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1. 发明授权

US5230862A Apparatus for extracorporeal blood oxygenation 失效
标题翻译：用于提取血液氧化的装置
公开(公告)号：US5230862A
公开(公告)日：1993-07-27
申请号：US746785
申请日：1991-08-16
申请人： Gaylord Berry , Shigemasa Osaki , J. D. Mortensen
发明人： Gaylord Berry , Shigemasa Osaki , J. D. Mortensen
IPC分类号： A61M1/18 , B01D63/02
CPC分类号： B01D63/02 , B01D63/021 , B01D63/025 , B01D63/027 , B01D2313/16 , B01D2319/06
摘要： An extracorporeal blood oxygenation device having a sealed casing containing a bundle comprised of a plurality of gas permeable tubes for efficient gas transfer. The bundle is woven from tubes having at least two different sizes, at least the smaller diameter tubes being gas permeable. The tubes are relatively non-thrombogenic and are open at each end to an enclosed annular chamber having attached input and output fittings. Oxygen-rich gas flows into one annular chamber through an input fitting before flowing through the gas permeable tubes. Venous blood to be oxygenated is introduced into the sealed casing directly into the center of the bundle for dispersement radially outward through the bundle and across the gas permeable tubes wherein the blood comes in contact with the membrane surface of the gas permeable tubes and exchanges carbon dioxide for oxygen across that surface before being collected from around the perimeter of the bundle for return to the patient.
摘要翻译：一种体外血液充氧装置，其具有密封壳体，该壳体包含由多个用于有效气体转移的透气管组成的束。该束由具有至少两种不同尺寸的管织成，至少较小直径的管是气体可透过的。管相对非血栓形成，并且在每个端部处开放到具有附接的输入和输出配件的封闭环形室。富氧气体在流过气体可渗透管之前通过输入配件流入一个环形室。要充氧的静脉血被直接引入密封外壳的中心，用于通过束径向向外穿过束并穿过透气管，其中血液与透气管的膜表面接触并交换二氧化碳在从束的周边收集之前将氧气穿过该表面返回到患者。

2. 发明授权

US5125902A Sheath/obturator to facilitate insertion of medical devices into a patient's venous system 失效
标题翻译：护理人员将医疗器械插入患者的静脉系统
公开(公告)号：US5125902A
公开(公告)日：1992-06-30
申请号：US488285
申请日：1990-03-02
申请人： Gaylord L. Berry , J. D. Mortensen , Mitchell D. Baldwin , Larry D. Rigby
发明人： Gaylord L. Berry , J. D. Mortensen , Mitchell D. Baldwin , Larry D. Rigby
IPC分类号： A61M1/18 , A61M1/14 , A61M1/16 , A61M25/06 , A61M25/08
CPC分类号： A61M25/0662 , A61M1/1678 , A61M1/1698
摘要： A sheath and obturator is provided for facilitating the insertion of certain medical devices into a patient's vascular system, a vein, or venous system and in particular an in vivo extrapulmonary blood gas exchange device having a bundle comprised of a plurality of elongated gas permeable tubes being potted at each end and enclosed within a respective air tight proximal and distal chamber. The sheath is hollow and substantially tubular with a tapered receiving portion and a nontapered, curved entry portion. The obturator has a tip at the distal end of the obturator and a trip at the proximal end with an elongate member therebetween. The sheath is configured to receive the obturator in sliding engagement such that when the obturator is fully inserted within the sheath, the tip closes the opening at the entry end of the sheath and protrudes slightly therefrom. The obturator has a vent which provides a passage from space exterior to the sheath into the hollow interior of the sheath. The sheath and obturator are inserted into the patient through a single incision. Upon removal of the obturator from the sheath, a extrapulmonary blood gas exchange device may be inserted into and through the sheath into one of the right external iliac, common femoral or internal jugular veins, and then into the vena cavae where the elongate gas permeable tubes may be deployed for blood oxygenation.
摘要翻译：提供护套和闭塞器，以便于将某些医疗装置插入到患者的血管系统，静脉或静脉系统中，特别是体内肺外血液气体交换装置，其具有由多个细长的气体可渗透管组成的束，在每个端部盆盖并封闭在相应的气密近端和远端室内。护套是中空的并且基本上是管状的，具有锥形接收部分和无钳子的弯曲入口部分。闭塞器在封闭器的远端处具有尖端，并且在近端处具有在其间的细长构件的跳闸。护套构造成接收滑动接合的闭孔器，使得当闭孔器完全插入护套内时，尖端封闭护套入口端处的开口并稍微突出。封闭器具有通气口，其提供从外部空间到护套的通道到护套的中空内部。鞘和闭孔器通过单个切口插入患者体内。在从鞘中取出闭孔器之后，可以将肺外血液气体交换装置插入并穿过皮套进入右外髂骨，普通股或颈内静脉中的一个，然后进入腔静脉，其中细长的气体可渗透管可以部署用于血氧合。

