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1. 发明授权

US5489439A Granular pharmaceutical formulations 失效
标题翻译：颗粒药物制剂
公开(公告)号：US5489439A
公开(公告)日：1996-02-06
申请号：US203471
申请日：1993-10-19
申请人： Tarlok S. Bola
发明人： Tarlok S. Bola
IPC分类号： A61K9/16 , A61K9/20 , A61K9/50 , A61K9/14
CPC分类号： A61K9/5078 , A61K9/1676 , A61K9/2081 , A61K9/2095
摘要： A process for the preparation of a granule comprising a pharmaceutical which process comprises contacting a particulate, spray-dried substrate and a particulate pharmaceutical to obtain a particle comprising a substrate core carrying an adsorbed pharmaceutical and contacting the particle with a particulate pharmaceutical and a melted or thermally softened pharmaceutically acceptable excipient which is solid at room temperature to obtain, after cooling to solidify or harden the excipient, a granule comprising a spray-dried substrate core carrying pharmaceutically acceptable excipient and pharmaceutical.
摘要翻译：一种用于制备包含药物的颗粒的方法，该方法包括使颗粒状，喷雾干燥的基质和颗粒状药物接触，以获得包含载有吸附药物的底物核心并使颗粒与颗粒药物接触的颗粒，以及熔化或热软化的药学上可接受的赋形剂，其在室温下是固体，以在冷却固化或硬化赋形剂之后获得包含带有药学上可接受的赋形剂和药物的喷雾干燥的底物核心的颗粒。

2. 发明授权

US5419909A Packaging for liquid products 失效
公开(公告)号：US5419909A
公开(公告)日：1995-05-30
申请号：US166120
申请日：1993-12-13
申请人： David B. Edwards , William J. McCarthy , Alan J. Aldred , Anthony D. Jackman
发明人： David B. Edwards , William J. McCarthy , Alan J. Aldred , Anthony D. Jackman
IPC分类号： A01N25/34 , B29C65/00 , B29C65/76 , B65D65/46 , B65D77/06 , A01N25/00
CPC分类号： B65D77/06 , A01N25/34 , B29C65/76 , B29C66/112 , B29C66/131 , B29C66/242 , B29C66/24244 , B29C66/53461 , B29C66/723 , B29C66/73793 , B65D65/46 , B29C66/71 , B29C66/72321 , B29C66/72328 , B29C66/7234 , B29L2031/7128 , B29L2031/7132 , Y10T428/1345
摘要： A package for a liquid, to be dissolved or dispersed in water, contained in an envelope of water soluble or dispersible material, the envelope having a flexible wall and a water soluble or water dispersible heat seal.

3. 发明授权

US5394990A Shock protection packaging for liquids 失效
标题翻译：液体防震包装
公开(公告)号：US5394990A
公开(公告)日：1995-03-07
申请号：US179878
申请日：1994-01-11
申请人： David B. Edwards , William J. McCarthy , Alan J. Aldred , Anthony D. Jackman
发明人： David B. Edwards , William J. McCarthy , Alan J. Aldred , Anthony D. Jackman
IPC分类号： A01N25/34 , B29C65/00 , B29C65/76 , B65D65/46 , B65D77/06 , B65D85/82 , B65D81/02
CPC分类号： B65D77/06 , A01N25/34 , B29C65/76 , B29C66/112 , B29C66/131 , B29C66/242 , B29C66/53461 , B29C66/723 , B29C66/73793 , B65D65/46 , B29C66/24221 , B29C66/24244 , B29C66/24245 , B29C66/71 , B29C66/72321 , B29C66/72328 , B29C66/7234 , B29L2031/7128 , B29L2031/7132
摘要： A package for liquid concentrate comprises an outer container (1) and an inner water-soluble or water-dispersible envelope (3) containing the concentrate. The container (1) has a shock absorbing base formed by joining a base-part (9) to the main body-part (8) with an S-shaped or corrugated strip (10), thus providing a flexible connection allowing relative movement between the base-part (9) and main body-part (8). The container (1) is sealed with a removable foil lid (2) and is tapered towards its bottom and has a wide neck to allow easy exit of the envelope (3).
摘要翻译：用于液体浓缩物的包装包括外容器（1）和含有浓缩物的内部水溶性或水分散性外壳（3）。容器（1）具有通过将基部（9）与主体部分（8）与S形或波纹条（10）接合而形成的减震基座，从而提供柔性连接，基部（9）和主体部（8）。容器（1）用可移除的箔盖（2）密封，并且朝向其底部逐渐变细并且具有宽的颈部以容易地离开信封（3）。

