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1. 发明申请

US20160346547A1 SELECTIVE STIMULATION SYSTEMS AND SIGNAL PARAMETERS FOR MEDICAL CONDITIONS 审中-公开
公开(公告)号：US20160346547A1
公开(公告)日：2016-12-01
申请号：US15231555
申请日：2016-08-08
申请人： Eyad KISHAWI , Mir A. IMRAN , Brian J. MOSSOP , Jeffery M. KRAMER , Richard W. O'CONNOR
发明人： Eyad KISHAWI , Mir A. IMRAN , Brian J. MOSSOP , Jeffery M. KRAMER , Richard W. O'CONNOR
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36157 , A61N1/37247
摘要： Devices, systems and methods are provided for targeted treatment of a variety of conditions, particularly conditions that are associated with or influenced by the nervous system, such as pain. Targeted treatment of such conditions is provided with minimal deleterious side effects, such as undesired motor responses or undesired stimulation of unaffected body regions. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies.

2. 发明申请

US20160082258A1 SELECTIVE STIMULATION TO MODULATE THE SYMPATHETIC NERVOUS SYSTEM 有权
标题翻译：选择性刺激来调节症状性神经系统
公开(公告)号：US20160082258A1
公开(公告)日：2016-03-24
申请号：US14954740
申请日：2015-11-30
申请人： Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
发明人： Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36057 , A61N1/36071 , A61N1/36135
摘要： Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
摘要翻译：提供了系统，方法和装置，用于通过直接神经调节与条件相关联的目标解剖结构，同时最小化或排除其他解剖结构的不期望的神经调节来定向治疗各种医学状况。通常，目标解剖结构包括一个或多个背根神经节，背根，背根进入区或其部分。这些目标刺激区域部分地由于它们对交感神经系统的影响而被利用。

3. 发明授权

US09056197B2 Selective stimulation systems and signal parameters for medical conditions 有权
标题翻译：选择性刺激系统和医疗条件的信号参数
公开(公告)号：US09056197B2
公开(公告)日：2015-06-16
申请号：US12607009
申请日：2009-10-27
申请人： Eyad Kishawi , Mir A. Imran , Brian J. Mossop , Jeffery M. Kramer , Richard W. O'Connor
发明人： Eyad Kishawi , Mir A. Imran , Brian J. Mossop , Jeffery M. Kramer , Richard W. O'Connor
IPC分类号： A61N1/08 , A61N1/05 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36157 , A61N1/37247
摘要： Devices, systems and methods are provided for targeted treatment of a variety of conditions, particularly conditions that are associated with or influenced by the nervous system, such as pain. Targeted treatment of such conditions is provided with minimal deleterious side effects, such as undesired motor responses or undesired stimulation of unaffected body regions. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies.
摘要翻译：提供装置，系统和方法用于各种条件的靶向治疗，特别是与神经系统相关或受其影响的条件，例如疼痛。提供这种病症的靶向治疗具有最小的有害副作用，例如不期望的运动反应或不受影响的身体区域的刺激。这是通过直接神经调节与病症相关的目标解剖结构来实现的，同时最小化或排除其他解剖结构的不希望的神经调节。

4. 发明授权

US08914128B2 Methods, devices and systems for programming neurostimulation 有权
标题翻译：用于编程神经刺激的方法，装置和系统
公开(公告)号：US08914128B2
公开(公告)日：2014-12-16
申请号：US13558271
申请日：2012-07-25
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372 , A61N1/05
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for a specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译：提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，对于每个重新测试的特定神经刺激信号参数的值减少相同的量神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。

