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1. 发明申请

US20040115830A1 Components for nano-scale Reactor 审中-公开
标题翻译：纳米级反应器组件
公开(公告)号：US20040115830A1
公开(公告)日：2004-06-17
申请号：US10605354
申请日：2003-09-24
发明人： Igor Touzov
IPC分类号： G01N021/29
CPC分类号： B01F13/0071 , B01F5/061 , B01F13/0001 , B01F13/0008 , B01F13/0059 , B01L3/0262 , B01L3/5025 , B01L3/502746 , B01L3/502784 , B01L3/50857 , B01L2200/0652 , B01L2200/0673 , B01L2300/0896 , B01L2300/10 , B01L2400/0403 , B01L2400/0406 , B01L2400/0448 , B01L2400/046 , B82Y30/00 , Y10T436/2575
摘要： Microfluidic devices and methods for operations on micro through nano-meter scales. Methods of processing, handling and analysis of yocto-liter scale volumes. Methods and devices for single-molecule transports in milli-scale dimensions. Methods of laser propulsion of individual cells and droplets. Methods of packaging and manufacturing of micro and nanofluidic devices. Method of improving dispensing accuracy. Methods of uses and manufacturing of micro-optico-fluidic devices. Bottom up processing method. Ionic particle deflector device. Smart package device and methods for high-throughput synthesis and screening. Methods and devices for controlled refills of micro stamps. Methods and devices for insitu concentration and dilution of micro volumes of solids and liquids. Methods and devices for eliminating undesirable dry outs and evaporation of microscale volumes of fluids.
摘要翻译：微流量装置和微纳米尺度操作方法。处理，处理和分析yocto-liter量表的方法。用于单分子运输的方法和装置，以毫米尺寸。单个细胞和液滴的激光推进方法。包装和制造微纳米流体装置的方法。提高分配精度的方法。微光流体装置的使用和制造方法。自下而上处理方法。离子粒子偏转装置智能封装器件和高通量合成和筛选方法。用于微型邮票的控制重新填充的方法和装置。用于固体和液体的微量体积浓缩和稀释的方法和装置。消除不需要的干燥和微量体积流体的蒸发的方法和装置。

2. 发明申请

US20030175159A1 Regulation of a wash column in a melt crystallization process 有权
标题翻译：在熔融结晶过程中调节洗涤柱
公开(公告)号：US20030175159A1
公开(公告)日：2003-09-18
申请号：US10333721
申请日：2003-01-24
发明人： Jorg Heilek , Bernd Eck , Dieter Baumann
IPC分类号： B01D009/00 , B32B027/04 , G01N021/29
CPC分类号： C07C51/43 , B01D9/0013 , B01D9/0036 , B01D9/004 , B01D9/0045 , C07C51/47 , C07C57/04
摘要： The present invention relates to the use of an optical line detector for regulating the position of the wash front and/or of the build-up front of the crystal bed of a wash column in a melt crystallization process and a corresponding regulation method. The line detector, for example a CCD camera or a linear array of reflection probes, is arranged in such a way that optical properties of the crystal bed can be detected continuously in a region running parallel to the longitudinal axis of the wash column, this region covering the desired setpoint position of the wash front or of the build-up front.
摘要翻译：本发明涉及一种光线路检测器，用于在熔融结晶过程和相应的调节方法中调节洗涤柱的洗涤前沿和/或洗涤塔的积层前沿的位置。线检测器，例如CCD照相机或反射探针的线性阵列被布置成使得可以在平行于洗涤塔的纵向轴线的区域中连续检测晶体床的光学性质，该区域覆盖洗涤前部或堆积前部的所需设定点位置。

3. 发明申请

US20040197927A1 Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US20040197927A1
公开(公告)日：2004-10-07
申请号：US10829777
申请日：2004-04-22
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N021/29
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如生物样品的尿素，例如，例如尿。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

4. 发明申请

US20040178338A1 Differentiable spectral bar code methods and systems 有权
公开(公告)号：US20040178338A1
公开(公告)日：2004-09-16
申请号：US10807616
申请日：2004-03-23
申请人： QUANTUM DOT CORPORATION, A California Corporation
发明人： Stephen A. Empedocles , Joseph A. Treadway , Andrew R. Watson
IPC分类号： G01N021/29
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Devices, systems, methods, and compositions of matter can track and/or identify a library of elements, particularly for use with fluids, particulates, cells, and the like. Signals from one or more semiconductor nanocrystals may be combined to define spectral codes. Separation of signal wavelengths within dedicated wavelength ranges or windows facilitates differentiation of spectral codes, while calibration signals within the spectral codes can avoid ambiguity. Modeling based on prior testing can help derive libraries of acceptable codes.

