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1. 发明授权

US5182317A Multifunctional thrombo-resistant coatings and methods of manufacture 失效
标题翻译：多功能抗血栓涂层及其制造方法
公开(公告)号：US5182317A
公开(公告)日：1993-01-26
申请号：US716843
申请日：1991-06-17
申请人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
发明人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
IPC分类号： A61L33/00 , A61M1/16 , A61M1/36
CPC分类号： A61M1/1678 , A61L33/0029 , A61L33/0047 , A61M1/3673 , A61M1/1698 , Y10S530/812 , Y10S530/815 , Y10S530/816
摘要： The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The method of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.
摘要翻译：本发明涉及用于生物医学装置和植入物的多功能抗血栓涂层，例如包含多个胺官能团已经键合在其上的硅氧烷表面的涂层。与胺官能团共价连接的是多个聚（环氧乙烷）链，使得单个聚（环氧乙烷）链与单个胺官能团结合。设计用于抵消特定血液 - 物质不相容性反应的多种不同的生物活性分子共价键合到聚（环氧乙烷）链，使得单个生物活性分子与单个聚环氧乙烷链偶联。制造本发明的方法包括制备具有多个胺官能团已经结合的硅氧烷表面的材料。这是通过用氨气等离子体蚀刻或通过在氨气存在下的硅氧烷单体的等离子体聚合来实现的。含胺的硅氧烷表面与聚硅氧烷表面上与胺基反应的官能团封端的聚（环氧乙烷）链反应。然后将该材料与多种不同的生物活性分子反应，所述生物活性分子抵消特定的血液 - 材料不相容性反应，使得单个生物活性分子与单个聚（环氧乙烷）链偶联。所得的硅氧烷表面含有多个不同的生物活性分子，能够与靠近硅氧烷表面的血液成分反应，以抵抗血液 - 物质不相容反应。

2. 发明授权

US5125902A Sheath/obturator to facilitate insertion of medical devices into a patient's venous system 失效
标题翻译：护理人员将医疗器械插入患者的静脉系统
公开(公告)号：US5125902A
公开(公告)日：1992-06-30
申请号：US488285
申请日：1990-03-02
申请人： Gaylord L. Berry , J. D. Mortensen , Mitchell D. Baldwin , Larry D. Rigby
发明人： Gaylord L. Berry , J. D. Mortensen , Mitchell D. Baldwin , Larry D. Rigby
IPC分类号： A61M1/18 , A61M1/14 , A61M1/16 , A61M25/06 , A61M25/08
CPC分类号： A61M25/0662 , A61M1/1678 , A61M1/1698
摘要： A sheath and obturator is provided for facilitating the insertion of certain medical devices into a patient's vascular system, a vein, or venous system and in particular an in vivo extrapulmonary blood gas exchange device having a bundle comprised of a plurality of elongated gas permeable tubes being potted at each end and enclosed within a respective air tight proximal and distal chamber. The sheath is hollow and substantially tubular with a tapered receiving portion and a nontapered, curved entry portion. The obturator has a tip at the distal end of the obturator and a trip at the proximal end with an elongate member therebetween. The sheath is configured to receive the obturator in sliding engagement such that when the obturator is fully inserted within the sheath, the tip closes the opening at the entry end of the sheath and protrudes slightly therefrom. The obturator has a vent which provides a passage from space exterior to the sheath into the hollow interior of the sheath. The sheath and obturator are inserted into the patient through a single incision. Upon removal of the obturator from the sheath, a extrapulmonary blood gas exchange device may be inserted into and through the sheath into one of the right external iliac, common femoral or internal jugular veins, and then into the vena cavae where the elongate gas permeable tubes may be deployed for blood oxygenation.
摘要翻译：提供护套和闭塞器，以便于将某些医疗装置插入到患者的血管系统，静脉或静脉系统中，特别是体内肺外血液气体交换装置，其具有由多个细长的气体可渗透管组成的束，在每个端部盆盖并封闭在相应的气密近端和远端室内。护套是中空的并且基本上是管状的，具有锥形接收部分和无钳子的弯曲入口部分。闭塞器在封闭器的远端处具有尖端，并且在近端处具有在其间的细长构件的跳闸。护套构造成接收滑动接合的闭孔器，使得当闭孔器完全插入护套内时，尖端封闭护套入口端处的开口并稍微突出。封闭器具有通气口，其提供从外部空间到护套的通道到护套的中空内部。鞘和闭孔器通过单个切口插入患者体内。在从鞘中取出闭孔器之后，可以将肺外血液气体交换装置插入并穿过皮套进入右外髂骨，普通股或颈内静脉中的一个，然后进入腔静脉，其中细长的气体可渗透管可以部署用于血氧合。