3. 发明授权

US5342693A Multifunctional thrombo-resistant coating and methods of manufacture 失效
标题翻译：多功能抗血栓涂层及其制造方法
公开(公告)号：US5342693A
公开(公告)日：1994-08-30
申请号：US35426
申请日：1993-03-22
申请人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
发明人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
IPC分类号： A61L33/00 , A61M1/16 , A61M1/36 , B32B27/06 , A01N1/00
CPC分类号： A61M1/1678 , A61L33/0029 , A61L33/0047 , A61M1/3673 , A61M1/1698 , Y10S530/812 , Y10S530/815 , Y10S530/816 , Y10T428/31663 , Y10T428/31667
摘要： The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.
摘要翻译：本发明涉及用于生物医学装置和植入物的多功能抗血栓涂层，例如包含多个胺官能团已经键合在其上的硅氧烷表面的涂层。与胺官能团共价连接的是多个聚（环氧乙烷）链，使得单个聚（环氧乙烷）链与单个胺官能团结合。设计用于抵消特定血液 - 物质不相容性反应的多种不同的生物活性分子共价键合到聚（环氧乙烷）链，使得单个生物活性分子与单个聚环氧乙烷链偶联。制造本发明的方法包括制备具有多个胺官能团已经结合到其上的具有硅氧烷表面的材料。这是通过用氨气等离子体蚀刻或通过在氨气存在下的硅氧烷单体的等离子体聚合来实现的。含胺的硅氧烷表面与聚硅氧烷表面上与胺基反应的官能团封端的聚（环氧乙烷）链反应。然后将该材料与多种不同的生物活性分子反应，所述生物活性分子抵消特定的血液 - 材料不相容性反应，使得单个生物活性分子与单个聚（环氧乙烷）链偶联。所得的硅氧烷表面含有多个不同的生物活性分子，能够与靠近硅氧烷表面的血液成分反应，以抵抗血液 - 物质不相容反应。

4. 发明授权

US5262451A Multifunctional thrombo-resistant coatings and methods of manufacture 失效
标题翻译：多功能抗血栓涂层及其制造方法
公开(公告)号：US5262451A
公开(公告)日：1993-11-16
申请号：US215014
申请日：1988-07-05
申请人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
发明人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
IPC分类号： A61L33/10 , A61L33/00 , A61M1/16 , A61M1/36 , B01D67/00 , B01D69/12 , C12N11/06 , A01N1/00
CPC分类号： A61L33/0047 , A61L33/0005 , A61L33/0029 , A61L33/0094 , A61M1/1678 , A61M1/3673 , B01D67/009 , B01D67/0093 , B01D69/127 , C12N11/06 , A61M1/1698 , A61M2205/04 , B01D2323/30 , Y10S530/812 , Y10S530/815 , Y10S530/816
摘要： The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.
摘要翻译：本发明涉及用于生物医学装置和植入物的多功能抗血栓涂层，例如包含多个胺官能团已经键合在其上的硅氧烷表面的涂层。与胺官能团共价连接的是多个聚（环氧乙烷）链，使得单个聚（环氧乙烷）链与单个胺官能团结合。设计用于抵消特定血液 - 物质不相容性反应的多种不同的生物活性分子共价键合到聚（环氧乙烷）链，使得单个生物活性分子与单个聚环氧乙烷链偶联。制造本发明的方法包括制备具有多个胺官能团已经结合到其上的具有硅氧烷表面的材料。这是通过用氨气等离子体蚀刻或通过在氨气存在下的硅氧烷单体的等离子体聚合来实现的。含胺的硅氧烷表面与聚硅氧烷表面上与胺基反应的官能团封端的聚（环氧乙烷）链反应。然后将该材料与多种不同的生物活性分子反应，所述生物活性分子抵消特定的血液 - 材料不相容性反应，使得单个生物活性分子与单个聚（环氧乙烷）链偶联。所得的硅氧烷表面含有多个不同的生物活性分子，能够与靠近硅氧烷表面的血液成分反应，以抵抗血液 - 物质不相容反应。

