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1. 发明申请

US20220280654A1 IMPROVED CONJUGATION LINKERS 有权
公开(公告)号：US20220280654A1
公开(公告)日：2022-09-08
申请号：US17601575
申请日：2020-04-03
申请人： ProLynx LLC
发明人： Gary W. ASHLEY , Brian HEARN , Shaun FONTAINE , Eric L. SCHNEIDER
IPC分类号： A61K47/69 , A61K38/12 , A61K38/26 , A61K38/28 , A61K47/54 , A61K47/60
摘要： Provided are β-eliminative linkers suitable for the conjugation of small molecule, peptide, and protein and compounds comprising the linkers.

2. 发明授权

US11179470B2 Hydrogels with biodegradable crosslinking 有权
公开(公告)号：US11179470B2
公开(公告)日：2021-11-23
申请号：US16248537
申请日：2019-01-15
申请人： ProLynx LLC
发明人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
IPC分类号： A61K47/34
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

3. 发明授权

US09649385B2 Hydrogels with biodegradable crosslinking 有权
公开(公告)号：US09649385B2
公开(公告)日：2017-05-16
申请号：US14343819
申请日：2012-09-07
申请人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
发明人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
IPC分类号： A61K47/30 , A61K47/34 , A61K47/48 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08
CPC分类号： A61K47/34 , A61K47/60 , A61K47/6903 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08 , C08G2650/30
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.

4. 发明公开

US20240181397A1 HIGH-THROUGHPUT MICROEMULSIFICATION MEMBRANE 审中-公开
公开(公告)号：US20240181397A1
公开(公告)日：2024-06-06
申请号：US18282976
申请日：2022-03-18
申请人： ProLynx LLC
发明人： Jeffrey C. HENISE , Brian YAO
IPC分类号： B01D63/06 , B01D69/04 , B01D71/52
CPC分类号： B01D63/06 , B01D69/04 , B01D71/5222 , B01D2325/38
摘要： The present disclosure is related to high-throughput membranes for preparation of microdroplet emulsions and microparticle suspensions and apparatus and systems comprising the same. Also provided are methods of preparing microdroplet emulsions and microparticle suspensions.

5. 发明公开

US20230321286A1 PROTOCOL FOR MINIMIZING TOXICITY OF COMBINATION DOSAGES AND IMAGING AGENT FOR VERIFICATION 审中-公开
公开(公告)号：US20230321286A1
公开(公告)日：2023-10-12
申请号：US18118650
申请日：2023-03-07
申请人： ProLynx LLC
发明人： Brian HEARN , Daniel V. SANTI , Shaun FONTAINE , Gary W. ASHLEY
IPC分类号： A61K51/06 , A61P35/00 , A61K47/60 , A61K9/51 , A61K31/4745 , A61K45/06 , B82Y5/00
CPC分类号： A61K51/065 , A61K9/51 , A61K31/4745 , A61K47/60 , A61P35/00 , A61K45/06 , B82Y5/00
摘要： Advantage is taken of the enhanced permeability and retention effect (EPR effect) to shield normal tissue from exposure to combinations of chemotherapeutic agents. Imaging agents that exhibit the enhanced permeability and retention (EPR) effect in solid tumors are useful in mimicking the behavior of chemotherapeutic or other drugs for treatment of said tumor conjugated to carriers of similar size and shape to the carriers of said imaging agents.

6. 发明授权

US11454861B2 Hydrogels with biodegradable crosslinking 有权
公开(公告)号：US11454861B2
公开(公告)日：2022-09-27
申请号：US16557243
申请日：2019-08-30
申请人： ProLynx LLC
发明人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
IPC分类号： A61K47/61 , G02F1/361 , A61K47/69 , A61K47/60 , A61L15/44 , A61L15/60 , A61L15/64 , A61L27/54 , A61L27/58 , C07C317/18 , C08J3/075 , C09B23/01 , A61K47/50 , A61K9/06 , A61K47/30 , A61K47/34 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

7. 发明授权

US10086049B2 Conjugates of somatostatin analogues 有权
公开(公告)号：US10086049B2
公开(公告)日：2018-10-02
申请号：US15030353
申请日：2014-10-22
申请人： ProLynx LLC
发明人： Eric L. Schneider , Brian Hearn , Gary W. Ashley , Daniel V. Santi
IPC分类号： A61K38/31 , A61K47/48 , A61K47/60 , A61K47/69
摘要： Conjugates of carriers and hydrogels for controlling the biological half-life of somatostatin and its analogs are disclosed.

8. 发明授权

US08946405B2 Controlled release from solid supports 有权
标题翻译：从固体支持物控制释放
公开(公告)号：US08946405B2
公开(公告)日：2015-02-03
申请号：US13696300
申请日：2011-05-05
申请人： Gary Ashley , Daniel V. Santi
发明人： Gary Ashley , Daniel V. Santi
IPC分类号： A61K47/48 , A61K49/00 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16
CPC分类号： A61K47/48215 , A61K47/58 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61K47/6953 , A61K47/6957 , A61K49/0043 , A61K49/0054 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/258
摘要： The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.
摘要翻译：本发明涉及用于医疗应用中的固体支持物，其提供药物如肽，核酸和小分子的受控释放。这些药物通过通过控制β消除释放药物或前药的连接共价偶联到固体支持物上。

9. 发明申请

US20140288190A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING 有权
标题翻译： HYDROGELS可生物降解的交织
公开(公告)号：US20140288190A1
公开(公告)日：2014-09-25
申请号：US14343819
申请日：2012-09-07
申请人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
发明人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
IPC分类号： A61K47/34 , A61L27/52 , A61L27/18 , A61L15/26 , C07C271/08
CPC分类号： A61K47/34 , A61K47/60 , A61K47/6903 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08 , C08G2650/30
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.
摘要翻译：描述了在适当的pH和温度条件下通过切割消除反应的交联化合物降解的水凝胶。水凝胶可用于递送各种试剂，例如药物。本发明提供在暴露于生理条件时以非酶过程降解成较小的可溶组分的水凝胶以及制备它们的方法。水凝胶由在生理条件下进行消除反应的交联剂制备，从而从水凝胶的骨架切割交联剂。本发明还涉及交联剂本身和形成本发明的水凝胶的中间体。根据本发明的方法制备的可生物降解的水凝胶可用于各种领域，包括生物医学工程，吸收材料和用于药物递送的载体。

10. 发明申请

US20230135347A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING 有权
公开(公告)号：US20230135347A1
公开(公告)日：2023-05-04
申请号：US17930381
申请日：2022-09-07
申请人： ProLynx LLC
发明人： Gary W. ASHLEY , Daniel V. SANTI , Jeffrey C. HENISE
IPC分类号： A61K47/34 , A61K47/61 , A61K47/69 , A61K47/60 , A61L15/44 , A61L15/60 , A61L15/64 , A61L27/54 , A61L27/58 , C07C317/18 , C08J3/075 , G02F1/361 , C09B23/01 , A61K47/50 , A61K9/06 , A61K47/30 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

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