3. 发明授权

US06936222B2 Methods, apparatuses, and applications for compliant membrane blood gas exchangers 有权
标题翻译：用于顺应性膜血气换气器的方法，装置和应用
公开(公告)号：US06936222B2
公开(公告)日：2005-08-30
申请号：US10244181
申请日：2002-09-13
申请人： J. D Mortensen , Robert N. Schaap , Barry Bagley
发明人： J. D Mortensen , Robert N. Schaap , Barry Bagley
IPC分类号： A61M1/16 , A61M1/36 , A61M37/00
CPC分类号： A61M1/16 , A61M1/1625 , A61M1/1698 , Y10S128/03 , Y10S261/28
摘要： A compliant blood gas exchanger is provided including a housing having a first end cap, a second end cap, and an elastomeric sidewall or sleeve extending there between forming a chamber. A hollow fiber assembly is disposed in the chamber. The hollow fiber assembly has a first mounting collar, a second mounting collar and a plurality of hollow fibers disposed there between. The first end cap is disposed in communication with the first mounting collar and the second end cap is disposed in communication with the second mounting collar. The end caps are connected to a gas inlet and a gas outlet. The chamber is in communication with a blood inlet and a blood outlet. The elastomeric sidewall is responsive to internal and external pressures affecting the chamber. The first chamber can also be placed adjacent to a second chamber and both chambers placed within a rigid outer housing. Thus, a dual-chamber pulsatile blood gas exchanger can be provided. That is, the second chamber may be in connection with a pump mechanism or vacuum mechanism such that the chamber creates a pulsatile flow within the first chamber.
摘要翻译：提供了一种兼容的血液气体交换器，其包括具有第一端盖，第二端盖和在其之间延伸形成腔室的弹性体侧壁或套管的壳体。中空纤维组件设置在腔室中。中空纤维组件具有第一安装套环，第二安装环和布置在其间的多个中空纤维。第一端盖设置成与第一安装轴环连通，并且第二端盖设置成与第二安装轴环连通。端盖连接到气体入口和气体出口。腔室与血液入口和血液出口连通。弹性体侧壁响应影响腔室的内部和外部压力。第一室也可以放置在第二室附近，并且两个室都放置在刚性外壳内。因此，可以提供双室脉动血液换气器。也就是说，第二室可以与泵机构或真空机构连接，使得室在第一室内产生脉动流。

4. 发明授权

US5230862A Apparatus for extracorporeal blood oxygenation 失效
标题翻译：用于提取血液氧化的装置
公开(公告)号：US5230862A
公开(公告)日：1993-07-27
申请号：US746785
申请日：1991-08-16
申请人： Gaylord Berry , Shigemasa Osaki , J. D. Mortensen
发明人： Gaylord Berry , Shigemasa Osaki , J. D. Mortensen
IPC分类号： A61M1/18 , B01D63/02
CPC分类号： B01D63/02 , B01D63/021 , B01D63/025 , B01D63/027 , B01D2313/16 , B01D2319/06
摘要： An extracorporeal blood oxygenation device having a sealed casing containing a bundle comprised of a plurality of gas permeable tubes for efficient gas transfer. The bundle is woven from tubes having at least two different sizes, at least the smaller diameter tubes being gas permeable. The tubes are relatively non-thrombogenic and are open at each end to an enclosed annular chamber having attached input and output fittings. Oxygen-rich gas flows into one annular chamber through an input fitting before flowing through the gas permeable tubes. Venous blood to be oxygenated is introduced into the sealed casing directly into the center of the bundle for dispersement radially outward through the bundle and across the gas permeable tubes wherein the blood comes in contact with the membrane surface of the gas permeable tubes and exchanges carbon dioxide for oxygen across that surface before being collected from around the perimeter of the bundle for return to the patient.
摘要翻译：一种体外血液充氧装置，其具有密封壳体，该壳体包含由多个用于有效气体转移的透气管组成的束。该束由具有至少两种不同尺寸的管织成，至少较小直径的管是气体可透过的。管相对非血栓形成，并且在每个端部处开放到具有附接的输入和输出配件的封闭环形室。富氧气体在流过气体可渗透管之前通过输入配件流入一个环形室。要充氧的静脉血被直接引入密封外壳的中心，用于通过束径向向外穿过束并穿过透气管，其中血液与透气管的膜表面接触并交换二氧化碳在从束的周边收集之前将氧气穿过该表面返回到患者。

