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1. 发明申请

US20140241998A1 BODY CAVITY FOAMS 有权
标题翻译：身体健康
公开(公告)号：US20140241998A1
公开(公告)日：2014-08-28
申请号：US14272551
申请日：2014-05-08
申请人： Foamix Ltd.
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61K9/46
CPC分类号： A61K47/46 , A01N25/16 , A61K8/046 , A61K8/60 , A61K9/0007 , A61K9/0014 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K9/122 , A61K31/137 , A61K31/351 , A61K31/4164 , A61K31/4174 , A61K31/522 , A61K31/535 , A61K31/567 , A61K31/573 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/212 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/34 , A61K47/38 , A61K2800/75 , A61Q7/00 , A61Q7/02 , A61Q17/02 , A61Q17/04 , A61Q19/02 , A61Q19/04
摘要： The invention relates to an alcohol-free cosmetic or therapeutic foam carrier comprising water, a hydrophobic organic carrier, a foam adjuvant agent, a surface-active agent and a gelling agent. The cosmetic or therapeutic foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble therapeutic and cosmetic agents.
摘要翻译：本发明涉及包含水，疏水性有机载体，泡沫助剂，表面活性剂和胶凝剂的无醇化妆品或治疗泡沫载体。化妆品或治疗泡沫载体不含脂肪醇，使其不刺激和不干燥。无醇泡沫载体适合包含水溶性和油溶性治疗和美容剂。

2. 发明申请

US20140219929A1 OLEAGINOUS PHARMACEUTICAL AND COSMETIC FOAM 有权
标题翻译： OLEAGOOUS PHARMACEUTICAL和COSMETIC FOAM
公开(公告)号：US20140219929A1
公开(公告)日：2014-08-07
申请号：US14246533
申请日：2014-04-07
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12 , A61K31/351 , A61K31/436 , A61K38/13 , A61K31/522 , A61K31/573 , A61K31/496
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种选自疏水性溶剂，硅油，软化剂，助溶剂及其混合物的溶剂，其中溶剂的浓度为约70重量％至约96.5重量％总组合物，至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

3. 发明申请

US20140182585A1 AEROSOL CONTAINER FOR FOAMABLE COMPOSITIONS 审中-公开
标题翻译：可燃组合物的气溶胶容器
公开(公告)号：US20140182585A1
公开(公告)日：2014-07-03
申请号：US14200126
申请日：2014-03-07
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61M11/04 , A61K31/41
CPC分类号： A61M11/04 , A01N25/16 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/496 , A61K47/14 , A61K47/26 , A61K47/36 , A61K47/38
摘要： A composition and therapeutic kit provide a therapeutic azole with increased solubility. The kit includes an aerosol packaging assembly containing a container accommodating a pressurized product and an outlet capable of releasing the pressurized product as a foam. The pressurized product includes a foamable composition including: i. a therapeutic azole, wherein the solubility of the azole in the composition before foaming is less than the solubility of the azole in the composition after foaming; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a co-solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：组合物和治疗试剂盒提供治疗性唑，溶解度增加。该试剂盒包括含有容纳加压产品的容器和能够释放作为泡沫的加压产品的出口的气溶胶包装组件。加压产品包括可发泡组合物，其包括：i。治疗性唑，其中唑在发泡前在组合物中的溶解度小于发泡后唑类在组合物中的溶解度; ii。选自浓度为约2重量％至约50重量％的至少一种选自疏水性有机载体，共溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; v。水和vi。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。

4. 发明申请

US20140121188A1 COMPOSITIONS FOR THE IMPROVED TREATMENT OF ACNE AND RELATED DISORDERS 审中-公开
标题翻译：改善治疗ACNE和相关疾病的组合物
公开(公告)号：US20140121188A1
公开(公告)日：2014-05-01
申请号：US14147376
申请日：2014-01-03
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Elana Gazal , Rita Keynan , Meir Eini , David Schuz
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , A61K9/0014 , A61K9/06 , A61K9/122 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/44
摘要： Methods of treatment and dosage regimes using hydrophobic gel or foam composition comprising a tetracycline antibiotic in treating or alleviating a disorder including, acne, acne related symptoms, a tetracycline antibiotic responsive acne related disorder, skin disorder caused by a bacteria, and a tetracycline antibiotic responsive sebaceous gland disease, P. acne bacteria associated disorders and other superficial infections, including skin infections wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin.
摘要翻译：使用包含四环素抗生素的疏水性凝胶或泡沫组合物在治疗或缓解包括痤疮，痤疮相关症状，四环素抗生素反应性痤疮相关病症，由细菌引起的皮肤病，以及四环素抗生素反应性皮肤腺病，P.痤疮细菌相关疾病和其他浅表感染，包括皮肤感染，其中泡沫组合物或凝胶局部施用于具有病症的受试者的靶区域，并且其中所述目标区域包括皮肤区域。