5. 发明授权

US5125915A Locking Y-connector for selective attachment to exterior of medical tubing 失效
标题翻译：用于选择性连接到医疗管道外部的锁定Y型连接器
公开(公告)号：US5125915A
公开(公告)日：1992-06-30
申请号：US488742
申请日：1990-03-02
申请人： Gaylord L. Berry , W. Lynn Kerby
发明人： Gaylord L. Berry , W. Lynn Kerby
IPC分类号： A61M39/00 , A61M25/00 , A61M39/06
CPC分类号： A61M39/0613
摘要： A connector for applying to the exterior of an elongated member of circular cross-section circumferentially uniform radially directed compressive forces by which to effect attachment and fluid-tight sealing thereagainst. The connector comprises an attachment fitting having formed therethrough a bore for slidably receiving the elongated member and a coaxially disposed, radially enlarged compression recess communicating therewith. A flexible annular gripping member resides in the compression recess slidably circling the elongated member. A locking hub disposed at the end of the compression recess remote from the bore has a compression face which extends into compression recess. The locking hub is longitudinally slidable relative to the attachment fitting between a disengaged position in which the elongated member is slidable relative to the gripping member and an engaged position in which the compression face bears against and deforms the gripping member to preclude sliding of the tubing relative to the gripping member by urging the gripping member into radial engagement with the portion of the tubing in the compression recess. A retention pin and cooperating retention slot on opposed portions of attachment fitting and the locking hub secure the locking hub in its engaged position. The connector has specific utility in terminating the proximal end of a coaxial lumen tube assembly used to interconnect an implanted extrapulmonary blood gas exchange device with extracorporeal support equipment.
摘要翻译：用于向圆形横截面的细长构件的外部施加周向均匀的径向指向的压缩力的连接器，通过该连接件在其附近进行附着和流体密封。连接器包括一个通过其形成的孔，用于可滑动地容纳细长构件和与之连通的同轴设置的径向扩大的压缩凹部。柔性环形夹持构件位于可滑动地环绕细长构件的压缩凹部中。设置在远离孔的压缩凹部的端部处的锁定毂具有延伸到压缩凹部中的压缩面。锁定轮毂可以相对于附接配件纵向滑动，在脱离位置之间，细长构件可相对于夹紧构件滑动，在该接合位置中，压缩面抵靠并使变形夹紧构件变形，从而阻止管道相对的滑动通过推动夹持构件与压缩凹部中的管道的一部分径向接合而到达夹持构件。保持销和配合的保持槽在附接配件的相对部分上，并且锁定毂将锁定毂固定在其接合位置。连接器在终止用于将植入的肺外血液气体交换装置与体外支持设备相互连接的同轴管腔组件的近端具有特定用途。

6. 发明授权

US5098376A Apparatus and methods for furling and introducing an extrapulmonary blood gas exchange device 失效
标题翻译：用于肛门造口术和引进外科手术气体交换装置的装置及方法
公开(公告)号：US5098376A
公开(公告)日：1992-03-24
申请号：US454773
申请日：1989-12-22
申请人： Gaylord L. Berry , J. D. Mortensen , Mitchell D. Baldwin
发明人： Gaylord L. Berry , J. D. Mortensen , Mitchell D. Baldwin
IPC分类号： A61F2/02 , A61M1/16 , A61M25/01 , A61M37/00
CPC分类号： A61M25/01 , A61M1/1678 , A61M1/1698
摘要： An in vivo extrapulmonary blood gas exchange device is disclosed having a hollow fiber bundle in gaseous communication with a coaxial dual lumen tube and having a furling apparatus for twisting one coaxial lumen relative to the other. The furling apparatus enables the outside diameter of the bundle of gas permeable tubes to be selectively adjusted to provide either a furled, small insertion diameter when inserting the apparatus into the venae cavae of a patient or an unfurled, expanded oxygenation diameter after the apparatus is in place within the venae cavae and the bundle of gas permeable tubes is deployed therein. The oxygenator is inserted into the patient through a single incision at one of the right external iliac, common femoral, or internal jugular veins. A novel distal tip configuration permits the oxygenator to be inserted into the patient utilizing an over-the-guidewire intravascular insertion technique.
摘要翻译：公开了一种体内肺外血液气体交换装置，其具有与同轴双腔管气体连通的中空纤维束，并具有用于相对于另一个共轴管腔扭转一个同轴管腔的卷装装置。该装置能够选择性地调节气体可渗透管束的外径，以便在装置进入装置之后将装置插入患者的静脉卡瓦或展开的扩张氧合直径时提供卷曲的小插入直径将其放置在静脉内，将可透气管束捆在其中。通过在右外髂骨，普通股或颈内静脉中的一个单一切口将氧合器插入患者体内。一种新颖的远端尖端构造允许使用超导线血管内插入技术将氧合器插入患者体内。

