专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06996473B2 Method for screening and producing compound libraries 失效
公开(公告)号：US06996473B2
公开(公告)日：2006-02-07
申请号：US09989533
申请日：2001-11-21
申请人： George M. Grass , Glen D. Leesman , Daniel A. Norris , Patrick J. Sinko , John E. Wehrli
发明人： George M. Grass , Glen D. Leesman , Daniel A. Norris , Patrick J. Sinko , John E. Wehrli
IPC分类号： G06N3/00 , G06N7/60 , G06F9/455
CPC分类号： C40B30/02 , C40B50/02 , Y02A90/26
摘要： A secondary compound library produced by a method of screening a compound library or portion thereof by absorption is provided. The method includes a step (i) that screens a primary compound library or portion thereof having a plurality of test samples containing isolated compounds or isolated mixtures of compounds per test sample by generating an in vivo absorption profile for each of the test samples from initial dose data and from in vitro bioavailability data comprising permeability and solubility data for each of the test samples, wherein the absorption profile includes at least one of rate of absorption, extent of absorption, and concentration of a test sample. Step (ii) produces a secondary compound library that includes at least one compound from the primary compound library having a desired absorption profile.

2. 发明授权

US06647358B2 Pharmacokinetic-based drug design tool and method 失效
标题翻译：药代动力学药物设计工具及方法
公开(公告)号：US06647358B2
公开(公告)日：2003-11-11
申请号：US09320371
申请日：1999-05-26
申请人： George M. Grass , Glen D. Leesman , Daniel A. Norris , Patrick J. Sinko , John E. Wehrli
发明人： George M. Grass , Glen D. Leesman , Daniel A. Norris , Patrick J. Sinko , John E. Wehrli
IPC分类号： G06N300
CPC分类号： C40B30/02 , C40B50/02 , Y02A90/26
摘要： The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data. The PK tool of the invention may be provided as a computer system, as an article of manufacture in the form of a computer-readable medium, or a computer program product and the like. Subsystems and individual components of the PK tool also can be utilized and adapted in a variety of disparate applications for predicting the fate of an administered compound. The PK tool and methods of the invention can be used to screen and design compound libraries, select and design drugs, as well as predict drug efficacy in mammals from in vitro and/or in vivo data of one or more compounds of interest. The PK tool and methods of the invention also finds use in selecting, designing, and preparing drug compounds, and multi-compound drugs and drug formulations (i.e., drug delivery system) for preparation of medicaments for use in treating mammalian disorders.
摘要翻译：本发明涉及基于药代动力学的设计和选择工具（PK工具）以及用于预测目标化合物的吸收的方法。该方法利用该工具，以及可选的单独可操作的组件或子系统。 PK工具包括计算机可读组件：（1）输入/输出系统; （2）基于所选择的给药途径的具有一种或多种吸收生理屏障的哺乳动物系统的一个或多个区段的基于生理学的模拟模型; 和（3）具有微分方程求解器的模拟引擎。本发明还提供用于优化的方法以及实现最小输入需求，用于从体外或体内数据预测体内吸收以及任选的一种或多种另外的性质的生理学模拟模型。本发明的PK工具可以作为计算机系统提供，作为计算机可读介质或计算机程序产品等形式的制品。 PK工具的子系统和各个组分也可以用于各种不同的应用中，用于预测给药化合物的命运。本发明的PK工具和方法可用于筛选和设计化合物库，选择和设计药物，以及从一种或多种感兴趣的化合物的体外和/或体内数据预测哺乳动物的药物功效。本发明的PK工具和方法还可用于选择，设计和制备用于制备用于治疗哺乳动物疾病的药物的药物化合物和多重复合药物和药物制剂（即药物递送系统）。

