(公告)日：2015-02-12
申请号：US14371294
申请日：2013-01-10
申请人： UNIVERSITE JOSEPH FOURIER - GRENOBLE , CENTRE HOSPITALIER UNIVERSITAIRE GRENOBLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIQUE (CNRS) , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Mary Callanan , Anouk Emadali , Myriam Ferro , Saadi Khochbin , Sophie Pison-Rousseaux
IPC分类号： G01N33/574 , A61K31/713 , A61K45/06 , A61K39/395 , C07K16/28 , C12Q1/68
CPC分类号： G01N33/57496 , A61K31/713 , A61K39/39558 , A61K45/06 , C07K16/2887 , C07K2317/73 , C07K2317/734 , C07K2317/75 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N2333/4715 , A61K2300/00
摘要： The present disclosure concerns a method for the identification of the presence or absence of cancer cells in a biological sample, more particularly a method for the identification of the susceptibility or resistance to a treatment with CD20 agonists of cancer cells in a biological sample, the methods including determining the level of expression of the gene Cyclon in the cells and comparing the level of expression to the level of expression in a non-cancer cell, wherein a level of expression higher than the level of expression in a non-cancer cell is an indication of the presence of a cancer cell, more particularly an indication of cancer cells with a resistance to treatment with antagonists. Kits for the determination of a level of expression of the Cyclon gene in a biological sample, a method for the identification of Cyclon expression antagonists, and methods for treating patients are provided.
摘要翻译：本公开涉及用于鉴定生物样品中癌细胞存在或不存在的方法，更具体地，涉及用于鉴定生物样品中癌细胞的CD20激动剂治疗的敏感性或抗性的方法，所述方法包括确定细胞中基因Cyclon的表达水平，并比较非癌细胞中表达水平与表达水平，其中高于非癌细胞中表达水平的表达水平为指示癌细胞的存在，更具体地说是具有抗拮抗剂治疗耐药性的癌细胞的指征。提供了用于确定生物样品中Cyclon基因表达水平的方法，用于鉴定Cyclon表达拮抗剂的方法和用于治疗患者的方法。

2. 发明授权

US10307328B2 Device for discrimination of stages of a patient's sleep 有权
公开(公告)号：US10307328B2
公开(公告)日：2019-06-04
申请号：US14617514
申请日：2015-02-09
申请人： SORIN CRM SAS , INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , UNIVERSITÉ DE RENNES 1 , UNIVERSITE JOSEPH FOURIER—GRENOBLE 1
发明人： Laurence Graindorge , Amel Amblard , Christine Henry , Marcel Limousin , Laure Duchemin Laporte , Alfredo Hernandez , Jean-Louis Pépin
IPC分类号： A61B5/00 , A61B5/024 , A61H23/00 , A61H23/02 , A61M21/00 , A61B5/0404
摘要： A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.

3. 发明授权

US09493761B2 Procoagulant molecular decoy for treating hemophilia A or B with or without inhibitor 有权
标题翻译：用于治疗血友病A或B伴有或不伴有抑制剂的促凝血分子诱饵
公开(公告)号：US09493761B2
公开(公告)日：2016-11-15
申请号：US14002253
申请日：2012-02-29
申请人： Benoit Polack , Aline Thomas
发明人： Benoit Polack , Aline Thomas
IPC分类号： C12N9/64 , A61K38/48
CPC分类号： C12N9/6432 , A61K38/4846 , C12Y304/21006
摘要： The present invention relates to a pharmaceutical composition including a modified factor Xa (GDXa), said modified GDXa being nonthrombogenic, able to bind to TFPI but not able to bind to phospholipids, for preventing or treating a hemorrhagic accident in a patient with hemophilia A or B with or without inhibitor.
摘要翻译：本发明涉及包含修饰因子Xa（GDXa），所述修饰的GDXa是非血栓形成的，能够结合TFPI但不能结合磷脂的药物组合物，用于预防或治疗血友病A患者的出血性事故或 B有或没有抑制剂。