7. 发明授权

US4850958A Apparatus and method for extrapulmonary blood gas exchange 失效
标题翻译：用于肺外血液气体交换的装置和方法
公开(公告)号：US4850958A
公开(公告)日：1989-07-25
申请号：US204115
申请日：1988-06-08
申请人： Gaylord Berry , J. D. Mortensen , Larry D. Rigby
发明人： Gaylord Berry , J. D. Mortensen , Larry D. Rigby
IPC分类号： A61M1/14 , A61M1/16 , A61M1/18 , A61M1/36
CPC分类号： A61M1/1678 , A61M1/3673 , A61M1/1698
摘要： An in vivo extrapulmonary blood gas exchange device having a bundle comprised of a plurality of elongated gas permeable tubes being bound at each end and enclosed within a respective air tight proximal and distal chamber. A dual lumen tube having an outer lumen and an inner lumen is situated relative to the gas permeable tubes such that the outer lumen terminates within the proximal chamber and such that the inner lumen terminates within the distal chamber. The apparatus includes means for selectively adjusting the overall, outside diameter of the bundle of gas permeable tubes to provide either a furled, small insertion diameter when inserting the apparatus into the venae cavae of a patient or an unfurled, expanded oxygenation diameter after the apparatus is in place within the venae cavae and the bundle of gas permeable tubes is deployed therein. The apparatus is inserted into the patient through a single incision at one of the right external iliac, common femoral or internal jugular veins. A plurality of crimps along the length of the gas permeable tubes maintain the tubes in a spaced relation one from another such that blood surface contact with the gas permeable tubes is maximized, disturbed flow of blood over the tubes is achieved and laminar blood flow between and around the gas permeable tubes is inhibited.
摘要翻译：一种体内肺外血液气体交换装置，其具有由多个细长的气体可渗透管组成的束，每个端部被结合并封闭在相应的气密近端和远端腔室内。具有外腔和内腔的双腔管相对于气体可渗透管定位，使得外腔终止于近端腔室内，并且使得内腔终止于远侧腔室内。该装置包括用于选择性地调整气体可透过管束的整体外径的装置，以便在将装置插入患者的静脉卡瓦后或在装置为在静脉内部的适当位置，并且在其中部署可透气管束。该装置通过在右外髂骨，普通股或颈内静脉中的一个上的单个切口插入患者体内。沿着气体可渗透管的长度的多个卷曲保持管彼此间隔开的关系，使得与透气管的血液表面接触最大化，使血液在管上的扰动流动被实现，层流血流在气体可渗透管周围被抑制。

8. 发明授权

US5338770A Gas permeable thrombo-resistant coatings and methods of manufacture 失效
标题翻译：透气性抗血栓涂层及其制造方法
公开(公告)号：US5338770A
公开(公告)日：1994-08-16
申请号：US509063
申请日：1990-04-12
申请人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , JD Mortensen , Gaylord Berry
发明人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , JD Mortensen , Gaylord Berry
IPC分类号： A61L33/00 , A61M1/16 , A61M1/36 , B01D67/00 , B01D69/12 , C08G65/32 , C08G77/46 , C08J7/04 , C12N11/06 , A01N1/00 , A61M25/00
CPC分类号： B01D67/009 , A61L33/0005 , A61L33/0029 , A61L33/0047 , A61L33/0094 , A61M1/1678 , A61M1/3673 , B01D67/0093 , B01D69/127 , C12N11/06 , A61M1/1698 , A61M2205/04 , B01D2323/30 , Y10S530/812 , Y10S530/815 , Y10S530/816
摘要： The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a solution of at least one bioactive molecule which counteracts a blood-material incompatibility reaction, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface is capable of resisting blood-material incompatibility reactions while maintaining high gas permeability.
摘要翻译：本发明涉及用于透气性生物医学装置和植入物的抗血栓涂层。涂层包括其上已结合有多个胺官能团的硅氧烷表面。与胺官能团共价连接的是多个聚（环氧乙烷）链，使得单个聚（环氧乙烷）链与单个胺官能团结合。设计用于抵抗特定血液 - 物质不相容性反应的至少一种生物活性分子的量共价键合到聚（环氧乙烷）链，使得单个生物活性分子与单个聚环氧乙烷链偶联。制造本发明的方法包括制备具有多个胺官能团已经结合到其上的具有硅氧烷表面的材料。这优选通过用氨气等离子体蚀刻来实现。含胺的硅氧烷表面与聚硅氧烷表面上与胺基反应的官能团封端的聚（环氧乙烷）链反应。然后将该材料与至少一种抵抗血液 - 材料不相容反应的生物活性分子的溶液反应，使得单个生物活性分子与单个聚（环氧乙烷）链偶联。所得的硅氧烷表面能够在保持高的透气性的同时抵抗血液物质不相容反应。

