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1. 发明申请

US20230132965A1 OR PULSE COMINATION DIGITAL PHOTOMULTIPLIER 有权
公开(公告)号：US20230132965A1
公开(公告)日：2023-05-04
申请号：US17799804
申请日：2021-02-11
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) , UNIVERSIDAD DE SEVILLA
发明人： Ion VORNICU , Ricardo CARMONA GALÁN , Ángel RODRÍGUEZ VÁZQUEZ
IPC分类号： G01J1/44
摘要： The photomultiplier includes a set of macrocells, each comprising at least two microcells, each being connected to an output node according to an OR diagram, and achieving great energy efficiency upon deactivating each of the microcells when these are activated almost simultaneously, and that otherwise would have been masked by the OR diagram. To this end, each of the microcells comprises an active quenching and recharge circuit; an avalanche diode; a first deactivation transistor with its gate connected to an external processor, and its drain and source associated with the active quenching and recharge circuit; a second deactivation transistor with its gate connected to an external processor, and its source associated with the active quenching and recharge circuit.

2. 发明申请

US20220007975A1 Portable Device and Method for Non-Invasive Blood Glucose Level Estimation 有权
公开(公告)号：US20220007975A1
公开(公告)日：2022-01-13
申请号：US17424734
申请日：2020-01-17
申请人： UNIVERSIDAD DE SEVILLA
发明人： Luis Javier REINA TOSINA , Laura Mª ROA ROMERO , David NARANJO HERNÁNDEZ
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/0205 , A61B5/024 , A61B5/0531 , A61B5/08 , A61B5/11 , A61B5/318
摘要： The invention relates to a device (1) comprising a measuring unit (2) with a measuring module (4) for measuring the glucose level, a first computer module (5) for processing data from a first part of the process for measuring the glucose level, a first communications module (6), a first data storage module (7) and a pushbutton (8). The device also comprises a personal monitoring unit (3) with second and third communication modules (17, 20), a second computer module (18) for processing data from a second part of the process for measuring the glucose level, an interface module (19) and a second data storage module (22). Also described is a method for non-invasive blood glucose level estimation.

3. 发明申请

US20210121414A1 METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION OF POLYMERIC NANOPARTICLES FOR TREATING NEUROPATHIC PAIN CAUSED BY PERIPHERAL NERVE COMPRESSION 有权
公开(公告)号：US20210121414A1
公开(公告)日：2021-04-29
申请号：US17142164
申请日：2021-01-05
申请人： UNIVERSIDAD DE SEVILLA , UNIVERSIDAD DE CÁDIZ , CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED (CIBER)
发明人： Lucía MARTÍN BANDERAS , Mercedes Fernández Arévalo , Esther Berrocoso Dominguez , Juan Antonio Mico Segura
IPC分类号： A61K9/51 , A61P25/02 , A61K31/12
摘要： The object of the present invention is the method for obtaining a pharmaceutical composition of polymeric nanoparticles for the treatment of neuropathic pain caused by peripheral nerve compression, related to the pharmaceutical industry and nanotechnology. The invention particularly relates to a novel system for orally administering the cannabinoid drug CB13 based on polymeric nanoparticles capable of alleviating pain for nine days following a single oral administration of an aqueous suspension of nanoparticles.

4. 发明授权

US10870119B2 Apparatus and a method for generating droplets 有权
公开(公告)号：US10870119B2
公开(公告)日：2020-12-22
申请号：US15551893
申请日：2016-02-22
申请人： Ingeniatrics Tecnologias , Universidad de Sevilla
发明人： Miguel Angel Asensio Caño , Beatriz Talavera Almena , María Flores Mosquera , Alfonso Miguel Gañán-Calvo
IPC分类号： B05B7/06 , B29C48/885 , D01D5/14 , B05B12/18 , B01D1/18 , B01J2/06 , F26B3/12 , B01J2/04
CPC分类号： B05B7/066 , B01D1/18 , B01J2/04 , B01J2/06 , B05B12/18 , B29C48/885 , D01D5/14 , F26B3/12
摘要： An apparatus is described. The apparatus comprises a liquid dispenser comprising a liquid outlet, the liquid dispenser being configured to generate a droplet stream. The apparatus also comprises a first fluid flow device configured to generate a confinement fluid flow for confining a trajectory of the droplet stream therein, the first fluid flow device comprising an outlet arranged to allow the droplet stream to exit therefrom, wherein the fluid outlet is arranged within the confinement fluid flow device. Furthermore, the apparatus comprises a second fluid flow device configured to generate a reaction fluid flow for reacting with droplets in the droplet stream, wherein the outlet of the first fluid flow device is arranged within the second fluid flow device. A method is also described.