4. 发明授权

US09241372B2 Device and method for heating an object in an intense magnetic field 有权
标题翻译：用于在强磁场中加热物体的装置和方法
公开(公告)号：US09241372B2
公开(公告)日：2016-01-19
申请号：US14345925
申请日：2012-09-20
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE JOSEPH FOURIER—GRENOBLE 1
发明人： Pierre-Frederic Sibeud , Eric Beaugnon , Gilles Pont
IPC分类号： F26B3/30 , F26B19/00 , H01L51/56 , H05B3/00 , C21D1/04 , C21D1/09 , C21D1/34 , B23K26/06
CPC分类号： H05B3/0061 , B23K26/0643 , B23K26/0648 , C21D1/04 , C21D1/09 , C21D1/34
摘要： The invention concerns a device for heating an object (6) in an intense magnetic field, comprising:—a light source (1), an optic fiber (2) for transporting the light emitted by said light source (1) and emitting a beam of light in the direction of the object (6) to be heated, a converging optical system (3), a diaphragm (4) positioned at the focusing point of the optical system (3),—a reflector (5), whereof the inner wall is defined by the revolution of a semi-parabola around an axis perpendicular to the optical axis of the parabola and passing through the focal point of said parabola, the optical axis of said reflector (5) coinciding with the optical axis (A) of the optical system (3) and the focal point (F″) of said reflector coinciding with the focusing point of said optical system (3).
摘要翻译：本发明涉及一种用于在强磁场中加热物体（6）的装置，包括： - 光源（1），用于传输由所述光源（1）发射的光并发射光束的光纤（2）在被加热物体（6）的方向上的光，会聚光学系统（3），位于光学系统（3）的聚焦点处的光阑（4）， - 反射器（5）内壁由半抛物线围绕垂直于抛物线的光轴并穿过所述抛物线的焦点的轴的旋转限定，所述反射器（5）的光轴与光轴（A）重合，的光学系统（3）的焦点（F“）与所述光学系统（3）的聚焦点重合。

5. 发明申请

US20160007952A1 METHOD FOR GENERATING AN ELASTICITY IMAGE 有权
标题翻译：用于产生弹性图像的方法
公开(公告)号：US20160007952A1
公开(公告)日：2016-01-14
申请号：US14769685
申请日：2014-02-17
申请人： UNIVERSITE JOSEPH FOURIER - GRENOBLE 1
发明人： Jacques OHAYON , Flavien DELEAVAL , Guy CLOUTIER
IPC分类号： A61B8/08
CPC分类号： A61B8/0891 , A61B5/02007 , A61B5/021 , A61B8/485 , A61B8/5246 , G01S7/52042
摘要： An image processing method enables an elasticity image of a body including a cavity to be produced on the basis of the material(s) forming the body, wherein the method includes the steps of: receiving a deformation image illustrating a field of movement of the points of the body on the basis of a pressure difference in the body, estimating a shape function of the body from the deformation image, calculating an elasticity image of the body on the basis of the shape function, of the pressure difference and of the deformation image.
摘要翻译：图像处理方法能够基于形成身体的材料来形成包括空腔的主体的弹性图像，其中，该方法包括以下步骤：接收示出点的移动场的变形图像基于身体的压力差，从变形图像估计身体的形状函数，基于形状函数，压力差和变形图像计算身体的弹性图像。

6. 发明授权

US09181596B2 Method and device for treating a material exposed to a magnetic field 有权
标题翻译：用于处理暴露于磁场的材料的方法和装置
公开(公告)号：US09181596B2
公开(公告)日：2015-11-10
申请号：US13388171
申请日：2010-07-29
申请人： Thomas Garcin , Sophie Rivoirard , Pierre-Frédéric Sibeud , Eric Beaugnon
发明人： Thomas Garcin , Sophie Rivoirard , Pierre-Frédéric Sibeud , Eric Beaugnon
IPC分类号： C21D1/04
CPC分类号： C21D1/04
摘要： The disclosure concerns a method for treating a material in a static magnetic field having an intensity of more than 1 Tesla, including the following steps: a first step to heat the material, a second step to apply to the material a thermal shock and/or thermomechanical treatment and/or chemical treatment, wherein during at least the second treatment step, the material is subjected to the magnetic field while being held in position within the magnetic field. The disclosure also concerns a device for implementing the method, the device including: a support to hold the material during the steps of the cycle, a device to apply the static magnetic field capable of generating a magnetic field of intensity higher than 1 Tesla, a first system allowing heating of the material, a second system for implementing the subsequent step of the cycle.
摘要翻译：本公开涉及一种用于处理具有大于1特斯拉的强度的静态磁场中的材料的方法，包括以下步骤：加热材料的第一步骤，向材料施加热冲击和/或热机械处理和/或化学处理，其中在至少第二处理步骤期间，材料在磁场内保持就位的同时受到磁场的影响。本发明还涉及一种用于实施该方法的装置，该装置包括：在周期步骤期间保持材料的支撑件，施加能够产生强度高于1特斯拉的磁场的静态磁场的装置，允许加热材料的第一系统，用于实施循环的后续步骤的第二系统。

