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1. 发明公开

US20230278076A1 WASHING AN ELEMENT IN A CHROMATOGRAPHY SYSTEM 审中-公开
公开(公告)号：US20230278076A1
公开(公告)日：2023-09-07
申请号：US18173972
申请日：2023-02-24
申请人： DIONEX SOFTRON GMBH
发明人： Runsheng Zheng , Benjamin Eggart , Anne Morgenstern , Martin Samonig
IPC分类号： B08B3/04
CPC分类号： B08B3/04 , G01N2030/121
摘要： A method of washing an element in a chromatography system, wherein the method includes performing an element rinse step. The element rinse step includes providing a first washing liquid with a first composition towards the element, and providing a second washing liquid with a second composition towards the element, wherein the second composition is different from the first composition.

2. 发明公开

US20230243791A1 Chromatography Operational Status Analysis 审中-公开
公开(公告)号：US20230243791A1
公开(公告)日：2023-08-03
申请号：US18151162
申请日：2023-01-06
申请人： Dionex Softron GmbH
发明人： Stefan Andreas Seitz , Christoph Strobl , Bastian Engelmann
IPC分类号： G01N30/88 , G01N30/32 , G01N30/16
CPC分类号： G01N30/88 , G01N30/32 , G01N30/16 , G01N2030/027
摘要： Disclosed herein are chromatography support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, the systems and methods disclosed herein may enable the automatic identification of error or fault conditions in a chromatography system.

3. 发明申请

US20230033664A1 Operation of a Fluidic System 有权
公开(公告)号：US20230033664A1
公开(公告)日：2023-02-02
申请号：US17747734
申请日：2022-05-18
申请人： Dionex Softron GmbH
发明人： Martin Rendl , Anne Morgenstern
IPC分类号： G01N30/32
摘要： The present invention relates to a method of operating a fluidic system, wherein the fluidic system comprises a fluidic resistive element, wherein the method comprises a defined volume flow step, wherein in the defined volume flow step, a defined volume of a fluid is forced to flow out of the fluidic resistive element, wherein the defined volume is the fluid flowing out of the fluidic resistive element in a first time interval defined by a time tstart and a time tend, wherein the defined volume flow step comprises: at the time tstart, switching the system from a first operating state to a second operating state, to bring a pressure in the fluidic resistive element from a first pressure value to a second pressure value, the second pressure value exceeding the first pressure value, and at a time treduce, which is after the time tstart and not later than the time tend, switching the system to a third operating state to bring the pressure in the fluidic resistive element to a third pressure value, the third pressure value being below the second pressure value. The present invention also relates to a corresponding system and a corresponding computer program product.

4. 发明申请

US20210215648A1 Capillary Tube Connection 有权
公开(公告)号：US20210215648A1
公开(公告)日：2021-07-15
申请号：US17218018
申请日：2021-03-30
申请人： DIONEX SOFTRON GMBH
发明人： Thomas WACHINGER , Daniel BUERGER
IPC分类号： G01N30/60 , F16L19/02
摘要： A plug for connecting capillaries includes at least one capillary tube, at least one sealing, and at least one pressure piece. The capillary tube includes a first inner diameter and an open end section. The sealing includes a second inner diameter, a first end section and a shape adapted to seal the open end section of the capillary tube when connected. The pressure piece is adapted to exert at least axial pressure and/or force to at least a part of the sealing. The pressure piece is also adapted to host the first end section of the sealing in abutment with the open end section of the capillary tube so that the capillary tube and the sealing are aligned.

5. 发明申请

US20210102922A1 Method of introducing a sample into a separation column and corresponding system 有权
公开(公告)号：US20210102922A1
公开(公告)日：2021-04-08
申请号：US17072997
申请日：2020-10-16
申请人： Dionex Softron GmbH
发明人： Christoph HOLLNAGEL , Hermann HOCHGRAEBER , Thomas WACHINGER
IPC分类号： G01N30/20 , G01N30/14
摘要： A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.

