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1. 发明申请

US20050154690A1 Document knowledge management apparatus and method 审中-公开
标题翻译：文件知识管理手段和方法
公开(公告)号：US20050154690A1
公开(公告)日：2005-07-14
申请号：US10503387
申请日：2003-02-04
申请人： Kiyoshi Nitta , Hirofumi Doi , Yasuhiro Kikuchi , Hisayuki Horai
发明人： Kiyoshi Nitta , Hirofumi Doi , Yasuhiro Kikuchi , Hisayuki Horai
IPC分类号： G06F17/22 , G06F17/30 , G06F17/24 , G06F17/21 , G06F15/00 , G06F17/00 , G06N5/02 , G06F17/27
CPC分类号： G06F17/2217 , G06F16/30
摘要： In the present invention, a textual document is syntactically analyzed and knowledge is constructed from a single word or plural words. The knowledge is then marked, from the broken down knowledge (represented by the underscores in FIG. 1) or from a part-of-speech, as a related object (node) or a relation (edge) (represented by ‘n’ or ‘e’ shown in FIG. 1). In other words, in the present invention a textual document is treated as knowledge constructed from a single word or plural words. The knowledge extracted from the textual document is structured to form a knowledge structure (such as a graph structure constituted from nodes and edges). At least one link can be established between each of the knowledge structure elements and a semantically closest concept entry in a hierarchical concept dictionary.
摘要翻译：在本发明中，文本文档被语法分析，并从单个单词或多个单词构成知识。然后将知识从分解的知识（由图1中的下划线表示）或从词性部分标记为相关对象（节点）或关系（边缘）（由“n”或 'e'）。换句话说，在本发明中，文本文档被视为从单个单词或多个单词构成的知识。从文本文档中提取的知识被构造成形成知识结构（例如由节点和边缘构成的图形结构）。可以在每个知识结构元素和分层概念词典中的语义上最接近的概念条目之间建立至少一个链接。

2. 发明申请

US20070259805A1 Remedy For Melanoma 审中-公开
标题翻译：治疗黑色素瘤
公开(公告)号：US20070259805A1
公开(公告)日：2007-11-08
申请号：US11658652
申请日：2005-08-03
申请人： Hirofumi Doi , Seiji Saito , Kenji Murakami , Yukako Kurita
发明人： Hirofumi Doi , Seiji Saito , Kenji Murakami , Yukako Kurita
IPC分类号： A61K38/00 , C12N5/06 , G01N33/53
CPC分类号： G01N33/566
摘要： The present invention was aimed at reducing transcription activating activity of MITF-M to inhibit production of BCL2 gene product and thereby to allow treatment and/or prevention of melanoma The present invention provided a method of inhibiting production of BCL2 gene product and an agent for inhibiting the same, which inhibit binding of protein selected from a group consisting of HLF, ELK4 and CLOCK to MITF-M, a method of inducing cell death of melanoma cells, an agent for inducing the same, an agent for treating and/or preventing diseases accompanied by enhanced production of BCL2 gene product, such as melanoma, a method of treating and/or preventing the diseases, a method of identifying any one of the following compounds: a compound that inhibits the aforementioned binding; a compound that inhibits production of BCL2 gene product; and a compound that increases sensitivity of melanoma to melanoma drugs, as well as a reagent kit.
摘要翻译：本发明旨在降低MITF-M的转录激活活性以抑制BCL2基因产物的产生，从而能够治疗和/或预防黑素瘤本发明提供了抑制BCL2基因产物的生成和抑制作用的方法相同的，其抑制了选自由HLF，ELK4和CLOCK组成的组的蛋白质与MITF-M的结合，诱导黑素瘤细胞的细胞死亡的方法，诱导它们的药剂，用于治疗和/或预防疾病的药剂伴随着BCL2基因产物如黑素瘤的增强生产，治疗和/或预防疾病的方法，鉴定任何一种以下化合物的方法：抑制上述结合的化合物; 抑制BCL2基因产物生成的化合物; 以及增加黑素瘤对黑素瘤药物敏感性以及试剂盒的化合物。