7. 发明申请

US20150126880A1 METHOD AND DEVICE FOR MONITORING BLOOD PRESSURE MEASUREMENT BY ARTERIAL CATHETERIZATION OF A PATIENT 审中-公开
标题翻译：用于监测患者血压测量的方法和装置
公开(公告)号：US20150126880A1
公开(公告)日：2015-05-07
申请号：US14366512
申请日：2012-12-21
申请人： UNIVERSITE JOSEPH FOURIER - GRENOBLE 1 , AUTOMATISME ET INFORMATIQUE INDUSTRIELLE
发明人： Francis Grimbert , Yves Lavault
IPC分类号： A61B5/0215 , A61B5/00
CPC分类号： A61B5/0215 , A61B5/0004 , A61B5/6852 , A61B5/7203 , A61B5/743 , A61B5/746 , A61B2560/0266 , A61B2560/066 , A61B2562/0247 , A61B2562/225
摘要： A method is disclosed for continuously monitoring a blood pressure measurement using a sensor connected by a hydraulic link to an arterial catheter, the method includes determining the dynamic parameters of the link, analyzing the frequency content of the incident signal, detecting one of the following situations: (a) ability of the link to transmit the incident signal with a distortion below a threshold, (b) ability of the link to transmit the incident signal with a distortion above the threshold and possibility of correcting the measured signal, (c) inability of the link to transmit the incident signal with a distortion below the threshold and impossibility of correcting the measured signal, periodic application of a mechanical action to the tubing providing the hydraulic link.
摘要翻译：公开了一种用于使用通过与动脉导管的液压连杆连接的传感器来连续监测血压测量的方法，所述方法包括确定链路的动态参数，分析入射信号的频率内容，检测以下情况之一（a）链路以低于阈值的失真发送入射信号的能力，（b）链路以高于阈值的失真发送入射信号的能力和校正测量信号的可能性，（c）无效性以将失真低于阈值的入射信号传输，并且不可能校正测量信号，对提供液压连杆的管道周期性地施加机械作用。

8. 发明申请

US20140335125A1 ATTENUATED AND ADAPTED STRAIN OF PSEUDOMONAS FOR DELIVERING ANTIGENS 有权
标题翻译：用于递送抗原的PSEUDOMONAS的衰减和适应菌株
公开(公告)号：US20140335125A1
公开(公告)日：2014-11-13
申请号：US14364322
申请日：2012-12-12
申请人： UNIVERSITE JOSEPH FOURIER - GRENOBLE 1 , CENTRE HOSPITALIER UNIVERSITAIRE GRENOBLE
发明人： Audrey Le Gouellec , Bertrand Toussaint , Benoît Polack
IPC分类号： C12N15/78 , C07K14/435 , A61K39/00
CPC分类号： C12N1/36 , A61K39/0005 , A61K39/0011 , A61K2039/522 , A61K2039/523 , C07K14/435 , C12N1/20 , C12N15/102 , C12N15/78 , C12R1/38
摘要： A process for obtaining an adapted strain of Pseudomonas includes the following steps: deleting the genes ExoS, ExoT, aroA and IasI in an initial Pseudomonas strain cultivated in a LB medium; progressively cultivating this strain in a chemically defined medium based on a glucose minimal medium supplemented with magnesium and calcium; wherein the adapted strain presents the same toxicity and secretion capacities than the initial strain, and its doubling time when cultivated in the chemically defined medium is less than 60 minutes. An adapted strain is furthermore treated to become ‘killed but metabolically active’.
摘要翻译：获得拟南芥假单胞菌菌株的方法包括以下步骤：在LB培养基中培养的初始假单胞菌菌株中删除ExoS，ExoT，aroA和IasI基因; 基于补充有镁和钙的葡萄糖基本培养基在化学上限定的培养基中逐渐培养该菌株; 其中所述适应菌株具有与初始菌株相同的毒性和分泌能力，并且其在化学确定的培养基中培养时的倍增时间小于60分钟。此外，适应性菌株被处理成“杀死但代谢活性”。

