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1. 发明申请

US20040178338A1 Differentiable spectral bar code methods and systems 有权
公开(公告)号：US20040178338A1
公开(公告)日：2004-09-16
申请号：US10807616
申请日：2004-03-23
申请人： QUANTUM DOT CORPORATION, A California Corporation
发明人： Stephen A. Empedocles , Joseph A. Treadway , Andrew R. Watson
IPC分类号： G01N021/29
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Devices, systems, methods, and compositions of matter can track and/or identify a library of elements, particularly for use with fluids, particulates, cells, and the like. Signals from one or more semiconductor nanocrystals may be combined to define spectral codes. Separation of signal wavelengths within dedicated wavelength ranges or windows facilitates differentiation of spectral codes, while calibration signals within the spectral codes can avoid ambiguity. Modeling based on prior testing can help derive libraries of acceptable codes.

2. 发明申请

US20020028457A1 Single target counting assays using semiconductor nanocrystals 审中-公开
标题翻译：使用半导体纳米晶体的单目标计数测定
公开(公告)号：US20020028457A1
公开(公告)日：2002-03-07
申请号：US09882193
申请日：2001-06-13
申请人： Quantum Dot Corporation
发明人： Stephen Alexander Empedocles , Andrew R. Watson , Vince Phillips , Edith Wong
IPC分类号： C12Q001/68
CPC分类号： B82Y15/00 , G01N33/588
摘要： The present invention provides assays that allow for the detection of a single copy of a target of interest. The target species is either directly or indirectly labeled with a semiconductor nanocrytal, nullquantum dot.null The bright and tunable fluorescence of the quantum dot is readily detected using methods described herein. Also provided are assays that are based on the colocalization of two or more differently colored quantum dots on a single target species, which provides superbly sensitive assays in which the decrease in assay sensitivity caused by non-specific binding of assay mixture components to the assay substrate is minimized. The assays are of use to detect target species including, but are not limited to, nucleic acids, polypeptides, small organic bioactive agents (e.g., drugs, agents of war, herbicides, pesticides, etc.) and organisms.
摘要翻译：本发明提供允许检测感兴趣的靶标的单拷贝的测定。目标物种直接或间接用半导体纳米碳“”量子点“标记。使用本文所述的方法容易地检测量子点的明亮和可调谐的荧光。还提供了基于在单个靶物种上两种或更多种不同颜色的量子点共定位的测定法，其提供了非常敏感的测定，其中由测定混合物组分非特异性结合到测定底物引起的测定灵敏度降低被最小化。该测定法用于检测靶物种，包括但不限于核酸，多肽，小有机生物活性剂（例如药物，战争剂，除草剂，农药等）和生物体。

3. 发明申请

US20050214536A1 Preparation of stable, bright luminescent nanoparticles having compositionally engineered properties 有权
标题翻译：具有组成工程化特性的稳定的，明亮的发光纳米颗粒的制备
公开(公告)号：US20050214536A1
公开(公告)日：2005-09-29
申请号：US11011827
申请日：2004-12-13
申请人： Marc Schrier , Donald Zehnder , Joseph Treadway , Joseph Bartel
发明人： Marc Schrier , Donald Zehnder , Joseph Treadway , Joseph Bartel
IPC分类号： B05D7/00 , B32B1/00 , C09C1/10 , C09K11/02 , C09K11/56 , C09K11/88
CPC分类号： H01L33/28 , B82Y30/00 , C01P2004/04 , C01P2004/64 , C09C1/10 , C09K11/02 , C09K11/565 , C09K11/883 , Y10S977/824 , Y10S977/834 , Y10T428/2991
摘要： A method is provided for preparing luminescent semiconductor nanoparticles composed of a first component X, a second component A, and a third component B, wherein X, A, and B are different, by combining B with X and A in an amount such that the molar ratio B:(A+B) is in the range of approximately 0.001 to 0.20 and the molar ratio X:(A+B) is in the range of approximately 0.5:1.0 to 2:1. The characteristics of the thus-prepared nanoparticles can be substantially similar to those of nanoparticles containing only X and B while maintaining many useful properties characteristic of nanoparticles containing only X and A. The nanoparticles so prepared can additionally exhibit emergent properties such as a peak emission energy less than that characteristic of a particle composed of XA or XB alone; this method is particularly applicable to the preparation of stable, bright nanoparticles that emit in the red to infrared regions of the electromagnetic spectrum. Luminescent semiconductor nanoparticles having exemplary properties are also provided.
摘要翻译：提供一种制备由第一组分X，第二组分A和第三组分B组成的发光半导体纳米颗粒的方法，其中X，A和B不同，通过将B与X和A组合使得其量使得摩尔比B：（A + B）在约0.001至0.20的范围内，摩尔比X：（A + B）在约0.5:1.0至2:1的范围内。如此制备的纳米颗粒的特征可以与仅含有X和B的纳米颗粒的特征基本相似，同时保持了仅含有X和A的纳米颗粒的许多有用特性。如此制备的纳米颗粒可另外显示出出现特性，例如峰值发射能小于单独由XA或XB组成的颗粒的特征; 该方法特别适用于在电磁光谱的红色至红外区域中发射的稳定的明亮纳米粒子的制备。还提供了具有示例性质的发光半导体纳米颗粒。

