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1. 发明申请

US20140286894A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS AND CALCIUM AND/OR MAGNESIUM CATIONS, AND USES THEREOF 审中-公开
标题翻译：包含交联的结合聚合物和钙和/或镁合金的组合物及其用途
公开(公告)号：US20140286894A1
公开(公告)日：2014-09-25
申请号：US13978872
申请日：2012-01-10
申请人： Alan D. Strickland , George M. Grass
发明人： Alan D. Strickland , George M. Grass
IPC分类号： A61K31/78
CPC分类号： A61K31/78 , A23L33/10 , A61K9/1611 , A61K9/1635
摘要： The present disclosure relates generally to crosslinked cation-binding polymers comprising monomers containing carboxylic acid groups, wherein the polymer contains calcium and/or magnesium cations that are counterions to about 15% to about 35% of the carboxylic acid groups in the polymer. The present disclosure also relates to methods of preparation of the polymers, and compositions, formulations, and dosage forms containing the polymers, and methods of using the polymers, compositions, formulations, and/or dosage forms to treat various diseases or disorders, including those involving ion and/or fluid imbalances.
摘要翻译：本公开通常涉及包含含有羧酸基团的单体的交联阳离子结合聚合物，其中所述聚合物含有与聚合物中约15％至约35％的羧酸基团的抗衡离子的钙和/或镁阳离子。本公开还涉及制备聚合物的方法，以及含有聚合物的组合物，制剂和剂型，以及使用聚合物，组合物，制剂和/或剂型来治疗各种疾病或病症的方法，包括那些涉及离子和/或流体不平衡。

2. 发明申请

US20130195975A1 IN VIVO USE OF WATER ABSORBENT POLYMERS 审中-公开
标题翻译：吸水聚合物在血液中的使用
公开(公告)号：US20130195975A1
公开(公告)日：2013-08-01
申请号：US13589699
申请日：2012-08-20
申请人： Jaime Simon , Alan D. Strickland
发明人： Jaime Simon , Alan D. Strickland
IPC分类号： A61K31/78 , A61K9/00
CPC分类号： A61K31/78 , A61K9/00 , A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译：本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。优选的聚合物包括优选以珠粒形式提供的超吸收性丙烯酸聚合物。聚合物可以包括用于选择性地去除血液传播的废物的功能基团，例如。尿素，来自G.I. 道。

3. 发明申请

US20110123604A1 ABSORBENT POLYMERIC COMPOSITIONS WITH VARYING COUNTERION CONTENT AND THEIR METHODS OF PREPARATION AND USE 审中-公开
标题翻译：吸收聚合物组合物及其制备和使用方法
公开(公告)号：US20110123604A1
公开(公告)日：2011-05-26
申请号：US12675705
申请日：2008-08-29
申请人： Alan Strickland , George Grass
发明人： Alan Strickland , George Grass
IPC分类号： A61K9/48 , A61K9/00 , A61K31/74 , B01J39/18 , B01J39/20 , A61P9/04 , A61P13/12 , A61P9/12 , A61P43/00
CPC分类号： C08F2/32 , A61K9/1688 , A61K9/4891 , A61K31/78 , C08F220/06 , C08F222/1006 , C08J3/12 , C08J3/128 , C08J2300/14 , C08J2333/08
摘要： Cross-linked polyelectrolyte polymers with bound counterions that absorb about 20-fold or more of their mass in saline such as physiological saline a with the proviso that sodium does not exceed 60% of total bound counterions when hydrogen is the sole other counterion, are disclosed. Methods of preparing the disclosed polymers and for treating subjects such as patients in need of fluid removal and/or modulation of ions (e.g., sodium and/or potassium) are provided.
摘要翻译：披露了具有结合的抗衡离子的交联聚电解质聚合物，其吸收盐水如生理盐水中其质量的约20倍或更多，条件是当氢是唯一的其它抗衡离子时，钠不超过总结合的抗衡离子的60％。提供制备所公开的聚合物和治疗受试者（例如需要流体移除和/或调节离子的患者（例如钠和/或钾））的方法。

4. 发明申请

US20110104212A1 POLYMERIC COMPOSITIONS WITH ENHANCED SALINE HOLDING CAPACITY AND THEIR METHOD OF PREPARATION AND USE 审中-公开
标题翻译：具有增强的海盐保持能力的聚合物组合物及其制备和使用方法
公开(公告)号：US20110104212A1
公开(公告)日：2011-05-05
申请号：US12675689
申请日：2008-08-29
申请人： Alan Strickland , George Grass
发明人： Alan Strickland , George Grass
IPC分类号： A61K9/00 , A61K31/78 , B01J39/20
CPC分类号： C08F2/32 , A61K9/1688 , A61K9/4891 , A61K31/78 , C08F220/06 , C08F222/1006 , C08J3/12 , C08J3/128 , C08J2300/14 , C08J2333/08
摘要： Cross-linked polyelectrolyte polymers that absorb 60-fold or more, including greater than 60-fold, greater than 70-fold, greater than 80-fold, greater than 90-fold, greater than 100-fold, or greater than 110-fold or more, of their mass in a saline solution are disclosed. Methods for preparing such polymers with enhanced saline holding capacity and methods for treating diseases, disorders or conditions involving fluid overload and/or ion imbalances by administering the polymers are disclosed.
摘要翻译：吸收60倍以上的交联聚电解质聚合物，包括大于60倍，大于70倍，大于80倍，大于90倍，大于100倍或大于110倍公开了其在盐水溶液中的质量。公开了通过施用聚合物制备具有增强的盐水容量的这种聚合物的方法和用于治疗涉及流体过载和/或离子失衡的疾病，病症或病症的方法。

5. 发明授权

US08263112B2 In vivo use of water absorbent polymers 失效
标题翻译：体内使用吸水性聚合物
公开(公告)号：US08263112B2
公开(公告)日：2012-09-11
申请号：US10840112
申请日：2004-05-06
申请人： Jaime Simon , Alan D. Strickland
发明人： Jaime Simon , Alan D. Strickland
IPC分类号： A61K9/16
CPC分类号： A61K31/78 , A61K9/00 , A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译：本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。优选的聚合物包括优选以珠粒形式提供的超吸收性丙烯酸聚合物。聚合物可以包括用于选择性地去除血液传播的废物的功能基团，例如。尿素，来自G.I. 道。

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