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1. 发明授权

US09314618B2 Implantable flexible circuit leads and methods of use 有权
标题翻译：可植入的柔性电路引线及使用方法
公开(公告)号：US09314618B2
公开(公告)日：2016-04-19
申请号：US11952062
申请日：2007-12-06
申请人： Mir A. Imran , Albert G. Burdulis , Matthew D. Hills , Eyad Kishawi
发明人： Mir A. Imran , Albert G. Burdulis , Matthew D. Hills , Eyad Kishawi
IPC分类号： A61B5/04 , A61N1/00 , A61N1/05 , H05K1/11
CPC分类号： A61N1/0553 , A61N1/0556 , H05K1/118
摘要： Devices, systems and methods are provided for stimulation of tissues and structures within a body of a patient. In particular, implantable leads are provided which are comprised of a flexible circuit. Typically, the flexible circuit includes an array of conductors bonded to a thin dielectric film. Example dielectric films include polyimide, polyvinylidene fluoride (PVDF) or other biocompatible materials to name a few. Such leads are particularly suitable for stimulation of the spinal anatomy, more particularly suitable for stimulation of specific nerve anatomies, such as the dorsal root (optionally including the dorsal root ganglion).
摘要翻译：提供装置，系统和方法用于刺激患者体内的组织和结构。特别地，提供了由柔性电路组成的可植入引线。通常，柔性电路包括结合到薄介电膜的导体阵列。示例性电介质膜包括聚酰亚胺，聚偏二氟乙烯（PVDF）或其它生物相容性材料。这种引线特别适用于刺激脊柱解剖结构，更特别适用于刺激特定的神经解剖结构，例如背根（任选地包括背根神经节）。

2. 发明授权

US09113473B2 Power efficient wireless RF communication between a base station and a medical device 有权
标题翻译：基站和医疗设备之间的高效无线RF通信
公开(公告)号：US09113473B2
公开(公告)日：2015-08-18
申请号：US13425867
申请日：2012-03-21
申请人： April C. Pixley , Cary W R Campbell , Steven T. Brandon
发明人： April C. Pixley , Cary W R Campbell , Steven T. Brandon
IPC分类号： H04W52/02 , H04W88/08 , H04W76/04
CPC分类号： H04W52/0216 , H04W72/042 , H04W76/28 , H04W88/08 , Y02D70/00
摘要： Specific embodiments of the present invention are for use by a base station (BS) that enables power efficient wireless radio frequency (RF) communication between the BS and a medical device (MD), which may or may not be an implantable medical device (IMD). In an embodiment, once a communication session is established between the BS and the MD, the BS selectively turns a drop link mode on and off. The drop link mode is a communication mode that while turned on (i.e., enabled) reduces and preferably minimizes the length of time that an RF link is maintained between the BS and the MD. In accordance with an embodiment, at any given time during a communication session the drop link mode is either turned on (i.e., enabled) or turned off (i.e., disabled).
摘要翻译：本发明的具体实施例由基站（BS）使用，基站（BS）能够实现BS与医疗设备（MD）之间的功率有效的无线射频（RF）通信，其可以是或可以不是可植入医疗设备（IMD ）。在一个实施例中，一旦在BS和MD之间建立通信会话，BS选择性地打开和关闭下拉链路模式。丢弃链接模式是通信模式，其在接通（即，使能）时减小并且优选地最小化在BS和MD之间维持RF链路的时间长度。根据实施例，在通信会话期间的任何给定时间，丢弃链路模式被接通（即，启用）或关闭（即禁用）。