3. 发明申请

US20050107961A1 Apparatus for managing gene expression data 审中-公开
标题翻译：用于管理基因表达数据的装置
公开(公告)号：US20050107961A1
公开(公告)日：2005-05-19
申请号：US10504956
申请日：2003-02-18
申请人： Yasuo Uemura , Hirofumi Doi , Akira Kawamura
发明人： Yasuo Uemura , Hirofumi Doi , Akira Kawamura
IPC分类号： C12N1/00 , C12N15/09 , G01N33/48 , G01N33/50 , G06F17/30 , G06F19/20 , G06F19/22 , G06F19/00
CPC分类号： G16B25/00 , G16B30/00
摘要： Genetic clones aligned on a multiwell plate are produced and a collection of genes expressed in a specific tissue are produced. Nucleotide sequences of genetic clones are determined. An analysis is performed based on the nucleotide sequences. An in situ hybridization experiment is conducted, and expression statuses of genes that correspond to the genetic clones in a specific cell, tissue or organ are examined.
摘要翻译：产生在多孔板上排列的遗传克隆，并产生在特定组织中表达的基因的集合。确定遗传克隆的核苷酸序列。基于核苷酸序列进行分析。进行原位杂交实验，检查与特定细胞，组织或器官中的遗传克隆相对应的基因的表达状态。

4. 发明授权

US07211647B2 DNA synthetase 失效
标题翻译： DNA合成酶
公开(公告)号：US07211647B2
公开(公告)日：2007-05-01
申请号：US10343049
申请日：2001-07-27
申请人： Yoshizumi Ishino , Isaac Cann , Arnaud Bocquier , Lidong Liu
发明人： Yoshizumi Ishino , Isaac Cann , Arnaud Bocquier , Lidong Liu
IPC分类号： C07K14/195
CPC分类号： C12N9/1252 , C12N15/10 , C12P19/34 , Y10S530/82 , Y10S530/825
摘要： The object of the invention is to provide proteins that have both DNA primase activity and DNA polymerase activity. This subject is solved by a protein (p41) that has an amino acid sequence shown in SEQ ID NO: 1. This is for the first time that proteins that have both DNA primase activity and DNA polymerase activity were found. A protein (p46) that has amino acid sequence shown in SEQ ID NO: 2 forms a complex with p41, and enforces DNA synthesis activity that is independent and/or dependent from primer of p41.
摘要翻译：本发明的目的是提供具有DNA引物酶活性和DNA聚合酶活性两者的蛋白质。通过具有SEQ ID NO：1所示的氨基酸序列的蛋白质（p41）来解决该问题。这是首次发现具有DNA引物酶活性和DNA聚合酶活性两者的蛋白质。具有SEQ ID NO：2所示氨基酸序列的蛋白质（p46）与p41形成复合物，并且实施与p41引物独立和/或依赖的DNA合成活性。

5. 发明申请

US20050270370A1 Microscope image processing system, microscope image processing method, program, and recording medium 审中-公开
标题翻译：显微镜图像处理系统，显微镜图像处理方法，程序和记录介质
公开(公告)号：US20050270370A1
公开(公告)日：2005-12-08
申请号：US10526485
申请日：2003-09-05
申请人： Yasuo Uemura , Akira Kawamura
发明人： Yasuo Uemura , Akira Kawamura
IPC分类号： G02B21/36 , H04N7/18
CPC分类号： H04N7/183 , G02B21/36 , G02B21/365
摘要： An image analysis device (100) integratively takes photographs within each well at a predetermined magnification. An image controlling device (200) communicates with the image analysis device (100) via a network (300) for acquiring the taken images and displays the same as thumbnails. On the display of the image controlling device (200), the operator designates locations of the sample to be photographed for each well. The image controlling device (200) informs the image analysis device (100) of the instructions for photographing in accordance with the designated conditions. The image analysis device (100) individually takes photographs in accordance with the locations and conditions designated by the image controlling device (200).
摘要翻译：图像分析装置（100）以预定的倍率一体地拍摄各孔内的照片。图像控制装置（200）经由用于获取拍摄图像的网络（300）与图像分析装置（100）进行通信，并且将其显示为缩略图。在图像控制装置（200）的显示器上，操作者指定每个孔要拍摄的样本的位置。图像控制装置（200）根据指定的条件向图像分析装置（100）通知拍摄指示。图像分析装置（100）根据由图像控制装置（200）指定的位置和条件分别拍摄照片。