4. 发明授权

US4963575A Derivatives of N-phenylpyrazoles, compositions and use 失效
标题翻译： N-苯基吡唑的衍生物，组成和用途
公开(公告)号：US4963575A
公开(公告)日：1990-10-16
申请号：US379982
申请日：1989-07-14
申请人： Ian G. Buntain , Leslie R. Hatton , David W. Hawkins , Christopher J. Pearson , David A. Roberts
发明人： Ian G. Buntain , Leslie R. Hatton , David W. Hawkins , Christopher J. Pearson , David A. Roberts
IPC分类号： C07D231/18 , A01N43/56 , A01N43/647 , A01N47/02 , A61K31/415 , A61K31/445 , A61K31/495 , A61P33/10 , C07D231/14 , C07D231/38 , C07D231/44 , C07D401/00 , C07D403/04 , C07D521/00
CPC分类号： C07D231/38 , C07D231/12 , C07D233/56 , C07D249/08 , C07D403/04
摘要： An N-phenylpyrazole derivative of the formula: ##STR1## wherein R.sup.1 represents cyano, nitro or halogen;R.sup.2 represents a group R.sup.5 SO.sub.2, R.sup.5 SO, or R.sup.5 S in which R.sup.5 represents alkyl, alkenyl or alkynyl unsubstituted or substituted by halogen;R.sup.3 represents azido or hydrazino, or pyrrol-1-yl, pyrazol-1-yl, imidazol-1-yl, 1,2,4-triazol-4-yl, 1,2,4-triazol-1-yl, 1,2,3-triazol-1-yl, 1,2,3-triazol-2-yl, piperidino, pyrrolidino, morpholino or N-alkylpiperazino, which may be substituted by alkyl or phenyl; andR.sup.4 represents phenyl substituted in the 2-position by fluorine, chlorine, bromine or iodine;in the 4-position by alkyl or alkoxy unsubstituted or substituted by halogen, or fluorine, chlorine, bromine or iodine; and unsubstituted or substituted in the 6-position by fluorine, chlorine, bromine or iodine and pesticidally acceptable acid addition salts thereof possess arthropodicidal, nematocidal, anthelmintic and anti-protozoal activity.

5. 发明授权

US3922160A Isothiazole derivatives 失效
标题翻译：异噻唑衍生物
公开(公告)号：US3922160A
公开(公告)日：1975-11-25
申请号：US41719273
申请日：1973-11-19
申请人： MAY & BAKER LTD
发明人： BUTTIMORE DAVID
IPC分类号： A01N47/36 , C07D275/02 , A01N9/12
CPC分类号： C07D275/02 , A01N47/36
摘要： Isothiazole derivatives with an alkyl substituent in the 3position, an alkoxycarbonyl or cyano group in the 4-position; and a grouping -NHCONR3R4 in the 5-position, R3 being hydrogen and R4 being alkyl or alkenyl or cyclopropyl when the 4-position substituent is alkoxycarbonyl, or R3 and R4 each represent methyl or ethyl when the 4-position substituent is cyano, possess herbicidal properties against dicotyledonous and monocotyledonous weeds.
摘要翻译： 3-位烷基取代基的异噻唑衍生物，4-位的烷氧基羰基或氰基; 并且当4-位取代基为烷氧基羰基时，R 3为氢，R 4为烷基或链烯基或环丙基，或者当4-位取代基为氰基时，R 3和R 4各自表示甲基或乙基，具有5-位的-NHCONR 3 R 4基团对双子叶和单子叶杂草的除草性能。