3. 发明申请

US20150209592A1 IMPLANTABLE NEUROSTIMULATOR DEVICES INCLUDING BOTH NON-RECHARGEABLE AND RECHARGEABLE BATTERIES AND METHODS OF USE THEREWITH 有权
标题翻译：可植入神经元装置，其中包括两个不可再充电和可充电电池及其使用方法
公开(公告)号：US20150209592A1
公开(公告)日：2015-07-30
申请号：US14606795
申请日：2015-01-27
申请人： SPINAL MODULATION, INC.
发明人： Mir A. Imran , Lynn Elliott
IPC分类号： A61N1/372 , A61N1/36 , A61N1/378
CPC分类号： A61N1/3787 , A61N1/3605 , A61N1/37223 , H02J5/005 , H02J7/0068 , H02J7/025 , H02J9/06 , H02J50/10 , H02J50/12 , H04B5/0031 , H04B5/0037 , H04B5/0081
摘要： An implantable neurostimulation (INS) device includes a non-rechargeable battery, a rechargeable battery, an antenna, an inductive coil, a neurostimulation module and a telemetry module. The neurostimulation module produces neurostimulation signals for delivery to target neural tissue, and the telemetry module wirelessly communicates with a non-implantable device using at least one of the antenna and the inductive coil. The non-rechargeable battery provides power to the neurostimulation module, and the rechargeable battery provides power to the telemetry module. The INS device also includes a charge module that charges the rechargeable battery in dependence on signals received from a non-implantable device via the inductive coil. Additional modules, such a sensor module, can be powered by the rechargeable battery. Additionally modules, such as controller, can be powered by the non-rechargeable battery. The rechargeable battery can power components normally powered by the non-rechargeable battery, when a capacity of the non-chargeable battery falls below a threshold.
摘要翻译：可植入神经刺激（INS）装置包括不可充电电池，可充电电池，天线，感应线圈，神经刺激模块和遥测模块。神经刺激模块产生用于递送到目标神经组织的神经刺激信号，并且遥测模块使用天线和感应线圈中的至少一个与非植入装置无线地通信。不可充电电池为神经刺激模块提供电力，并且可再充电电池为遥测模块提供电力。 INS装置还包括充电模块，其根据通过感应线圈从不可植入装置接收的信号对可充电电池充电。附加模块，如传感器模块，可由可充电电池供电。此外，模块（如控制器）可以由不可充电电池供电。当不可充电电池的容量下降到阈值以下时，可充电电池可以对通常由不可充电电池供电的部件供电。

4. 发明申请

US20120290042A1 METHODS, DEVICES AND SYSTEMS FOR PROGRAMMING NEUROSTIMULATION 有权
标题翻译：方法，用于编程神经细胞的装置和系统
公开(公告)号：US20120290042A1
公开(公告)日：2012-11-15
申请号：US13558271
申请日：2012-07-25
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
IPC分类号： A61N1/36
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for a specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译：提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，对于每个重新测试的特定神经刺激信号参数的值减少相同的量神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。

5. 发明申请

US20120158096A1 DIRECT MEMORY ACCESS (DMA) CONTROLLED STIMULATION 有权
标题翻译：直接记忆访问（DMA）控制刺激
公开(公告)号：US20120158096A1
公开(公告)日：2012-06-21
申请号：US13023470
申请日：2011-02-08
申请人： NEIL S. SHERMAN
发明人： NEIL S. SHERMAN
IPC分类号： A61N1/08
CPC分类号： G06F13/28 , A61N1/025 , A61N1/36071 , A61N1/36125 , A61N1/36185
摘要： An implantable stimulation system (e.g., an implantable neurostimulation system (INS)) comprises memory including a first table and a second table. The first table stores blocks of stimulation event data corresponding to stimulation events that are to be performed during a period of time (e.g., a 0.5 sec. or 1 sec. period of time). The second table stores blocks of next stimulation event time data corresponding to the period of time. The implantable stimulation system also includes a direct memory access (DMA) controller including a first DMA channel and a second DMA channel. The first DMA channel selectively transfers one of the blocks stimulation event data from the first table to one or more registers that are used to control stimulation events. The second DMA channel selectively transfers one of the blocks of next stimulation event time data from the second table to a timer that is used to control timing associated with the stimulation events. In this manner, the DMA controller is able to control stimulation.
摘要翻译：可植入刺激系统（例如，可植入神经刺激系统（INS））包括包含第一表和第二表的存储器。第一表存储对应于将在一段时间（例如，0.5秒或1秒的时间段）期间执行的刺激事件的刺激事件数据块。第二表存储对应于该时间段的下一个刺激事件时间数据的块。可植入刺激系统还包括直接存储器访问（DMA）控制器，其包括第一DMA通道和第二DMA通道。第一DMA通道选择性地将来自第一表的块刺激事件数据之一传送到用于控制刺激事件的一个或多个寄存器。第二DMA通道选择性地将下一个刺激事件时间数据块中的一个从第二表传输到用于控制与刺激事件相关联的定时的定时器。以这种方式，DMA控制器能够控制刺激。

