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    • 1. 发明申请
    • Remedy For Melanoma
    • 治疗黑色素瘤
    • US20070259805A1
    • 2007-11-08
    • US11658652
    • 2005-08-03
    • Hirofumi DoiSeiji SaitoKenji MurakamiYukako Kurita
    • Hirofumi DoiSeiji SaitoKenji MurakamiYukako Kurita
    • A61K38/00C12N5/06G01N33/53
    • G01N33/566
    • The present invention was aimed at reducing transcription activating activity of MITF-M to inhibit production of BCL2 gene product and thereby to allow treatment and/or prevention of melanoma The present invention provided a method of inhibiting production of BCL2 gene product and an agent for inhibiting the same, which inhibit binding of protein selected from a group consisting of HLF, ELK4 and CLOCK to MITF-M, a method of inducing cell death of melanoma cells, an agent for inducing the same, an agent for treating and/or preventing diseases accompanied by enhanced production of BCL2 gene product, such as melanoma, a method of treating and/or preventing the diseases, a method of identifying any one of the following compounds: a compound that inhibits the aforementioned binding; a compound that inhibits production of BCL2 gene product; and a compound that increases sensitivity of melanoma to melanoma drugs, as well as a reagent kit.
    • 本发明旨在降低MITF-M的转录激活活性以抑制BCL2基因产物的产生,从而能够治疗和/或预防黑素瘤本发明提供了抑制BCL2基因产物的生成和抑制作用的方法 相同的,其抑制了选自由HLF,ELK4和CLOCK组成的组的蛋白质与MITF-M的结合,诱导黑素瘤细胞的细胞死亡的方法,诱导它们的药剂,用于治疗和/或预防疾病的药剂 伴随着BCL2基因产物如黑素瘤的增强生产,治疗和/或预防疾病的方法,鉴定任何一种以下化合物的方法:抑制上述结合的化合物; 抑制BCL2基因产物生成的化合物; 以及增加黑素瘤对黑素瘤药物敏感性以及试剂盒的化合物。
    • 2. 发明授权
    • Power supply system and image forming apparatus
    • 电源系统和成像设备
    • US08660452B2
    • 2014-02-25
    • US13115212
    • 2011-05-25
    • Seiji SaitoTomoo AkizukiTakeshi ShinjiKeisuke IshizumiJun Matsumoto
    • Seiji SaitoTomoo AkizukiTakeshi ShinjiKeisuke IshizumiJun Matsumoto
    • G03G15/00G03G15/16
    • H02M5/12G03G15/1675G03G15/5004G03G2215/1614H02M2001/0077
    • An image forming apparatus includes an image bearing member, a transfer member, and a power supply unit that outputs a voltage to the transfer member. The power supply unit includes a first voltage generation circuit that includes a piezoelectric transformer driven at a drive frequency within a predetermined frequency area to output a first voltage having a predetermined polarity, and a second voltage generation circuit that outputs a second voltage with a polarity opposite to the predetermined polarity. In addition, a control unit controls the power supply unit to output a superposed voltage as a voltage having the predetermined polarity and corresponding to a voltage output from the piezoelectric transformer by driving the piezoelectric transformer at a driven frequency out of range of the predetermined frequency area, with the superposed voltage being a voltage in which the first voltage and the second voltage are superposed.
    • 图像形成装置包括图像承载部件,转印部件和向转印部件输出电压的电源单元。 电源单元包括:第一电压产生电路,其包括以预定频率区域内的驱动频率驱动的压电变压器,以输出具有预定极性的第一电压;以及第二电压产生电路,其输出极性相反的第二电压 达到预定的极性。 此外,控制单元控制电源单元输出叠加的电压作为具有预定极性的电压并且对应于从压电变压器输出的电压,通过驱动压电变压器在超出预定频率区域的范围内的驱动频率 ,叠加电压是第一电压和第二电压叠加的电压。
    • 3. 发明申请
    • IMAGE FORMING APPARATUS, PRINT SETTING UNIT, AND MAKING PRINT SETTING METHOD
    • 图像形成装置,打印设置单元和打印设置方法
    • US20120243020A1
    • 2012-09-27
    • US13422342
    • 2012-03-16
    • Seiji Saito
    • Seiji Saito
    • G06K15/02
    • B41J3/46G06F3/0483G06F3/0486G06F17/212
    • An image forming apparatus of the embodiments includes a display section, an input section, a controller, and a printing section. A plurality of first images in the form of sheets and a plurality of second images targeted for printing. The input section acquires information about a position designated by a user, the position being within a display region of the display section. The controller detects that one or two or more of the plurality of second images are selected on the basis of the information about the position. In response to release of the selected second image on one of the plurality of first images, the controller makes setting such that the released second image is categorized in one group, and makes print setting for each group. The printing section prints the second image on a sheet on the basis of the print setting made by the controller.
