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1. 发明公开

US20230302454A1 SAMPLE COLLECTION CONTAINERS, PROCESSES AND COLLECTED SAMPLES 审中-公开
公开(公告)号：US20230302454A1
公开(公告)日：2023-09-28
申请号：US18020893
申请日：2021-08-13
申请人： STRECK, INC.
发明人： Sean Salamifar , Nick George , Brad Hunsley
IPC分类号： B01L3/00
CPC分类号： B01L3/5082 , B01L2200/16 , B01L2300/16
摘要： The present teachings relate to a method of making a biological sample collection container, an internally coated biological sample collection container, and uses of the same, particularly for omic analysis. A reagent (or a reagent precursor) is deposited in a liquid state at least partially along at least one side wall of the container. The reagent precursor is dried to form a dried coating having a predefined pattern and topology along at least a portion of the at least one side wall. A container thus results having a coating that includes, in a dried state, a stabilizer agent, or reaction product of a stabilizer agent and an anticoagulant, and upon collection of a sample enables stabilization of any present white blood cells, cell-free nucleic acids, extracellular vesicles, circulating tumor cells, proteins, metabolites, lipids, or any combination thereof, and preserving them in sufficient quantity and quality for omic analysis.

2. 发明授权

US09926590B2 Devices and compositions for preservation of cell-free nucleic acids 有权
公开(公告)号：US09926590B2
公开(公告)日：2018-03-27
申请号：US15601682
申请日：2017-05-22
申请人： Streck, Inc.
发明人： M. Rohan Fernando
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C09K15/20 , C12Q2527/125 , C12Q2527/127
摘要： Devices including a composition for preserving and processing cell-free nucleic acids located within a blood sample and methods of using the same are disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The device may include a direct blood draw tube comprising a composition formulated for stabilizing cell-free nucleic acids within a blood sample including one or more formaldehyde releaser preservative agents, ethylenediaminetetraacetic acid (EDTA), one or more solvents, and formaldehyde. The composition is free of separately added formaldehyde but contains the formaldehyde as a result of the one or more formaldehyde releaser preservative agents. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

3. 发明申请

US20130078641A1 SAMPLE PROCESSING METHOD AND DEVICE 审中-公开
标题翻译：样品处理方法和装置
公开(公告)号：US20130078641A1
公开(公告)日：2013-03-28
申请号：US13700817
申请日：2011-06-01
申请人： Hendrik J. Viljoen , Scott E. Whitney , Alison Freifeld , Christine Booth , Xing Zhao
发明人： Hendrik J. Viljoen , Scott E. Whitney , Alison Freifeld , Christine Booth , Xing Zhao
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/5023 , B01L3/5029 , B01L3/505 , B01L2300/0825
摘要： The present invention provides a method and device for treating and analyzing a biological specimen. The biological specimen is introduced into a processing device and treated thermally, mechanically, chemically or any combination thereof within the processing device to alter at least one constitutive characteristic of the biological specimen and to release or create one or more biological indicators from the biological specimen. The biological specimen is further contacted with a treated polymeric material so that at least a portion of the polymeric material binds to the one or more biological indicators.
摘要翻译：本发明提供一种用于处理和分析生物样本的方法和装置。将生物样品引入处理装置中并在加工装置内热处理，机械地，化学地或其任何组合进行处理，以改变生物样本的至少一个构成特征并从生物样品中释放或产生一个或多个生物指示剂。生物样品进一步与经处理的聚合物材料接触，使得至少一部分聚合物材料与一种或多种生物指示剂结合。

4. 外观设计

USD637235S1 Blood sample tube label 有权
公开(公告)号：USD637235S1
公开(公告)日：2011-05-03
申请号：US29345313
申请日：2009-10-14
申请人： Rebecca Anne Reiss , Matthew Robert Kreifels , David Lee Oliver
设计人： Rebecca Anne Reiss , Matthew Robert Kreifels , David Lee Oliver

5. 发明申请

US20100291536A1 SAMPLE PROCESSING CASSETTE, SYSTEM, AND METHOD 审中-公开
标题翻译：样品加工CASSETTE，系统和方法
公开(公告)号：US20100291536A1
公开(公告)日：2010-11-18
申请号：US12780345
申请日：2010-05-14
申请人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. Termaat , Alison Freifeld , Elsje Pienaar
发明人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. Termaat , Alison Freifeld , Elsje Pienaar
IPC分类号： C12P19/34 , C12N1/06 , C12Q1/00 , C12M1/00
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： The present invention provides a method and device for collecting treating and analysis of biological or chemical material by introducing a source material into a specimen container, transferring the source material to a processing device and thermally, chemically and/or mechanically treating the source material to alter at least one constitutive characteristic of the source material and to release or create a target material from the source material.
摘要翻译：本发明提供了一种通过将源材料引入到样本容器中来收集生物或化学材料的处理和分析的方法和装置，将源材料转移到处理装置，并且热，化学和/或机械地处理源材料以改变源材料的至少一个构成特征并且从源材料释放或产生靶材料。

6. 发明申请

US20100209930A1 PRESERVATION OF CELL-FREE NUCLEIC ACIDS 有权
标题翻译：无细胞核酸的保存
公开(公告)号：US20100209930A1
公开(公告)日：2010-08-19
申请号：US12704030
申请日：2010-02-11
申请人： M. Rohan Fernando
发明人： M. Rohan Fernando
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C09K15/20 , C12Q2527/125 , C12Q2527/127
摘要： A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.
摘要翻译：公开了一种用于保存和处理位于血液样品内的无细胞核酸的方法，其中处理含有无细胞核酸的血液样品以降低血液样品中的血细胞裂解和核酸酶活性。样品的处理有助于增加可以鉴定和测试的无细胞核酸的量，同时保持核酸的结构和完整性。