5. 发明授权

US10466238B2 Determination of levels of immunogenic gluten peptides in human samples 有权
公开(公告)号：US10466238B2
公开(公告)日：2019-11-05
申请号：US15201906
申请日：2016-07-05
申请人： UNIVERSIDAD DE SEVILLA
发明人： Carolina Sousa Martin , Isabel Comino Montilla , Ana Real Calderon , Santiago Vivas Alegre , Angel Cebolla Ramirez
IPC分类号： G01N33/53 , G01N33/564
摘要： The present invention fitted in the medical-clinical sector, shows a method for monitoring the ingestion of gluten by measuring protein/gluten peptides present in fecal samples with antibodies against immunogenic peptides resistant to gastrointestinal digestion. The presence or absence of these immunogenic peptides is controlled by immunological assays based on antibodies reactive against immunogenic gluten peptides that are resistant to proteolysis. These assays may be quantitative techniques ELISAs, or qualitative as rapid immunochromatographic assays, immunoblots, etc. These measures may also be applied to verify compliance with the gluten-free diet, to improve diagnosis in cases of refractory or severe symptoms of celiac disease in which a gluten-free diet is supposedly being respected, or to clinical research on the effectiveness of enzymatic therapies related with prolamin detoxification.

6. 发明授权

US09884816B2 Sulforaphane-derived compounds, production method thereof and the medical, food and cosmetic use of same 有权
公开(公告)号：US09884816B2
公开(公告)日：2018-02-06
申请号：US14383780
申请日：2013-03-06
申请人： Consejo Superior De Investigaciones Científicas (CSIC) , Univerversidad De Sevilla
发明人： Noureddine Khiar El Wahabi , Inmaculada Fernández Fernández , Rocío Recio Jiménez
IPC分类号： C07C331/20 , A61K45/06 , A61K31/26 , A61K31/795
CPC分类号： C07C331/20 , A61K31/26 , A61K31/795 , A61K45/06
摘要： The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the family of sulforaphane derivatives. The invention also relates to the production method thereof. The invention further relates to the multiple medical (pharmaceutical, homeopathic and phytotherapeutic), food, cosmetic and dietary uses of said series of compounds, especially the use thereof in the prevention and/or treatment of diseases and any type of illness or damage associated with an oxidative process or which, although not involved in said process, are mediated by the Nrf2 transcription factor, such as, for example, cancer. The compounds can be used alone or, alternatively, encapsulated in cyclodextrins.

7. 发明授权

US09789451B2 Method and electro-fluidic device to produce emulsions and particle suspensions 有权
公开(公告)号：US09789451B2
公开(公告)日：2017-10-17
申请号：US13392908
申请日：2010-08-30
申请人： Ignacio González-Loscertales , Venkata Ramana Gundabala , Alberto Fernandes-Nieves , Regina Gil Garcia
发明人： Antonio Barrero Ripoll , Ignacio González-Loscertales , Venkata Ramana Gundabala , Alberto Fernandes-Nieves
IPC分类号： B01F3/08 , B01F13/00 , B01F5/00
CPC分类号： B01F3/0815 , B01F3/0807 , B01F13/0062 , B01F13/0076 , B01F2005/0034 , B01F2215/0445
摘要： The invention refers to a method, and to a device to produce emulsions and particle suspensions by using electro-hydrodinamic forces and microfluidics This combined use allow the production of droplets with mean diameters which may be either smaller than those obtained in conventional microfluidic devices or larger than those obtained by electrospray, bridging the gap between the two methods acting independently.

8. 发明授权

US08440814B2 Derivatives of cyclodextrins, process for their preparation and their use in particular for solubilizing pharmacologically active substances 失效
标题翻译：环糊精的衍生物，其制备方法及其用途，特别是用于增溶药理活性物质
公开(公告)号：US08440814B2
公开(公告)日：2013-05-14
申请号：US12468356
申请日：2009-05-19
申请人： Jacques Defaye , Carmen Ortiz-Mellet , Jose Manuel Garcia-Fernandez , Maria Gomez-Garcia , Kazimierz Chmurski , Jian-Xin Yu
发明人： Jacques Defaye , Carmen Ortiz-Mellet , Jose Manuel Garcia-Fernandez , Maria Gomez-Garcia , Kazimierz Chmurski , Jian-Xin Yu
IPC分类号： C08B37/16 , A01N43/04 , A61K31/715
CPC分类号： B82Y5/00 , A61K47/6951 , C08B37/0012 , C08B37/0015
摘要： The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1 is an OH group, all R1 s are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n=1, m=6, Z=NH2 and R1=OH is excluded.
摘要翻译：本发明涉及对应于通式（I）的化合物，其中n为1-6的整数，m为等于5,6或7的整数，R 1为OH基，全部R 1相同，Z 是NHX基团，X是氢原子，R是氢原子或生物鉴定元素，条件是排除n = 1，m = 6，Z = NH 2和R 1 = OH的化合物。