5. 发明申请

US20130085476A1 SYSTEM AND METHOD FOR DELIVERY OF A THERAPEUTIC AGENT TO THE INNER EAR 审中-公开
标题翻译：将治疗药物输送到内脏的系统和方法
公开(公告)号：US20130085476A1
公开(公告)日：2013-04-04
申请号：US13627346
申请日：2012-09-26
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61F11/00
CPC分类号： A61F11/00 , A61F11/004 , A61K9/0046
摘要： Embodiments of the invention provide systems and methods for delivering therapeutic compositions to the inner-ear to treat inner-ear disorders. An embodiment of such a system comprises a sheath for insertion into the auditory canal and a cannula which can be inserted through the sheath. The cannula can include a tip for piercing the tympanic membrane and delivering the composition to an inner-ear tissue surface. The system may also include a therapeutic composition comprising a therapeutic agent and a thixotropic material which allows the composition to be delivered (e.g., by injection) through the cannula in liquid form and transition to gel-form once delivered to the tissue surface. A method for using the system comprises introducing the sheath into the ear, introducing the cannula through the sheath to pierce the tympanic membrane and position the tip adjacent an inner-ear tissue surface; and delivering the composition through the cannula to adhere to the tissue surface.
摘要翻译：本发明的实施方案提供了用于将治疗组合物递送至内耳以治疗内耳障碍的系统和方法。这种系统的一个实施例包括用于插入到耳道中的护套和可插入穿过护套的套管。套管可以包括用于刺穿鼓膜并将组合物输送到内耳组织表面的尖端。该系统还可以包括包含治疗剂和触变材料的治疗组合物，其允许组合物以液体形式通过插管递送（例如通过注射），并且一旦递送至组织表面则转变成凝胶形式。使用该系统的方法包括将护套引入耳朵中，通过护套引入套管以刺穿鼓膜并将尖端定位在内耳组织表面附近; 并且通过套管输送组合物以粘附到组织表面。

6. 发明授权

US08229565B2 Methods for stimulating a dorsal root ganglion 有权
标题翻译：刺激背根神经节的方法
公开(公告)号：US08229565B2
公开(公告)日：2012-07-24
申请号：US12369706
申请日：2009-02-11
申请人： Daniel H. Kim , Mir A. Imran
发明人： Daniel H. Kim , Mir A. Imran
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译：本发明的一些实施例通过在背根神经节内或周围植入电极来提供用于选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件。本发明的一些其他实施方案提供了一种或多种背根神经节的选择性神经刺激的方法以及将神经刺激应用于脊髓的技术。本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件，其与药理学组合。

7. 发明申请

US20120177700A1 Nanonized Iron Compositions and Methods of Use Thereof 审中-公开
标题翻译：纳米铁组合物及其使用方法
公开(公告)号：US20120177700A1
公开(公告)日：2012-07-12
申请号：US13338210
申请日：2011-12-27
申请人： Mir A. Imran , Mir Hashim , Lu Wang , Sanjay Patel , Joel M. Harris , Phil Morgan
发明人： Mir A. Imran , Mir Hashim , Lu Wang , Sanjay Patel , Joel M. Harris , Phil Morgan
IPC分类号： A61K9/00 , A61K33/42 , B82Y5/00
CPC分类号： A61K9/14 , A61K33/26
摘要： Embodiments of the invention provide nanonized iron compositions for treatment of iron deficiency such as iron deficiency anemia. Many embodiments provide nanonized iron compositions which are sized to minimize adverse reaction such as immune response, adverse GI reaction and allergic reaction to iron compound included in the composition. The nanonized iron compositions can be used in a variety of drug delivery forms, including an oral dosage form, a transdermal patch, in an intravenous solution or in a dialysate for treatment of a patient with chronic kidney disease (CKD). Embodiments of the invention also provide methods of using the nanonized iron compositions for the treatment of iron deficiency in a patient in need thereof including patients with iron deficiency anemia and CKD.
摘要翻译：本发明的实施方案提供了用于治疗铁缺乏症（例如缺铁性贫血）的纳米铁组合物。许多实施方案提供纳米级铁组合物，其尺寸设定成使包括在组合物中的铁化合物的不良反应如免疫应答，不良GI反应和过敏反应最小化。纳米铁组合物可以以各种药物递送形式使用，包括口服剂型，透皮贴剂，静脉内溶液或用于治疗慢性肾脏病（CKD）患者的透析液。本发明的实施方案还提供了使用纳米铁组合物治疗需要其的患者缺铁的方法，包括缺铁性贫血和CKD患者。