9. 发明授权

US5182317A Multifunctional thrombo-resistant coatings and methods of manufacture 失效
标题翻译：多功能抗血栓涂层及其制造方法
公开(公告)号：US5182317A
公开(公告)日：1993-01-26
申请号：US716843
申请日：1991-06-17
申请人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
发明人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
IPC分类号： A61L33/00 , A61M1/16 , A61M1/36
CPC分类号： A61M1/1678 , A61L33/0029 , A61L33/0047 , A61M1/3673 , A61M1/1698 , Y10S530/812 , Y10S530/815 , Y10S530/816
摘要： The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The method of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.
摘要翻译：本发明涉及用于生物医学装置和植入物的多功能抗血栓涂层，例如包含多个胺官能团已经键合在其上的硅氧烷表面的涂层。与胺官能团共价连接的是多个聚（环氧乙烷）链，使得单个聚（环氧乙烷）链与单个胺官能团结合。设计用于抵消特定血液 - 物质不相容性反应的多种不同的生物活性分子共价键合到聚（环氧乙烷）链，使得单个生物活性分子与单个聚环氧乙烷链偶联。制造本发明的方法包括制备具有多个胺官能团已经结合的硅氧烷表面的材料。这是通过用氨气等离子体蚀刻或通过在氨气存在下的硅氧烷单体的等离子体聚合来实现的。含胺的硅氧烷表面与聚硅氧烷表面上与胺基反应的官能团封端的聚（环氧乙烷）链反应。然后将该材料与多种不同的生物活性分子反应，所述生物活性分子抵消特定的血液 - 材料不相容性反应，使得单个生物活性分子与单个聚（环氧乙烷）链偶联。所得的硅氧烷表面含有多个不同的生物活性分子，能够与靠近硅氧烷表面的血液成分反应，以抵抗血液 - 物质不相容反应。

10. 发明授权

US5158534A Automated gas delivery system for blood gas exchange devices 失效
标题翻译：用于气体交换装置的自动气体输送系统
公开(公告)号：US5158534A
公开(公告)日：1992-10-27
申请号：US548290
申请日：1990-07-03
申请人： Gaylord L. Berry , Yansong Shan
发明人： Gaylord L. Berry , Yansong Shan
IPC分类号： A61M1/14 , A61M1/16
CPC分类号： A61M1/1698
摘要： A system for delivering oxygen to a gas permeable membrane oxygenator is disclosed. The system may include an integral source of gas under pressure and a source of vacuum. A first mass flow controller is connected to the source of gas upstream in the gas flow from the gas exchange device. A pressure valve is positioned in the gas flow between the first mass flow controller and the membrane oxygenator. An atmospheric vent is positioned between the pressure valve and the first mass flow controller. A second mass flow controller is positioned downstream from the gas exchange device and is connected to the source of vacuum. A central controller commands the pressure valve to maintain the pressure at the inlet of the gas exchange device at a subatmospheric pressure. The second mass flow controller is commanded to maintain a rate of flow which is desired through the gas exchange device. The first mass flow controller is commanded to maintain a rate of flow higher than the second mass flow controller to ensure that a sufficient flow of gas is available through the pressure valve and the gas exchange device. The excess gas is exhausted through the vent. The present invention ensures sufficient gas flow at the gas permeable membrane to provide transfer of gases with the blood. Also, the pressure of the gas within the membrane oxygenator is low enough that outgassing through the membrane of bubbles into the blood is avoided.
摘要翻译：公开了一种将氧输送到透气膜氧合器的系统。该系统可以包括在压力下和气体源的整体气体源。第一质量流量控制器连接到来自气体交换装置的气流中的上游气体源。压力阀位于第一质量流量控制器和膜式氧合器之间的气流中。大气排气口位于压力阀和第一质量流量控制器之间。第二质量流量控制器位于气体交换装置的下游并连接到真空源。中央控制器命令压力阀将气体交换装置的入口处的压力保持在低于大气压的压力。命令第二质量流量控制器通过气体交换装置保持期望的流量。命令第一质量流量控制器保持比第二质量流量控制器更高的流量，以确保通过压力阀和气体交换装置获得足够的气体流。多余的气体通过排气口排出。本发明确保气体可渗透膜处的足够的气体流动以提供气体与血液的转移。此外，膜氧合器内的气体的压力足够低，从而避免了通过气泡膜进入血液的气体。

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