9. 发明申请

US20120050725A1 METHOD FOR POSITIONING A SURFACE IN RELATION TO A LIGHT SOURCE USING SENSORS 有权
标题翻译：使用传感器定位与光源相关的表面的方法
公开(公告)号：US20120050725A1
公开(公告)日：2012-03-01
申请号：US13146116
申请日：2010-01-25
申请人： José Manuel Quero Reboul
发明人： José Manuel Quero Reboul
IPC分类号： G01B11/26
CPC分类号： G01S3/7861 , F24S30/45 , F24S50/20 , Y02B10/20 , Y02E10/47
摘要： The invention relates to a method for positioning a surface in relation to a light source using sensors. The method can be used to control the position of a reflective surface (2) such that the reflected light (7) originating from a light source (1) falls on an objective point (8), through the use of a first sensor (4) which determines the position of the light source (1) in relation to a reference direction (9) and a second sensor (4) which is solidly connected to the reflective surface (2) and which determines the relative position of the reflective surface (2) in relation to the light source (1). Having ascertained these positions and the relative position of the reflective surface (2) in relation to the objective point (8), the method is used to determine the necessary movement to be applied to the reflective surface (2) so that the reflected light (7) falls on the objective point (8). The invention is intended to be used to reflect sunlight on a remote collector in order to illuminate buildings and, in general, for any use requiring reflected light to be directed to an objective point (8).
摘要翻译：本发明涉及一种使用传感器定位相对于光源的表面的方法。该方法可用于控制反射表面（2）的位置，使得源自光源（1）的反射光（7）通过使用第一传感器（4）落在目标点（8）上），其确定光源（1）相对于参考方向（9）的位置和固定地连接到反射表面（2）的第二传感器（4），并且确定反射表面的相对位置 2）相对于光源（1）。通过确定这些位置和反射表面（2）相对于目标点（8）的相对位置，该方法用于确定要施加到反射表面（2）的必要移动，使得反射光 7）落在客观点上（8）。本发明旨在用于将太阳光反射在远程收集器上以便照亮建筑物，并且通常用于需要反射光的任何用途被引导到目标点（8）。

10. 发明申请

US20100086648A1 CARAMELS WITH HIGH CONTENT IN PREBIOTIC OLIGOSACCHARIDES, PROCEDURE OF PREPARATION AND USE 审中-公开
标题翻译：预处理低密度脂蛋白中含有高含量的蛋白质，制备和使用程序
公开(公告)号：US20100086648A1
公开(公告)日：2010-04-08
申请号：US12530331
申请日：2008-03-07
申请人： Miguel Enrique Rubio Castillo , Marta Gomez Garcia , Carmen Ortiz Mellet , Manuel Jose Garcia Fernandez , Antonio Zarzuelo Zurita , Juan Julio Galvez Peralta , Raphael Duval
发明人： Miguel Enrique Rubio Castillo , Marta Gomez Garcia , Carmen Ortiz Mellet , Manuel Jose Garcia Fernandez , Antonio Zarzuelo Zurita , Juan Julio Galvez Peralta , Raphael Duval
IPC分类号： A23G3/32 , B01J38/48 , A23K1/00
CPC分类号： A23G3/32 , A23G3/364 , A23G3/42 , A23L5/00 , A23L29/30 , A23L33/125 , A23V2002/00 , A61K31/702 , C08B37/00 , Y02P20/584 , A23V2200/3202
摘要： The present invention relates to the transformation of food-grade sugars containing D-fructose, in caramels enriched in oligosaccharides with prebiotic activity by using solid acid catalysts, such as zeolites, clays or ion-exchange resins in its acid form, under heterogeneous conditions, or by using soluble acid polymer catalysts of high molecular weight, under homogeneous conditions, with the possibility of recycling the catalyst, being compatible with discontinuous or continuous production processes. The resulting caramel exhibits prebiotic properties, favoring the development of a beneficial intestinal flora and a repairing effect in the damaged colon.
摘要翻译：本发明涉及通过在异质条件下使用固体酸催化剂，例如其酸形式的沸石，粘土或离子交换树脂，富含具有益生元活性的寡糖的焦糖中的含有D-果糖的食品级糖的转化，或通过使用在均相条件下具有高分子量的可溶性酸性聚合物催化剂，具有可再循环催化剂的可能性，与不连续或连续的生产方法相容。所得焦糖显示益生元特性，有利于发育有益肠道菌群，并在损伤的结肠中产生修复效果。

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