5. 发明申请

US20040146431A1 Silicon on insulator resonator sensors and modulators and method of operating the same 有权
标题翻译：绝缘体上的绝缘体传感器和调制器及其操作方法
公开(公告)号：US20040146431A1
公开(公告)日：2004-07-29
申请号：US10729242
申请日：2003-12-04
发明人： Axel Scherer , Alex Dickinson
IPC分类号： G01N021/29
CPC分类号： G01N21/7746 , G01N2021/7783
摘要： A microsensor for sensing a substance comprises a substrate, a source of light, an optical microresonator or semiconductor optical ring microresonator fabricated in the substrate exposed to the substance to allow an interaction between the microresonator and substance, a waveguide coupling the source of light to the optical microresonator, and a detector coupled to the microresonator to measure the resonant frequency of the microresonator, the absorption loss of whispering gallery modes in the microresonator or the quality factor of the microresonator, which are sensitive to interaction of the substance with the optical microresonator. A polymer coating disposed on the microresonator is reactive with the substance. The microsensor may comprise a plurality of microresonators corresponding to a plurality of different resonant frequencies to generate an absorption spectrum of the substance.
摘要翻译：用于感测物质的微传感器包括衬底，光源，在暴露于物质的衬底中制造的光学微谐振器或半导体光环微谐振器，以允许微谐振器和物质之间的相互作用，将光源耦合到光学微谐振器和耦合到微谐振器的检测器，以测量微谐振器的谐振频率，微谐振器中的语音库模式的吸收损失或微谐振器的质量因子，其对物质与光学微谐振器的相互作用敏感。设置在微谐振器上的聚合物涂层与物质反应。微传感器可以包括对应于多个不同谐振频率的多个微谐振器以产生该物质的吸收光谱。

6. 发明申请

US20040247484A1 Multi-way LED-based surface reflectance sensor and spectrophotometer 失效
标题翻译：多路LED基表面反射传感器和分光光度计
公开(公告)号：US20040247484A1
公开(公告)日：2004-12-09
申请号：US10802501
申请日：2004-03-17
发明人： William S. Yerazunis
IPC分类号： G01N021/29
CPC分类号： G01N21/78
摘要： A light sensor circuit based on direct connection of LEDs to I/O pins of a microcontroller. The LEDs are reverse biased and the parasitic junction capacitance is charged in an output mode. Then, the I/O pins placed into an high-impedance input mode. The time for the capacitance to be discharged by photoconduction caused by light incident on the LEDs is inversely proportional to an intensity of the incident light, and can be directly measured as the time required for the I/O pin to transition from fully-charged (5 volts) to a logic threshold level (1.7 volts). By using multiple LEDs, multiplexed between emissive and sensing modes, a wide variety of sensors can be constructed, particularly, when the LEDs emit light at different wavelength.
摘要翻译：一种基于将LED直接连接到微控制器的I / O引脚的光传感器电路。 LED反向偏置，寄生结电容在输出模式下充电。然后，I / O引脚置于高阻输入模式。由入射到LED上的光引起的电容放电的时间与入射光的强度成反比，并且可以直接测量为I / O引脚从完全充电过渡所需的时间（ 5伏特）到逻辑阈值电平（1.7伏特）。通过使用在发射和感测模式之间复用的多个LED，可以构建各种各样的传感器，特别是当LED发射不同波长的光时。

7. 发明申请

US20040071596A1 Optically and fluidically enhanced in vitro dianostic test chamber 有权
标题翻译：光学和流体增强的体外二维测试室
公开(公告)号：US20040071596A1
公开(公告)日：2004-04-15
申请号：US10221527
申请日：2003-03-05
发明人： Dianna Innerst , Adonis Kassinos , C Benjamin Wooley , Brett Wilmarth , William J Sell , Emi Zychlinsky , Donald Marino , Sandy Yamada , Renee Ryan , Karen Ding , Michael Zatzke
IPC分类号： G01N021/29
CPC分类号： B01L3/5025 , B01L2300/087 , B01L2400/0406 , G01N21/0303 , G01N21/253 , G01N21/76 , G01N2021/6482 , Y10T436/11
摘要： An enclosed chamber is used in a system for screening of a liquid specimen through binding assays. The enclosed chamber includes an inlet, an outlet, and a plurality of discrete reactant containing wells communicated by a common reagent flow path between the inlet and the outlet. A transparent member or coverslip defines on an inside thereof the plurality of wells. Each well has a bottom for receiving an allergent/antigen/reactant, which emits light upon reacting. The coverslip can optionally define at least one lens at each well. A bottom encloses the plurality of wells and defines between the inlet and the outlet a common reagent flow path between the inlet and the outlet. This bottom defines for each of the plurality of wells a flow-diverting member. An opaque partition is disclosed for surrounding the individual lenses and generally isolating the light path from each well.
摘要翻译：在通过结合测定筛选液体样品的系统中使用封闭室。封闭室包括入口，出口和多个离散的反应物容纳孔，其通过入口和出口之间的公共试剂流路连通。透明构件或盖玻片在其内部限定多个孔。每个井都有一个底部，用于接收过敏原/抗原/反应物，反应会发光。盖玻片可以可选地在每个孔处限定至少一个透镜。底部包围多个孔并且在入口和出口之间限定入口和出口之间的公共试剂流动路径。该底部为多个井中的每一个限定了一个流动分流构件。公开了一种不透明分隔件，用于围绕各个透镜，并且通常将光路与每个孔隔离。