7. 发明授权

US07608457B2 Blood collection and testing improvements 有权
标题翻译：血液收集和检测改进
公开(公告)号：US07608457B2
公开(公告)日：2009-10-27
申请号：US11077397
申请日：2005-03-10
申请人： Bradford A. Hunsley
发明人： Bradford A. Hunsley
IPC分类号： G01N33/86
CPC分类号： B01L3/5082 , B01L2200/085 , B01L2300/0854 , B01L2300/16
摘要： Improvements in blood collection and testing. In one aspect, an improved method of manufacturing a blood collection tube, particularly illustrated for use in sedimentation rate testing, including providing an elongated glass tube with an open first end for receiving a venipuncture blood sample of at least 1 ml, formed with a closed end opposite the first end; and applying to a substantial portion of the receptacle a containment barrier.
摘要翻译：血液收集和检测的改进。在一个方面，一种制造采血管的改进方法，特别示出用于沉降速率测试，包括提供具有开放的第一端的细长玻璃管，用于接收至少1ml的静脉穿刺血液样品，形成为封闭的在第一端相对端; 并向容器的大部分施加容纳屏障。

8. 发明授权

US07361513B2 Cellular controls for glycated hemoglobin Hb A1c 有权
标题翻译：糖化血红蛋白Hb A1c的细胞控制
公开(公告)号：US07361513B2
公开(公告)日：2008-04-22
申请号：US11102378
申请日：2005-04-08
申请人： Wayne L. Ryan , Jiong Wu
发明人： Wayne L. Ryan , Jiong Wu
IPC分类号： G01N33/72 , G01N33/50
CPC分类号： G01N33/723 , Y10T436/10 , Y10T436/105831 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： Disclosed are cellular hemoglobin A1c (Hb A1c) normal and abnormal (high) controls for use in detecting Hb A1c levels. The present invention also relates to methods for generating cellular Hb A1c controls using red blood cells and methods for using the cellular controls. The present invention encompasses several methods for the preparation of Hb A1c cellular controls including: (1) a boronate method where the glycation occurs non-specifically; (2) a stabilized diabetic blood method where the glycation occurs specifically on Hb A1c, and (3) the glycation of normal blood method that is achieved by controlling conditions such that glycation occurs predominantly on Hb A1c. These methods produce cellular Hb A1c controls with desirable stability and that can be detected on a variety of instruments.
摘要翻译：公开了用于检测HbA1c水平的细胞血红蛋白A1c（Hb A1c）正常和异常（高）对照。本发明还涉及使用红细胞生成细胞HbA1c对照的方法和使用细胞对照的方法。本发明包括制备Hb A1c细胞对照的几种方法，包括：（1）非特异性发生糖基化的硼酸盐法; （2）稳定的糖尿病血型，其糖化特异性地发生在HbA1c上，和（3）通过控制使糖基化主要发生在HbA1c上的病症来实现的正常血液法糖化。这些方法产生具有期望稳定性的细胞Hb A1c对照，并且可以在各种仪器上检测。

9. 发明授权

US07270013B2 Dispenser volume determination method 有权
标题翻译：分配器体积确定方法
公开(公告)号：US07270013B2
公开(公告)日：2007-09-18
申请号：US11095298
申请日：2005-03-31
申请人： Balwant S. Bhullar , Daniel T. Bourne
发明人： Balwant S. Bhullar , Daniel T. Bourne
IPC分类号： G01F25/00 , G01F13/00 , G01F22/00 , G01N21/84 , G01N21/93
CPC分类号： G01F1/661 , G01F22/00 , G01F25/0092
摘要： The present invention includes methods of determining the volume of liquid dispensed by a dispenser. Initially, a refractive index analysis is preformed on a first liquid that has been dispensed from the dispenser in question. From the refractive index analysis, information is obtained about the volume of first liquid dispensed. The invention also includes methods for verifying the volumetric accuracy of a dispenser. The methods include dispensing a first liquid having a known refractive index into a vessel having a second liquid with a known volume and a known refractive index to form a test mixture. The refractive index of the test mixture is measured and then correlated with the refractive index of the first liquid to obtain information about the volume of first liquid dispensed. The dispensed volume is then compared to the theoretical volume of liquid dispensed by the dispenser.
摘要翻译：本发明包括确定由分配器分配的液体的体积的方法。首先，在从所述分配器分配的第一液体上进行折射率分析。从折射率分析得到关于第一液体分配的体积的信息。本发明还包括用于验证分配器的体积精度的方法。所述方法包括将具有已知折射率的第一液体分配到具有已知体积和已知折射率的第二液体的容器中以形成测试混合物。测量测试混合物的折射率，然后与第一液体的折射率相关，以获得关于分配的第一液体的体积的信息。然后将分配的体积与由分配器分配的液体的理论体积进行比较。

10. 发明申请

US20220326157A1 DEVICES FOR REAL-TIME POLYMERASE CHAIN REACTION 有权
公开(公告)号：US20220326157A1
公开(公告)日：2022-10-13
申请号：US17843132
申请日：2022-06-17
申请人： STRECK, INC.
发明人： Matthew R. Kreifels , Scott E. Whitney , Gregg Wilder , John Flanagan , James Dowling , Philip Hills , Michael Tilleman , Jeremie Jackson
IPC分类号： G01N21/64 , C12Q1/686
摘要： An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

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