    • 实施例的图像形成装置包括显示部分,输入部分,控制器和打印部分。 以片材形式的多个第一图像和用于打印的多个第二图像。 输入部分获取关于用户指定的位置的信息,该位置在显示部分的显示区域内。 控制器基于关于位置的信息来检测多个第二图像中的一个或两个以上。 响应于在所述多个第一图像之一上释放所选择的第二图像,所述控制器进行设置,使得所述释放的第二图像被分类为一组,并且对于每个组进行打印设置。 打印部根据由控制器进行的打印设定,将第二张图像打印在纸张上。
    • 6. 发明授权
    • Image display apparatus having different display mode and method thereof
    • 具有不同显示模式的图像显示装置及其方法
    • US06710781B1
    • 2004-03-23
    • US09654853
    • 2000-09-05
    • Seiji Saito
    • Seiji Saito
    • G09G500
    • G09G1/165G09G2310/0232G09G2320/043G09G2340/0414H04N7/0122
    • When an image having an aspect ratio of 16:9 is compressed in a vertical direction to be displayed on a display screen having an aspect ratio of 4:3, a gray scale signal is inserted into a top and a bottom of an image signal and a brightness level of the inserted gray scale signal is made to correspond to an average brightness level of the image signal. In addition, when an image having an aspect ratio of 4:3 is compressed in a horizontal direction to be displayed on a display screen having an aspect ratio of 16:9, a gray scale signal is inserted into a right edge and a left edge of an image signal and a brightness level of the inserted gray scale signal is made to correspond to an average brightness level of the image signal. Accordingly, a boundary line between a video image area and a non-video image area due to the difference in luminous characteristics of phosphors becomes hardly recognizable.
    • 当纵横比为16:9的图像在垂直方向上被压缩以显示在具有纵横比为4:3的显示屏幕上时,将灰度信号插入图像信号的顶部和底部,并且 使插入的灰度信号的亮度水平对应于图像信号的平均亮度水平。 此外,当具有纵横比为4:3的图像在水平方向被压缩以显示在具有16:9的纵横比的显示屏幕上时,灰度信号被插入到右边缘和左边缘 的图像信号和所插入的灰度信号的亮度水平对应于图像信号的平均亮度水平。 因此,由于荧光体的发光特性的差异导致的视频图像区域和非视频图像区域之间的边界线几乎不被识别。
    • 8. 发明授权
    • Developing device, process cartridge and electrophotographic image forming apparatus
    • 显影装置,处理盒和电子照相成像装置
    • US06282384B1
    • 2001-08-28
    • US09577874
    • 2000-05-25
    • Seiji SaitoHiroaki SakaiMasaru Shimura
    • Seiji SaitoHiroaki SakaiMasaru Shimura
    • G03G1508
    • G03G21/1814G03G15/0856G03G15/086G03G2221/183
    • A developing device mounted on a main body of an electrophotographic image forming apparatus and adapted to develop an electrostatic latent image formed on an electrophotographic photosensitive member, includes a developer container which contains a developer therein and has a developer bearing member for feeding the developer to the electrophotographic photosensitive member in order to develop the electrostatic latent image formed on the electrophotographic photosensitive member, and N (N≧2) antenna electrodes for detecting the residual amount of developer within the developer container by detecting a variation of capacitance due to a developing bias voltage applied to the developer bearing member; wherein a projected area (S) and a distance (R) of the n-th antenna from the developer bearing member satisfy Sn−1≦Sn, and Rn−1≦Rn (2≦n≦N).
    • 一种显影装置,其安装在电子照相成像设备的主体上并适于显影形成在电子照相感光构件上的静电潜像,包括显影剂容器,其中含有显影剂,并具有用于将显影剂供给到显影剂的显影剂承载部件 为了显影形成在电子照相感光构件上的静电潜像和N(N> = 2)个天线电极,用于通过检测由显影偏压引起的电容变化来检测显影剂容器内的显影剂残留量 施加到显影剂承载构件的电压; 其中所述第n天线与所述显影剂承载部件的投影面积(S)和距离(R)满足Sn-1≤Sn,并且Rn-1≤Rn(2≤n≤N)。
    • 9. 发明授权
    • Imaging data processing apparatus
    • 成像数据处理装置
    • US5006937A
    • 1991-04-09
    • US560294
    • 1990-07-27
    • Hiroshi NonoshitaSeiji Saito
    • Hiroshi NonoshitaSeiji Saito
    • H04N1/387H04N1/405
    • H04N1/3872H04N1/4055
    • An image processing apparatus includes input circuitry for inputting an analog video signal, first conversion circuitry for converting the input analog video signal into multi-value data, and a memory for storing the multi-value data. Second conversion circuitry is provided for converting the multi-value data stored in the memory to binary data when executing its conversion process. The second conversion circuitry (1) detects a density gradient by comparing the multi-value data of pixels around a pixel to be converted with each other in each of vertical, lateral, and oblique directions, and (2) selects a multi-bit image pattern from a plurality of image patterns in response to the detected density gradient.
    • 图像处理装置包括用于输入模拟视频信号的输入电路,用于将输入的模拟视频信号转换为多值数据的第一转换电路和用于存储多值数据的存储器。 提供第二转换电路,用于在执行其转换处理时将存储在存储器中的多值数据转换为二进制数据。 第二转换电路(1)通过在垂直方向,横向方向和倾斜方向中的每一个中比较要转换的像素周围的像素的多值数据来检测密度梯度,以及(2)选择多位图像 响应于检测到的密度梯度,从多个图像图案模式。