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1. 发明申请

US20170274212A1 SELECTIVE STIMULATION TO MODULATE THE SYMPATHETIC NERVOUS SYSTEM 审中-公开
公开(公告)号：US20170274212A1
公开(公告)日：2017-09-28
申请号：US15346587
申请日：2016-11-08
申请人： Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
发明人： Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36057 , A61N1/36071 , A61N1/36135
摘要： Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.

2. 发明申请

US20160250468A1 METHODS FOR STIMULATING A DORSAL ROOT GANGLION 审中-公开
公开(公告)号：US20160250468A1
公开(公告)日：2016-09-01
申请号：US14960280
申请日：2015-12-04
申请人： Daniel H. KIM , Mir A. IMRAN
发明人： Daniel H. KIM , Mir A. IMRAN
IPC分类号： A61N1/36 , A61M25/06 , A61M5/142 , A61N1/05
CPC分类号： A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

3. 发明申请

US20150251004A1 SUTURELESS LEAD RETENTION FEATURES 审中-公开
标题翻译：无懈可击的铅保持功能
公开(公告)号：US20150251004A1
公开(公告)日：2015-09-10
申请号：US14719076
申请日：2015-05-21
申请人： Mir A. IMRAN , Albert G. BURDULIS , Kamran BEHZADIAN , Fred I. LINKER , Nicholas C. DEBEER , Arturo ROSQUETA
发明人： Mir A. IMRAN , Albert G. BURDULIS , Kamran BEHZADIAN , Fred I. LINKER , Nicholas C. DEBEER , Arturo ROSQUETA
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61N1/057 , A61N2001/0585
摘要： A system includes a lead having a lead body and at least one electrode; and a retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in atraumatically anchoring the lead to nearby tissue when the lead is positioned in the body. Alternatively, a system includes a lead, a lead body, at least one electrode; with a coiled retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in anchoring the lead to nearby tissue. A lead for stimulating a target neural tissue includes an elongate body; at least one electrode disposed along the elongate body; and a passive retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in anchoring the elongate body to tissue near the target neural tissue.
摘要翻译：一种系统包括具有引线体和至少一个电极的引线; 以及保持特征，沿着所述引线体设置在所述至少一个电极的近侧，并且被配置为当所述引线位于所述主体中时辅助将所述引线无损伤地固定到附近的组织。或者，系统包括引线，引线体，至少一个电极; 具有螺旋保持特征，沿着所述引线主体设置在所述至少一个电极附近并且被配置成有助于将所述引线附着到附近的组织。用于刺激靶神经组织的引线包括细长体; 沿着所述细长体设置的至少一个电极; 以及被动保持特征，沿着所述引线体设置在所述至少一个电极的近侧，并被配置为有助于将所述细长主体锚定到所述靶神经组织附近的组织。

4. 发明申请

US20130165991A1 NEUROSTIMULATION METHODS AND SYSTEMS 有权
标题翻译：神经病学方法与系统
公开(公告)号：US20130165991A1
公开(公告)日：2013-06-27
申请号：US13706100
申请日：2012-12-05
申请人： Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
发明人： Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61B5/01 , A61B5/4836 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36164
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译：本发明的一些实施例通过在背根神经节内或周围植入电极来提供用于选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件。本发明的一些其他实施方案提供了一种或多种背根神经节的选择性神经刺激的方法以及将神经刺激应用于脊髓的技术。本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件，其与药理学组合。

5. 发明申请

US20080140152A1 IMPLANTABLE FLEXIBLE CIRCUIT LEADS AND METHODS OF USE 有权
标题翻译：可伸缩柔性电路引线及其使用方法
公开(公告)号：US20080140152A1
公开(公告)日：2008-06-12
申请号：US11952062
申请日：2007-12-06
申请人： Mir A. IMRAN , Albert G. Burdulis , Matthew D. Hills , Eyad Kishawi
发明人： Mir A. IMRAN , Albert G. Burdulis , Matthew D. Hills , Eyad Kishawi
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0556 , H05K1/118
摘要： Devices, systems and methods are provided for stimulation of tissues and structures within a body of a patient. In particular, implantable leads are provided which are comprised of a flexible circuit. Typically, the flexible circuit includes an array of conductors bonded to a thin dielectric film. Example dielectric films include polyimide, polyvinylidene fluoride (PVDF) or other biocompatible materials to name a few. Such leads are particularly suitable for stimulation of the spinal anatomy, more particularly suitable for stimulation of specific nerve anatomies, such as the dorsal root (optionally including the dorsal root ganglion).
摘要翻译：提供装置，系统和方法用于刺激患者体内的组织和结构。特别地，提供了由柔性电路组成的可植入引线。通常，柔性电路包括结合到薄介电膜的导体阵列。示例性电介质膜包括聚酰亚胺，聚偏二氟乙烯（PVDF）或其它生物相容性材料。这种引线特别适用于刺激脊柱解剖结构，更特别适用于刺激特定的神经解剖结构，例如背根（任选地包括背根神经节）。