5. 发明授权

US4173981A Cannula for arterial and venous bypass cannulation 失效
标题翻译：插管用于动脉和静脉旁路插管
公开(公告)号：US4173981A
公开(公告)日：1979-11-13
申请号：US799418
申请日：1977-05-23
申请人： J. D. Mortensen
发明人： J. D. Mortensen
IPC分类号： A61M1/36 , A61M25/00
CPC分类号： A61M25/007 , A61M1/3659 , A61M25/0021 , A61M25/005
摘要： A cannula suitable for total bypass procedures in arterial and venous cannulation for extracorporeal perfusion of blood. The cannula has a tapered body of sufficient length for peripheral cannulation and openings through the cannula wall appropriately positioned to provide fluid transfer at various anatomical diversion sites within a patient's circulatory system in accordance with flow requirements necessary to maintain proper circulation is disclosed. The cannula structure can be adapted for bidirectional as well as unidirectional flow to maintain circulation in extremities otherwise ignored by single-directional flow cannulation. Reinforcing structure is disclosed for developing the required strength characteristics for the cannula wall, particularly for arterial applications.
摘要翻译：适用于动脉和静脉插管中用于体外灌注血液的总旁路手术的插管。套管具有足够长度的锥形体，用于外周插管，并且通过套管壁的开口适当定位，以根据维持适当循环所需的流动要求在患者的循环系统内的各种解剖学转向位置处提供流体转移。套管结构可以适用于双向和单向流动，以保持四肢中的循环，否则由单向流动插管所忽略。公开了加强结构，用于显示套管壁所需的强度特性，特别是对于动脉应用。

6. 发明授权

US5342693A Multifunctional thrombo-resistant coating and methods of manufacture 失效
标题翻译：多功能抗血栓涂层及其制造方法
公开(公告)号：US5342693A
公开(公告)日：1994-08-30
申请号：US35426
申请日：1993-03-22
申请人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
发明人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
IPC分类号： A61L33/00 , A61M1/16 , A61M1/36 , B32B27/06 , A01N1/00
CPC分类号： A61M1/1678 , A61L33/0029 , A61L33/0047 , A61M1/3673 , A61M1/1698 , Y10S530/812 , Y10S530/815 , Y10S530/816 , Y10T428/31663 , Y10T428/31667
摘要： The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.
摘要翻译：本发明涉及用于生物医学装置和植入物的多功能抗血栓涂层，例如包含多个胺官能团已经键合在其上的硅氧烷表面的涂层。与胺官能团共价连接的是多个聚（环氧乙烷）链，使得单个聚（环氧乙烷）链与单个胺官能团结合。设计用于抵消特定血液 - 物质不相容性反应的多种不同的生物活性分子共价键合到聚（环氧乙烷）链，使得单个生物活性分子与单个聚环氧乙烷链偶联。制造本发明的方法包括制备具有多个胺官能团已经结合到其上的具有硅氧烷表面的材料。这是通过用氨气等离子体蚀刻或通过在氨气存在下的硅氧烷单体的等离子体聚合来实现的。含胺的硅氧烷表面与聚硅氧烷表面上与胺基反应的官能团封端的聚（环氧乙烷）链反应。然后将该材料与多种不同的生物活性分子反应，所述生物活性分子抵消特定的血液 - 材料不相容性反应，使得单个生物活性分子与单个聚（环氧乙烷）链偶联。所得的硅氧烷表面含有多个不同的生物活性分子，能够与靠近硅氧烷表面的血液成分反应，以抵抗血液 - 物质不相容反应。