8. 发明申请

US20030176453A1 Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor 失效
标题翻译： 9-硝基喜树碱多晶型物的组成和配方及其使用方法
公开(公告)号：US20030176453A1
公开(公告)日：2003-09-18
申请号：US10080530
申请日：2002-02-21
发明人： Sanjeev Redkar , Ashok Gore
IPC分类号： B32B005/02 , G01N021/29 , G01N021/41 , G01N021/47 , B32B027/04 , B32B027/12 , C07D491/02 , A61K031/4745
CPC分类号： C07D491/22
摘要： A polymorphic form of 9-nitrocamptothecin is provided, the polymorph being characterizable as having, by differential scanning calorimetry, no observable endotherm and an exotherm at between 273.6 and 275.6null C., and a solution NMR spectrum with multiplets at 1.7 and 3.7 ppm shifts.
摘要翻译：提供了9-硝基喜树碱的多晶形式，通过差示扫描量热法可以观察到多晶型物在273.6和275.6℃之间没有可观察到的吸热和放热，以及具有1.7和3.7ppm偏移的多重峰的溶液NMR谱。

9. 发明申请

US20030156986A1 Tuning compensation for automated NMR analysis 有权
标题翻译：调整自动化NMR分析的补偿
公开(公告)号：US20030156986A1
公开(公告)日：2003-08-21
申请号：US10061027
申请日：2002-01-29
发明人： Jason W. Cosman
IPC分类号： G01N021/29 , G01V003/00 , G01N021/41 , G01N021/47 , B32B005/02 , B32B027/04 , B32B027/12
CPC分类号： G01R33/30 , G01R33/3628
摘要： Test tubes with different dielectric properties are used for holding different samples/solvents within a nuclear magnetic resonance (NMR) probe of an NMR spectrometer. The test tube dielectric properties are chosen such that the overall capacitance seen by the NMR probe coils remains constant as different samples and test tubes are inserted into the probe. Samples having different solvents introduce substantially equal frequency shifts into the measurement circuitry. The disclosed systems and methods facilitate automated NMR measurements, and do not require specialized electronic or moving mechanical components for tuning compensation.
摘要翻译：不同介电特性的试管用于在NMR光谱仪的核磁共振（NMR）探针中保持不同的样品/溶剂。选择试管介电性质，使得由于不同的样品和试管被插入到探针中，NMR探针线圈所看到的整体电容保持恒定。具有不同溶剂的样品将基本相等的频移引入测量电路。所公开的系统和方法便于自动化NMR测量，并且不需要用于调谐补偿的专门的电子或移动机械部件。

10. 发明申请

US20030090654A1 Method and apparatus for evaluating degree of characteristic of a substance 审中-公开
标题翻译：用于评估物质特性程度的方法和装置
公开(公告)号：US20030090654A1
公开(公告)日：2003-05-15
申请号：US10270002
申请日：2002-10-15
发明人： Roland Bazin , Eric Doublet
IPC分类号： B32B005/02 , G01N021/29
CPC分类号： G06T13/80
摘要： Systems and methods may facilitate evaluation of at least one degree of at least one characteristic of a substance. The systems and methods may generate at least one sequence of images expressing at least one characteristic varying in at least one degree, and receive information reflecting at least one identification of at least one image from the at least one sequence. The at least one image may correspond to at least one degree of at least one characteristic of a substance.
摘要翻译：系统和方法可有助于评估物质的至少一个至少一种特征。系统和方法可以产生至少一个表现至少一个在至少一个程度上变化的特征的图像序列，并且从至少一个序列接收反映至少一个图像的至少一个标识的信息。所述至少一个图像可以对应于物质的至少一个至少一个特征。

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