6. 发明授权

US10962394B2 Measurement of fluid flow 有权
公开(公告)号：US10962394B2
公开(公告)日：2021-03-30
申请号：US16114523
申请日：2018-08-28
申请人： DIONEX SOFTRON GMBH
发明人： Gervin Ruegenberg , Martin Rendl
IPC分类号： G01F1/696 , G01F25/00 , G01F1/684 , G01F1/688 , G01F1/69 , G01N30/30 , G01N30/36 , G01N30/02 , G01N30/32
摘要： A method for measuring a flow of a fluid in a tube includes heating the fluid in the tube with a heating element. A first signal is measured with a first temperature sensing element at a first location. A second signal is measured with a second temperature sensing element at a second location. At least one temperature signal is calculated based on the first signal and the second signal. The at least one temperature signal includes a difference temperature signal and a sum temperature signal. The difference temperature signal is calculated based on a difference between the second signal and the first signal. The sum temperature signal is calculated based on a sum of the second signal and the first signal. The flow is derived based on the difference temperature signal, the sum temperature signal, or a combination thereof.

7. 发明授权

US10816115B2 Capillary connection system 有权
公开(公告)号：US10816115B2
公开(公告)日：2020-10-27
申请号：US15621516
申请日：2017-06-13
申请人： DIONEX SOFTRON GMBH
发明人： Daniel Buerger , Adolf Satzinger
IPC分类号： B01D15/22 , F16L19/00 , F16L21/02 , F16L21/04 , G01N30/02 , G01N30/60
摘要： A socket unit for a capillary connection system, especially for use in HPLC applications, includes a housing with a housing outer surface and a housing inner surface that define a housing axial cavity. The socket unit also includes a socket connecting mechanism adapted to engage with a corresponding plug connecting mechanism of a plug unit to connect the plug unit and the socket unit together, wherein the socket connecting mechanism is adapted for a predetermined number of discrete connection states between the socket unit and the plug unit.

8. 发明授权

US10067102B2 Plug unit and connection system for connecting capillaries, particularly for high-performance liquid chromatography 有权
公开(公告)号：US10067102B2
公开(公告)日：2018-09-04
申请号：US14792215
申请日：2015-07-06
申请人： DIONEX SOFTRON GMBH
发明人： Hermann Hochgraeber , Adolf Satzinger , Daniel Buerger , Andreas Unger
IPC分类号： F16L25/00 , G01N30/60 , F16L37/02 , G01N30/02
摘要： A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.

9. 发明授权

US09448210B2 Plug unit and connection system for connecting capillary tubes, especially for high-performance liquid chromatography 有权
公开(公告)号：US09448210B2
公开(公告)日：2016-09-20
申请号：US14938029
申请日：2015-11-11
申请人： DIONEX SOFTRON GMBH
发明人： Hermann Hochgraeber , Adolf Satzinger , Daniel Buerger , Andreas Unger
IPC分类号： F16L17/00 , G01N30/60 , F16L25/00 , F16L37/02 , G01N30/02
CPC分类号： G01N30/6026 , F16L25/0018 , F16L37/02 , G01N2030/027
摘要： A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.

10. 发明授权

US09400265B2 Switching valve for high-performance liquid chromatography 有权
标题翻译：高效液相色谱切换阀
公开(公告)号：US09400265B2
公开(公告)日：2016-07-26
申请号：US13961637
申请日：2013-08-07
申请人： Joachim Wiechers , Hermann Hochgraeber
发明人： Joachim Wiechers , Hermann Hochgraeber
IPC分类号： F16K25/00 , G01N30/26 , G01N30/22 , F16K3/10 , F16K11/074 , G01N30/20
CPC分类号： G01N30/26 , F16K3/10 , F16K11/0743 , G01N30/22 , G01N2030/202
摘要： A switching valve is described that has a stator which is arranged in a housing and which has multiple connection ports. The switching valve also has a rotatable rotor which is arranged in the housing and which, in predetermined switching positions defined by associated angular positions, interacts with the stator for the fluidic connection or separation of predetermined connection ports. The rotor is rotatably mounted, and acted on with a predefined pressing force in the direction of the stator, by means of a bearing and pressing device arranged in the housing. The bearing and pressing device has a spring device which exerts a load on the rotor or on an element that is capable of performing a wobbling movement.
摘要翻译：描述了具有布置在壳体中并且具有多个连接端口的定子的切换阀。切换阀还具有可转动的转子，该转子布置在壳体中，并且在由关联的角位置限定的预定切换位置中与定子相互作用以进行流体连接或预定连接端口的分离。转子通过设置在壳体中的轴承和加压装置可旋转地安装并以预定的按压力在定子的方向上作用。轴承和加压装置具有弹簧装置，该弹簧装置对转子或能够进行摆动运动的元件施加负载。

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