4. 发明申请

US20040247517A1 Flow synthesis of quantum dot nanocrystals 有权
公开(公告)号：US20040247517A1
公开(公告)日：2004-12-09
申请号：US10726716
申请日：2003-12-02
申请人： Quantum Dot Corporation, a corporation of the state of California
发明人： Donald A. Zehnder , Marcel P. Bruchez , Joseph A. Treadway , Jonathan P. Earhart
IPC分类号： C01B019/04 , H01L021/00 , C01B019/00 , C01B025/14
CPC分类号： B82Y30/00 , B82Y10/00 , C30B7/00 , C30B29/605 , Y10T117/10
摘要： Nanocrystals are synthesized with a high degree of control over reaction conditions and hence product quality in a flow-through reactor in which the reaction conditions are maintained by on-line detection of characteristic properties of the product and by adjusting the reaction conditions accordingly. The coating of nanocrystals is achieved in an analogous manner.

5. 发明申请

US20040166505A1 Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label 审中-公开
标题翻译：使用半导体纳米晶体作为可检测标记物检测样品中的分析物的方法
公开(公告)号：US20040166505A1
公开(公告)日：2004-08-26
申请号：US10631573
申请日：2003-07-30
申请人： Quantum Dot Corporation
发明人： Marcel P. Bruchez , R. Hugh Daniels , Stephen A. Empedocles , Vince E. Phillips , Edith Y. Wong , Donald A. Zehnder
IPC分类号： C12Q001/68
CPC分类号： G01N33/54346 , B82Y15/00 , G01N33/533 , G01N33/588 , G01N2458/00 , Y10S977/924
摘要： The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.
摘要翻译：公开了在各种化学和生物应用中使用半导体纳米晶体作为可检测标记。该方法用于通过使用多于一种半导体纳米晶体作为可检测标记来检测单个分析物以及多个分析物，每个分析物以不同的波长发射。

6. 发明申请

US20010034034A1 Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label 有权
公开(公告)号：US20010034034A1
公开(公告)日：2001-10-25
申请号：US09887914
申请日：2001-06-21
申请人： Quantum Dot Corporation
发明人： Marcel P. Bruchez , R. Hugh Daniels , Stephen A. Empedocles , Vince E. Phillips , Edith Y. Wong , Donald A. Zehnder
IPC分类号： C12Q001/68
CPC分类号： G01N33/54346 , B82Y15/00 , G01N33/533 , G01N33/588 , G01N2458/00 , Y10S977/924
摘要： The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.

7. 发明申请

US20050059031A1 Method for enhancing transport of semiconductor nanocrystals across biological membranes 审中-公开
标题翻译：增强生物膜上半导体纳米晶体传输的方法
公开(公告)号：US20050059031A1
公开(公告)日：2005-03-17
申请号：US10735608
申请日：2003-12-12
申请人： Marcel Bruchez , R. Daniels , Jennifer Dias , Larry Mattheakis , Hongjian Liu , Aquanette Burt , Berndt Christoffer , Danith Ly
发明人： Marcel Bruchez , R. Daniels , Jennifer Dias , Larry Mattheakis , Hongjian Liu , Aquanette Burt , Berndt Christoffer , Danith Ly
IPC分类号： C12N5/00 , C12N5/06 , G01N33/50 , G01N33/566 , G01N33/58 , C12Q1/68 , A61K33/24
CPC分类号： G01N33/588 , B82Y15/00 , C07K7/06 , G01N33/5008 , G01N33/5014 , G01N33/5076 , G01N33/566 , G01N2333/726 , G01N2500/10
摘要： Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. Kits comprising reagents for performing such methods are also provided.
摘要翻译：描述了包含与阳离子聚合物结合的半导体纳米颗粒的半导体纳米颗粒络合物。还描述了用于增强跨越生物膜的半导体纳米颗粒的输送以提供编码细胞的方法。该方法在多重设置中特别有用，其中要测定多个编码的细胞。还提供了包含用于执行这些方法的试剂的试剂盒。