7. 发明授权

US5262451A Multifunctional thrombo-resistant coatings and methods of manufacture 失效
标题翻译：多功能抗血栓涂层及其制造方法
公开(公告)号：US5262451A
公开(公告)日：1993-11-16
申请号：US215014
申请日：1988-07-05
申请人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
发明人： Suzanne Winters , Kenneth A. Solen , Clifton G. Sanders , J. D. Mortensen , Gaylord Berry
IPC分类号： A61L33/10 , A61L33/00 , A61M1/16 , A61M1/36 , B01D67/00 , B01D69/12 , C12N11/06 , A01N1/00
CPC分类号： A61L33/0047 , A61L33/0005 , A61L33/0029 , A61L33/0094 , A61M1/1678 , A61M1/3673 , B01D67/009 , B01D67/0093 , B01D69/127 , C12N11/06 , A61M1/1698 , A61M2205/04 , B01D2323/30 , Y10S530/812 , Y10S530/815 , Y10S530/816
摘要： The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.
摘要翻译：本发明涉及用于生物医学装置和植入物的多功能抗血栓涂层，例如包含多个胺官能团已经键合在其上的硅氧烷表面的涂层。与胺官能团共价连接的是多个聚（环氧乙烷）链，使得单个聚（环氧乙烷）链与单个胺官能团结合。设计用于抵消特定血液 - 物质不相容性反应的多种不同的生物活性分子共价键合到聚（环氧乙烷）链，使得单个生物活性分子与单个聚环氧乙烷链偶联。制造本发明的方法包括制备具有多个胺官能团已经结合到其上的具有硅氧烷表面的材料。这是通过用氨气等离子体蚀刻或通过在氨气存在下的硅氧烷单体的等离子体聚合来实现的。含胺的硅氧烷表面与聚硅氧烷表面上与胺基反应的官能团封端的聚（环氧乙烷）链反应。然后将该材料与多种不同的生物活性分子反应，所述生物活性分子抵消特定的血液 - 材料不相容性反应，使得单个生物活性分子与单个聚（环氧乙烷）链偶联。所得的硅氧烷表面含有多个不同的生物活性分子，能够与靠近硅氧烷表面的血液成分反应，以抵抗血液 - 物质不相容反应。

8. 发明授权

US4583969A Apparatus and method for in vivo extrapulmonary blood gas exchange 失效
标题翻译：用于体内肺外血液气体交换的装置和方法
公开(公告)号：US4583969A
公开(公告)日：1986-04-22
申请号：US624627
申请日：1984-06-26
申请人： J. D. Mortensen
发明人： J. D. Mortensen
IPC分类号： A61M1/00 , A61M1/14 , A61M1/16 , A61M1/18 , A61M37/00 , A61M3/00
CPC分类号： A61M1/1678 , H04W52/241 , H04W52/248 , A61M1/1698
摘要： A method and apparatus for the in vivo oxygenation of blood without using or disturbing the patient's lungs. The apparatus comprises a plurality of small diameter gas permeable tubes connected to headers at each end. The headers in turn are connected on one end to a source of oxygen rich gas and on the other end to an exhaust means. The apparatus is positioned within the circulatory system of a patient. Particularly, an incision is made in the patient's femoral or iliac vein and the apparatus is threaded through the venae cavae and eventually out an incision in the patient's jugular vein. Both headers are positioned so that a source of oxygen rich gas can be attached and the gas circulated through the device.
摘要翻译：一种用于血液体内氧合而不使用或扰乱患者肺部的方法和装置。该装置包括在每一端连接到集管的多个小直径的气体可渗透管。集管又一端连接到富氧气体源，另一端连接到排气装置。该装置位于患者的循环系统内。特别地，在患者的股骨或髂静脉中进行切口，并且将装置穿过静脉卡塞并且最终在患者的颈静脉中切开切口。这两个集管被定位成使得可以连接富氧气体源，并且气体通过该装置循环。