3. 发明授权

US6146883A Packing device for transporting confluent cell monolayers 失效
标题翻译：用于输送汇合细胞单层的包装装置
公开(公告)号：US6146883A
公开(公告)日：2000-11-14
申请号：US320512
申请日：1999-05-26
申请人： George M. Grass
发明人： George M. Grass
IPC分类号： C12M1/12 , C12M3/06 , C12M3/00
CPC分类号： C12M25/02 , C12M23/38 , C12M45/22 , A61B10/0096
摘要： A disposable or recyclable device is provided for packaging and transporting ready-to-use viable cell monolayers, particularly confluent cell monolayers. The device includes a liquid impervious housing having a housing base defining an interior filled with fluid medium, a plurality of detachable and spatially separated permeable membrane inserts each having a confluent cell monolayer attached thereon, and a removable lid. The permeable membrane inserts are disposed in an interior of the housing in a spatially addressable array and the housing base is sealed by the lid so as to separate the membrane inserts from an external environment and to exclude excess air from the fluid filled interior. The device optionally includes a disposable or recyclable environmental control system for regulating chemical and/or physical conditions during transport. Cell monolayers of the device are protected from mechanical injury so that assays or other experiments requiring even growth and dense cell populations can be performed upon delivery. The device of the invention also can be utilized for packaging and transporting multiple different types of cell monolayers on a variety of solid and microporous substrata, the cells normalized to any desired stage of cell cycle and/or growth, without the need to recalibrate cell cycle or synchronize growth upon receipt.
摘要翻译：提供一次性或可回收装置用于包装和运输即用型活细胞单层，特别是汇合的细胞单层。该装置包括液体不可渗透的壳体，其具有限定充满流体介质的内部的壳体基座，多个可拆卸和空间上分离的可渗透膜插入件，每个具有汇合的细胞单层附着在其上，以及可移除的盖。可渗透膜插入物以空间可寻址的阵列设置在壳体的内部，并且壳体基座由盖子密封，以便将膜插入件与外部环境分离，并且从填充流体的内部排除多余的空气。该装置可选地包括用于在运输期间调节化学和/或物理状况的一次性或可循环使用的环境控制系统。保护装置的细胞单层免受机械损伤，从而可以在递送时进行需要均匀生长和致密细胞群体的测定或其他实验。本发明的装置还可以用于在多种固体和微孔基质上包装和运输多种不同类型的细胞单层，所述细胞被标准化到任何所需的细胞周期和/或生长阶段，而不需要重新校准细胞周期或在收到时同步增长。

4. 发明授权

US06542858B1 Pharmacokinetic-based drug design tool and method 失效
标题翻译：药代动力学药物设计工具及方法
公开(公告)号：US06542858B1
公开(公告)日：2003-04-01
申请号：US09320545
申请日：1999-05-26
申请人： George M. Grass , Glen D. Leesman , Daniel A. Norris , Patrick J. Sinko , John E. Wehrli
发明人： George M. Grass , Glen D. Leesman , Daniel A. Norris , Patrick J. Sinko , John E. Wehrli
IPC分类号： G06N300
CPC分类号： C40B30/02 , C40B50/02 , Y02A90/26
摘要： The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver: The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data. The PK tool of the invention may be provided as a computer system, as an article of manufacture in the form of a computer-readable medium, or a computer program product and the like. Subsystems and individual components of the PK tool also can be utilized and adapted in a variety of disparate applications for predicting the fate of an administered compound. The PK tool and methods of the invention can be used to screen and design compound libraries, select and design drugs, as well as predict drug efficacy in mammals from in vitro and/or in vivo data of one or more compounds of interest. The PK tool and methods of the invention also finds use in selecting, designing, and preparing drug compounds, and multi-compound drugs and drug formulations (i.e., drug delivery system) for preparation of medicaments for use in treating mammalian disorders.
摘要翻译：本发明涉及基于药代动力学的设计和选择工具（PK工具）以及用于预测目标化合物的吸收的方法。该方法利用该工具，以及可选的单独可操作的组件或子系统。 PK工具包括计算机可读组件：（1）输入/输出系统; （2）基于所选择的给药途径的具有一种或多种吸收生理屏障的哺乳动物系统的一个或多个区段的基于生理学的模拟模型; 和（3）具有微分方程求解器的模拟引擎：本发明还提供用于优化并且能够实现最小输入要求的方法，用于从体外预测体内吸收和任选的一种或多种另外的性质的基于生理学的模拟模型或体内数据。本发明的PK工具可以作为计算机系统提供，作为计算机可读介质或计算机程序产品等形式的制品。 PK工具的子系统和各个组分也可以用于各种不同的应用中并用于预测给药化合物的命运。本发明的PK工具和方法可用于筛选和设计化合物库，选择和设计药物，以及从一种或多种感兴趣的化合物的体外和/或体内数据预测哺乳动物的药物功效。本发明的PK工具和方法还可用于选择，设计和制备用于制备用于治疗哺乳动物疾病的药物的药物化合物和多重复合药物和药物制剂（即药物递送系统）。