6. 发明申请

US20160346547A1 SELECTIVE STIMULATION SYSTEMS AND SIGNAL PARAMETERS FOR MEDICAL CONDITIONS 审中-公开
公开(公告)号：US20160346547A1
公开(公告)日：2016-12-01
申请号：US15231555
申请日：2016-08-08
申请人： Eyad KISHAWI , Mir A. IMRAN , Brian J. MOSSOP , Jeffery M. KRAMER , Richard W. O'CONNOR
发明人： Eyad KISHAWI , Mir A. IMRAN , Brian J. MOSSOP , Jeffery M. KRAMER , Richard W. O'CONNOR
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36157 , A61N1/37247
摘要： Devices, systems and methods are provided for targeted treatment of a variety of conditions, particularly conditions that are associated with or influenced by the nervous system, such as pain. Targeted treatment of such conditions is provided with minimal deleterious side effects, such as undesired motor responses or undesired stimulation of unaffected body regions. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies.

7. 发明申请

US20160082258A1 SELECTIVE STIMULATION TO MODULATE THE SYMPATHETIC NERVOUS SYSTEM 有权
标题翻译：选择性刺激来调节症状性神经系统
公开(公告)号：US20160082258A1
公开(公告)日：2016-03-24
申请号：US14954740
申请日：2015-11-30
申请人： Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
发明人： Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36057 , A61N1/36071 , A61N1/36135
摘要： Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
摘要翻译：提供了系统，方法和装置，用于通过直接神经调节与条件相关联的目标解剖结构，同时最小化或排除其他解剖结构的不期望的神经调节来定向治疗各种医学状况。通常，目标解剖结构包括一个或多个背根神经节，背根，背根进入区或其部分。这些目标刺激区域部分地由于它们对交感神经系统的影响而被利用。

8. 发明申请

US20090043375A1 COMPOSITE EXPANDABLE DEVICE WITH IMPERVIOUS POLYMERIC COVERING AND BIOACTIVE COATING THEREON, DELIVERY APPARATUS AND METHOD 审中-公开
标题翻译：具有非常好的聚合物覆盖和生物涂层的复合可扩展装置，传送装置和方法
公开(公告)号：US20090043375A1
公开(公告)日：2009-02-12
申请号：US12105502
申请日：2008-04-18
申请人： Leon V. RUDAKOV , Mir A. IMRAN , Ara DAVIDIAN , Kevin T. LARKIN , Mai Huong DANG , Phillip CHIU
发明人： Leon V. RUDAKOV , Mir A. IMRAN , Ara DAVIDIAN , Kevin T. LARKIN , Mai Huong DANG , Phillip CHIU
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/07 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2230/0013 , A61F2250/0067
摘要： A composite expandable device for delivery into a vessel carrying blood comprising an expandable support frame having first and second end portions. An impervious polymer sleeve having inner and outer surfaces extending over the support frame. A coating is disposed on at least one of the inner and outer surfaces of the polymer sleeve for enhancing endothelial cell growth on the device and polymer sleeve.
摘要翻译：一种用于输送到携带血液的血管的复合可扩张装置，包括具有第一和第二端部的可扩张支撑框架。不透水的聚合物套筒，其具有在支撑框架上方延伸的内表面和外表面。在聚合物套筒的内表面和外表面中的至少一个上设置涂层以增强器件和聚合物套筒上的内皮细胞生长。

9. 发明申请

US20170128725A1 NEUROSTIMULATION METHODS AND SYSTEMS 审中-公开
公开(公告)号：US20170128725A1
公开(公告)日：2017-05-11
申请号：US15406522
申请日：2017-01-13
申请人： Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
发明人： Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
IPC分类号： A61N1/36 , A61N1/05 , A61B5/00 , A61B5/01
CPC分类号： A61N1/36071 , A61B5/01 , A61B5/4836 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36164
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

10. 发明申请

US20160250469A1 NEUROSTIMULATION METHODS AND SYSTEMS 审中-公开
公开(公告)号：US20160250469A1
公开(公告)日：2016-09-01
申请号：US14960291
申请日：2015-12-04
申请人： Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
发明人： Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36071 , A61B5/01 , A61B5/4836 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36164
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

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