8. 发明申请

US20110306897A1 CAPSULE AND METHOD FOR TREATING OR DIAGNOSING CONDITIONS OR DISEASES OF THE INTESTINAL TRACT 有权
标题翻译：治疗或诊断INTESTINAL TRACT的病症或疾病的胶囊和方法
公开(公告)号：US20110306897A1
公开(公告)日：2011-12-15
申请号：US13215182
申请日：2011-08-22
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61B5/053 , A61B5/01
CPC分类号： A61M31/002 , A61B1/00016 , A61B1/00082 , A61B1/041 , A61B5/002 , A61B5/0084 , A61B5/01 , A61B5/036 , A61B5/0538 , A61B5/06 , A61B5/061 , A61B5/065 , A61B5/073 , A61B5/11 , A61B5/14503 , A61B5/14539 , A61B5/1459 , A61B5/42 , A61B5/4233 , A61B5/4255 , A61B5/4839 , A61B5/6801 , A61B5/6873 , A61B18/14 , A61B2018/00482 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00821 , A61B2562/162 , A61M5/172 , A61M5/1723 , A61N1/36007 , A61N1/37205
摘要： A device and method for mapping, diagnosing and treating inflammatory disorders (such as Crohn's disease) or other diseases, disorders or conditions of the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed impedance and or temperature may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose, or mark the intestinal tract at a determined location along its length.
摘要翻译：使用通过肠道的胶囊提供用于映射，诊断和治疗炎症性疾病（例如克罗恩病）或肠道的其它疾病，病症或病症的装置和方法。此外，提供了胶囊跟踪系统，用于沿着肠道长度跟踪胶囊的位置，因为采用各种治疗和/或感测方式。在一个变型中，使用声信号来确定胶囊的位置。感测阻抗和/或温度的图可以从胶囊的通过导出以诊断疾病或疾病。胶囊或随后通过的胶囊可以沿着其长度在确定的位置处理，进一步诊断或标记肠道。

9. 发明授权

US08034118B2 Implantable digestive tract organ 有权
标题翻译：植入性消化道器官
公开(公告)号：US08034118B2
公开(公告)日：2011-10-11
申请号：US11549573
申请日：2006-10-13
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61F2/04
CPC分类号： A61F2/04 , A61F2002/045 , A61F2002/482 , A61F2250/008 , A61F2250/0096
摘要： An implantable digestive organ is provided for the transport of materials through the digestive tract and in one particular application to an artificial large bowel for replacing all or part of a colon or large bowel. The prosthetic organ of one embodiment includes an outer support structure, an expandable member or members located within the outer support structure, and a flexible inner member forming a conduit for the passage of material. The flexible inner member is located within the outer member and the expandable member or members are located between the inner member and the outer support structure. The expandable members are expanded and contracted, or inflated and deflated to provide a pumping action that pumps the material through the organ. The prosthesis may also include valves or sphincters at the entrance and/or exit points of the organ where material moves into and out of the prosthesis. An implantable pump unit may be included for inflating and deflating the expandable members according to a desired sequence.
摘要翻译：提供可植入的消化器官用于通过消化道运输材料，并且在一个特定应用中提供用于替换全部或部分结肠或大肠的人造大肠。一个实施例的假体器官包括外部支撑结构，位于外部支撑结构内的可扩张构件或构件，以及形成用于材料通过的导管的柔性内部构件。柔性内部构件位于外部构件内，并且可膨胀构件位于内部构件和外部支撑结构之间。可膨胀构件膨胀和收缩，或膨胀和放气，以提供泵送物质通过器官的泵送作用。假体还可以包括在器官的入口和/或出口处的瓣膜或括约肌，其中材料移入和移出假体。可以包括可植入泵单元，用于根据期望的顺序对可膨胀构件进行充气和放气。

10. 发明申请

US20100121408A1 METHODS, DEVICES AND SYSTEMS FOR PROGRAMMING NEUROSTIMULATION 有权
标题翻译：方法，用于编程神经细胞的装置和系统
公开(公告)号：US20100121408A1
公开(公告)日：2010-05-13
申请号：US12579179
申请日：2009-10-14
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. Each neurostimulation parameter set defines electrode parameters and neurostimulation signal parameters. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. All of the tested neurostimulation parameter sets comprise a same value for a specific neurostimulation signal parameter (e.g., pulse width) that if reduced reduces power consumption. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for the specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译：提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。每个神经刺激参数集定义电极参数和神经刺激信号参数。在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。所有测试的神经刺激参数组对于特定神经刺激信号参数（例如，脉冲宽度）包含相同的值，如果减少，则降低功率消耗。如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，其中针对每个重新测试的特定神经刺激信号参数的值减少相同的量神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。

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