5. 发明授权

US6156731A Polypeptide composition for oral administration 失效
标题翻译：口服多肽组合物
公开(公告)号：US6156731A
公开(公告)日：2000-12-05
申请号：US567501
申请日：1995-12-05
申请人： George M. Grass , Stephanie A. Sweetana
发明人： George M. Grass , Stephanie A. Sweetana
IPC分类号： A61K38/09 , A61K38/12 , A61K38/31 , A61K38/55 , C07K7/23 , A61K38/00 , A61K39/00 , C07K5/00 , C07K7/00
CPC分类号： C07K7/23 , A61K38/08 , A61K38/09 , A61K38/57
摘要： There is disclosed a composition containing a biologically active polypeptide selected from LHRH, an LHRH analog, somatostatin and a somatostatin analog, in a therapeutically effective amount, a membrane permeability enhancing agent, and a protease enzyme inhibitor enveloped within an enteric coating. The composition possesses enhanced bioavailability upon oral administration.
摘要翻译：公开了一种组合物，其含有治疗有效量的选自LHRH，LHRH类似物，生长抑素和生长抑素类似物的生物活性多肽，膜渗透性增强剂和包封在肠溶衣内的蛋白酶抑制剂。组合物在口服给药时具有增强的生物利用度。

6. 发明授权

US5591636A Membrane holder 失效
标题翻译：膜架
公开(公告)号：US5591636A
公开(公告)日：1997-01-07
申请号：US505921
申请日：1995-07-24
申请人： George M. Grass
发明人： George M. Grass
IPC分类号： B01D61/18 , B01D63/08 , C12M1/12 , C12M1/34
CPC分类号： B01D63/087 , B01D61/18
摘要： The invention provides a compact device of simple construction for holding a membrane in contact with a pair of fluids, one on each side of the membrane. According to the invention, the membrane holder comprises a base and an upper cap, with the membrane held between them. Fluids may be circulated over the surfaces of the membrane. Electrode ports are provided through which electrodes may be placed in proximity to the membrane for measuring or applying electrical potential across the membrane. The membrane holder comprises a base, which includes a lower plate and a center plate secured thereto, and an upper cap, which screws into the base by means of a threaded connection between them. The upper cap may be sealed to provide an enclosed volume for holding one of the fluids or the upper cap may be open to provide an open reservoir for holding the fluid. One or more membrane holders according to the invention may be placed in and held by a specially constructed heater stand. The heater stand includes internal channels for circulating a temperature controlled fluid through the heater stand to transfer heat to or from the base of the membrane holder.
摘要翻译：本发明提供了一种简单结构的紧凑的装置，用于保持膜与一对流体接触，一个在膜的每一侧。根据本发明，膜保持器包括基座和上盖，膜保持在它们之间。流体可以在膜的表面上循环。提供了电极端口，通过电极端口可以将电极放置在膜附近，用于测量或施加穿过膜的电势。膜保持器包括底座，其包括下板和固定到其上的中心板，以及上盖，其通过它们之间的螺纹连接而拧入基座。上盖可以被密封以提供用于保持流体之一的封闭容积，或者上盖可以是开放的，以提供用于保持流体的开放储存器。根据本发明的一个或多个膜保持器可以放置在特殊构造的加热器支架中并由其保持。加热器支架包括用于使受温度控制的流体循环通过加热器支架的内部通道，以将热量传递到膜支架的底部或从该支架的底部传热。

7. 发明申请

US20140286894A1 COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS AND CALCIUM AND/OR MAGNESIUM CATIONS, AND USES THEREOF 审中-公开
标题翻译：包含交联的结合聚合物和钙和/或镁合金的组合物及其用途
公开(公告)号：US20140286894A1
公开(公告)日：2014-09-25
申请号：US13978872
申请日：2012-01-10
申请人： Alan D. Strickland , George M. Grass
发明人： Alan D. Strickland , George M. Grass
IPC分类号： A61K31/78
CPC分类号： A61K31/78 , A23L33/10 , A61K9/1611 , A61K9/1635
摘要： The present disclosure relates generally to crosslinked cation-binding polymers comprising monomers containing carboxylic acid groups, wherein the polymer contains calcium and/or magnesium cations that are counterions to about 15% to about 35% of the carboxylic acid groups in the polymer. The present disclosure also relates to methods of preparation of the polymers, and compositions, formulations, and dosage forms containing the polymers, and methods of using the polymers, compositions, formulations, and/or dosage forms to treat various diseases or disorders, including those involving ion and/or fluid imbalances.
摘要翻译：本公开通常涉及包含含有羧酸基团的单体的交联阳离子结合聚合物，其中所述聚合物含有与聚合物中约15％至约35％的羧酸基团的抗衡离子的钙和/或镁阳离子。本公开还涉及制备聚合物的方法，以及含有聚合物的组合物，制剂和剂型，以及使用聚合物，组合物，制剂和/或剂型来治疗各种疾病或病症的方法，包括那些涉及离子和/或流体不平衡。