8. 发明授权

US06838243B2 Methods and compositions for polynucleotide analysis using generic capture sequences 有权
标题翻译：使用通用捕获序列的多核苷酸分析的方法和组合物
公开(公告)号：US06838243B2
公开(公告)日：2005-01-04
申请号：US09846430
申请日：2001-04-30
申请人： Jennifer H. Lai , Vincent E. Phillips , Andrew R. Watson
发明人： Jennifer H. Lai , Vincent E. Phillips , Andrew R. Watson
IPC分类号： C07H21/02 , C07H21/04 , C12M1/34 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6844 , C12Q1/6834 , C12Q2565/519 , C12Q2537/143 , C12Q2531/113
摘要： Methods, compositions and articles of manufacture for assaying a sample for an amplification product from a target polynucleotide are provided. An amplification reaction is used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay the sample for the target polynucleotide. A sample suspected of containing the target polynucleotide is contacted with first and second primers to amplify the target polynucleotide; the first primer comprises a tag sequence, the complement of which is formed on the opposite strand during amplification and is referred to as a capture sequence. That opposite strand is referred to as a second primer extension product or an amplification product, and comprises a label. A capture probe is provided that is conjugated to a substrate and can bind to the capture sequence to form an amplification product detection complex. Methods of detecting the amplification product thus produced are also provided, as are amplification product assay arrays, along with methods of forming the same. The methods are particularly useful in multiplex settings where a plurality of target polynucleotides are to be assayed. Kits comprising reagents for performing such methods are also provided.
摘要翻译：提供了用于从靶多核苷酸测定扩增产物样品的方法，组合物和制品。使用扩增反应从靶多核苷酸产生扩增产物，使其可用于间接测定靶多核苷酸的样品。将怀疑含有靶多核苷酸的样品与第一和第二引物接触以扩增靶多核苷酸; 第一引物包含标签序列，其互补体在扩增过程中在相对的链上形成并被称为捕获序列。该相对链被称为第二引物延伸产物或扩增产物，并且包含标记。提供了捕获探针，其与底物缀合并且可以结合捕获序列以形成扩增产物检测复合物。还提供了检测如此生产的扩增产物的方法，扩增产物测定阵列以及其形成方法。所述方法在多重设置中特别有用，其中将测定多个靶多核苷酸。还提供了包含用于执行这些方法的试剂的试剂盒。

9. 发明申请

US20060008921A1 Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels 审中-公开
公开(公告)号：US20060008921A1
公开(公告)日：2006-01-12
申请号：US10911364
申请日：2004-08-03
申请人： Robert Daniels , Andrew Watson
发明人： Robert Daniels , Andrew Watson
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N30/02 , B01D15/3804
摘要： Immunochromatographic test strip assays which employ semiconductor nanocrystals as detectable labels are disclosed, as are methods for detecting and quantifying one or more analytes of interest in a test sample using those assays. The test strips of the present invention permit detection and quantitation of one or more analytes of interest present in a test sample suspected of containing them, by using more than one semiconductor nanocrystal as a detectable label, each of which emits exhibits a unique emission peak.

10. 发明申请

US20040197816A1 Two-dimensional spectral imaging system 审中-公开
标题翻译：二维光谱成像系统
公开(公告)号：US20040197816A1
公开(公告)日：2004-10-07
申请号：US10832635
申请日：2004-04-26
申请人： Quantum Dot Corporation
发明人： Stephen A. Empedocles , Andrew R. Watson
IPC分类号： C12Q001/68 , G01N033/53
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Improved devices, systems, and methods for sensing and/or identifying signals from within a signal detection region are well-suited for identification of spectral codes. Large numbers of independently identifiable spectral codes can be generated by quite small bodies, and a plurality of such bodies or probes may be present within a detection region. Simultaneously imaging of identifiable spectra from throughout the detection region allows the probes to be identified. As the identifiable spectra can be treated as being generated from a point source within a much larger detection field, a prism, diffractive grading, holographic transmissive grading, or the like can spectrally disperse the images of the labels across a sensor surface. A CCD can identify the relative wavelengths of signals making up the spectra. Absolute signal wavelengths may be identified by determining positions of the labels, by an internal wavelength reference within the spectra, or the like.
摘要翻译：用于感测和/或识别来自信号检测区域内的信号的改进的设备，系统和方法非常适于识别频谱代码。可以由相当小的物体产生大量可独立识别的光谱代码，并且可以在检测区域内存在多个这样的主体或探针。从整个检测区域同时对可识别的光谱进行成像，可以识别探针。由于可识别的光谱可以被视为从大得多的检测区域内的点源产生的，所以棱镜，衍射分级，全息透射分级等可以通过传感器表面对标签的图像进行光谱分散。 CCD可以识别构成光谱的信号的相对波长。绝对信号波长可以通过确定标签的位置，通过光谱内的内部波长参考等来识别。

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