6. 发明授权

US3884942A Process for the preparation of cyclopentane 失效
标题翻译：环戊烷的制备方法
公开(公告)号：US3884942A
公开(公告)日：1975-05-20
申请号：US34346073
申请日：1973-03-21
申请人： MAY & BAKER LTD
发明人： CATON MICHAEL PETER LEAR , COFFEE EDWARD CHARLES JOHN , WATKINS GORDON LEONARD
IPC分类号： C07C405/00 , C07D1/22 , C07C69/74 , C07D1/20
CPC分类号： C07C405/00 , C07C2601/08
摘要： Cyclopentane derivatives of the prostaglandin type of the formula:

(WHEREIN R1 represents hydrogen or lower alkyl, R2 represents alkyl of 1 to 10 carbon atoms, the symbols R3 are the same and represent hydrogen, lower alkyl, lower alkenyl, phenyl(lower)alkyl or lower alkanoyl, R4 represents a carboxy or alkoxycarbonyl group, or an amido group unsubstituted or substituted on the nitrogen atom, X represents vinylene, ethylene, epoxyethylene or cyclopropylene, and n represents an integer of 5 to 8), which possess pharmacological properties in particular the production of hypotension, bronchodilation, inhibition of gastric acid secretion and stimulation of uterine contraction are prepared by a new six-stage process involving initially the reaction of an enamine of a cyclopentanone with an aldehyde to form a 2-hydroxyalkyl-2-cyclopenten-1-one, reacting the cyclopentenone with a source of hydrogen cyanide to form a 2hydroxyalkyl-3-oxocyclopentane-carbonitrile, reducing the carbonitrile to a 3-hydroxy-2-hydroxyalkylcyclopentanecarbaldehyde, reacting the carbaldehyde with an alkanoylmethylenephosphorane to convert the formyl group to CH CH-CO-R2, oxidising the terminal hydroxymethyl group in the 2position substituent to carboxy and the ring hydroxy group to oxo, and reducing the two oxo groups in the resulting cyclopentanonealkanoic acid to yield a 2-hydroxy-5-(3hydroxyalkenyl)cyclopentyl-alkanoic acid, and optionally converting the product into another compound of the foregoing formula:
摘要翻译：环戊烷衍生物的前列腺素类型为：

7. 发明授权

US3865948A Treatment of helminth infections with substituted phenyl-thioureas 失效
标题翻译：用取代的苯基硫脲处理蠕虫感染
公开(公告)号：US3865948A
公开(公告)日：1975-02-11
申请号：US15340871
申请日：1971-06-15
申请人： MAY & BAKER LTD
发明人： EICHLER DAVID ANTHONY , LUCAS JOSHUA MICHAEL STUART , MARTIN GEORGE CHRISTOPHER JAME , PARNELL EDGAR WILLIAM , THOMPSON GARTH MOLESDALE
IPC分类号： C07C335/28 , C07D295/14 , A61K27/00
CPC分类号： C07D295/14 , C07C335/28
摘要： Benzene derivatives of the formula:

WHEREIN R represents an aliphatic hydrocarbon group optionally substituted by halogen or alkoxy, R1 represents hydrogen or methyl, and R2 represents hydrogen, halogen, alkyl, alkanoylamino optionally substituted by cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonylamino, alkanoyl, benzoyl or N-methylmethanesulphonylamino, possess anthelmintic and anti-viral activity. New compounds within that formula also possess fungicidal properties.
摘要翻译：苯衍生物的结构式如下：