8. 发明授权

US5599688A Device and method for circulating fluid over a membrane 失效
标题翻译：在膜上循环流体的装置和方法
公开(公告)号：US5599688A
公开(公告)日：1997-02-04
申请号：US506049
申请日：1995-07-24
申请人： George M. Grass
发明人： George M. Grass
IPC分类号： B01D61/18 , B01D61/28 , B01D63/08 , C12M3/06 , C12Q1/02 , C12M1/12
CPC分类号： B01D63/087 , B01D61/18 , B01D61/28 , C12M29/04
摘要： The invention provides a compact device and simple method for circulating fluid over the surface of a membrane. The device comprises a housing that in combination with the surface of the membrane defines an enclosed volume through which the fluid is circulated. Some embodiments will include a membrane holding layer, a fluid dispersing layer, or both. The membrane holding layer has an opening through it to expose a predetermined surface area of the membrane to the fluid. The dispersing layer has a set of openings, typically slits, through the dispersing layer to disperse fluid over the surface of the membrane. Some embodiments may include electrodes for sensing or applying electrical potential to the membrane. A particularly preferred embodiment comprises a double sided device including a first housing, dispersing layer and membrane holding layer on one side of a membrane and a second housing dispersing layer and membrane holding layer on the other side of the membrane. A separate fluid may be circulated through each housing over the two sides of the membrane. In some embodiments the membrane will be provided with at least one ridge that defines at least two parallel channels in which different types of cells may be held.
摘要翻译：本发明提供了一种紧凑的装置和用于在膜的表面上循环流体的简单方法。该装置包括壳体，其与膜的表面组合限定了流体循环通过的封闭容积。一些实施方案将包括膜保持层，流体分散层或两者。膜保持层具有通过其的开口以将膜的预定表面区域暴露于流体。分散层具有通过分散层的一组开口，通常为狭缝，以将流体分散在膜的表面上。一些实施例可以包括用于感测或向膜施加电势的电极。特别优选的实施方案包括双面装置，其包括在膜的一侧上的第一壳体，分散层和膜保持层，以及在膜的另一侧上的第二壳体分散层和膜保持层。单独的流体可以在膜的两侧通过每个壳体循环。在一些实施例中，膜将设置有限定至少两个平行通道的至少一个脊，其中可以保持不同类型的细胞。

9. 发明授权

US5183760A Apparatus for in vitro determination of substances across membranes, biological tissues, or cell cultures 失效
标题翻译：用于体外测定跨膜，生物组织或细胞培养物质的装置
公开(公告)号：US5183760A
公开(公告)日：1993-02-02
申请号：US685167
申请日：1991-04-12
申请人： Stephanie A. Sweetana , George M. Grass
发明人： Stephanie A. Sweetana , George M. Grass
IPC分类号： G01N13/04
CPC分类号： G01N13/04
摘要： An apparatus for determining transport characteristics across membranes and tissue sections comprises a plurality of cell blocks, where each cell block includes a pair of half-cells which hold the membrane or tissure section therebetween. A circulation path is provided in each half-cell block for exposing a fluid to one side of the membrane or tissue section. The cell blocks are maintained linearly within a base unit including a front plate and a back plate. The front and back plates are heated to maintain the cell blocks at a desired temperature.
摘要翻译：用于确定跨越膜和组织部分的传输特性的装置包括多个单元块，其中每个单元块包括一对半单元，其将膜或组织部分保持在其间。在每个半单元块中提供循环路径，用于将流体暴露于膜或组织区段的一侧。电池块在包括前板和后板的基本单元内线性地保持。加热前板和后板以将电池块保持在所需的温度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式