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1. 发明授权

US09492412B2 Penetrating pharmaceutical foam 有权
公开(公告)号：US09492412B2
公开(公告)日：2016-11-15
申请号：US14258700
申请日：2014-04-22
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12 , A61K9/00 , A61K8/02 , A61K31/19 , A61K31/17 , A61K31/196 , A61K8/04 , A61K8/06 , A61K8/31 , A61K9/107 , A61Q17/02 , A61Q19/00 , A61Q19/10 , A61K45/00 , A61K45/06 , A61K8/42 , A61K31/167 , A61K31/497 , A01N25/16 , A61K8/365 , A61Q19/08
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/06 , A61K8/062 , A61K8/31 , A61K8/365 , A61K8/42 , A61K9/0014 , A61K9/107 , A61K9/12 , A61K9/124 , A61K31/167 , A61K31/17 , A61K31/19 , A61K31/196 , A61K31/496 , A61K31/497 , A61K45/00 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K47/36 , A61K47/38 , A61K47/44 , A61K2800/75 , A61Q17/02 , A61Q19/00 , A61Q19/08 , A61Q19/10 , Y10S514/945 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

2. 发明授权

US09161916B2 Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof 有权
标题翻译：载体，制剂，用于制备外用不稳定活性剂的方法及其用途
公开(公告)号：US09161916B2
公开(公告)日：2015-10-20
申请号：US13732024
申请日：2012-12-31
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Helena Shifrin
IPC分类号： A61K9/12 , A61K9/00 , A61K8/04 , A61K31/65 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.
摘要翻译：本公开教导了用于局部施用四环素抗生素的独特制剂，其中四环素抗生素保持稳定。

3. 发明申请

US20130189196A1 Foamable Composition 审中-公开
标题翻译：可发泡组合物
公开(公告)号：US20130189196A1
公开(公告)日：2013-07-25
申请号：US13795831
申请日：2013-03-12
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K8/04 , A61Q19/08 , A61Q19/02 , A61Q19/00 , A61K9/12 , A61Q17/04
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/731 , A61K8/736 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61K2800/30 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： A foamable composition, includes (1) about 6% to about 70% by weight of at least one organic carrier; (2) about 0.1% to about 5% by weight of at least one surface-active agent; (3) about 0.01% to about 5% by weight of at least one film forming agent; (4) water; and (5) about 3% to about 25% by weight of the total composition of at least one liquefied or compressed gas propellant. The composition is substantially alcohol free and is used in treating, alleviating or preventing a disorder.
摘要翻译：可发泡组合物包括（1）约6重量％至约70重量％的至少一种有机载体; （2）约0.1重量％至约5重量％的至少一种表面活性剂; （3）约0.01重量％至约5重量％的至少一种成膜剂; （4）水; 和（5）总组合物重量的约3％至约25％的至少一种液化或压缩气体推进剂。该组合物基本上不含醇，并用于治疗，缓解或预防病症。

4. 发明申请

US20130295022A1 Moisturizing Foam Containing Lanolin 审中-公开
标题翻译：含羊毛脂的保湿泡沫
公开(公告)号：US20130295022A1
公开(公告)日：2013-11-07
申请号：US13911470
申请日：2013-06-06
申请人： Foamix Ltd.
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61K9/12 , A61K45/06 , A61K31/575
CPC分类号： A61K45/06 , A61K8/046 , A61K8/062 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K31/575 , A61Q19/00
摘要： The present invention provides a highly tolerable, hydrating lanolin containing foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable composition includes lanolin, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明提供了一种用于给予皮肤，身体表面，体腔或粘膜表面的高度耐受的水合羊毛脂含可发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜。可发泡组合物包括羊毛脂，表面活性剂，约0.01％至约5％重量的至少一种聚合物添加剂，其选自生物粘附剂，胶凝剂，成膜剂和相变剂，水和液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

5. 发明申请

US20130189195A1 DICARBOXYLIC ACID FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：二羧酸可燃性汽车及其药用组合物
公开(公告)号：US20130189195A1
公开(公告)日：2013-07-25
申请号：US13796860
申请日：2013-03-12
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/362 , A61K8/37 , A61K8/4993 , A61K8/86 , A61K9/0014 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
摘要翻译：本发明教导了一种可发泡药物载体，其包含选自二羧酸和二羧酸酯的有益剂; 选自由至少一种表面活性剂组成的组的稳定剂; 至少一种聚合物及其混合物; 选自水，亲水溶剂，疏水溶剂，有效溶剂，极性溶剂，硅氧烷，软化剂及其混合物的溶剂，其中选择有益剂，稳定剂和溶剂以提供组合物其基本上耐老化和相分离，或基本上稳定其它活性成分。本发明还涉及另外含有液化烃气体推进剂的可发泡组合物。