8. 发明授权

US3857943A New phenothiazine derivatives in the treatment of spasticity of muscles 失效
标题翻译：新的苯并噻唑衍生物在治疗肌肉的弹性方面
公开(公告)号：US3857943A
公开(公告)日：1974-12-31
申请号：US25933972
申请日：1972-06-02
申请人： MAY & BAKER LTD
发明人： AMIN S , JONES D , MAXWELL D
IPC分类号： A61K31/54 , C07D279/18 , C07D279/28 , A61K27/00
CPC分类号： C07D279/18 , A61K31/54 , C07D279/28
摘要： WHEREIN R1 represents alkyl of 1 through 4 carbon atoms, or cycloalkyl of 3 through 6 carbon atoms, and R2 and R3 represent alkyl of 1 through 4 carbon atoms, for example 10-(3dimethylamino-2-methylpropyl)-2-valerylphenothiazine, and their oximes, are useful in the treatment of spasticity without inducing significant undesirable sedative sideeffects.
The new phenothiazine derivatives of the formula:
摘要翻译：新的吩噻嗪衍生物具有下式：

9. 发明授权

US3627553A Pigments 失效
公开(公告)号：US3627553A
公开(公告)日：1971-12-14
申请号：US3627553D
申请日：1968-09-06
申请人： MAY & BAKER LTD
发明人： CLARK DAVID WILLIAM HAROLD , THRELFALL TERENCE LESLIE
IPC分类号： C09C1/00 , C09C1/36
CPC分类号： C09C1/0024 , C01P2004/86 , C09C1/0015 , C09C1/0051 , C09C2200/1004 , C09C2220/106 , Y10T428/2991
摘要： THE INVENTION PROVIDES NOVEL PIGMENTS COMPRISING A PLURALITY OF HIGH RREFRACTIVE INDEX LAYERS OF TITANIUM OR ZIRCONIUM DIOXIDE OR OF AN ALKALINE EARTH METAL TITANATE SEPARATED BY ONE OR MORE LAYERS OF LOWER REFRACTIVE INDEX OF AN ORGANIC FILM-FORMING SUBSTANCE OR OF AN INORGANIC OXIDE OR HYDROXIDE. THESE PIGMENTS ARE MADE BY SUCCESSIVELY DEPOSITING THE VARIOUS LAYERS ON A SUPPORT, STRIPPING THE PRODUCT FROM THE SUPPORT AND COMMINUTING IT.

10. 发明授权

US3592814A Phenazine derivatives 失效
公开(公告)号：US3592814A
公开(公告)日：1971-07-13
申请号：US3592814D
申请日：1968-09-12
申请人： MAY & BAKER LTD
发明人： BARRY VINCENT C , BYRNE JOAN , BELTON JAMES G , CONALTY MICHAEL L
IPC分类号： C07D241/44 , C07D241/46 , C07D487/04 , C07D51/80
CPC分类号： C07D487/04 , C07D241/44 , C07D241/46 , Y10S514/924
摘要： PHENAZINE DERIVATIVES OF THE FORMULA:

2-(R1-NH-),3-(C6H5-HN-),R2,10-R3-2,1O-DIHYDROPHENAZINE

WHEREIN (A) R1 REPRESENTS ISOPROPYL OR PHENYL, R2 REPRESENTS METHOXY ON POSITION 8 OF THE PHENAZINE NUCLEUS, AND R3 REPRESENTS PHENYL, OR (B) R1 REPRESENTS ISOPROPYL OR CYCLOHEXYL, R2 REPRESENTS CHLORINE ON POSITION 8 OF THE PHENAZINE NUCLEUS, AND R3 REPRESENTS PHENYL, OR (C) R1 REPRESENTS PHENYL, R2 REPRESENTS METHOXY ON POSITION 7 OF THE PHENAZINE NUCLEUS, AND R3 REPRESENTS PHENYL OR P-CHLOROPHENYL, ARE ACTIVE AGAINST TUBERCULOSIS AND LEPROSY.

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