9. 发明授权

US5098376A Apparatus and methods for furling and introducing an extrapulmonary blood gas exchange device 失效
标题翻译：用于肛门造口术和引进外科手术气体交换装置的装置及方法
公开(公告)号：US5098376A
公开(公告)日：1992-03-24
申请号：US454773
申请日：1989-12-22
申请人： Gaylord L. Berry , J. D. Mortensen , Mitchell D. Baldwin
发明人： Gaylord L. Berry , J. D. Mortensen , Mitchell D. Baldwin
IPC分类号： A61F2/02 , A61M1/16 , A61M25/01 , A61M37/00
CPC分类号： A61M25/01 , A61M1/1678 , A61M1/1698
摘要： An in vivo extrapulmonary blood gas exchange device is disclosed having a hollow fiber bundle in gaseous communication with a coaxial dual lumen tube and having a furling apparatus for twisting one coaxial lumen relative to the other. The furling apparatus enables the outside diameter of the bundle of gas permeable tubes to be selectively adjusted to provide either a furled, small insertion diameter when inserting the apparatus into the venae cavae of a patient or an unfurled, expanded oxygenation diameter after the apparatus is in place within the venae cavae and the bundle of gas permeable tubes is deployed therein. The oxygenator is inserted into the patient through a single incision at one of the right external iliac, common femoral, or internal jugular veins. A novel distal tip configuration permits the oxygenator to be inserted into the patient utilizing an over-the-guidewire intravascular insertion technique.
摘要翻译：公开了一种体内肺外血液气体交换装置，其具有与同轴双腔管气体连通的中空纤维束，并具有用于相对于另一个共轴管腔扭转一个同轴管腔的卷装装置。该装置能够选择性地调节气体可渗透管束的外径，以便在装置进入装置之后将装置插入患者的静脉卡瓦或展开的扩张氧合直径时提供卷曲的小插入直径将其放置在静脉内，将可透气管束捆在其中。通过在右外髂骨，普通股或颈内静脉中的一个单一切口将氧合器插入患者体内。一种新颖的远端尖端构造允许使用超导线血管内插入技术将氧合器插入患者体内。

10. 发明授权

US4850958A Apparatus and method for extrapulmonary blood gas exchange 失效
标题翻译：用于肺外血液气体交换的装置和方法
公开(公告)号：US4850958A
公开(公告)日：1989-07-25
申请号：US204115
申请日：1988-06-08
申请人： Gaylord Berry , J. D. Mortensen , Larry D. Rigby
发明人： Gaylord Berry , J. D. Mortensen , Larry D. Rigby
IPC分类号： A61M1/14 , A61M1/16 , A61M1/18 , A61M1/36
CPC分类号： A61M1/1678 , A61M1/3673 , A61M1/1698
摘要： An in vivo extrapulmonary blood gas exchange device having a bundle comprised of a plurality of elongated gas permeable tubes being bound at each end and enclosed within a respective air tight proximal and distal chamber. A dual lumen tube having an outer lumen and an inner lumen is situated relative to the gas permeable tubes such that the outer lumen terminates within the proximal chamber and such that the inner lumen terminates within the distal chamber. The apparatus includes means for selectively adjusting the overall, outside diameter of the bundle of gas permeable tubes to provide either a furled, small insertion diameter when inserting the apparatus into the venae cavae of a patient or an unfurled, expanded oxygenation diameter after the apparatus is in place within the venae cavae and the bundle of gas permeable tubes is deployed therein. The apparatus is inserted into the patient through a single incision at one of the right external iliac, common femoral or internal jugular veins. A plurality of crimps along the length of the gas permeable tubes maintain the tubes in a spaced relation one from another such that blood surface contact with the gas permeable tubes is maximized, disturbed flow of blood over the tubes is achieved and laminar blood flow between and around the gas permeable tubes is inhibited.
摘要翻译：一种体内肺外血液气体交换装置，其具有由多个细长的气体可渗透管组成的束，每个端部被结合并封闭在相应的气密近端和远端腔室内。具有外腔和内腔的双腔管相对于气体可渗透管定位，使得外腔终止于近端腔室内，并且使得内腔终止于远侧腔室内。该装置包括用于选择性地调整气体可透过管束的整体外径的装置，以便在将装置插入患者的静脉卡瓦后或在装置为在静脉内部的适当位置，并且在其中部署可透气管束。该装置通过在右外髂骨，普通股或颈内静脉中的一个上的单个切口插入患者体内。沿着气体可渗透管的长度的多个卷曲保持管彼此间隔开的关系，使得与透气管的血液表面接触最大化，使血液在管上的扰动流动被实现，层流血流在气体可渗透管周围被抑制。

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