6. 发明授权

US08082039B2 Stimulation systems 有权
标题翻译：刺激系统
公开(公告)号：US08082039B2
公开(公告)日：2011-12-20
申请号：US11222513
申请日：2005-09-07
申请人： Daniel H. Kim , Mir A. Imran
发明人： Daniel H. Kim , Mir A. Imran
IPC分类号： A61N1/32
CPC分类号： A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译：本发明的一些实施例通过在背根神经节内或周围植入电极来提供用于选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件。本发明的一些其他实施方案提供了一种或多种背根神经节的选择性神经刺激的方法以及将神经刺激应用于脊髓的技术。本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件，其与药理学组合。

7. 发明授权

US07447546B2 Methods of neurostimulating targeted neural tissue 有权
标题翻译：神经刺激靶向神经组织的方法
公开(公告)号：US07447546B2
公开(公告)日：2008-11-04
申请号：US11221587
申请日：2005-09-07
申请人： Daniel H. Kim , Mir A. Imran
发明人： Daniel H. Kim , Mir A. Imran
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要： Some embodiments of the present invention provide methods of neurostimulating targeted neural tissues. Also described are stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译：本发明的一些实施方案提供神经刺激靶向神经组织的方法。还描述了通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件。本发明的一些其他实施方案提供了一种或多种背根神经节的选择性神经刺激的方法以及将神经刺激应用于脊髓的技术。本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件，其与药理学组合。

8. 发明申请

US20080140169A1 DELIVERY DEVICES, SYSTEMS AND METHODS FOR STIMULATING NERVE TISSUE ON MULTIPLE SPINAL LEVELS 有权
标题翻译：用于刺激多个脊柱水平的神经组织的递送装置，系统和方法
公开(公告)号：US20080140169A1
公开(公告)日：2008-06-12
申请号：US11952053
申请日：2007-12-06
申请人： Mir A. IMRAN
发明人： Mir A. IMRAN
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/05 , A61N1/0558 , A61N1/3605 , A61N1/3606 , A61N1/36071
摘要： Devices, systems and methods are provided for simultaneously stimulating the spinal anatomy at various locations, such as spinal levels, along the spinal cord. By stimulating multiple levels of the spinal column with the use of a single device, a single access path is created to an implantable pulse generator (IPG) rather than individual access paths for each lead at each spinal level to an IPG. By reducing the number of pathways, the procedure complexity, time and recovery are reduced. In addition, some embodiments provide additional specificity within each targeted level, such as selective stimulation of specific tissue, such as the dorsal root ganglion.
摘要翻译：提供了装置，系统和方法，用于同时沿着脊髓刺激各种位置（例如脊柱水平）的脊柱解剖结构。通过使用单个装置刺激脊柱的多个级别，将单个访问路径创建到可植入脉冲发生器（IPG），而不是将每个脊髓级别的每个引导线的单独访问路径用于IPG。通过减少路径数量，减少了程序的复杂性，时间和恢复。此外，一些实施方案在每个靶向水平内提供额外的特异性，例如特定组织的选择性刺激，例如背根神经节。

9. 发明授权

US09205261B2 Neurostimulation methods and systems 有权
标题翻译：神经刺激方法和系统
公开(公告)号：US09205261B2
公开(公告)日：2015-12-08
申请号：US13706100
申请日：2012-12-05
申请人： Spinal Modulation, Inc. , The Board of Trustees of the Leland Stanford Junior University
发明人： Daniel H. Kim , Mir A. Imran , Jeffery M. Kramer
IPC分类号： A61N1/34 , A61N1/05 , A61N1/36 , A61B5/01 , A61B5/00
CPC分类号： A61N1/36071 , A61B5/01 , A61B5/4836 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36164
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译：本发明的一些实施例通过在背根神经节内或周围植入电极来提供用于选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件。本发明的一些其他实施方案提供了一种或多种背根神经节的选择性神经刺激的方法以及将神经刺激应用于脊髓的技术。本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件，其与药理学组合。

10. 发明授权

US09205260B2 Methods for stimulating a dorsal root ganglion 有权
公开(公告)号：US09205260B2
公开(公告)日：2015-12-08
申请号：US13550439
申请日：2012-07-16
申请人： Daniel H. Kim , Mir A. Imran
发明人： Daniel H. Kim , Mir A. Imran
IPC分类号： A61K9/22 , A61N1/36 , A61N1/05
CPC分类号： A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

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