6. 发明申请

US20050164198A1 Mutant sequence analyzer 审中-公开
标题翻译：突变序列分析仪
公开(公告)号：US20050164198A1
公开(公告)日：2005-07-28
申请号：US10513928
申请日：2003-05-12
申请人： Kensaku Imai , Hisayuki Horai , Hirofumi Doi
发明人： Kensaku Imai , Hisayuki Horai , Hirofumi Doi
IPC分类号： C12M1/00 , C12Q1/68 , G06F17/30 , G06F19/22 , H04R23/00 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： H04R23/008 , G16B30/00
摘要： All DNA's of a mutant of a sequencing target organic species (e.g., a resistant bacterium, a tumor cell, or a virus) are extracted, and shotgun libraries are generated for the DNA's. DNA fragments are sequentially fetched from these libraries, and each fragment is subjected to sequencing using an automated DNA sequencer. Fragment sequence information such as base sequences of the respective DNA fragments of the mutant output from the sequencer is stored in a fragment sequence database.
摘要翻译：提取测序目标有机物种（例如抗性细菌，肿瘤细胞或病毒）的突变体的所有DNA，并为DNA产生猎枪文库。从这些文库顺序取出DNA片段，并使用自动化DNA测序仪对每个片段进行测序。片段序列信息，例如从定序器输出的突变体的各个DNA片段的碱基序列存储在片段序列数据库中。

7. 发明申请

US20090209003A1 MUTANT PCNA 有权
公开(公告)号：US20090209003A1
公开(公告)日：2009-08-20
申请号：US11994437
申请日：2006-07-04
申请人： Tadaaki Tokida , Satoshi Hihara , Takashi Kudou , Akira Kawamura , Hirofumi Doi , Yoshizumi Ishino
发明人： Tadaaki Tokida , Satoshi Hihara , Takashi Kudou , Akira Kawamura , Hirofumi Doi , Yoshizumi Ishino
IPC分类号： C12P21/00 , C07K14/00 , C07H21/00 , C12N1/00 , C12P19/34
CPC分类号： C07K14/4738 , C12N9/1252 , C12N15/69
摘要： The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors involved in DNA replication is prepared so that amino acid residues causing mutual charge repulsion constitute a site which causes, when an N terminal region of the PCNA monomer and a C terminal region of another PCNA monomer act as an interface to form a multimeric complex, an intermolecular interaction of the monomers in an interface region of the monomers.
摘要翻译：本发明是构建通用性优异且易于使用的DNA复制反应体系。制备作为涉及DNA复制的因素之一的PCNA单体的氨基酸序列，使得导致相互电荷排斥的氨基酸残基构成了当PCNA单体的N末端区域和另一个的C末端区域时引起的位点 PCNA单体作为形成多聚体复合物的界面，单体在界面区域中的分子间相互作用。