9. 发明申请

US20130199439A1 DEVICE AND METHOD FOR CRYSTALLIZING INORGANIC OR ORGANIC SUBSTANCES 有权
标题翻译：用于结晶无机或有机物质的装置和方法
公开(公告)号：US20130199439A1
公开(公告)日：2013-08-08
申请号：US13821053
申请日：2011-09-15
申请人： Monika Spano
发明人： Monika Spano
IPC分类号： C30B7/08
CPC分类号： C30B7/08 , C30B7/00 , C30B29/54 , C30B29/58 , Y10T117/1004
摘要： A device for crystallising a molecule to be crystallised, which includes: at least one crystallisation cell that includes a crystallisation chamber for receiving a first solution S1 containing the molecule to be crystallised and the crystal seeds thereof, a dialysis membrane, and a container to be filled with a second solution S2 that contains constituents selected from the group containing crystallisation agents, additives and buffers; and at least one image acquisition means. The crystallisation device is characterized in that it includes: at least one addition means arranged to add, to the container, constituents selected from the group containing crystallisation agents, additives and buffers of solution S2; and/or at least one sampling means arranged to collect, from the container, all or a portion of solution S2. The invention also relates to a crystallisation method.
摘要翻译：一种用于使待结晶的分子结晶的装置，其包括：至少一个结晶池，其包括用于接收含有待结晶分子的第一溶液S1和其晶体种子的结晶室，透析膜和容器填充含有选自含有结晶剂，添加剂和缓冲剂的组分的成分的第二溶液S2; 和至少一个图像获取装置。结晶装置的特征在于其包括：至少一个添加装置，其被设置成向容器中添加选自含有结晶剂的组的组分，溶液S2的添加剂和缓冲剂; 和/或至少一个采样装置，其布置成从容器收集溶液S2的全部或一部分。本发明还涉及一种结晶方法。

10. 发明授权

US08377418B2 Process for preparing thermosensitive (poly(ethylene oxide) poly(propylene oxide)) derivatives that can be used to functionalize chitosan 有权
标题翻译：用于制备可用于官能化壳聚糖的热敏（聚（环氧乙烷）聚（环氧丙烷））衍生物的方法
公开(公告)号：US08377418B2
公开(公告)日：2013-02-19
申请号：US12677211
申请日：2008-09-11
申请人： Rachel Auzely-Velty , Caroline Creuzet
发明人： Rachel Auzely-Velty , Caroline Creuzet
IPC分类号： A61K51/00 , A61K36/14 , A61K9/22 , C08B37/08
CPC分类号： A61L27/52 , A61K8/042 , A61K8/90 , A61K31/722 , A61L27/20 , A61Q19/00 , C08B37/003 , C08G65/331 , C08G65/3324 , C08G65/333 , C08G81/00 , C08G2261/126 , C08G2650/50 , C08J3/075 , C08J2387/00 , C08L5/08 , C08L71/02 , C08L3/00
摘要： The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.
摘要翻译：本发明涉及可用于官能化壳聚糖的热敏（聚（环氧乙烷）聚（环氧丙烷）） - 缩醛衍生物及其制备方法。因此，本发明还涉及通过接枝该热敏共聚物和任选的另一种热敏聚合物聚（环氧乙烷）官能化壳聚糖的方法。本发明的主题也是在生理pH下具有水溶性的优点的壳聚糖（聚（环氧乙烷）聚（环氧丙烷）） - 聚（环氧乙烷）衍生物。因此，本发明还涉及包含该衍生物的水性组合物以及该组合物用于通过加热制造凝胶的用途。

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