6. 发明申请

US20130189193A1 Foamable Vehicle and Pharmaceutical Compositions Thereof 有权
标题翻译：可发泡车辆及其药物组合物
公开(公告)号：US20130189193A1
公开(公告)日：2013-07-25
申请号：US13793893
申请日：2013-03-11
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K47/10
CPC分类号： A61K47/10 , A01N25/16 , A61K8/046 , A61K9/0014 , A61K9/0034 , A61K9/12 , A61K9/122 , A61K47/14 , A61K47/38 , A61Q19/00 , Y10S514/945 , A01N53/00
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

7. 发明申请

US20140241998A1 BODY CAVITY FOAMS 有权
标题翻译：身体健康
公开(公告)号：US20140241998A1
公开(公告)日：2014-08-28
申请号：US14272551
申请日：2014-05-08
申请人： Foamix Ltd.
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61K9/46
CPC分类号： A61K47/46 , A01N25/16 , A61K8/046 , A61K8/60 , A61K9/0007 , A61K9/0014 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K9/122 , A61K31/137 , A61K31/351 , A61K31/4164 , A61K31/4174 , A61K31/522 , A61K31/535 , A61K31/567 , A61K31/573 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/212 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/34 , A61K47/38 , A61K2800/75 , A61Q7/00 , A61Q7/02 , A61Q17/02 , A61Q17/04 , A61Q19/02 , A61Q19/04
摘要： The invention relates to an alcohol-free cosmetic or therapeutic foam carrier comprising water, a hydrophobic organic carrier, a foam adjuvant agent, a surface-active agent and a gelling agent. The cosmetic or therapeutic foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble therapeutic and cosmetic agents.
摘要翻译：本发明涉及包含水，疏水性有机载体，泡沫助剂，表面活性剂和胶凝剂的无醇化妆品或治疗泡沫载体。化妆品或治疗泡沫载体不含脂肪醇，使其不刺激和不干燥。无醇泡沫载体适合包含水溶性和油溶性治疗和美容剂。

8. 发明申请

US20140219929A1 OLEAGINOUS PHARMACEUTICAL AND COSMETIC FOAM 有权
标题翻译： OLEAGOOUS PHARMACEUTICAL和COSMETIC FOAM
公开(公告)号：US20140219929A1
公开(公告)日：2014-08-07
申请号：US14246533
申请日：2014-04-07
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12 , A61K31/351 , A61K31/436 , A61K38/13 , A61K31/522 , A61K31/573 , A61K31/496
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种选自疏水性溶剂，硅油，软化剂，助溶剂及其混合物的溶剂，其中溶剂的浓度为约70重量％至约96.5重量％总组合物，至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

9. 发明申请

US20140182585A1 AEROSOL CONTAINER FOR FOAMABLE COMPOSITIONS 审中-公开
标题翻译：可燃组合物的气溶胶容器
公开(公告)号：US20140182585A1
公开(公告)日：2014-07-03
申请号：US14200126
申请日：2014-03-07
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61M11/04 , A61K31/41
CPC分类号： A61M11/04 , A01N25/16 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/496 , A61K47/14 , A61K47/26 , A61K47/36 , A61K47/38
摘要： A composition and therapeutic kit provide a therapeutic azole with increased solubility. The kit includes an aerosol packaging assembly containing a container accommodating a pressurized product and an outlet capable of releasing the pressurized product as a foam. The pressurized product includes a foamable composition including: i. a therapeutic azole, wherein the solubility of the azole in the composition before foaming is less than the solubility of the azole in the composition after foaming; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a co-solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：组合物和治疗试剂盒提供治疗性唑，溶解度增加。该试剂盒包括含有容纳加压产品的容器和能够释放作为泡沫的加压产品的出口的气溶胶包装组件。加压产品包括可发泡组合物，其包括：i。治疗性唑，其中唑在发泡前在组合物中的溶解度小于发泡后唑类在组合物中的溶解度; ii。选自浓度为约2重量％至约50重量％的至少一种选自疏水性有机载体，共溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; v。水和vi。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。

10. 发明申请

US20130183251A1 PENETRATING PHARMACEUTICAL FOAM 有权
公开(公告)号：US20130183251A1
公开(公告)日：2013-07-18
申请号：US13784085
申请日：2013-03-04
申请人： Foamix Ltd.
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12 , A61K45/06 , A61K45/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/06 , A61K8/062 , A61K8/31 , A61K8/365 , A61K8/42 , A61K9/0014 , A61K9/107 , A61K9/12 , A61K9/124 , A61K31/167 , A61K31/17 , A61K31/19 , A61K31/196 , A61K31/496 , A61K31/497 , A61K45/00 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K47/36 , A61K47/38 , A61K47/44 , A61K2800/75 , A61Q17/02 , A61Q19/00 , A61Q19/08 , A61Q19/10 , Y10S514/945 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

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