8. 发明申请

US20070111934A1 Procaspase 1 activation inhibitor 审中-公开
标题翻译： Procaspase 1活化抑制剂
公开(公告)号：US20070111934A1
公开(公告)日：2007-05-17
申请号：US10580877
申请日：2004-11-26
申请人： Hirofumi Doi , Shoichi Masuda , Yoshitaka Isumi
发明人： Hirofumi Doi , Shoichi Masuda , Yoshitaka Isumi
IPC分类号： A61K38/55 , C12Q1/37
CPC分类号： C12N9/6475 , C07K14/47
摘要： A method and an agent for inhibiting the oligomerization of procaspase-1, a method and an agent for inhibiting the activation of procaspase-1, a method and an agent for inhibiting the production of caspase-1, a method of preventing and/or treating an inflammatory disease, and an agent for preventing and/or treating an inflammatory disease, all of which comprise inhibiting the binding of NOD2 to procaspase-1; a method of identifying a compound that inhibits the binding of NOD2 to procaspase-1; and a reagent kit for use in the identifying method are provided.
摘要翻译：用于抑制胱天蛋白酶原-1的低聚化的方法和试剂，抑制胱天蛋白酶-1的活化的方法和试剂，抑制半胱天冬酶-1的产生的方法和试剂，预防和/或治疗的方法炎症性疾病和预防和/或治疗炎性疾病的药物，所有这些都包括抑制NOD2与胱天蛋白酶原-1的结合; 鉴定抑制NOD2与胱天蛋白酶原-1结合的化合物的方法; 并提供了用于识别方法的试剂盒。

9. 发明申请

US20050146951A1 Knowledge search apparatus knowledge search method program and recording medium 审中-公开
标题翻译：知识搜索设备知识搜索方法程序和记录介质
公开(公告)号：US20050146951A1
公开(公告)日：2005-07-07
申请号：US10499911
申请日：2003-01-06
申请人： Hisayuki Horai , Kiyoshi Nitta , Hirofumi Doi
发明人： Hisayuki Horai , Kiyoshi Nitta , Hirofumi Doi
IPC分类号： G06F17/30 , G06F19/24 , G06F19/28 , G11C7/00
CPC分类号： G16B50/00
摘要： A user designates two targets a relation of which the user is to search as a search start target and a search end target, respectively. The user also designates various search conditions. A binary relation database that stores binary relational information extracted, in advance, from various types of biomolecular databases (e.g., databases that store sequence information on DNAs and the like, structural information on proteins and the like, etc), compound databases (e.g., databases that store characteristics of organic compounds and the like), and literature databases (e.g., databases that store technical literatures, papers, and the like) is accessed, and knowledge between the search start target and the search end target is automatically searched.
摘要翻译：用户分别将用户要搜索的关系的两个目标指定为搜索开始目标和搜索结束目标。用户还指定各种搜索条件。预先从各种类型的生物分子数据库中提取二进制关系信息的二元关系数据库（例如，存储关于DNA等的序列信息的数据库，关于蛋白质等的结构信息等），化合物数据库（例如，存储有机化合物的特征的数据库等），以及文献数据库（例如存储技术文献，论文等的数据库），自动搜索搜索开始对象与搜索结束目标之间的知识。

10. 发明授权

US08003346B2 Mutant PCNA 有权
标题翻译：突变型PCNA
公开(公告)号：US08003346B2
公开(公告)日：2011-08-23
申请号：US11994437
申请日：2006-07-04
申请人： Tadaaki Tokida , Satoshi Hihara , Takashi Kudou , Akira Kawamura , Hirofumi Doi , Yoshizumi Ishino
发明人： Tadaaki Tokida , Satoshi Hihara , Takashi Kudou , Akira Kawamura , Hirofumi Doi , Yoshizumi Ishino
IPC分类号： G01N33/52 , C07H17/00 , C07K14/00
CPC分类号： C07K14/4738 , C12N9/1252 , C12N15/69
摘要： The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors involved in DNA replication is prepared so that amino acid residues causing mutual charge repulsion constitute a site which causes, when an N terminal region of the PCNA monomer and a C terminal region of another PCNA monomer act as an interface to form a multimeric complex, an intermolecular interaction of the monomers in an interface region of the monomers.
摘要翻译：本发明是构建通用性优异且易于使用的DNA复制反应体系。制备作为涉及DNA复制的因素之一的PCNA单体的氨基酸序列，使得导致相互电荷排斥的氨基酸残基构成了当PCNA单体的N末端区域和另一个的C末端区域时引起的位点 PCNA单体作为形成多聚体复合物的界面，单体在界面区域中的分子间相互作用。

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