5. 发明申请

US20140086848A1 FOAMABLE COMPOSITIONS AND METHODS FOR DISORDERS OF THE SKIN OR MUCOSAL SURFACES 审中-公开
标题翻译：可泡沫组合物和方法用于皮肤或粘膜表面的疾病
公开(公告)号：US20140086848A1
公开(公告)日：2014-03-27
申请号：US14032872
申请日：2013-09-20
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Meir Eini , Ella Zlatkis
IPC分类号： A61K8/04 , A61Q15/00 , A61Q19/00 , A61Q19/02 , A01N25/16 , A61K9/12 , A61Q19/08
CPC分类号： A61K8/046 , A01N25/16 , A61K8/731 , A61K9/0014 , A61K9/12 , A61K9/122 , A61K2800/30 , A61Q7/00 , A61Q15/00 , A61Q17/02 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： The composition of the present invention is geared towards treating hyperhidrosis or any condition involving and/or promoting excessive sweating, typically involving the whole body, include hyperthyroidism or similar endocrine disorders; endocrine treatment for prostatic cancer or other types of malignant disorder; severe psychiatric disorders; obesity and menopause. The foamable composition of the present invention is suitable for treating palmar hyperhidrosis; axillary hyperhidrosis; plantar hyperhidrosis; hyperhidrosis of the trunk and/or the thighs; and facial hyperhidrosis; and any combination of them consisting of a therapeutic foamable composition including: an active agent, suitable for the treatment or prevention of hyperhidrosis.
摘要翻译：本发明的组合物用于治疗多汗症或涉及和/或促进过度出汗（通常涉及全身）的任何病症，包括甲状腺机能亢进或类似的内分泌紊乱; 内分泌治疗前列腺癌或其他类型的恶性疾病; 精神障碍严重; 肥胖和绝经。本发明的可发泡组合物适用于治疗手掌多汗症; 腋窝多汗; 足底多汗症; 树干和/或大腿多汗; 和面部多汗症; 以及它们由治疗性可发泡组合物组成的任何组合物，其包含：适于治疗或预防多汗症的活性剂。

6. 发明授权

US08636982B2 Wax foamable vehicle and pharmaceutical compositions thereof 有权
标题翻译：蜡可发泡车辆及其药物组合物
公开(公告)号：US08636982B2
公开(公告)日：2014-01-28
申请号：US12187840
申请日：2008-08-07
申请人： Dov Tamarkin , Rita Keynan , David Schuz , Tal Berman
发明人： Dov Tamarkin , Rita Keynan , David Schuz , Tal Berman
IPC分类号： A61K9/12
CPC分类号： A61K9/124 , A61K8/046 , A61K8/31 , A61K8/342 , A61K8/361 , A61K8/4993 , A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/1075 , A61K9/122 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61Q5/006 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
摘要翻译：提供了包含至少一种蜡，蜡质物质，对应物或衍生物，稳定剂，水和推进剂的独特的可发泡车辆或载体。在一些实施方案中，蜡是液体蜡。在一些实施方案中，蜡包括固体蜡和液体蜡。组合物基本上不含晶体。选择组分以提供基本上耐老化和相分离的组合物和/或可以基本上溶解和/或稳定活性成分。还提供了具有潜在增强的皮肤递送及其用途的药物和化妆品组合物。

7. 发明授权

US08618081B2 Compositions, gels and foams with rheology modulators and uses thereof 有权
标题翻译：具有流变调制剂的组合物，凝胶和泡沫及其用途
公开(公告)号：US08618081B2
公开(公告)日：2013-12-31
申请号：US13100724
申请日：2011-05-04
申请人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Irakliy Papiashvili
发明人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Irakliy Papiashvili
IPC分类号： A61K31/65 , A61P31/04 , A61P17/00 , A61P17/06 , A61P17/10
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
摘要翻译：本公开一般涉及用于化妆品或药物应用的组合物。组合物包括载体和流变学调节剂。

8. 发明申请

US20130183251A1 PENETRATING PHARMACEUTICAL FOAM 有权
公开(公告)号：US20130183251A1
公开(公告)日：2013-07-18
申请号：US13784085
申请日：2013-03-04
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12 , A61K45/06 , A61K45/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/06 , A61K8/062 , A61K8/31 , A61K8/365 , A61K8/42 , A61K9/0014 , A61K9/107 , A61K9/12 , A61K9/124 , A61K31/167 , A61K31/17 , A61K31/19 , A61K31/196 , A61K31/496 , A61K31/497 , A61K45/00 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K47/36 , A61K47/38 , A61K47/44 , A61K2800/75 , A61Q17/02 , A61Q19/00 , A61Q19/08 , A61Q19/10 , Y10S514/945 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

9. 发明申请

US20130164225A1 FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：可燃性车辆及其药用组合物
公开(公告)号：US20130164225A1
公开(公告)日：2013-06-27
申请号：US13708284
申请日：2012-12-07
申请人： FOAMIX LTD.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12
CPC分类号： A61K47/10 , A01N25/16 , A61K8/046 , A61K9/0014 , A61K9/0034 , A61K9/12 , A61K9/122 , A61K47/14 , A61K47/38 , A61Q19/00 , Y10S514/945 , A01N53/00
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

10. 发明授权

US08362091B2 Foamable vehicle and pharmaceutical compositions thereof 有权
标题翻译：可发泡车辆及其药物组合物
公开(公告)号：US08362091B2
公开(公告)日：2013-01-29
申请号：US12767511
申请日：2010-04-26
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A01N25/16 , A61K47/00 , A61K47/30 , A61K47/32
CPC分类号： A61K47/10 , A01N25/16 , A61K8/046 , A61K9/0014 , A61K9/0034 , A61K9/12 , A61K9/122 , A61K47/14 , A61K47/38 , A61Q19/00 , Y10S514/945 , A01N53/00
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

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