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1. 发明授权

US10117812B2 Foamable composition combining a polar solvent and a hydrophobic carrier 有权
公开(公告)号：US10117812B2
公开(公告)日：2018-11-06
申请号：US11488989
申请日：2006-07-19
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K8/04 , A61K47/14 , A61K47/22 , A61K8/49 , A61K8/06 , A61K8/31 , A61K8/37 , A61K9/00 , A61K9/107 , A61K9/12 , A61Q19/00 , A01N25/16 , A61K8/96 , A61K35/04 , A61K47/06 , A61K47/10 , A61K8/73 , A61K8/81 , A61K47/32 , A61K47/38 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition.The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

2. 发明授权

US09622947B2 Foamable composition combining a polar solvent and a hydrophobic carrier 有权
公开(公告)号：US09622947B2
公开(公告)日：2017-04-18
申请号：US12350854
申请日：2009-01-08
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K8/04 , A61K8/96 , A61K47/14 , A61K47/06 , A61K47/10 , A61K9/00 , A61K35/04 , A61K9/12 , A61K8/37 , A61K8/31 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A01N25/16
CPC分类号： A61K8/046 , A01N25/16 , A61K8/062 , A61K8/31 , A61K8/37 , A61K8/375 , A61K8/4973 , A61K8/731 , A61K8/8176 , A61K8/965 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K35/04 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/38 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition.The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

3. 发明授权

US08362091B2 Foamable vehicle and pharmaceutical compositions thereof 有权
标题翻译：可发泡车辆及其药物组合物
公开(公告)号：US08362091B2
公开(公告)日：2013-01-29
申请号：US12767511
申请日：2010-04-26
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A01N25/16 , A61K47/00 , A61K47/30 , A61K47/32
CPC分类号： A61K47/10 , A01N25/16 , A61K8/046 , A61K9/0014 , A61K9/0034 , A61K9/12 , A61K9/122 , A61K47/14 , A61K47/38 , A61Q19/00 , Y10S514/945 , A01N53/00
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

4. 发明授权

US07820145B2 Oleaginous pharmaceutical and cosmetic foam 有权
标题翻译：油性药用和化妆品泡沫
公开(公告)号：US07820145B2
公开(公告)日：2010-10-26
申请号：US10835505
申请日：2004-04-28
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种选自疏水性溶剂，硅油，软化剂，共溶剂及其混合物的溶剂，其中溶剂的浓度为约70重量％至约96.5重量％总组合物，至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

5. 发明申请

US20070020213A1 Foamable composition combining a polar solvent and a hydrophobic carrier 审中-公开
标题翻译：组合极性溶剂和疏水性载体的可发泡组合物
公开(公告)号：US20070020213A1
公开(公告)日：2007-01-25
申请号：US11488989
申请日：2006-07-19
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K8/00
CPC分类号： A61K8/046 , A01N25/16 , A61K8/062 , A61K8/31 , A61K8/37 , A61K8/375 , A61K8/4973 , A61K8/731 , A61K8/8176 , A61K8/965 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K35/04 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/38 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.
摘要翻译：本发明涉及可发泡载体或化妆品或药物组合物，其包含：（1）浓度为10重量％至70重量％的有机载体，其中所述有机载体同时包含：（i）至少一种疏水性有机物载体，和（ii）至少一种极性溶剂; （2）至少一种表面活性剂; （3）水; 和（4）至少一种浓度为总组合物重量的3％至25％的液化或压缩气体推进剂。本发明还提供了治疗，减轻或预防哺乳动物受试者病症的方法，包括将上述组合物施用于受影响的靶位点。

6. 发明授权

US08343945B2 Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof 有权
公开(公告)号：US08343945B2
公开(公告)日：2013-01-01
申请号：US12795164
申请日：2010-06-07
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Helena Shifrin
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Helena Shifrin
IPC分类号： A61K31/16 , A61K31/65 , A61K9/12
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.

7. 发明授权

US08114385B2 Oleaginous pharmaceutical and cosmetic foam 有权
标题翻译：油性药用和化妆品泡沫
公开(公告)号：US08114385B2
公开(公告)日：2012-02-14
申请号：US11645444
申请日：2006-12-26
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes a polyethylene glycol (PEG) or PEG derivative and mixtures thereof, wherein the PEG or PEG derivative is present at a concentration of about 70% to about 96.5% by weight of the total composition; a surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; and a therapeutically effective amount of at least one active agent.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括聚乙二醇（PEG）或PEG衍生物及其混合物，其中PEG或PEG衍生物以总组合物重量的约70％至约96.5％的浓度存在; 浓度为总组合物重量的约0.1％至小于约10％的表面活性剂; 和治疗有效量的至少一种活性剂。

8. 发明申请

US20100310476A1 CARRIERS, FORMULATIONS, METHODS FOR FORMULATING UNSTABLE ACTIVE AGENTS FOR EXTERNAL APPLICATION AND USES THEREOF 有权
标题翻译：载体，制剂，用于制备不稳定的活性剂用于外部应用的方法及其用途
公开(公告)号：US20100310476A1
公开(公告)日：2010-12-09
申请号：US12795164
申请日：2010-06-07
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Helena Shifrin
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Helena Shifrin
IPC分类号： A61K9/12 , A61P31/00 , A61P31/04 , A61P41/00
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.
摘要翻译：本公开教导了用于局部施用四环素抗生素的独特制剂，其中四环素抗生素保持稳定。

9. 发明申请

US20080050317A1 Oleaginous pharmaceutical and cosmetic foam 审中-公开
标题翻译：油性药用和化妆品泡沫
公开(公告)号：US20080050317A1
公开(公告)日：2008-02-28
申请号：US11894668
申请日：2007-08-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12 , A61P27/14 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61Q17/04 , A61Q19/02 , A61Q19/04 , A61Q19/06 , A61Q19/08 , B65D83/14
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种选自疏水性溶剂，硅油，软化剂，共溶剂及其混合物的溶剂，其中溶剂的浓度为约70重量％至约96.5重量％总组合物，至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

10. 发明申请

US20070280891A1 Oleaginous pharmaceutical and cosmetic foam 有权
标题翻译：油性药用和化妆品泡沫
公开(公告)号：US20070280891A1
公开(公告)日：2007-12-06
申请号：US11645444
申请日：2006-12-26
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12 , A61K8/04 , A61P17/00 , A61P17/06 , A61Q99/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes a polyethylene glycol (PEG) or PEG derivative and mixtures thereof, wherein the PEG or PEG derivative is present at a concentration of about 70% to about 96.5% by weight of the total composition; a surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; and a therapeutically effective amount of at least one active agent.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括聚乙二醇（PEG）或PEG衍生物及其混合物，其中PEG或PEG衍生物以总组合物重量的约70％至约96.5％的浓度存在; 浓度为总组合物重量的约0.1％至小于约10％的表面活性剂; 和治疗有效量的至少一种活性剂。

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